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P16370

- RPB3_YEAST

UniProt

P16370 - RPB3_YEAST

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Protein

DNA-directed RNA polymerase II subunit RPB3

Gene
RPB3, YIL021W
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB3 is part of the core element with the central large cleft and the clamp element that moves to open and close the cleft. Seems to be involved in transcription termination.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi86 – 861Zinc
Metal bindingi88 – 881Zinc
Metal bindingi92 – 921Zinc
Metal bindingi95 – 951Zinc

GO - Molecular functioni

  1. DNA binding Source: InterPro
  2. DNA-directed RNA polymerase activity Source: UniProtKB-KW
  3. metal ion binding Source: UniProtKB-KW
  4. protein binding Source: IntAct

GO - Biological processi

  1. termination of RNA polymerase II transcription Source: SGD
  2. transcription, RNA-templated Source: GOC
  3. transcription from RNA polymerase II promoter Source: SGD
Complete GO annotation...

Keywords - Biological processi

Transcription

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciYEAST:G3O-31296-MONOMER.
ReactomeiREACT_191540. mRNA Splicing - Minor Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA-directed RNA polymerase II subunit RPB3
Short name:
RNA polymerase II subunit 3
Short name:
RNA polymerase II subunit B3
Alternative name(s):
B44.5
DNA-directed RNA polymerase II 45 kDa polypeptide
Gene namesi
Name:RPB3
Ordered Locus Names:YIL021W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome IX

Organism-specific databases

CYGDiYIL021w.
SGDiS000001283. RPB3.

Subcellular locationi

GO - Cellular componenti

  1. DNA-directed RNA polymerase II, core complex Source: SGD
  2. nucleoplasm Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

DNA-directed RNA polymerase, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi9 – 91K → E: Transcript termination readthrough. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 318317DNA-directed RNA polymerase II subunit RPB3PRO_0000132748Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserine1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiP16370.
PaxDbiP16370.
PeptideAtlasiP16370.

Expressioni

Gene expression databases

GenevestigatoriP16370.

Interactioni

Subunit structurei

Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits.

Binary interactionsi

WithEntry#Exp.IntActNotes
RPB11P389024EBI-15773,EBI-15806
RPB2P085185EBI-15773,EBI-15767

Protein-protein interaction databases

BioGridi34967. 194 interactions.
DIPiDIP-837N.
IntActiP16370. 32 interactions.
MINTiMINT-613688.
STRINGi4932.YIL021W.

Structurei

Secondary structure

1
318
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi5 – 73
Beta strandi11 – 133
Beta strandi15 – 184
Beta strandi21 – 255
Helixi27 – 3913
Beta strandi43 – 5412
Beta strandi56 – 583
Helixi60 – 689
Beta strandi72 – 743
Helixi77 – 793
Turni83 – 853
Beta strandi86 – 905
Turni93 – 953
Beta strandi96 – 1049
Beta strandi107 – 1093
Beta strandi111 – 1144
Helixi115 – 1173
Beta strandi118 – 1203
Beta strandi128 – 1325
Beta strandi137 – 1393
Beta strandi142 – 1476
Beta strandi152 – 16211
Turni164 – 1663
Helixi168 – 1703
Beta strandi173 – 1808
Helixi184 – 1863
Helixi197 – 2004
Helixi205 – 2073
Beta strandi208 – 2103
Beta strandi215 – 2173
Beta strandi228 – 2347
Beta strandi236 – 2383
Helixi240 – 26526

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1I3QX-ray3.10C1-318[»]
1I50X-ray2.80C1-318[»]
1I6HX-ray3.30C1-318[»]
1K83X-ray2.80C1-318[»]
1NIKX-ray4.10C1-318[»]
1NT9X-ray4.20C1-318[»]
1PQVX-ray3.80C1-318[»]
1R5UX-ray4.50C1-318[»]
1R9SX-ray4.25C1-318[»]
1R9TX-ray3.50C1-318[»]
1SFOX-ray3.61C1-318[»]
1TWAX-ray3.20C1-318[»]
1TWCX-ray3.00C1-318[»]
1TWFX-ray2.30C1-318[»]
1TWGX-ray3.30C1-318[»]
1TWHX-ray3.40C1-318[»]
1WCMX-ray3.80C1-318[»]
1Y1VX-ray3.80C1-318[»]
1Y1WX-ray4.00C1-318[»]
1Y1YX-ray4.00C1-318[»]
1Y77X-ray4.50C1-318[»]
2B63X-ray3.80C1-318[»]
2B8KX-ray4.15C1-318[»]
2E2HX-ray3.95C1-318[»]
2E2IX-ray3.41C1-318[»]
2E2JX-ray3.50C1-318[»]
2JA5X-ray3.80C1-318[»]
2JA6X-ray4.00C1-318[»]
2JA7X-ray3.80C/O1-318[»]
2JA8X-ray3.80C1-318[»]
2NVQX-ray2.90C1-318[»]
2NVTX-ray3.36C1-318[»]
2NVXX-ray3.60C1-318[»]
2NVYX-ray3.40C1-318[»]
2NVZX-ray4.30C1-318[»]
2R7ZX-ray3.80C1-318[»]
2R92X-ray3.80C1-318[»]
2R93X-ray4.00C1-318[»]
2VUMX-ray3.40C1-318[»]
2YU9X-ray3.40C1-318[»]
3CQZX-ray2.80C1-318[»]
3FKIX-ray3.88C1-318[»]
3GTGX-ray3.78C1-318[»]
3GTJX-ray3.42C1-318[»]
3GTKX-ray3.80C1-318[»]
3GTLX-ray3.38C1-318[»]
3GTMX-ray3.80C1-318[»]
3GTOX-ray4.00C1-318[»]
3GTPX-ray3.90C1-318[»]
3GTQX-ray3.80C1-318[»]
3H3VX-ray4.00D1-318[»]
3HOUX-ray3.20C/O1-318[»]
3HOVX-ray3.50C1-318[»]
3HOWX-ray3.60C2-318[»]
3HOXX-ray3.65C2-318[»]
3HOYX-ray3.40C2-318[»]
3HOZX-ray3.65C2-318[»]
3I4MX-ray3.70C1-318[»]
3I4NX-ray3.90C1-318[»]
3J0Kelectron microscopy36.00C1-268[»]
3J1Nelectron microscopy16.00C1-268[»]
3K1FX-ray4.30C1-318[»]
3K7AX-ray3.80C1-318[»]
3M3YX-ray3.18C1-318[»]
3M4OX-ray3.57C1-318[»]
3PO2X-ray3.30C1-318[»]
3PO3X-ray3.30C1-318[»]
3QT1X-ray4.30C1-318[»]
3RZDX-ray3.30C1-318[»]
3RZOX-ray3.00C1-318[»]
3S14X-ray2.85C1-318[»]
3S15X-ray3.30C1-318[»]
3S16X-ray3.24C1-318[»]
3S17X-ray3.20C1-318[»]
3S1MX-ray3.13C1-318[»]
3S1NX-ray3.10C1-318[»]
3S1QX-ray3.30C1-318[»]
3S1RX-ray3.20C1-318[»]
3S2DX-ray3.20C1-318[»]
3S2HX-ray3.30C1-318[»]
4A3BX-ray3.50C1-318[»]
4A3CX-ray3.50C1-318[»]
4A3DX-ray3.40C1-318[»]
4A3EX-ray3.40C1-318[»]
4A3FX-ray3.50C1-318[»]
4A3GX-ray3.50C1-318[»]
4A3IX-ray3.80C1-318[»]
4A3JX-ray3.70C1-318[»]
4A3KX-ray3.50C1-318[»]
4A3LX-ray3.50C1-318[»]
4A3MX-ray3.90C1-318[»]
4A93X-ray3.40C1-318[»]
4BBRX-ray3.40C1-318[»]
4BBSX-ray3.60C1-318[»]
4BXXX-ray3.28C1-318[»]
4BXZX-ray4.80C1-318[»]
4BY1X-ray3.60C1-318[»]
4BY7X-ray3.15C1-318[»]
ProteinModelPortaliP16370.
SMRiP16370. Positions 3-268.

Miscellaneous databases

EvolutionaryTraceiP16370.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0202.
GeneTreeiENSGT00640000091532.
HOGENOMiHOG000230844.
KOiK03011.
OMAiHTDYWYE.
OrthoDBiEOG776T14.

Family and domain databases

Gene3Di2.170.120.12. 1 hit.
InterProiIPR001514. DNA-dir_RNA_pol_30-40kDasu_CS.
IPR011262. DNA-dir_RNA_pol_insert.
IPR011263. DNA-dir_RNA_pol_RpoA/D/Rpb3.
IPR009025. RBP11-like_dimer.
[Graphical view]
PfamiPF01000. RNA_pol_A_bac. 1 hit.
PF01193. RNA_pol_L. 1 hit.
[Graphical view]
SMARTiSM00662. RPOLD. 1 hit.
[Graphical view]
SUPFAMiSSF55257. SSF55257. 1 hit.
SSF56553. SSF56553. 1 hit.
PROSITEiPS00446. RNA_POL_D_30KD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P16370-1 [UniParc]FASTAAdd to Basket

« Hide

MSEEGPQVKI REASKDNVDF ILSNVDLAMA NSLRRVMIAE IPTLAIDSVE    50
VETNTTVLAD EFIAHRLGLI PLQSMDIEQL EYSRDCFCED HCDKCSVVLT 100
LQAFGESEST TNVYSKDLVI VSNLMGRNIG HPIIQDKEGN GVLICKLRKG 150
QELKLTCVAK KGIAKEHAKW GPAAAIEFEY DPWNKLKHTD YWYEQDSAKE 200
WPQSKNCEYE DPPNEGDPFD YKAQADTFYM NVESVGSIPV DQVVVRGIDT 250
LQKKVASILL ALTQMDQDKV NFASGDNNTA SNMLGSNEDV MMTGAEQDPY 300
SNASQMGNTG SGGYDNAW 318
Length:318
Mass (Da):35,298
Last modified:February 1, 1995 - v2
Checksum:i8E1D1E6BB7B51D89
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti30 – 301A → D in mutant RPB3-1.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti175 – 1751A → G in AAA34889. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z46881 Genomic DNA. Translation: CAA86971.1.
M27496 Genomic DNA. Translation: AAA34889.1.
BK006942 Genomic DNA. Translation: DAA08524.1.
PIRiS49961.
RefSeqiNP_012243.3. NM_001179371.3.

Genome annotation databases

EnsemblFungiiYIL021W; YIL021W; YIL021W.
GeneIDi854791.
KEGGisce:YIL021W.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z46881 Genomic DNA. Translation: CAA86971.1 .
M27496 Genomic DNA. Translation: AAA34889.1 .
BK006942 Genomic DNA. Translation: DAA08524.1 .
PIRi S49961.
RefSeqi NP_012243.3. NM_001179371.3.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1I3Q X-ray 3.10 C 1-318 [» ]
1I50 X-ray 2.80 C 1-318 [» ]
1I6H X-ray 3.30 C 1-318 [» ]
1K83 X-ray 2.80 C 1-318 [» ]
1NIK X-ray 4.10 C 1-318 [» ]
1NT9 X-ray 4.20 C 1-318 [» ]
1PQV X-ray 3.80 C 1-318 [» ]
1R5U X-ray 4.50 C 1-318 [» ]
1R9S X-ray 4.25 C 1-318 [» ]
1R9T X-ray 3.50 C 1-318 [» ]
1SFO X-ray 3.61 C 1-318 [» ]
1TWA X-ray 3.20 C 1-318 [» ]
1TWC X-ray 3.00 C 1-318 [» ]
1TWF X-ray 2.30 C 1-318 [» ]
1TWG X-ray 3.30 C 1-318 [» ]
1TWH X-ray 3.40 C 1-318 [» ]
1WCM X-ray 3.80 C 1-318 [» ]
1Y1V X-ray 3.80 C 1-318 [» ]
1Y1W X-ray 4.00 C 1-318 [» ]
1Y1Y X-ray 4.00 C 1-318 [» ]
1Y77 X-ray 4.50 C 1-318 [» ]
2B63 X-ray 3.80 C 1-318 [» ]
2B8K X-ray 4.15 C 1-318 [» ]
2E2H X-ray 3.95 C 1-318 [» ]
2E2I X-ray 3.41 C 1-318 [» ]
2E2J X-ray 3.50 C 1-318 [» ]
2JA5 X-ray 3.80 C 1-318 [» ]
2JA6 X-ray 4.00 C 1-318 [» ]
2JA7 X-ray 3.80 C/O 1-318 [» ]
2JA8 X-ray 3.80 C 1-318 [» ]
2NVQ X-ray 2.90 C 1-318 [» ]
2NVT X-ray 3.36 C 1-318 [» ]
2NVX X-ray 3.60 C 1-318 [» ]
2NVY X-ray 3.40 C 1-318 [» ]
2NVZ X-ray 4.30 C 1-318 [» ]
2R7Z X-ray 3.80 C 1-318 [» ]
2R92 X-ray 3.80 C 1-318 [» ]
2R93 X-ray 4.00 C 1-318 [» ]
2VUM X-ray 3.40 C 1-318 [» ]
2YU9 X-ray 3.40 C 1-318 [» ]
3CQZ X-ray 2.80 C 1-318 [» ]
3FKI X-ray 3.88 C 1-318 [» ]
3GTG X-ray 3.78 C 1-318 [» ]
3GTJ X-ray 3.42 C 1-318 [» ]
3GTK X-ray 3.80 C 1-318 [» ]
3GTL X-ray 3.38 C 1-318 [» ]
3GTM X-ray 3.80 C 1-318 [» ]
3GTO X-ray 4.00 C 1-318 [» ]
3GTP X-ray 3.90 C 1-318 [» ]
3GTQ X-ray 3.80 C 1-318 [» ]
3H3V X-ray 4.00 D 1-318 [» ]
3HOU X-ray 3.20 C/O 1-318 [» ]
3HOV X-ray 3.50 C 1-318 [» ]
3HOW X-ray 3.60 C 2-318 [» ]
3HOX X-ray 3.65 C 2-318 [» ]
3HOY X-ray 3.40 C 2-318 [» ]
3HOZ X-ray 3.65 C 2-318 [» ]
3I4M X-ray 3.70 C 1-318 [» ]
3I4N X-ray 3.90 C 1-318 [» ]
3J0K electron microscopy 36.00 C 1-268 [» ]
3J1N electron microscopy 16.00 C 1-268 [» ]
3K1F X-ray 4.30 C 1-318 [» ]
3K7A X-ray 3.80 C 1-318 [» ]
3M3Y X-ray 3.18 C 1-318 [» ]
3M4O X-ray 3.57 C 1-318 [» ]
3PO2 X-ray 3.30 C 1-318 [» ]
3PO3 X-ray 3.30 C 1-318 [» ]
3QT1 X-ray 4.30 C 1-318 [» ]
3RZD X-ray 3.30 C 1-318 [» ]
3RZO X-ray 3.00 C 1-318 [» ]
3S14 X-ray 2.85 C 1-318 [» ]
3S15 X-ray 3.30 C 1-318 [» ]
3S16 X-ray 3.24 C 1-318 [» ]
3S17 X-ray 3.20 C 1-318 [» ]
3S1M X-ray 3.13 C 1-318 [» ]
3S1N X-ray 3.10 C 1-318 [» ]
3S1Q X-ray 3.30 C 1-318 [» ]
3S1R X-ray 3.20 C 1-318 [» ]
3S2D X-ray 3.20 C 1-318 [» ]
3S2H X-ray 3.30 C 1-318 [» ]
4A3B X-ray 3.50 C 1-318 [» ]
4A3C X-ray 3.50 C 1-318 [» ]
4A3D X-ray 3.40 C 1-318 [» ]
4A3E X-ray 3.40 C 1-318 [» ]
4A3F X-ray 3.50 C 1-318 [» ]
4A3G X-ray 3.50 C 1-318 [» ]
4A3I X-ray 3.80 C 1-318 [» ]
4A3J X-ray 3.70 C 1-318 [» ]
4A3K X-ray 3.50 C 1-318 [» ]
4A3L X-ray 3.50 C 1-318 [» ]
4A3M X-ray 3.90 C 1-318 [» ]
4A93 X-ray 3.40 C 1-318 [» ]
4BBR X-ray 3.40 C 1-318 [» ]
4BBS X-ray 3.60 C 1-318 [» ]
4BXX X-ray 3.28 C 1-318 [» ]
4BXZ X-ray 4.80 C 1-318 [» ]
4BY1 X-ray 3.60 C 1-318 [» ]
4BY7 X-ray 3.15 C 1-318 [» ]
ProteinModelPortali P16370.
SMRi P16370. Positions 3-268.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 34967. 194 interactions.
DIPi DIP-837N.
IntActi P16370. 32 interactions.
MINTi MINT-613688.
STRINGi 4932.YIL021W.

Proteomic databases

MaxQBi P16370.
PaxDbi P16370.
PeptideAtlasi P16370.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YIL021W ; YIL021W ; YIL021W .
GeneIDi 854791.
KEGGi sce:YIL021W.

Organism-specific databases

CYGDi YIL021w.
SGDi S000001283. RPB3.

Phylogenomic databases

eggNOGi COG0202.
GeneTreei ENSGT00640000091532.
HOGENOMi HOG000230844.
KOi K03011.
OMAi HTDYWYE.
OrthoDBi EOG776T14.

Enzyme and pathway databases

BioCyci YEAST:G3O-31296-MONOMER.
Reactomei REACT_191540. mRNA Splicing - Minor Pathway.

Miscellaneous databases

EvolutionaryTracei P16370.
NextBioi 977585.
PROi P16370.

Gene expression databases

Genevestigatori P16370.

Family and domain databases

Gene3Di 2.170.120.12. 1 hit.
InterProi IPR001514. DNA-dir_RNA_pol_30-40kDasu_CS.
IPR011262. DNA-dir_RNA_pol_insert.
IPR011263. DNA-dir_RNA_pol_RpoA/D/Rpb3.
IPR009025. RBP11-like_dimer.
[Graphical view ]
Pfami PF01000. RNA_pol_A_bac. 1 hit.
PF01193. RNA_pol_L. 1 hit.
[Graphical view ]
SMARTi SM00662. RPOLD. 1 hit.
[Graphical view ]
SUPFAMi SSF55257. SSF55257. 1 hit.
SSF56553. SSF56553. 1 hit.
PROSITEi PS00446. RNA_POL_D_30KD. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "RNA polymerase II subunit RPB3 is an essential component of the mRNA transcription apparatus."
    Kolodziej P., Young R.A.
    Mol. Cell. Biol. 9:5387-5394(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 206-223.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  5. "cis- and trans-Acting determinants of transcription termination by yeast RNA polymerase II."
    Steinmetz E.J., Ng S.B., Cloute J.P., Brow D.A.
    Mol. Cell. Biol. 26:2688-2696(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, MUTAGENESIS OF LYS-9.
  6. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
  7. "RNA polymerase II/TFIIF structure and conserved organization of the initiation complex."
    Chung W.H., Craighead J.L., Chang W.H., Ezeokonkwo C., Bareket-Samish A., Kornberg R.D., Asturias F.J.
    Mol. Cell 12:1003-1013(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: ELECTRON MICROSCOPY OF THE RNA POL II/TFIIF COMPLEX.
  8. "Structural basis of transcription: RNA polymerase II at 2.8 A resolution."
    Cramer P., Bushnell D.A., Kornberg R.D.
    Science 292:1863-1876(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF THE RNA POL II CORE COMPLEX.
  9. "Structural basis of transcription: an RNA polymerase II elongation complex at 3.3 A resolution."
    Gnatt A.L., Cramer P., Fu J., Bushnell D.A., Kornberg R.D.
    Science 292:1876-1882(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.3 ANGSTROMS) OF THE RNA POL II CORE COMPLEX.
  10. "Structural basis of transcription: alpha-amanitin-RNA polymerase II cocrystal at 2.8 A resolution."
    Bushnell D.A., Cramer P., Kornberg R.D.
    Proc. Natl. Acad. Sci. U.S.A. 99:1218-1222(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF THE RNA POL II CORE COMPLEX IN COMPLEX WITH ALPHA-AMANITIN.
  11. "Architecture of the RNA polymerase II-TFIIS complex and implications for mRNA cleavage."
    Kettenberger H., Armache K.J., Cramer P.
    Cell 114:347-357(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.8 ANGSTROMS) OF THE RNA POL II COMPLEX IN COMPLEX WITH DST1.
  12. "Architecture of initiation-competent 12-subunit RNA polymerase II."
    Armache K.J., Kettenberger H., Cramer P.
    Proc. Natl. Acad. Sci. U.S.A. 100:6964-6968(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (4.2 ANGSTROMS) OF THE RNA POL II COMPLEX.
  13. "Complete, 12-subunit RNA polymerase II at 4.1-A resolution: implications for the initiation of transcription."
    Bushnell D.A., Kornberg R.D.
    Proc. Natl. Acad. Sci. U.S.A. 100:6969-6973(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (4.1 ANGSTROMS) OF THE RNA POL II CORE COMPLEX.
  14. "Structural basis of transcription: nucleotide selection by rotation in the RNA polymerase II active center."
    Westover K.D., Bushnell D.A., Kornberg R.D.
    Cell 119:481-489(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF THE RNA POL II CORE COMPLEX.
  15. "Complete RNA polymerase II elongation complex structure and its interactions with NTP and TFIIS."
    Kettenberger H., Armache K.J., Cramer P.
    Mol. Cell 16:955-965(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (4.5 ANGSTROMS).
  16. "Structural basis of transcription: an RNA polymerase II-TFIIB cocrystal at 4.5 Angstroms."
    Bushnell D.A., Westover K.D., Davis R.E., Kornberg R.D.
    Science 303:983-988(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (4.5 ANGSTROMS) OF THE RNA POL II CORE COMPLEX.
  17. "Structures of complete RNA polymerase II and its subcomplex, Rpb4/7."
    Armache K.J., Mitterweger S., Meinhart A., Cramer P.
    J. Biol. Chem. 280:7131-7134(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.8 ANGSTROMS) OF THE RNA POL II COMPLEX.
  18. "Structure of an RNA polymerase II-RNA inhibitor complex elucidates transcription regulation by noncoding RNAs."
    Kettenberger H., Eisenfuhr A., Brueckner F., Theis M., Famulok M., Cramer P.
    Nat. Struct. Mol. Biol. 13:44-48(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.8 ANGSTROMS) OF THE RNA POL II COMPLEX IN COMPLEX WITH INHIBITING NON-CODING RNA.
  19. "Phasing RNA polymerase II using intrinsically bound Zn atoms: an updated structural model."
    Meyer P.A., Ye P., Zhang M., Suh M.H., Fu J.
    Structure 14:973-982(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (4.15 ANGSTROMS) OF THE RNA POL II COMPLEX.

Entry informationi

Entry nameiRPB3_YEAST
AccessioniPrimary (citable) accession number: P16370
Secondary accession number(s): D6VVQ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: February 1, 1995
Last modified: September 3, 2014
This is version 151 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 10000 molecules/cell in log phase SD medium.

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome IX
    Yeast (Saccharomyces cerevisiae) chromosome IX: entries and gene names

External Data

Dasty 3

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