P16366 (CYB_HYPNI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cytochrome b

Alternative name(s):
Complex III subunit 3
Complex III subunit III
Cytochrome b-c1 complex subunit 3
Ubiquinol-cytochrome-c reductase complex cytochrome b subunit

Gene names

Name:	mt-cyb
Synonyms:	cob, cytb, mtcyb

Encoded on

Mitochondrion

Organism

Hypsophrys nicaraguensis (Moga) (Cichlasoma nicaraguense)

Taxonomic identifier

131240 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Actinopterygii › Actinopteri › Neopterygii › Teleostei › Elopocephala › Clupeocephala › Euteleostei › Neognathi › Neoteleostei › Eurypterygii › Ctenosquamata › Acanthomorpha › Euacanthomorpha › Holacanthopterygii › Acanthopterygii › Euacanthopterygii › Percomorpha › Perciformes › Labroidei › Cichlidae › New World cichlids › Cichlasomatinae › Cichlasomatini › Hypsophrys

Protein attributes

Sequence length	79 AA.
Sequence status	Fragment.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis By similarity.
Cofactor	Binds 2 heme groups non-covalently By similarity.
Subunit structure	The main subunits of complex b-c1 are: cytochrome b, cytochrome c1 and the Rieske protein By similarity.
Subcellular location	Mitochondrion inner membrane; Multi-pass membrane protein By similarity.
Miscellaneous	Heme 1 (or BL or b562) is low-potential and absorbs at about 562 nm, and heme 2 (or BH or b566) is high-potential and absorbs at about 566 nm By similarity.
Sequence similarities	Belongs to the cytochrome b family.

Ontologies

Keywords
Biological process	Electron transport Respiratory chain Transport
Cellular component	Membrane Mitochondrion Mitochondrion inner membrane
Domain	Transmembrane Transmembrane helix
Ligand	Heme Iron Metal-binding
Gene Ontology (GO)
Biological_process	respiratory electron transport chain Inferred from electronic annotation. Source: InterPro
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW mitochondrial inner membrane Inferred from electronic annotation. Source: UniProtKB-SubCell respiratory chain Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	electron carrier activity Inferred from electronic annotation. Source: InterPro metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW oxidoreductase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	‹1 – ›79	›79	Cytochrome b		PRO_0000060791
Regions
	Transmembrane	31 – 53	23	Helical; Potential
Sites
	Metal binding	37	1	Iron 1 (heme b562 axial ligand)
	Metal binding	51	1	Iron 2 (heme b566 axial ligand)
Experimental info
	Non-terminal residue	1	1
	Non-terminal residue	79	1

Sequences

	Sequence		Length	Mass (Da)
	P16366 [UniParc]. Last modified August 1, 1990. Version 1. Checksum: B7B82DD32FF975E7	FASTA	79	9,080
	10 20 30 40 50 60 TAMFLAMHYT SDIATAFSSV AHICRDVNYG WLIRNMHANG ASFFFICIYL HIGRGLYYGS 70 YLYKETWNVG VILLLLTMM

References

[1]

"Dynamics of mitochondrial DNA evolution in animals: amplification and sequencing with conserved primers." Kocher T.D., Thomas W.K., Meyer A., Edwards S.V., Paeaebo S., Villablanca F.X., Wilson A.C. Proc. Natl. Acad. Sci. U.S.A. 86:6196-6200(1989) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	M25694 Genomic DNA. Translation: AAA31688.1.
PIR	E33286.
3D structure databases
ProteinModelPortal	P16366.
SMR	P16366. Positions 1-78.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR016175. Cyt_b/b6. IPR005797. Cyt_b/b6_N. IPR016174. Di-haem_cyt_TM. [Graphical view]
PANTHER	PTHR19271. PTHR19271. 1 hit.
Pfam	PF13631. Cytochrom_B_N_2. 1 hit. [Graphical view]
SUPFAM	SSF81342. Transmembr_di-haem_cytochrome. 1 hit.
PROSITE	PS51002. CYTB_NTER. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CYB_HYPNI

Accession

Primary (citable) accession number: P16366

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1990
Last sequence update:	August 1, 1990
Last modified:	May 1, 2013
This is version 74 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program