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Protein

Aspartic protease inhibitor 11

Gene
N/A
Organism
Solanum tuberosum (Potato)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Inhibitor of cathepsin D (aspartic protease) and trypsin (serine protease). May protect the plant by inhibiting proteases of invading organisms.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei67 – 68Reactive bond for trypsin2
Sitei111 – 112Reactive bond for chymotrypsinBy similarity2

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Aspartic protease inhibitor, Protease inhibitor, Serine protease inhibitor

Names & Taxonomyi

Protein namesi
Recommended name:
Aspartic protease inhibitor 11
Alternative name(s):
Cathepsin D inhibitor PDI
Allergen: Sola t 2
OrganismiSolanum tuberosum (Potato)
Taxonomic identifieri4113 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesSolanaceaeSolanoideaeSolaneaeSolanum
Proteomesi
  • UP000011115 Componenti: Unassembled WGS sequence

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Vacuole

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human.

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei3491. Sola t 2.0101.
640. Sola t 2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000833131 – 188Aspartic protease inhibitor 11Add BLAST188

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi19N-linked (GlcNAc...)1 Publication1
Disulfide bondi48 ↔ 93By similarity
Disulfide bondi142 ↔ 159By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Structurei

Secondary structure

1188
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi20 – 25Combined sources6
Beta strandi36 – 39Combined sources4
Beta strandi51 – 54Combined sources4
Beta strandi66 – 74Combined sources9
Beta strandi81 – 85Combined sources5
Helixi91 – 97Combined sources7
Beta strandi98 – 101Combined sources4
Turni106 – 109Combined sources4
Beta strandi112 – 115Combined sources4
Beta strandi119 – 121Combined sources3
Beta strandi127 – 130Combined sources4
Beta strandi133 – 141Combined sources9
Turni155 – 157Combined sources3
Beta strandi160 – 167Combined sources8
Beta strandi170 – 178Combined sources9
Beta strandi183 – 188Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5DZUX-ray2.12A/B1-188[»]
ProteinModelPortaliP16348.
SMRiP16348.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Family and domain databases

CDDicd00178. STI. 1 hit.
InterProiIPR011065. Kunitz_inhibitor_ST1-like.
IPR002160. Prot_inh_Kunz-lg.
[Graphical view]
PfamiPF00197. Kunitz_legume. 1 hit.
[Graphical view]
PRINTSiPR00291. KUNITZINHBTR.
SMARTiSM00452. STI. 1 hit.
[Graphical view]
SUPFAMiSSF50386. SSF50386. 1 hit.
PROSITEiPS00283. SOYBEAN_KUNITZ. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P16348-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
ESPLPKPVLD TNGKELNPNS SYRIISIGRG ALGGDVYLGK SPNSDAPCPD
60 70 80 90 100
GVFRYNSDVG PSGTPVRFIP LSGGIFEDQL LNIQFNIATV KLCVSYTIWK
110 120 130 140 150
VGNLNAYFRT MLLETGGTIG QADSSYFKIV KLSNFGYNLL YCPITPPFLC
160 170 180
PFCRDDNFCA KVGVVIQNGK RRLALVNENP LDVLFQEV
Length:188
Mass (Da):20,590
Last modified:August 1, 1990 - v1
Checksum:i4E8A49113EF6F10D
GO

Sequence databases

PIRiS05025. XKPODC.

Cross-referencesi

Sequence databases

PIRiS05025. XKPODC.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5DZUX-ray2.12A/B1-188[»]
ProteinModelPortaliP16348.
SMRiP16348.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

Allergomei3491. Sola t 2.0101.
640. Sola t 2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

CDDicd00178. STI. 1 hit.
InterProiIPR011065. Kunitz_inhibitor_ST1-like.
IPR002160. Prot_inh_Kunz-lg.
[Graphical view]
PfamiPF00197. Kunitz_legume. 1 hit.
[Graphical view]
PRINTSiPR00291. KUNITZINHBTR.
SMARTiSM00452. STI. 1 hit.
[Graphical view]
SUPFAMiSSF50386. SSF50386. 1 hit.
PROSITEiPS00283. SOYBEAN_KUNITZ. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAPI11_SOLTU
AccessioniPrimary (citable) accession number: P16348
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: November 2, 2016
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Allergens
    Nomenclature of allergens and list of entries
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.