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P16344 (ITR4_HETCR) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Kunitz-type trypsin inhibitor IV
OrganismHeteractis crispa (Leathery sea anemone) (Radianthus macrodactylus)
Taxonomic identifier175771 [NCBI]
Taxonomic lineageEukaryotaMetazoaCnidariaAnthozoaHexacoralliaActiniariaStichodactylidaeHeteractis

Protein attributes

Sequence length56 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Inhibitor of trypsin.

Subcellular location

Secreted. Nematocyst.

Sequence similarities

Belongs to the cnidaria Kunitz-type proteinase inhibitor family.

Contains 1 BPTI/Kunitz inhibitor domain.

Ontologies

Keywords
   Cellular componentNematocyst
Secreted
   Molecular functionProtease inhibitor
Serine protease inhibitor
   PTMDisulfide bond
   Technical termDirect protein sequencing
Gene Ontology (GO)
   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

nematocyst

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionserine-type endopeptidase inhibitor activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 5656Kunitz-type trypsin inhibitor IV
PRO_0000155418

Regions

Domain4 – 5451BPTI/Kunitz inhibitor

Sites

Site14 – 152Reactive bond By similarity

Amino acid modifications

Disulfide bond4 ↔ 54 By similarity
Disulfide bond13 ↔ 37 By similarity
Disulfide bond29 ↔ 50 By similarity

Sequences

Sequence LengthMass (Da)Tools
P16344 [UniParc].

Last modified August 1, 1990. Version 1.
Checksum: 68374D2025B841C0

FASTA566,172
        10         20         30         40         50 
GSICLEPKVV GPCTAYFPRF YFDSETGKCT PFIYGGCEGN SYVDEKLHAC RAICRA 

« Hide

References

[1]"Amino-acid sequence of trypsin inhibitor IV from Radiantis macrodactylus."
Zykova T.A., Vinokurov L.M., Markova L.F., Kozlovskaya E.P., Elyakov G.B.
Bioorg. Khim. 11:293-301(1985)
Cited for: PROTEIN SEQUENCE.

Cross-references

Sequence databases

PIRJN0380.

3D structure databases

ProteinModelPortalP16344.
SMRP16344. Positions 2-56.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

MEROPSI02.061.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D4.10.410.10. 1 hit.
InterProIPR002223. Prot_inh_Kunz-m.
[Graphical view]
PfamPF00014. Kunitz_BPTI. 1 hit.
[Graphical view]
PRINTSPR00759. BASICPTASE.
SMARTSM00131. KU. 1 hit.
[Graphical view]
SUPFAMSSF57362. SSF57362. 1 hit.
PROSITEPS50279. BPTI_KUNITZ_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameITR4_HETCR
AccessionPrimary (citable) accession number: P16344
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: April 16, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families