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P16341 (KAX51_LEIQH) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 84. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Potassium channel toxin alpha-KTx 5.1
Alternative name(s):
Leiurotoxin I
Short name=LeTx I
Leiurotoxin-1
Scyllatoxin
Short name=ScyTx
OrganismLeiurus quinquestriatus hebraeus (Yellow scorpion)
Taxonomic identifier6884 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaScorpionesButhidaButhoideaButhidaeLeiurus

Protein attributes

Sequence length31 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Blocker for the small conductance calcium-activated potassium channels (SK-Ca); also known as apamine-sensitive potassium channel.

Subcellular location

Secreted.

Tissue specificity

Expressed by the venom gland.

Domain

Has the structural arrangement of an alpha-helix connected to a beta-sheet by disulfide bonds (CSalpha/beta).

Sequence similarities

Belongs to the short scorpion toxin superfamily. Potassium channel inhibitor family. Alpha-KTx 5 subfamily.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Peptide1 – 3131Potassium channel toxin alpha-KTx 5.1
PRO_0000044924

Amino acid modifications

Modified residue311Histidine amide Ref.1
Disulfide bond3 ↔ 21 Ref.2 Ref.4
Disulfide bond8 ↔ 26 Ref.2 Ref.4
Disulfide bond12 ↔ 28 Ref.2 Ref.4

Secondary structure

....... 31
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P16341 [UniParc].

Last modified April 1, 1990. Version 1.
Checksum: BB3183DC5CEA53A7

FASTA313,430
        10         20         30 
AFCNLRMCQL SCRSLGLLGK CIGDKCECVK H 

« Hide

References

[1]"Purification and characterization of a unique, potent inhibitor of apamin binding from Leiurus quinquestriatus hebraeus venom."
Chicci G.G., Gimenez-Gallego G., Ber E., Garcia M.L., Winquist R., Cascieri M.A.
J. Biol. Chem. 263:10192-10197(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE.
Tissue: Venom.
[2]"Leiurotoxin I (scyllatoxin), a peptide ligand for Ca2(+)-activated K+ channels. Chemical synthesis, radiolabeling, and receptor characterization."
Auguste P., Hugues M., Grave B., Gesquiere J.C., Maes P., Tartar A., Romey G., Schweitz H., Lazdunski M.
J. Biol. Chem. 265:4753-4759(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: SYNTHESIS.
[3]"Moving pieces in a taxonomic puzzle: venom 2D-LC/MS and data clustering analyses to infer phylogenetic relationships in some scorpions from the Buthidae family (Scorpiones)."
Nascimento D.G., Rates B., Santos D.M., Verano-Braga T., Barbosa-Silva A., Dutra A.A.A., Biondi I., Martin-Eauclaire M.-F., De Lima M.E., Pimenta A.M.C.
Toxicon 47:628-639(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY.
[4]"Solution conformation of leiurotoxin I (scyllatoxin) by 1H nuclear magnetic resonance. Resonance assignment and secondary structure."
Martins J.C., Zhang W., Tartar A., Lazdunski M., Borremans F.A.M.
FEBS Lett. 260:249-253(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: STRUCTURE BY NMR, DISULFIDE BONDS.
+Additional computationally mapped references.

Cross-references

Sequence databases

PIRA28805.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1SCYNMR-A1-31[»]
ProteinModelPortalP16341.
SMRP16341. Positions 2-31.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR003614. Scorpion_toxin-like.
IPR001947. Scorpion_toxinS_K_inh.
[Graphical view]
PfamPF00451. Toxin_2. 1 hit.
[Graphical view]
SUPFAMSSF57095. SSF57095. 1 hit.
PROSITEPS01138. SCORP_SHORT_TOXIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP16341.

Entry information

Entry nameKAX51_LEIQH
AccessionPrimary (citable) accession number: P16341
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: October 16, 2013
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Scorpion potassium channel toxins

Nomenclature of scorpion potassium channel toxins and list of entries

PDB cross-references

Index of Protein Data Bank (PDB) cross-references