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Protein

Protein translocase subunit SecY

Gene

secY

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.UniRule annotation

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Translocation, Transport

Enzyme and pathway databases

BioCyciBSUB:BSU01360-MONOMER.

Protein family/group databases

TCDBi3.A.5.2.1. the general secretory pathway (sec) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein translocase subunit SecYUniRule annotation
Gene namesi
Name:secYUniRule annotation
Ordered Locus Names:BSU01360
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001570 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 17CytoplasmicSequence analysisAdd BLAST17
Transmembranei18 – 38HelicalUniRule annotationAdd BLAST21
Topological domaini39 – 66ExtracellularSequence analysisAdd BLAST28
Transmembranei67 – 87HelicalUniRule annotationAdd BLAST21
Topological domaini88 – 115CytoplasmicSequence analysisAdd BLAST28
Transmembranei116 – 136HelicalUniRule annotationAdd BLAST21
Topological domaini137 – 145ExtracellularSequence analysis9
Transmembranei146 – 166HelicalUniRule annotationAdd BLAST21
Topological domaini167 – 177CytoplasmicSequence analysisAdd BLAST11
Transmembranei178 – 198HelicalUniRule annotationAdd BLAST21
Topological domaini199 – 213ExtracellularSequence analysisAdd BLAST15
Transmembranei214 – 234HelicalUniRule annotationAdd BLAST21
Topological domaini235 – 261CytoplasmicSequence analysisAdd BLAST27
Transmembranei262 – 282HelicalUniRule annotationAdd BLAST21
Topological domaini283 – 308ExtracellularSequence analysisAdd BLAST26
Transmembranei309 – 329HelicalUniRule annotationAdd BLAST21
Topological domaini330 – 368CytoplasmicSequence analysisAdd BLAST39
Transmembranei369 – 389HelicalUniRule annotationAdd BLAST21
Transmembranei390 – 410HelicalUniRule annotationAdd BLAST21
Topological domaini411 – 431CytoplasmicSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001317111 – 431Protein translocase subunit SecYAdd BLAST431

Proteomic databases

PaxDbiP16336.

Interactioni

Subunit structurei

Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.UniRule annotation

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100000700.

Structurei

3D structure databases

ProteinModelPortaliP16336.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SecY/SEC61-alpha family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105CGG. Bacteria.
COG0201. LUCA.
HOGENOMiHOG000080586.
InParanoidiP16336.
KOiK03076.
OMAiQTYVISQ.
PhylomeDBiP16336.

Family and domain databases

Gene3Di1.10.3370.10. 1 hit.
HAMAPiMF_01465. SecY. 1 hit.
InterProiIPR026593. SecY.
IPR002208. SecY/SEC61-alpha.
IPR030659. SecY_CS.
IPR023201. SecY_su_dom.
[Graphical view]
PANTHERiPTHR10906. PTHR10906. 1 hit.
PfamiPF00344. SecY. 1 hit.
[Graphical view]
PIRSFiPIRSF004557. SecY. 1 hit.
SUPFAMiSSF103491. SSF103491. 1 hit.
TIGRFAMsiTIGR00967. 3a0501s007. 1 hit.
PROSITEiPS00755. SECY_1. 1 hit.
PS00756. SECY_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P16336-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFKTISNFMR VSDIRNKIIF TLLMLIVFRI GAFIPVPYVN AEALQAQSQM
60 70 80 90 100
GVFDLLNTFG GGALYQFSIF AMGITPYITA SIIIQLLQMD VVPKFTEWSK
110 120 130 140 150
QGEVGRRKLA QFTRYFTIVL GFIQALGMSY GFNNLANGML IEKSGVSTYL
160 170 180 190 200
IIALVLTGGT AFLMWLGEQI TSHGVGNGIS IIIFAGIVSS IPKTIGQIYE
210 220 230 240 250
TQFVGSNDQL FIHIVKVALL VIAILAVIVG VIFIQQAVRK IAIQYAKGTG
260 270 280 290 300
RSPAGGGQST HLPLKVNPAG VIPVIFAVAF LITPRTIASF FGTNDVTKWI
310 320 330 340 350
QNNFDNTHPV GMAIYVALII AFTYFYAFVQ VNPEQMADNL KKQGGYIPGV
360 370 380 390 400
RPGKMTQDRI TSILYRLTFV GSIFLAVISI LPIFFIQFAG LPQSAQIGGT
410 420 430
SLLIVVGVAL ETMKQLESQL VKRNYRGFMK N
Length:431
Mass (Da):47,243
Last modified:August 1, 1990 - v1
Checksum:i6AB949378D17D8B4
GO

Sequence cautioni

The sequence BAA00495 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X51329 Genomic DNA. Translation: CAA35712.1.
M31102 Genomic DNA. Translation: AAB59118.1.
D00619 Genomic DNA. Translation: BAA00495.1. Different initiation.
L47971 Genomic DNA. Translation: AAB06819.1.
AL009126 Genomic DNA. Translation: CAB11912.1.
PIRiS08629. BWBSSY.
RefSeqiNP_388017.1. NC_000964.3.
WP_004399662.1. NZ_JNCM01000029.1.

Genome annotation databases

EnsemblBacteriaiCAB11912; CAB11912; BSU01360.
GeneIDi936779.
KEGGibsu:BSU01360.
PATRICi18971781. VBIBacSub10457_0139.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X51329 Genomic DNA. Translation: CAA35712.1.
M31102 Genomic DNA. Translation: AAB59118.1.
D00619 Genomic DNA. Translation: BAA00495.1. Different initiation.
L47971 Genomic DNA. Translation: AAB06819.1.
AL009126 Genomic DNA. Translation: CAB11912.1.
PIRiS08629. BWBSSY.
RefSeqiNP_388017.1. NC_000964.3.
WP_004399662.1. NZ_JNCM01000029.1.

3D structure databases

ProteinModelPortaliP16336.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100000700.

Protein family/group databases

TCDBi3.A.5.2.1. the general secretory pathway (sec) family.

Proteomic databases

PaxDbiP16336.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAB11912; CAB11912; BSU01360.
GeneIDi936779.
KEGGibsu:BSU01360.
PATRICi18971781. VBIBacSub10457_0139.

Phylogenomic databases

eggNOGiENOG4105CGG. Bacteria.
COG0201. LUCA.
HOGENOMiHOG000080586.
InParanoidiP16336.
KOiK03076.
OMAiQTYVISQ.
PhylomeDBiP16336.

Enzyme and pathway databases

BioCyciBSUB:BSU01360-MONOMER.

Family and domain databases

Gene3Di1.10.3370.10. 1 hit.
HAMAPiMF_01465. SecY. 1 hit.
InterProiIPR026593. SecY.
IPR002208. SecY/SEC61-alpha.
IPR030659. SecY_CS.
IPR023201. SecY_su_dom.
[Graphical view]
PANTHERiPTHR10906. PTHR10906. 1 hit.
PfamiPF00344. SecY. 1 hit.
[Graphical view]
PIRSFiPIRSF004557. SecY. 1 hit.
SUPFAMiSSF103491. SSF103491. 1 hit.
TIGRFAMsiTIGR00967. 3a0501s007. 1 hit.
PROSITEiPS00755. SECY_1. 1 hit.
PS00756. SECY_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSECY_BACSU
AccessioniPrimary (citable) accession number: P16336
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: October 5, 2016
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.