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Protein

2',3'-cyclic-nucleotide 3'-phosphodiesterase

Gene

Cnp

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May participate in RNA metabolism in the myelinating cell, CNP is the third most abundant protein in central nervous system myelin.1 Publication

Catalytic activityi

Nucleoside 2',3'-cyclic phosphate + H2O = nucleoside 2'-phosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei250Proton acceptor1 Publication1
Binding sitei252Substrate1
Active sitei329Proton donor1 Publication1
Binding sitei331Substrate1

GO - Molecular functioni

GO - Biological processi

  • adult locomotory behavior Source: MGI
  • aging Source: Ensembl
  • axonogenesis Source: MGI
  • cyclic nucleotide catabolic process Source: InterPro
  • forebrain development Source: Ensembl
  • microtubule cytoskeleton organization Source: Ensembl
  • oligodendrocyte differentiation Source: MGI
  • regulation of mitochondrial membrane permeability Source: Ensembl
  • response to lipopolysaccharide Source: Ensembl
  • response to toxic substance Source: MGI

Keywordsi

Molecular functionHydrolase, RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
2',3'-cyclic-nucleotide 3'-phosphodiesterase (EC:3.1.4.37)
Short name:
CNP
Short name:
CNPase
Gene namesi
Name:Cnp
Synonyms:Cnp1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:88437 Cnp

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000899621 – 4172',3'-cyclic-nucleotide 3'-phosphodiesteraseAdd BLAST417
PropeptideiPRO_0000422297418 – 420Removed in mature formCurated3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei9PhosphoserineBy similarity1
Modified residuei110PhosphotyrosineCombined sources1
Modified residuei169PhosphoserineCombined sources1
Modified residuei227PhosphoserineBy similarity1
Modified residuei239PhosphoserineBy similarity1
Modified residuei358PhosphoserineBy similarity1
Modified residuei417Cysteine methyl esterCurated1
Lipidationi417S-farnesyl cysteine1 Publication1

Keywords - PTMi

Lipoprotein, Methylation, Phosphoprotein, Prenylation

Proteomic databases

PaxDbiP16330
PeptideAtlasiP16330
PRIDEiP16330

PTM databases

iPTMnetiP16330
PhosphoSitePlusiP16330

Expressioni

Gene expression databases

BgeeiENSMUSG00000006782
CleanExiMM_CNP
ExpressionAtlasiP16330 baseline and differential
GenevisibleiP16330 MM

Interactioni

Subunit structurei

Exists as monomers and homodimers.1 Publication

Protein-protein interaction databases

BioGridi198792, 11 interactors
IntActiP16330, 16 interactors
MINTiP16330
STRINGi10090.ENSMUSP00000099409

Structurei

Secondary structure

1420
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi187 – 193Combined sources7
Helixi195 – 214Combined sources20
Helixi216 – 220Combined sources5
Helixi221 – 224Combined sources4
Helixi237 – 240Combined sources4
Beta strandi246 – 248Combined sources3
Beta strandi250 – 255Combined sources6
Helixi257 – 259Combined sources3
Helixi264 – 269Combined sources6
Helixi271 – 276Combined sources6
Beta strandi280 – 290Combined sources11
Beta strandi292 – 300Combined sources9
Helixi303 – 306Combined sources4
Helixi317 – 319Combined sources3
Beta strandi320 – 322Combined sources3
Turni324 – 327Combined sources4
Beta strandi329 – 334Combined sources6
Helixi342 – 354Combined sources13
Turni356 – 359Combined sources4
Beta strandi364 – 366Combined sources3
Beta strandi369 – 375Combined sources7
Beta strandi378 – 396Combined sources19

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2XMIX-ray1.74A179-398[»]
2Y1PX-ray1.82A179-398[»]
2Y3XX-ray2.10A/B/E179-398[»]
2YDBX-ray2.15A179-398[»]
2YDCX-ray2.05A179-398[»]
2YDDX-ray2.40A179-398[»]
2YOZX-ray2.10A179-398[»]
2YP0X-ray2.30A179-398[»]
2YPCX-ray1.89A179-398[»]
2YPEX-ray1.90A179-398[»]
2YPHX-ray2.10A179-398[»]
2YQ9X-ray1.90A179-398[»]
3ZBRX-ray2.30A/B179-398[»]
3ZBSX-ray2.45A179-398[»]
3ZBZX-ray2.10A179-398[»]
4WBIX-ray2.00A179-398[»]
4WBLX-ray2.50A179-398[»]
4WC9X-ray2.00A179-398[»]
4WCAX-ray1.85A179-398[»]
4WCBX-ray1.57A179-398[»]
4WCCX-ray2.70A179-398[»]
4WDAX-ray1.85A179-398[»]
4WDBX-ray1.60A179-398[»]
4WDDX-ray2.10A179-398[»]
4WDEX-ray2.40A/B179-398[»]
4WDFX-ray2.00A179-398[»]
4WDGX-ray2.05A179-398[»]
4WDHX-ray1.90A179-398[»]
4WEXX-ray2.10A179-398[»]
4WFRX-ray2.00A179-398[»]
5AE0X-ray1.04A179-398[»]
ProteinModelPortaliP16330
SMRiP16330
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410IT06 Eukaryota
ENOG4111F3B LUCA
GeneTreeiENSGT00510000048410
HOGENOMiHOG000111838
HOVERGENiHBG001451
InParanoidiP16330
KOiK01121
OMAiLWPNDVD
OrthoDBiEOG091G0I8Z
PhylomeDBiP16330
TreeFamiTF332157

Family and domain databases

InterProiView protein in InterPro
IPR008431 CNPase
IPR009097 cNuc_Pdiesterase
IPR027417 P-loop_NTPase
PANTHERiPTHR10156 PTHR10156, 1 hit
PfamiView protein in Pfam
PF05881 CNPase, 1 hit
PIRSFiPIRSF000970 CNPase, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
SSF55144 SSF55144, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform CNPII (identifier: P16330-1) [UniParc]FASTAAdd to basket
Also known as: DNAII

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNTSFTRKSH TFLPKLFFRK MSSSGAKEKP ELQFPFLQDE DTVATLHECK
60 70 80 90 100
TLFILRGLPG SGKSTLARLI LEKYHDGTKM VSADAYKIIP GSRADFSEAY
110 120 130 140 150
KRLDEDLAGY CRRDIRVLVL DDTNHERERL DQLFEMADQY QYQVVLVEPK
160 170 180 190 200
TAWRLDCAQL KEKNQWQLSA DDLKKLKPGL EKDFLPLYFG WFLTKKSSET
210 220 230 240 250
LRKAGQVFLE ELGNHKAFKK ELRHFISGDE PKEKLELVSY FGKRPPGVLH
260 270 280 290 300
CTTKFCDYGK AAGAEEYAQQ EVVKRSYGKA FKLSISALFV TPKTAGAQVV
310 320 330 340 350
LTDQELQLWP SDLDKPSASE GLPPGSRAHV TLGCAADVQP VQTGLDLLDI
360 370 380 390 400
LQQVKGGSQG EAVGELPRGK LYSLGKGRWM LSLTKKMEVK AIFTGYYGKG
410 420
KPVPIHGSRK GGAMQICTII
Length:420
Mass (Da):47,123
Last modified:August 16, 2004 - v3
Checksum:i2FAFFDE5F0E99EAB
GO
Isoform CNPI (identifier: P16330-2) [UniParc]FASTAAdd to basket
Also known as: DNAI

The sequence of this isoform differs from the canonical sequence as follows:
     1-20: Missing.

Show »
Length:400
Mass (Da):44,654
Checksum:iB974404499DE29BE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti115I → M in BAA07621 (PubMed:2558653).Curated1
Sequence conflicti115I → M in BAA07622 (PubMed:2558653).Curated1
Sequence conflicti136M → L in BAA07621 (PubMed:2558653).Curated1
Sequence conflicti136M → L in BAA07622 (PubMed:2558653).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0041721 – 20Missing in isoform CNPI. 2 PublicationsAdd BLAST20

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D38642 Genomic DNA Translation: BAA07621.1
D38642 Genomic DNA Translation: BAA07622.1
M31810 mRNA Translation: AAA37429.1
M58045 mRNA Translation: AAA37430.1
M58047, M58046 Genomic DNA Translation: AAA37431.1
AF332055 mRNA Translation: AAK56084.1
AF332056 mRNA Translation: AAK56085.1
BC005544 mRNA Translation: AAH05544.1
BC021904 mRNA Translation: AAH21904.1
AK050628 mRNA Translation: BAC34351.1
CCDSiCCDS25427.1 [P16330-1]
PIRiA35708 ESMS32
RefSeqiNP_001139790.1, NM_001146318.1 [P16330-2]
NP_034053.2, NM_009923.2 [P16330-1]
XP_017169734.1, XM_017314245.1 [P16330-2]
UniGeneiMm.15711

Genome annotation databases

EnsembliENSMUST00000103120; ENSMUSP00000099409; ENSMUSG00000006782 [P16330-1]
GeneIDi12799
KEGGimmu:12799
UCSCiuc007llo.2 mouse [P16330-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiCN37_MOUSE
AccessioniPrimary (citable) accession number: P16330
Secondary accession number(s): Q61424
, Q8C7C9, Q91V42, Q923F3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 16, 2004
Last modified: March 28, 2018
This is version 167 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome
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Main funding by: National Institutes of Health