P16312 (PEPT1_DERMI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Peptidase 1
EC=3.4.22.65

Alternative name(s):
Allergen Der m I
Major mite fecal allergen Der m 1
Allergen=Der m 1

Gene names

Name:

DERM1

Organism

Dermatophagoides microceras (House dust mite)

Taxonomic identifier

6955 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Panarthropoda › Arthropoda › Chelicerata › Arachnida › Acari › Acariformes › Sarcoptiformes › Astigmata › Psoroptidia › Analgoidea › Pyroglyphidae › Dermatophagoidinae › Dermatophagoides

Protein attributes

Sequence length	30 AA.
Sequence status	Fragment.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Thiol protease that hydrolyzes proteins, with a preference for Phe or basic residues.
Catalytic activity	Broad endopeptidase specificity.
Subcellular location	Secreted.
Allergenic properties	Causes an allergic reaction in human. Common symptoms of mite allergy are bronchial asthma, allergic rhinitis and conjunctivitis.
Sequence similarities	Belongs to the peptidase C1 family.

Ontologies

Keywords
Cellular component	Secreted
Disease	Allergen
Molecular function	Hydrolase Protease Thiol protease
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological_process	proteolysis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	cysteine-type peptidase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – ›30	›30	Peptidase 1		PRO_0000050547
Experimental info
	Non-terminal residue	30	1

Sequences

	Sequence		Length	Mass (Da)
	P16312 [UniParc]. Last modified August 1, 1990. Version 1. Checksum: D60B742967194886	FASTA	30	3,314
	10 20 30 TQACRINSGN VPSELDLRSL RTVTPIRMQG

References

[1]

"The binding of mouse hybridoma and human IgE antibodies to the major fecal allergen, Der p I, of Dermatophagoides pteronyssinus. Relative binding site location and species specificity studied by solid-phase inhibition assays with radiolabeled antigen." Lind P., Hansen O.C., Horn N. J. Immunol. 140:4256-4262(1988) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE.

Cross-references

Sequence databases
PIR	B27634.
3D structure databases
ProteinModelPortal	P16312.
SMR	P16312. Positions 1-30.
ModBase	Search...
Protein family/group databases
Allergome	309. Der m 1. 3257. Der m 1.0101.
MEROPS	C01.151.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
PROSITE	PS00640. THIOL_PROTEASE_ASN. Partial match. PS00139. THIOL_PROTEASE_CYS. Partial match. PS00639. THIOL_PROTEASE_HIS. Partial match. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PEPT1_DERMI

Accession

Primary (citable) accession number: P16312

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1990
Last sequence update:	August 1, 1990
Last modified:	April 3, 2013
This is version 74 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)