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P16312

- PEPT1_DERMI

UniProt

P16312 - PEPT1_DERMI

Protein

Peptidase 1

Gene

DERM1

Organism
Dermatophagoides microceras (House dust mite)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Thiol protease that hydrolyzes proteins, with a preference for Phe or basic residues.

    Catalytic activityi

    Broad endopeptidase specificity.

    GO - Molecular functioni

    1. cysteine-type peptidase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase, Protease, Thiol protease

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Peptidase 1 (EC:3.4.22.65)
    Alternative name(s):
    Allergen Der m I
    Major mite fecal allergen Der m 1
    Allergen: Der m 1
    Gene namesi
    Name:DERM1
    OrganismiDermatophagoides microceras (House dust mite)
    Taxonomic identifieri6955 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaAcariAcariformesSarcoptiformesAstigmataPsoroptidiaAnalgoideaPyroglyphidaeDermatophagoidinaeDermatophagoides

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Allergenic propertiesi

    Causes an allergic reaction in human. Common symptoms of mite allergy are bronchial asthma, allergic rhinitis and conjunctivitis.

    Keywords - Diseasei

    Allergen

    Protein family/group databases

    Allergomei309. Der m 1.
    3257. Der m 1.0101.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – ›30›30Peptidase 1PRO_0000050547Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliP16312.
    SMRiP16312. Positions 1-30.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase C1 family.PROSITE-ProRule annotation

    Sequencei

    Sequence statusi: Fragment.

    P16312-1 [UniParc]FASTAAdd to Basket

    « Hide

    TQACRINSGN VPSELDLRSL RTVTPIRMQG                         30
    Length:30
    Mass (Da):3,314
    Last modified:August 1, 1990 - v1
    Checksum:iD60B742967194886
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei30 – 301

    Sequence databases

    PIRiB27634.

    Cross-referencesi

    Sequence databases

    PIRi B27634.

    3D structure databases

    ProteinModelPortali P16312.
    SMRi P16312. Positions 1-30.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    Allergomei 309. Der m 1.
    3257. Der m 1.0101.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. "The binding of mouse hybridoma and human IgE antibodies to the major fecal allergen, Der p I, of Dermatophagoides pteronyssinus. Relative binding site location and species specificity studied by solid-phase inhibition assays with radiolabeled antigen."
      Lind P., Hansen O.C., Horn N.
      J. Immunol. 140:4256-4262(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE.

    Entry informationi

    Entry nameiPEPT1_DERMI
    AccessioniPrimary (citable) accession number: P16312
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1990
    Last sequence update: August 1, 1990
    Last modified: October 1, 2014
    This is version 78 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Keywords - Technical termi

    Direct protein sequencing

    Documents

    1. Allergens
      Nomenclature of allergens and list of entries
    2. Peptidase families
      Classification of peptidase families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3