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Protein

Peptidase 1

Gene

DERM1

Organism
Dermatophagoides microceras (House dust mite)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Thiol protease that hydrolyzes proteins, with a preference for Phe or basic residues.

Catalytic activityi

Broad endopeptidase specificity.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Protein family/group databases

MEROPSiC01.027.

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidase 1 (EC:3.4.22.65)
Alternative name(s):
Allergen Der m I
Major mite fecal allergen Der m 1
Allergen: Der m 1
Gene namesi
Name:DERM1
OrganismiDermatophagoides microceras (House dust mite)
Taxonomic identifieri6955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaAcariAcariformesSarcoptiformesAstigmataPsoroptidiaAnalgoideaPyroglyphidaeDermatophagoidinaeDermatophagoides

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human. Common symptoms of mite allergy are bronchial asthma, allergic rhinitis and conjunctivitis.

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei309. Der m 1.
3257. Der m 1.0101.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000505471 – ›30Peptidase 1Add BLAST›30

Structurei

3D structure databases

ProteinModelPortaliP16312.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase C1 family.PROSITE-ProRule annotation

Sequencei

Sequence statusi: Fragment.

P16312-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30
TQACRINSGN VPSELDLRSL RTVTPIRMQG
Length:30
Mass (Da):3,314
Last modified:August 1, 1990 - v1
Checksum:iD60B742967194886
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei301

Sequence databases

PIRiB27634.

Cross-referencesi

Sequence databases

PIRiB27634.

3D structure databases

ProteinModelPortaliP16312.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

Allergomei309. Der m 1.
3257. Der m 1.0101.
MEROPSiC01.027.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiPEPT1_DERMI
AccessioniPrimary (citable) accession number: P16312
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: October 5, 2016
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. Allergens
    Nomenclature of allergens and list of entries
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.