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P16312 (PEPT1_DERMI) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 76. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Peptidase 1

EC=3.4.22.65
Alternative name(s):
Allergen Der m I
Major mite fecal allergen Der m 1
Allergen=Der m 1
Gene names
Name:DERM1
OrganismDermatophagoides microceras (House dust mite)
Taxonomic identifier6955 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaAcariAcariformesSarcoptiformesAstigmataPsoroptidiaAnalgoideaPyroglyphidaeDermatophagoidinaeDermatophagoides

Protein attributes

Sequence length30 AA.
Sequence statusFragment.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Thiol protease that hydrolyzes proteins, with a preference for Phe or basic residues.

Catalytic activity

Broad endopeptidase specificity.

Subcellular location

Secreted.

Allergenic properties

Causes an allergic reaction in human. Common symptoms of mite allergy are bronchial asthma, allergic rhinitis and conjunctivitis.

Sequence similarities

Belongs to the peptidase C1 family.

Ontologies

Keywords
   Cellular componentSecreted
   DiseaseAllergen
   Molecular functionHydrolase
Protease
Thiol protease
   Technical termDirect protein sequencing
Gene Ontology (GO)
   Biological_processproteolysis

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functioncysteine-type peptidase activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – ›30›30Peptidase 1
PRO_0000050547

Experimental info

Non-terminal residue301

Sequences

Sequence LengthMass (Da)Tools
P16312 [UniParc].

Last modified August 1, 1990. Version 1.
Checksum: D60B742967194886

FASTA303,314
        10         20         30 
TQACRINSGN VPSELDLRSL RTVTPIRMQG 

« Hide

References

[1]"The binding of mouse hybridoma and human IgE antibodies to the major fecal allergen, Der p I, of Dermatophagoides pteronyssinus. Relative binding site location and species specificity studied by solid-phase inhibition assays with radiolabeled antigen."
Lind P., Hansen O.C., Horn N.
J. Immunol. 140:4256-4262(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE.

Cross-references

Sequence databases

PIRB27634.

3D structure databases

ProteinModelPortalP16312.
SMRP16312. Positions 1-30.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

Allergome309. Der m 1.
3257. Der m 1.0101.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

ProtoNetSearch...

Entry information

Entry namePEPT1_DERMI
AccessionPrimary (citable) accession number: P16312
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: February 19, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries

Allergens

Nomenclature of allergens and list of entries