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Protein

Gamma-aminobutyric acid receptor subunit alpha-6

Gene

Gabra6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chloride channel, Ion channel, Ligand-gated ion channel, Receptor

Keywords - Biological processi

Ion transport, Transport

Keywords - Ligandi

Chloride

Enzyme and pathway databases

ReactomeiR-MMU-975298. Ligand-gated ion channel transport.
R-MMU-977441. GABA A receptor activation.

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-aminobutyric acid receptor subunit alpha-6
Alternative name(s):
GABA(A) receptor subunit alpha-6
Gene namesi
Name:Gabra6
Synonyms:Gabra-6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:95618. Gabra6.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini20 – 242223ExtracellularCuratedAdd
BLAST
Transmembranei243 – 26422HelicalCuratedAdd
BLAST
Transmembranei269 – 29022HelicalCuratedAdd
BLAST
Transmembranei301 – 32424HelicalCuratedAdd
BLAST
Topological domaini325 – 41995CytoplasmicCuratedAdd
BLAST
Transmembranei420 – 44122HelicalCuratedAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL2094133.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence analysisAdd
BLAST
Chaini20 – 453434Gamma-aminobutyric acid receptor subunit alpha-6PRO_0000000448Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi31 – 311N-linked (GlcNAc...)Sequence analysis
Glycosylationi128 – 1281N-linked (GlcNAc...)Sequence analysis
Glycosylationi141 – 1411N-linked (GlcNAc...)Sequence analysis
Disulfide bondi156 ↔ 170By similarity
Modified residuei375 – 3751PhosphoserineCombined sources

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiP16305.
PaxDbiP16305.
PeptideAtlasiP16305.
PRIDEiP16305.

PTM databases

iPTMnetiP16305.
PhosphoSiteiP16305.

Expressioni

Tissue specificityi

Only found in cerebellar granule cells.

Gene expression databases

BgeeiENSMUSG00000020428.
GenevisibleiP16305. MM.

Interactioni

Subunit structurei

Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho. Binds UBQLN1.

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000126114.

Structurei

3D structure databases

ProteinModelPortaliP16305.
SMRiP16305. Positions 32-441.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3642. Eukaryota.
ENOG410XNQG. LUCA.
GeneTreeiENSGT00760000119010.
HOGENOMiHOG000231337.
HOVERGENiHBG051707.
InParanoidiP16305.
KOiK05175.
OMAiPWLYIIL.
OrthoDBiEOG091G0805.
TreeFamiTF315453.

Family and domain databases

Gene3Di2.70.170.10. 1 hit.
InterProiIPR006028. GABAA/Glycine_rcpt.
IPR001390. GABAAa_rcpt.
IPR005436. GABBAa6_rcpt.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 2 hits.
PfamiPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view]
PRINTSiPR01079. GABAARALPHA.
PR01619. GABAARALPHA6.
PR00253. GABAARECEPTR.
PR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
TIGRFAMsiTIGR00860. LIC. 1 hit.
PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P16305-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVLLLPWLFI ILWLENAQAQ LEDEGNFYSE NVSRILDNLL EGYDNRLRPG
60 70 80 90 100
FGGAVTEVKT DIYVTSFGPV SDVEMEYTMD VFFRQTWTDE RLKFKGPAEI
110 120 130 140 150
LSLNNLMVSK IWTPDTFFRN GKKSIAHNMT TPNKLFRLMQ NGTILYTMRL
160 170 180 190 200
TINADCPMRL VNFPMDGHAC PLKFGSYAYP KTEIIYTWKK GPLYSVEVPE
210 220 230 240 250
ESSSLLQYDL IGQTVSSETI KSNTGEYVIM TVYFHLQRKM GYFMIQIYTP
260 270 280 290 300
CIMTVILSQV SFWINKESVP ARTVFGITTV LTMTTLSISA RHSLPKVSYA
310 320 330 340 350
TAMDWFIAVC FAFVFSALIE FAAVNYFTNL QSQKAERQAQ TAATPPVAKS
360 370 380 390 400
KASESLQAEI VVHSDSKYHL KKRISSLTLP IVPSSEASKA LSRTPILKST
410 420 430 440 450
PVSPPLLLPA TGGTSKIDQY SRILFPVAFA GFNLVYWIVY LSKDTMEVSS

TVE
Length:453
Mass (Da):51,106
Last modified:July 27, 2011 - v3
Checksum:iACCDF38AE8D4695D
GO
Isoform 2 (identifier: P16305-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     76-85: Missing.

Show »
Length:443
Mass (Da):49,789
Checksum:i688CF66DC6503652
GO
Isoform 3 (identifier: P16305-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-13: MVLLLPWLFIILW → MRNMKDLEDFSR

Show »
Length:452
Mass (Da):50,991
Checksum:i2381E676A8F3C780
GO
Isoform 4 (identifier: P16305-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-13: MVLLLPWLFIILW → MRNMKDLEDFSR
     76-85: Missing.

Show »
Length:442
Mass (Da):49,673
Checksum:iDF2F09AF5E35C766
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti357 – 3571Q → E in CAA36244 (PubMed:2167378).Curated
Sequence conflicti357 – 3571Q → E in AAD52001 (Ref. 2) Curated
Sequence conflicti357 – 3571Q → E in AAD52002 (Ref. 2) Curated
Sequence conflicti357 – 3571Q → E in AAD52003 (Ref. 2) Curated
Sequence conflicti357 – 3571Q → E in AAD52004 (Ref. 2) Curated
Sequence conflicti357 – 3571Q → E in AAG28024 (Ref. 3) Curated
Sequence conflicti357 – 3571Q → E in AAG28025 (Ref. 3) Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 1313MVLLL…FIILW → MRNMKDLEDFSR in isoform 3 and isoform 4. CuratedVSP_000085Add
BLAST
Alternative sequencei76 – 8510Missing in isoform 2 and isoform 4. 1 PublicationVSP_000086

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X51986 mRNA. Translation: CAA36244.1.
U77411, U77409, U77410 Genomic DNA. Translation: AAD52001.1.
U77411, U77409, U77410 Genomic DNA. Translation: AAD52002.1.
U77411, U77409, U77410 Genomic DNA. Translation: AAD52003.1.
U77411, U77409, U77410 Genomic DNA. Translation: AAD52004.1.
AF256197 mRNA. Translation: AAG28024.1.
AF256198 mRNA. Translation: AAG28025.1.
AK135145 mRNA. Translation: BAE22438.1.
AL645823 Genomic DNA. Translation: CAI24931.1.
BC145158 mRNA. Translation: AAI45159.1.
BC145702 mRNA. Translation: AAI45703.1.
CCDSiCCDS24554.1. [P16305-2]
CCDS48769.1. [P16305-1]
PIRiS11396.
RefSeqiNP_001093111.1. NM_001099641.2. [P16305-1]
NP_032094.2. NM_008068.3. [P16305-2]
XP_006532260.1. XM_006532197.2. [P16305-3]
UniGeneiMm.4915.

Genome annotation databases

EnsembliENSMUST00000020703; ENSMUSP00000020703; ENSMUSG00000020428. [P16305-2]
ENSMUST00000109286; ENSMUSP00000104909; ENSMUSG00000020428. [P16305-3]
ENSMUST00000155218; ENSMUSP00000126114; ENSMUSG00000020428. [P16305-1]
GeneIDi14399.
KEGGimmu:14399.
UCSCiuc007img.2. mouse. [P16305-2]
uc007imh.2. mouse. [P16305-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X51986 mRNA. Translation: CAA36244.1.
U77411, U77409, U77410 Genomic DNA. Translation: AAD52001.1.
U77411, U77409, U77410 Genomic DNA. Translation: AAD52002.1.
U77411, U77409, U77410 Genomic DNA. Translation: AAD52003.1.
U77411, U77409, U77410 Genomic DNA. Translation: AAD52004.1.
AF256197 mRNA. Translation: AAG28024.1.
AF256198 mRNA. Translation: AAG28025.1.
AK135145 mRNA. Translation: BAE22438.1.
AL645823 Genomic DNA. Translation: CAI24931.1.
BC145158 mRNA. Translation: AAI45159.1.
BC145702 mRNA. Translation: AAI45703.1.
CCDSiCCDS24554.1. [P16305-2]
CCDS48769.1. [P16305-1]
PIRiS11396.
RefSeqiNP_001093111.1. NM_001099641.2. [P16305-1]
NP_032094.2. NM_008068.3. [P16305-2]
XP_006532260.1. XM_006532197.2. [P16305-3]
UniGeneiMm.4915.

3D structure databases

ProteinModelPortaliP16305.
SMRiP16305. Positions 32-441.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000126114.

Chemistry

ChEMBLiCHEMBL2094133.

PTM databases

iPTMnetiP16305.
PhosphoSiteiP16305.

Proteomic databases

MaxQBiP16305.
PaxDbiP16305.
PeptideAtlasiP16305.
PRIDEiP16305.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000020703; ENSMUSP00000020703; ENSMUSG00000020428. [P16305-2]
ENSMUST00000109286; ENSMUSP00000104909; ENSMUSG00000020428. [P16305-3]
ENSMUST00000155218; ENSMUSP00000126114; ENSMUSG00000020428. [P16305-1]
GeneIDi14399.
KEGGimmu:14399.
UCSCiuc007img.2. mouse. [P16305-2]
uc007imh.2. mouse. [P16305-1]

Organism-specific databases

CTDi2559.
MGIiMGI:95618. Gabra6.

Phylogenomic databases

eggNOGiKOG3642. Eukaryota.
ENOG410XNQG. LUCA.
GeneTreeiENSGT00760000119010.
HOGENOMiHOG000231337.
HOVERGENiHBG051707.
InParanoidiP16305.
KOiK05175.
OMAiPWLYIIL.
OrthoDBiEOG091G0805.
TreeFamiTF315453.

Enzyme and pathway databases

ReactomeiR-MMU-975298. Ligand-gated ion channel transport.
R-MMU-977441. GABA A receptor activation.

Miscellaneous databases

PROiP16305.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000020428.
GenevisibleiP16305. MM.

Family and domain databases

Gene3Di2.70.170.10. 1 hit.
InterProiIPR006028. GABAA/Glycine_rcpt.
IPR001390. GABAAa_rcpt.
IPR005436. GABBAa6_rcpt.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 2 hits.
PfamiPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view]
PRINTSiPR01079. GABAARALPHA.
PR01619. GABAARALPHA6.
PR00253. GABAARECEPTR.
PR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
TIGRFAMsiTIGR00860. LIC. 1 hit.
PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGBRA6_MOUSE
AccessioniPrimary (citable) accession number: P16305
Secondary accession number(s): Q5SUU5
, Q9R0V3, Q9R0V4, Q9R0V5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: July 27, 2011
Last modified: September 7, 2016
This is version 156 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.