##gff-version 3 P16298 UniProtKB Initiator methionine 1 1 . . . Note=Removed;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19413330;Dbxref=PMID:19413330 P16298 UniProtKB Chain 2 524 . . . ID=PRO_0000058825;Note=Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform P16298 UniProtKB Region 1 25 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P16298 UniProtKB Region 65 356 . . . Note=Catalytic;Ontology_term=ECO:0000305;evidence=ECO:0000305 P16298 UniProtKB Region 357 379 . . . Note=Calcineurin B binding;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26794871;Dbxref=PMID:26794871 P16298 UniProtKB Region 401 415 . . . Note=Calmodulin-binding;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26794871;Dbxref=PMID:26794871 P16298 UniProtKB Region 416 423 . . . Note=Autoinhibitory segment;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26794871;Dbxref=PMID:26794871 P16298 UniProtKB Region 474 496 . . . Note=Autoinhibitory domain;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26794871;Dbxref=PMID:26794871 P16298 UniProtKB Motif 316 320 . . . Note=SAPNY motif;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q08209 P16298 UniProtKB Active site 160 160 . . . Note=Proton donor;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q08209 P16298 UniProtKB Binding site 99 99 . . . Ontology_term=ECO:0000269,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0000269|PubMed:26794871,ECO:0007744|PDB:4OR9,ECO:0007744|PDB:4ORA,ECO:0007744|PDB:4ORC;Dbxref=PMID:26794871 P16298 UniProtKB Binding site 101 101 . . . Ontology_term=ECO:0000269,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0000269|PubMed:26794871,ECO:0007744|PDB:4OR9,ECO:0007744|PDB:4ORA,ECO:0007744|PDB:4ORC;Dbxref=PMID:26794871 P16298 UniProtKB Binding site 127 127 . . . Ontology_term=ECO:0000269,ECO:0007744,ECO:0007744;evidence=ECO:0000269|PubMed:26794871,ECO:0007744|PDB:4OR9,ECO:0007744|PDB:4ORC;Dbxref=PMID:26794871 P16298 UniProtKB Binding site 127 127 . . . Ontology_term=ECO:0000269,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0000269|PubMed:26794871,ECO:0007744|PDB:4OR9,ECO:0007744|PDB:4ORA,ECO:0007744|PDB:4ORC;Dbxref=PMID:26794871 P16298 UniProtKB Binding site 159 159 . . . Ontology_term=ECO:0000269,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0000269|PubMed:26794871,ECO:0007744|PDB:4OR9,ECO:0007744|PDB:4ORA,ECO:0007744|PDB:4ORC;Dbxref=PMID:26794871 P16298 UniProtKB Binding site 208 208 . . . Ontology_term=ECO:0000269,ECO:0007744,ECO:0007744;evidence=ECO:0000269|PubMed:26794871,ECO:0007744|PDB:4OR9,ECO:0007744|PDB:4ORC;Dbxref=PMID:26794871 P16298 UniProtKB Binding site 290 290 . . . Ontology_term=ECO:0000269,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0000269|PubMed:26794871,ECO:0007744|PDB:4OR9,ECO:0007744|PDB:4ORA,ECO:0007744|PDB:4ORC;Dbxref=PMID:26794871 P16298 UniProtKB Modified residue 2 2 . . . Note=N-acetylalanine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19413330;Dbxref=PMID:19413330 P16298 UniProtKB Modified residue 478 478 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P48453 P16298 UniProtKB Alternative sequence 137 137 . . . ID=VSP_005096;Note=In isoform 2. E->EHVLGTEDISINPHNNINE;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:2556704;Dbxref=PMID:2556704 P16298 UniProtKB Alternative sequence 395 395 . . . ID=VSP_043803;Note=In isoform 3 and isoform 4. D->DV;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:1848109;Dbxref=PMID:15489334,PMID:1848109 P16298 UniProtKB Alternative sequence 456 524 . . . ID=VSP_005097;Note=In isoform 2. ATVEAIEAEKAIRGFSPPHRICSFEEAKGLDRINERMPPRKDAVQQDGFNSLNTAHATENHGTGNHTAQ->GNDVMQLAVPQMDWGTPHSFANNSHNACREFLLFFSSCLSS;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:2556704;Dbxref=PMID:2556704 P16298 UniProtKB Alternative sequence 456 465 . . . ID=VSP_012617;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:1848109;Dbxref=PMID:1848109 P16298 UniProtKB Mutagenesis 2 21 . . . Note=Increases catalytic efficiency towards NFATC1 and DARPP32 but not towards a peptide substrate. Does not affect cytoplasmic localization and activation by calmodulin. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19154138;Dbxref=PMID:19154138 P16298 UniProtKB Mutagenesis 352 352 . . . Note=Severe loss of calmodulin-mediated activation. Probably prevents recognition of substrates. L->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26794871;Dbxref=PMID:26794871 P16298 UniProtKB Mutagenesis 353 353 . . . Note=Reduction of basal catalytic activity in absence of calmodulin. P->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26794871;Dbxref=PMID:26794871 P16298 UniProtKB Mutagenesis 356 356 . . . Note=Modest increase in catalytic activity in absence of calmodulin. M->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26794871;Dbxref=PMID:26794871 P16298 UniProtKB Mutagenesis 357 524 . . . Note=Loss of catalytic activity. Loss of interaction with PPP3R1/calreticulin B and calmodulin. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26794871;Dbxref=PMID:26794871 P16298 UniProtKB Mutagenesis 361 361 . . . Note=Severe reduction of basal catalytic activity in absence of calmodulin. Severe loss of calmodulin-mediated activation. Probably prevents recognition of substrates. W->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26794871;Dbxref=PMID:26794871 P16298 UniProtKB Mutagenesis 365 365 . . . Note=Moderate loss of calmodulin-mediated activation. Probably prevents recognition of substrates. F->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26794871;Dbxref=PMID:26794871 P16298 UniProtKB Mutagenesis 398 524 . . . Note=Increases catalytic activity independently of calmodulin. Loss of interaction with calmodulin. Does not affect interaction with PPP3R1/calreticulin B. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26794871;Dbxref=PMID:26794871 P16298 UniProtKB Mutagenesis 415 524 . . . Note=Increases catalytic activity independently of calmodulin. Does not affect interaction with PPP3R1/calreticulin B and calmodulin. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26794871;Dbxref=PMID:26794871 P16298 UniProtKB Mutagenesis 417 417 . . . Note=Modest increase in catalytic activity in absence of calmodulin. Does not affect interaction with calmodulin. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26794871;Dbxref=PMID:26794871 P16298 UniProtKB Mutagenesis 418 418 . . . Note=Does not affect catalytic activity in absence of calmodulin. Does not affect interaction with calmodulin. V->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26794871;Dbxref=PMID:26794871 P16298 UniProtKB Mutagenesis 419 419 . . . Note=Modest increase in catalytic activity in absence of calmodulin. Does not affect interaction with calmodulin. F->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26794871;Dbxref=PMID:26794871 P16298 UniProtKB Mutagenesis 420 420 . . . Note=Does not affect catalytic activity in absence of calmodulin. Does not affect interaction with calmodulin. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26794871;Dbxref=PMID:26794871 P16298 UniProtKB Mutagenesis 421 421 . . . Note=Modest increase in catalytic activity in absence of calmodulin. Does not affect interaction with calmodulin. V->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26794871;Dbxref=PMID:26794871 P16298 UniProtKB Mutagenesis 422 422 . . . Note=Modest increase in catalytic activity in absence of calmodulin. Does not affect interaction with calmodulin. L->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26794871;Dbxref=PMID:26794871 P16298 UniProtKB Mutagenesis 423 423 . . . Note=Modest increase in catalytic activity in absence of calmodulin. Does not affect interaction with calmodulin. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26794871;Dbxref=PMID:26794871 P16298 UniProtKB Mutagenesis 451 524 . . . Note=Increases basal catalytic activity. Does not affect interaction with PPP3R1/calreticulin B and calmodulin. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26794871;Dbxref=PMID:26794871 P16298 UniProtKB Helix 21 23 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4ORA P16298 UniProtKB Helix 40 43 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4OR9 P16298 UniProtKB Helix 52 60 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4OR9 P16298 UniProtKB Helix 67 82 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4OR9 P16298 UniProtKB Beta strand 86 90 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4OR9 P16298 UniProtKB Beta strand 92 97 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4OR9 P16298 UniProtKB Helix 104 114 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4OR9 P16298 UniProtKB Turn 117 119 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4OR9 P16298 UniProtKB Beta strand 122 124 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4OR9 P16298 UniProtKB Beta strand 129 132 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4OR9 P16298 UniProtKB Helix 135 148 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4OR9 P16298 UniProtKB Turn 150 152 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4OR9 P16298 UniProtKB Beta strand 153 155 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4OR9 P16298 UniProtKB Helix 163 168 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4OR9 P16298 UniProtKB Helix 171 178 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4OR9 P16298 UniProtKB Helix 181 192 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4OR9 P16298 UniProtKB Beta strand 196 200 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4OR9 P16298 UniProtKB Turn 201 203 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4OR9 P16298 UniProtKB Beta strand 204 209 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4OR9 P16298 UniProtKB Helix 218 222 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4OR9 P16298 UniProtKB Beta strand 232 234 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4OR9 P16298 UniProtKB Helix 235 241 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4OR9 P16298 UniProtKB Turn 246 249 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4OR9 P16298 UniProtKB Beta strand 256 259 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4OR9 P16298 UniProtKB Turn 261 263 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4OR9 P16298 UniProtKB Beta strand 264 269 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4OR9 P16298 UniProtKB Helix 271 281 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4OR9 P16298 UniProtKB Beta strand 284 288 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4OR9 P16298 UniProtKB Beta strand 296 299 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4OR9 P16298 UniProtKB Turn 304 306 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4OR9 P16298 UniProtKB Beta strand 308 315 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4OR9 P16298 UniProtKB Helix 320 322 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4OR9 P16298 UniProtKB Beta strand 328 334 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4OR9 P16298 UniProtKB Beta strand 337 343 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4OR9 P16298 UniProtKB Helix 353 355 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4OR9 P16298 UniProtKB Helix 358 378 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4OR9 P16298 UniProtKB Beta strand 381 383 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4ORA P16298 UniProtKB Turn 384 386 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4OR9 P16298 UniProtKB Helix 479 485 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4OR9 P16298 UniProtKB Helix 488 490 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4OR9