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Protein

Interleukin-2 receptor subunit beta

Gene

Il2rb

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Receptor for interleukin-2. This beta subunit is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2.

GO - Molecular functioni

  • interleukin-2 binding Source: MGI
  • interleukin-2 receptor activity Source: MGI

GO - Biological processi

Keywordsi

Molecular functionReceptor

Enzyme and pathway databases

ReactomeiR-MMU-392451 G beta:gamma signalling through PI3Kgamma
R-MMU-5673001 RAF/MAP kinase cascade
R-MMU-8983432 Interleukin-15 signaling
R-MMU-9020558 Interleukin-2 signaling
R-MMU-912526 Interleukin receptor SHC signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-2 receptor subunit beta
Short name:
IL-2 receptor subunit beta
Short name:
IL-2R subunit beta
Short name:
IL-2RB
Alternative name(s):
High affinity IL-2 receptor subunit beta
p70-75
CD_antigen: CD122
Gene namesi
Name:Il2rb
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:96550 Il2rb

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini27 – 240ExtracellularSequence analysisAdd BLAST214
Transmembranei241 – 268HelicalSequence analysisAdd BLAST28
Topological domaini269 – 539CytoplasmicSequence analysisAdd BLAST271

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Add BLAST26
ChainiPRO_000001087927 – 539Interleukin-2 receptor subunit betaAdd BLAST513

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi30N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi36 ↔ 46By similarity
Glycosylationi43N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi55N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi71N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi74 ↔ 86By similarity
Glycosylationi150N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi216N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiP16297
PaxDbiP16297
PRIDEiP16297

PTM databases

iPTMnetiP16297
PhosphoSitePlusiP16297

Expressioni

Gene expression databases

BgeeiENSMUSG00000068227
CleanExiMM_IL2RB
GenevisibleiP16297 MM

Interactioni

Subunit structurei

Non-covalent dimer of an alpha and a beta subunit. IL2R exists in 3 different forms: a high affinity dimer, an intermediate affinity monomer (beta subunit), and a low affinity monomer (alpha subunit). The high and intermediate affinity forms also associate with a gamma subunit. Interacts with SHB upon interleukin stimulation (By similarity).By similarity

GO - Molecular functioni

  • interleukin-2 binding Source: MGI

Protein-protein interaction databases

IntActiP16297, 1 interactor
STRINGi10090.ENSMUSP00000086820

Structurei

3D structure databases

ProteinModelPortaliP16297
SMRiP16297
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini135 – 235Fibronectin type-IIIPROSITE-ProRule annotationAdd BLAST101

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi221 – 225WSXWS motif5
Motifi281 – 289Box 1 motif9

Domaini

The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
The box 1 motif is required for JAK interaction and/or activation.

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410II5H Eukaryota
ENOG410YXT9 LUCA
GeneTreeiENSGT00510000049239
HOGENOMiHOG000038003
HOVERGENiHBG052110
InParanoidiP16297
KOiK05069
OMAiACQVYFT
OrthoDBiEOG091G046N
PhylomeDBiP16297
TreeFamiTF337874

Family and domain databases

CDDicd00063 FN3, 1 hit
Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR003531 Hempt_rcpt_S_F1_CS
IPR013783 Ig-like_fold
SUPFAMiSSF49265 SSF49265, 2 hits
PROSITEiView protein in PROSITE
PS50853 FN3, 1 hit
PS01355 HEMATOPO_REC_S_F1, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P16297-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATIALPWSL SLYVFLLLLA TPWASAAVKN CSHLECFYNS RANVSCMWSH
60 70 80 90 100
EEALNVTTCH VHAKSNLRHW NKTCELTLVR QASWACNLIL GSFPESQSLT
110 120 130 140 150
SVDLLDINVV CWEEKGWRRV KTCDFHPFDN LRLVAPHSLQ VLHIDTQRCN
160 170 180 190 200
ISWKVSQVSH YIEPYLEFEA RRRLLGHSWE DASVLSLKQR QQWLFLEMLI
210 220 230 240 250
PSTSYEVQVR VKAQRNNTGT WSPWSQPLTF RTRPADPMKE ILPMSWLRYL
260 270 280 290 300
LLVLGCFSGF FSCVYILVKC RYLGPWLKTV LKCHIPDPSE FFSQLSSQHG
310 320 330 340 350
GDLQKWLSSP VPLSFFSPSG PAPEISPLEV LDGDSKAVQL LLLQKDSAPL
360 370 380 390 400
PSPSGHSQAS CFTNQGYFFF HLPNALEIES CQVYFTYDPC VEEEVEEDGS
410 420 430 440 450
RLPEGSPHPP LLPLAGEQDD YCAFPPRDDL LLFSPSLSTP NTAYGGSRAP
460 470 480 490 500
EERSPLSLHE GLPSLASRDL MGLQRPLERM PEGDGEGLSA NSSGEQASVP
510 520 530
EGNLHGQDQD RGQGPILTLN TDAYLSLQEL QAQDSVHLI
Length:539
Mass (Da):60,539
Last modified:August 1, 1990 - v1
Checksum:i365C9D206E86FE14
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M28052 mRNA Translation: AAA39283.1
AK017288 mRNA Translation: BAB30674.1
AK157572 mRNA Translation: BAE34125.1
CCDSiCCDS27616.1
PIRiA35052
RefSeqiNP_032394.1, NM_008368.4
XP_006520540.1, XM_006520477.3
XP_006520541.1, XM_006520478.3
XP_006520542.1, XM_006520479.2
XP_006520543.1, XM_006520480.3
XP_006520544.1, XM_006520481.2
UniGeneiMm.35287
Mm.384038

Genome annotation databases

EnsembliENSMUST00000089398; ENSMUSP00000086820; ENSMUSG00000068227
ENSMUST00000163494; ENSMUSP00000127006; ENSMUSG00000068227
GeneIDi16185
KEGGimmu:16185
UCSCiuc007wpk.2 mouse

Similar proteinsi

Entry informationi

Entry nameiIL2RB_MOUSE
AccessioniPrimary (citable) accession number: P16297
Secondary accession number(s): Q3TZT2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: June 20, 2018
This is version 159 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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