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Protein

Interleukin-2 receptor subunit beta

Gene

Il2rb

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for interleukin-2. This beta subunit is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2.

GO - Molecular functioni

  1. interleukin-2 binding Source: MGI
  2. interleukin-2 receptor activity Source: MGI

GO - Biological processi

  1. cytokine-mediated signaling pathway Source: MGI
  2. interleukin-2-mediated signaling pathway Source: MGI
  3. negative regulation of apoptotic process Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Enzyme and pathway databases

ReactomeiREACT_210793. Interleukin receptor SHC signaling.
REACT_220092. GPVI-mediated activation cascade.
REACT_223974. G beta:gamma signalling through PI3Kgamma.
REACT_261365. Interleukin-2 signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-2 receptor subunit beta
Short name:
IL-2 receptor subunit beta
Short name:
IL-2R subunit beta
Short name:
IL-2RB
Alternative name(s):
High affinity IL-2 receptor subunit beta
p70-75
CD_antigen: CD122
Gene namesi
Name:Il2rb
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 15

Organism-specific databases

MGIiMGI:96550. Il2rb.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini27 – 240214ExtracellularSequence AnalysisAdd
BLAST
Transmembranei241 – 26828HelicalSequence AnalysisAdd
BLAST
Topological domaini269 – 539271CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. external side of plasma membrane Source: MGI
  2. integral component of membrane Source: UniProtKB-KW
  3. membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626Add
BLAST
Chaini27 – 539513Interleukin-2 receptor subunit betaPRO_0000010879Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi30 – 301N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi36 ↔ 46By similarity
Glycosylationi43 – 431N-linked (GlcNAc...)Sequence Analysis
Glycosylationi55 – 551N-linked (GlcNAc...)Sequence Analysis
Glycosylationi71 – 711N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi74 ↔ 86By similarity
Glycosylationi150 – 1501N-linked (GlcNAc...)Sequence Analysis
Glycosylationi216 – 2161N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiP16297.

PTM databases

PhosphoSiteiP16297.

Expressioni

Gene expression databases

BgeeiP16297.
CleanExiMM_IL2RB.
GenevestigatoriP16297.

Interactioni

Subunit structurei

Non-covalent dimer of an alpha and a beta subunit. IL2R exists in 3 different forms: a high affinity dimer, an intermediate affinity monomer (beta subunit), and a low affinity monomer (alpha subunit). The high and intermediate affinity forms also associate with a gamma subunit. Interacts with SHB upon interleukin stimulation (By similarity).By similarity

Protein-protein interaction databases

IntActiP16297. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliP16297.
SMRiP16297. Positions 32-319.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini135 – 235101Fibronectin type-IIIPROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi221 – 2255WSXWS motif
Motifi281 – 2899Box 1 motif

Domaini

The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
The box 1 motif is required for JAK interaction and/or activation.

Sequence similaritiesi

Contains 1 fibronectin type-III domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG46659.
GeneTreeiENSGT00510000049239.
HOGENOMiHOG000038003.
HOVERGENiHBG052110.
InParanoidiP16297.
KOiK05069.
OMAiACQVYFT.
OrthoDBiEOG72RMZ6.
PhylomeDBiP16297.
TreeFamiTF337874.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR003961. FN3_dom.
IPR003531. Hempt_rcpt_S_F1_CS.
IPR013783. Ig-like_fold.
[Graphical view]
SMARTiSM00060. FN3. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 2 hits.
PROSITEiPS50853. FN3. 1 hit.
PS01355. HEMATOPO_REC_S_F1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P16297-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATIALPWSL SLYVFLLLLA TPWASAAVKN CSHLECFYNS RANVSCMWSH
60 70 80 90 100
EEALNVTTCH VHAKSNLRHW NKTCELTLVR QASWACNLIL GSFPESQSLT
110 120 130 140 150
SVDLLDINVV CWEEKGWRRV KTCDFHPFDN LRLVAPHSLQ VLHIDTQRCN
160 170 180 190 200
ISWKVSQVSH YIEPYLEFEA RRRLLGHSWE DASVLSLKQR QQWLFLEMLI
210 220 230 240 250
PSTSYEVQVR VKAQRNNTGT WSPWSQPLTF RTRPADPMKE ILPMSWLRYL
260 270 280 290 300
LLVLGCFSGF FSCVYILVKC RYLGPWLKTV LKCHIPDPSE FFSQLSSQHG
310 320 330 340 350
GDLQKWLSSP VPLSFFSPSG PAPEISPLEV LDGDSKAVQL LLLQKDSAPL
360 370 380 390 400
PSPSGHSQAS CFTNQGYFFF HLPNALEIES CQVYFTYDPC VEEEVEEDGS
410 420 430 440 450
RLPEGSPHPP LLPLAGEQDD YCAFPPRDDL LLFSPSLSTP NTAYGGSRAP
460 470 480 490 500
EERSPLSLHE GLPSLASRDL MGLQRPLERM PEGDGEGLSA NSSGEQASVP
510 520 530
EGNLHGQDQD RGQGPILTLN TDAYLSLQEL QAQDSVHLI
Length:539
Mass (Da):60,539
Last modified:August 1, 1990 - v1
Checksum:i365C9D206E86FE14
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M28052 mRNA. Translation: AAA39283.1.
AK017288 mRNA. Translation: BAB30674.1.
AK157572 mRNA. Translation: BAE34125.1.
CCDSiCCDS27616.1.
PIRiA35052.
RefSeqiNP_032394.1. NM_008368.4.
XP_006520540.1. XM_006520477.1.
XP_006520541.1. XM_006520478.1.
XP_006520542.1. XM_006520479.1.
XP_006520543.1. XM_006520480.1.
XP_006520544.1. XM_006520481.1.
UniGeneiMm.35287.
Mm.384038.

Genome annotation databases

EnsembliENSMUST00000089398; ENSMUSP00000086820; ENSMUSG00000068227.
ENSMUST00000163494; ENSMUSP00000127006; ENSMUSG00000068227.
GeneIDi16185.
KEGGimmu:16185.
UCSCiuc007wpk.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M28052 mRNA. Translation: AAA39283.1.
AK017288 mRNA. Translation: BAB30674.1.
AK157572 mRNA. Translation: BAE34125.1.
CCDSiCCDS27616.1.
PIRiA35052.
RefSeqiNP_032394.1. NM_008368.4.
XP_006520540.1. XM_006520477.1.
XP_006520541.1. XM_006520478.1.
XP_006520542.1. XM_006520479.1.
XP_006520543.1. XM_006520480.1.
XP_006520544.1. XM_006520481.1.
UniGeneiMm.35287.
Mm.384038.

3D structure databases

ProteinModelPortaliP16297.
SMRiP16297. Positions 32-319.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP16297. 1 interaction.

PTM databases

PhosphoSiteiP16297.

Proteomic databases

PRIDEiP16297.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000089398; ENSMUSP00000086820; ENSMUSG00000068227.
ENSMUST00000163494; ENSMUSP00000127006; ENSMUSG00000068227.
GeneIDi16185.
KEGGimmu:16185.
UCSCiuc007wpk.2. mouse.

Organism-specific databases

CTDi3560.
MGIiMGI:96550. Il2rb.

Phylogenomic databases

eggNOGiNOG46659.
GeneTreeiENSGT00510000049239.
HOGENOMiHOG000038003.
HOVERGENiHBG052110.
InParanoidiP16297.
KOiK05069.
OMAiACQVYFT.
OrthoDBiEOG72RMZ6.
PhylomeDBiP16297.
TreeFamiTF337874.

Enzyme and pathway databases

ReactomeiREACT_210793. Interleukin receptor SHC signaling.
REACT_220092. GPVI-mediated activation cascade.
REACT_223974. G beta:gamma signalling through PI3Kgamma.
REACT_261365. Interleukin-2 signaling.

Miscellaneous databases

NextBioi289077.
PROiP16297.
SOURCEiSearch...

Gene expression databases

BgeeiP16297.
CleanExiMM_IL2RB.
GenevestigatoriP16297.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR003961. FN3_dom.
IPR003531. Hempt_rcpt_S_F1_CS.
IPR013783. Ig-like_fold.
[Graphical view]
SMARTiSM00060. FN3. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 2 hits.
PROSITEiPS50853. FN3. 1 hit.
PS01355. HEMATOPO_REC_S_F1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Murine interleukin 2 receptor beta chain: dysregulated gene expression in lymphoma line EL-4 caused by a promoter insertion."
    Kono T., Doi T., Yamada G., Hatakeyama M., Minamoto S., Tsudo M., Miyasaka M., Miyata T., Taniguchi T.
    Proc. Natl. Acad. Sci. U.S.A. 87:1806-1810(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and NOD.
    Tissue: Head and Spleen.

Entry informationi

Entry nameiIL2RB_MOUSE
AccessioniPrimary (citable) accession number: P16297
Secondary accession number(s): Q3TZT2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: February 4, 2015
This is version 135 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.