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P16297

- IL2RB_MOUSE

UniProt

P16297 - IL2RB_MOUSE

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Protein

Interleukin-2 receptor subunit beta

Gene
Il2rb
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Receptor for interleukin-2. This beta subunit is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2.

GO - Molecular functioni

  1. interleukin-2 binding Source: MGI
  2. interleukin-2 receptor activity Source: Ensembl

GO - Biological processi

  1. negative regulation of apoptotic process Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Enzyme and pathway databases

ReactomeiREACT_210793. Interleukin receptor SHC signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-2 receptor subunit beta
Short name:
IL-2 receptor subunit beta
Short name:
IL-2R subunit beta
Short name:
IL-2RB
Alternative name(s):
High affinity IL-2 receptor subunit beta
p70-75
CD_antigen: CD122
Gene namesi
Name:Il2rb
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 15

Organism-specific databases

MGIiMGI:96550. Il2rb.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini27 – 240214Extracellular Reviewed predictionAdd
BLAST
Transmembranei241 – 26828Helical; Reviewed predictionAdd
BLAST
Topological domaini269 – 539271Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. external side of plasma membrane Source: MGI
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626Add
BLAST
Chaini27 – 539513Interleukin-2 receptor subunit betaPRO_0000010879Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi30 – 301N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi36 ↔ 46 By similarity
Glycosylationi43 – 431N-linked (GlcNAc...) Reviewed prediction
Glycosylationi55 – 551N-linked (GlcNAc...) Reviewed prediction
Glycosylationi71 – 711N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi74 ↔ 86 By similarity
Glycosylationi150 – 1501N-linked (GlcNAc...) Reviewed prediction
Glycosylationi216 – 2161N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiP16297.

PTM databases

PhosphoSiteiP16297.

Expressioni

Gene expression databases

BgeeiP16297.
CleanExiMM_IL2RB.
GenevestigatoriP16297.

Interactioni

Subunit structurei

Non-covalent dimer of an alpha and a beta subunit. IL2R exists in 3 different forms: a high affinity dimer, an intermediate affinity monomer (beta subunit), and a low affinity monomer (alpha subunit). The high and intermediate affinity forms also associate with a gamma subunit. Interacts with SHB upon interleukin stimulation By similarity.

Protein-protein interaction databases

IntActiP16297. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliP16297.
SMRiP16297. Positions 32-319.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini135 – 235101Fibronectin type-IIIAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi221 – 2255WSXWS motif
Motifi281 – 2899Box 1 motif

Domaini

The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
The box 1 motif is required for JAK interaction and/or activation.

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG46659.
GeneTreeiENSGT00510000049239.
HOGENOMiHOG000038003.
HOVERGENiHBG052110.
InParanoidiP16297.
KOiK05069.
OMAiACQVYFT.
OrthoDBiEOG72RMZ6.
PhylomeDBiP16297.
TreeFamiTF337874.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR003961. Fibronectin_type3.
IPR003531. Hempt_rcpt_S_F1_CS.
IPR013783. Ig-like_fold.
[Graphical view]
SMARTiSM00060. FN3. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 2 hits.
PROSITEiPS50853. FN3. 1 hit.
PS01355. HEMATOPO_REC_S_F1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P16297-1 [UniParc]FASTAAdd to Basket

« Hide

MATIALPWSL SLYVFLLLLA TPWASAAVKN CSHLECFYNS RANVSCMWSH    50
EEALNVTTCH VHAKSNLRHW NKTCELTLVR QASWACNLIL GSFPESQSLT 100
SVDLLDINVV CWEEKGWRRV KTCDFHPFDN LRLVAPHSLQ VLHIDTQRCN 150
ISWKVSQVSH YIEPYLEFEA RRRLLGHSWE DASVLSLKQR QQWLFLEMLI 200
PSTSYEVQVR VKAQRNNTGT WSPWSQPLTF RTRPADPMKE ILPMSWLRYL 250
LLVLGCFSGF FSCVYILVKC RYLGPWLKTV LKCHIPDPSE FFSQLSSQHG 300
GDLQKWLSSP VPLSFFSPSG PAPEISPLEV LDGDSKAVQL LLLQKDSAPL 350
PSPSGHSQAS CFTNQGYFFF HLPNALEIES CQVYFTYDPC VEEEVEEDGS 400
RLPEGSPHPP LLPLAGEQDD YCAFPPRDDL LLFSPSLSTP NTAYGGSRAP 450
EERSPLSLHE GLPSLASRDL MGLQRPLERM PEGDGEGLSA NSSGEQASVP 500
EGNLHGQDQD RGQGPILTLN TDAYLSLQEL QAQDSVHLI 539
Length:539
Mass (Da):60,539
Last modified:August 1, 1990 - v1
Checksum:i365C9D206E86FE14
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M28052 mRNA. Translation: AAA39283.1.
AK017288 mRNA. Translation: BAB30674.1.
AK157572 mRNA. Translation: BAE34125.1.
CCDSiCCDS27616.1.
PIRiA35052.
RefSeqiNP_032394.1. NM_008368.4.
XP_006520540.1. XM_006520477.1.
XP_006520541.1. XM_006520478.1.
XP_006520542.1. XM_006520479.1.
XP_006520543.1. XM_006520480.1.
XP_006520544.1. XM_006520481.1.
UniGeneiMm.35287.
Mm.384038.

Genome annotation databases

EnsembliENSMUST00000089398; ENSMUSP00000086820; ENSMUSG00000068227.
ENSMUST00000163494; ENSMUSP00000127006; ENSMUSG00000068227.
GeneIDi16185.
KEGGimmu:16185.
UCSCiuc007wpk.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M28052 mRNA. Translation: AAA39283.1 .
AK017288 mRNA. Translation: BAB30674.1 .
AK157572 mRNA. Translation: BAE34125.1 .
CCDSi CCDS27616.1.
PIRi A35052.
RefSeqi NP_032394.1. NM_008368.4.
XP_006520540.1. XM_006520477.1.
XP_006520541.1. XM_006520478.1.
XP_006520542.1. XM_006520479.1.
XP_006520543.1. XM_006520480.1.
XP_006520544.1. XM_006520481.1.
UniGenei Mm.35287.
Mm.384038.

3D structure databases

ProteinModelPortali P16297.
SMRi P16297. Positions 32-319.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P16297. 1 interaction.

PTM databases

PhosphoSitei P16297.

Proteomic databases

PRIDEi P16297.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000089398 ; ENSMUSP00000086820 ; ENSMUSG00000068227 .
ENSMUST00000163494 ; ENSMUSP00000127006 ; ENSMUSG00000068227 .
GeneIDi 16185.
KEGGi mmu:16185.
UCSCi uc007wpk.2. mouse.

Organism-specific databases

CTDi 3560.
MGIi MGI:96550. Il2rb.

Phylogenomic databases

eggNOGi NOG46659.
GeneTreei ENSGT00510000049239.
HOGENOMi HOG000038003.
HOVERGENi HBG052110.
InParanoidi P16297.
KOi K05069.
OMAi ACQVYFT.
OrthoDBi EOG72RMZ6.
PhylomeDBi P16297.
TreeFami TF337874.

Enzyme and pathway databases

Reactomei REACT_210793. Interleukin receptor SHC signaling.

Miscellaneous databases

NextBioi 289077.
PROi P16297.
SOURCEi Search...

Gene expression databases

Bgeei P16297.
CleanExi MM_IL2RB.
Genevestigatori P16297.

Family and domain databases

Gene3Di 2.60.40.10. 1 hit.
InterProi IPR003961. Fibronectin_type3.
IPR003531. Hempt_rcpt_S_F1_CS.
IPR013783. Ig-like_fold.
[Graphical view ]
SMARTi SM00060. FN3. 1 hit.
[Graphical view ]
SUPFAMi SSF49265. SSF49265. 2 hits.
PROSITEi PS50853. FN3. 1 hit.
PS01355. HEMATOPO_REC_S_F1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Murine interleukin 2 receptor beta chain: dysregulated gene expression in lymphoma line EL-4 caused by a promoter insertion."
    Kono T., Doi T., Yamada G., Hatakeyama M., Minamoto S., Tsudo M., Miyasaka M., Miyata T., Taniguchi T.
    Proc. Natl. Acad. Sci. U.S.A. 87:1806-1810(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and NOD.
    Tissue: Head and Spleen.

Entry informationi

Entry nameiIL2RB_MOUSE
AccessioniPrimary (citable) accession number: P16297
Secondary accession number(s): Q3TZT2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: September 3, 2014
This is version 131 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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