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P16297 (IL2RB_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 121. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Interleukin-2 receptor subunit beta
Short name=IL-2 receptor subunit beta
Short name=IL-2R subunit beta
Short name=IL-2RB
Alternative name(s):
High affinity IL-2 receptor subunit beta
p70-75
CD_antigen=CD122
Gene names
Name:Il2rb
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length539 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Receptor for interleukin-2. This beta subunit is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2.

Subunit structure

Non-covalent dimer of an alpha and a beta subunit. IL2R exists in 3 different forms: a high affinity dimer, an intermediate affinity monomer (beta subunit), and a low affinity monomer (alpha subunit). The high and intermediate affinity forms also associate with a gamma subunit. Interacts with SHB upon interleukin stimulation By similarity.

Subcellular location

Membrane; Single-pass type I membrane protein.

Domain

The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.

The box 1 motif is required for JAK interaction and/or activation.

Sequence similarities

Belongs to the type I cytokine receptor family. Type 4 subfamily.

Contains 1 fibronectin type-III domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2626
Chain27 – 539513Interleukin-2 receptor subunit beta
PRO_0000010879

Regions

Topological domain27 – 240214Extracellular Potential
Transmembrane241 – 26828Helical; Potential
Topological domain269 – 539271Cytoplasmic Potential
Domain132 – 23099Fibronectin type-III
Motif221 – 2255WSXWS motif
Motif281 – 2899Box 1 motif

Amino acid modifications

Glycosylation301N-linked (GlcNAc...) Potential
Glycosylation431N-linked (GlcNAc...) Potential
Glycosylation551N-linked (GlcNAc...) Potential
Glycosylation711N-linked (GlcNAc...) Potential
Glycosylation1501N-linked (GlcNAc...) Potential
Glycosylation2161N-linked (GlcNAc...) Potential
Disulfide bond36 ↔ 46 By similarity
Disulfide bond74 ↔ 86 By similarity

Sequences

Sequence LengthMass (Da)Tools
P16297 [UniParc].

Last modified August 1, 1990. Version 1.
Checksum: 365C9D206E86FE14

FASTA53960,539
        10         20         30         40         50         60 
MATIALPWSL SLYVFLLLLA TPWASAAVKN CSHLECFYNS RANVSCMWSH EEALNVTTCH 

        70         80         90        100        110        120 
VHAKSNLRHW NKTCELTLVR QASWACNLIL GSFPESQSLT SVDLLDINVV CWEEKGWRRV 

       130        140        150        160        170        180 
KTCDFHPFDN LRLVAPHSLQ VLHIDTQRCN ISWKVSQVSH YIEPYLEFEA RRRLLGHSWE 

       190        200        210        220        230        240 
DASVLSLKQR QQWLFLEMLI PSTSYEVQVR VKAQRNNTGT WSPWSQPLTF RTRPADPMKE 

       250        260        270        280        290        300 
ILPMSWLRYL LLVLGCFSGF FSCVYILVKC RYLGPWLKTV LKCHIPDPSE FFSQLSSQHG 

       310        320        330        340        350        360 
GDLQKWLSSP VPLSFFSPSG PAPEISPLEV LDGDSKAVQL LLLQKDSAPL PSPSGHSQAS 

       370        380        390        400        410        420 
CFTNQGYFFF HLPNALEIES CQVYFTYDPC VEEEVEEDGS RLPEGSPHPP LLPLAGEQDD 

       430        440        450        460        470        480 
YCAFPPRDDL LLFSPSLSTP NTAYGGSRAP EERSPLSLHE GLPSLASRDL MGLQRPLERM 

       490        500        510        520        530 
PEGDGEGLSA NSSGEQASVP EGNLHGQDQD RGQGPILTLN TDAYLSLQEL QAQDSVHLI

« Hide

References

« Hide 'large scale' references
[1]"Murine interleukin 2 receptor beta chain: dysregulated gene expression in lymphoma line EL-4 caused by a promoter insertion."
Kono T., Doi T., Yamada G., Hatakeyama M., Minamoto S., Tsudo M., Miyasaka M., Miyata T., Taniguchi T.
Proc. Natl. Acad. Sci. U.S.A. 87:1806-1810(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J and NOD.
Tissue: Head and Spleen.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		M28052 mRNA. Translation: AAA39283.1.
AK017288 mRNA. Translation: BAB30674.1.
AK157572 mRNA. Translation: BAE34125.1.
IPIIPI00132541.
PIRA35052.
RefSeqNP_032394.1. NM_008368.4.
UniGeneMm.35287.

3D structure databases

ProteinModelPortalP16297.
SMRP16297. Positions 32-319.
ModBaseSearch...

Protein-protein interaction databases

IntActP16297. 1 interaction.

PTM databases

PhosphoSiteP16297.

Proteomic databases

PRIDEP16297.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000089398; ENSMUSP00000086820; ENSMUSG00000068227.
ENSMUST00000163494; ENSMUSP00000127006; ENSMUSG00000068227.
GeneID16185.
KEGGmmu:16185.
UCSCuc007wpk.2. mouse.

Organism-specific databases

CTD3560.
MGIMGI:96550. Il2rb.

Phylogenomic databases

eggNOGNOG46659.
GeneTreeENSGT00510000049239.
HOGENOMHOG000038003.
HOVERGENHBG052110.
InParanoidP16297.
KOK05069.
OMALAFRTKP.
OrthoDBEOG42Z4Q0.

Gene expression databases

BgeeP16297.
CleanExMM_IL2RB.
GenevestigatorP16297.
GermOnlineENSMUSG00000068227. Mus musculus.

Family and domain databases

Gene3D2.60.40.10. 1 hit.
InterProIPR003961. Fibronectin_type3.
IPR003531. Hempt_rcpt_S_F1_CS.
IPR013783. Ig-like_fold.
[Graphical view]
SMARTSM00060. FN3. 1 hit.
[Graphical view]
SUPFAMSSF49265. FN_III-like. 2 hits.
PROSITEPS50853. FN3. 1 hit.
PS01355. HEMATOPO_REC_S_F1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio289077.
SOURCESearch...

Entry information

Entry nameIL2RB_MOUSE
AccessionPrimary (citable) accession number: P16297
Secondary accession number(s): Q3TZT2
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: May 1, 2013
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

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