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Protein

Interleukin-2 receptor subunit beta

Gene

Il2rb

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for interleukin-2. This beta subunit is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2.

GO - Molecular functioni

  • interleukin-2 binding Source: MGI
  • interleukin-2 receptor activity Source: MGI

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Enzyme and pathway databases

ReactomeiR-MMU-114604. GPVI-mediated activation cascade.
R-MMU-392451. G beta:gamma signalling through PI3Kgamma.
R-MMU-449147. Signaling by Interleukins.
R-MMU-451927. Interleukin-2 signaling.
R-MMU-5673001. RAF/MAP kinase cascade.
R-MMU-912526. Interleukin receptor SHC signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-2 receptor subunit beta
Short name:
IL-2 receptor subunit beta
Short name:
IL-2R subunit beta
Short name:
IL-2RB
Alternative name(s):
High affinity IL-2 receptor subunit beta
p70-75
CD_antigen: CD122
Gene namesi
Name:Il2rb
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:96550. Il2rb.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini27 – 240ExtracellularSequence analysisAdd BLAST214
Transmembranei241 – 268HelicalSequence analysisAdd BLAST28
Topological domaini269 – 539CytoplasmicSequence analysisAdd BLAST271

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Add BLAST26
ChainiPRO_000001087927 – 539Interleukin-2 receptor subunit betaAdd BLAST513

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi30N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi36 ↔ 46By similarity
Glycosylationi43N-linked (GlcNAc...)Sequence analysis1
Glycosylationi55N-linked (GlcNAc...)Sequence analysis1
Glycosylationi71N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi74 ↔ 86By similarity
Glycosylationi150N-linked (GlcNAc...)Sequence analysis1
Glycosylationi216N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiP16297.
PaxDbiP16297.
PRIDEiP16297.

PTM databases

PhosphoSitePlusiP16297.

Expressioni

Gene expression databases

BgeeiENSMUSG00000068227.
CleanExiMM_IL2RB.
GenevisibleiP16297. MM.

Interactioni

Subunit structurei

Non-covalent dimer of an alpha and a beta subunit. IL2R exists in 3 different forms: a high affinity dimer, an intermediate affinity monomer (beta subunit), and a low affinity monomer (alpha subunit). The high and intermediate affinity forms also associate with a gamma subunit. Interacts with SHB upon interleukin stimulation (By similarity).By similarity

GO - Molecular functioni

  • interleukin-2 binding Source: MGI

Protein-protein interaction databases

IntActiP16297. 1 interactor.
STRINGi10090.ENSMUSP00000086820.

Structurei

3D structure databases

ProteinModelPortaliP16297.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini135 – 235Fibronectin type-IIIPROSITE-ProRule annotationAdd BLAST101

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi221 – 225WSXWS motif5
Motifi281 – 289Box 1 motif9

Domaini

The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
The box 1 motif is required for JAK interaction and/or activation.

Sequence similaritiesi

Contains 1 fibronectin type-III domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410II5H. Eukaryota.
ENOG410YXT9. LUCA.
GeneTreeiENSGT00510000049239.
HOGENOMiHOG000038003.
HOVERGENiHBG052110.
InParanoidiP16297.
KOiK05069.
OMAiACQVYFT.
OrthoDBiEOG091G046N.
PhylomeDBiP16297.
TreeFamiTF337874.

Family and domain databases

CDDicd00063. FN3. 1 hit.
Gene3Di2.60.40.10. 1 hit.
InterProiIPR003961. FN3_dom.
IPR003531. Hempt_rcpt_S_F1_CS.
IPR013783. Ig-like_fold.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 2 hits.
PROSITEiPS50853. FN3. 1 hit.
PS01355. HEMATOPO_REC_S_F1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P16297-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATIALPWSL SLYVFLLLLA TPWASAAVKN CSHLECFYNS RANVSCMWSH
60 70 80 90 100
EEALNVTTCH VHAKSNLRHW NKTCELTLVR QASWACNLIL GSFPESQSLT
110 120 130 140 150
SVDLLDINVV CWEEKGWRRV KTCDFHPFDN LRLVAPHSLQ VLHIDTQRCN
160 170 180 190 200
ISWKVSQVSH YIEPYLEFEA RRRLLGHSWE DASVLSLKQR QQWLFLEMLI
210 220 230 240 250
PSTSYEVQVR VKAQRNNTGT WSPWSQPLTF RTRPADPMKE ILPMSWLRYL
260 270 280 290 300
LLVLGCFSGF FSCVYILVKC RYLGPWLKTV LKCHIPDPSE FFSQLSSQHG
310 320 330 340 350
GDLQKWLSSP VPLSFFSPSG PAPEISPLEV LDGDSKAVQL LLLQKDSAPL
360 370 380 390 400
PSPSGHSQAS CFTNQGYFFF HLPNALEIES CQVYFTYDPC VEEEVEEDGS
410 420 430 440 450
RLPEGSPHPP LLPLAGEQDD YCAFPPRDDL LLFSPSLSTP NTAYGGSRAP
460 470 480 490 500
EERSPLSLHE GLPSLASRDL MGLQRPLERM PEGDGEGLSA NSSGEQASVP
510 520 530
EGNLHGQDQD RGQGPILTLN TDAYLSLQEL QAQDSVHLI
Length:539
Mass (Da):60,539
Last modified:August 1, 1990 - v1
Checksum:i365C9D206E86FE14
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M28052 mRNA. Translation: AAA39283.1.
AK017288 mRNA. Translation: BAB30674.1.
AK157572 mRNA. Translation: BAE34125.1.
CCDSiCCDS27616.1.
PIRiA35052.
RefSeqiNP_032394.1. NM_008368.4.
XP_006520540.1. XM_006520477.3.
XP_006520541.1. XM_006520478.3.
XP_006520542.1. XM_006520479.2.
XP_006520543.1. XM_006520480.3.
XP_006520544.1. XM_006520481.2.
UniGeneiMm.35287.
Mm.384038.

Genome annotation databases

EnsembliENSMUST00000089398; ENSMUSP00000086820; ENSMUSG00000068227.
ENSMUST00000163494; ENSMUSP00000127006; ENSMUSG00000068227.
GeneIDi16185.
KEGGimmu:16185.
UCSCiuc007wpk.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M28052 mRNA. Translation: AAA39283.1.
AK017288 mRNA. Translation: BAB30674.1.
AK157572 mRNA. Translation: BAE34125.1.
CCDSiCCDS27616.1.
PIRiA35052.
RefSeqiNP_032394.1. NM_008368.4.
XP_006520540.1. XM_006520477.3.
XP_006520541.1. XM_006520478.3.
XP_006520542.1. XM_006520479.2.
XP_006520543.1. XM_006520480.3.
XP_006520544.1. XM_006520481.2.
UniGeneiMm.35287.
Mm.384038.

3D structure databases

ProteinModelPortaliP16297.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP16297. 1 interactor.
STRINGi10090.ENSMUSP00000086820.

PTM databases

PhosphoSitePlusiP16297.

Proteomic databases

EPDiP16297.
PaxDbiP16297.
PRIDEiP16297.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000089398; ENSMUSP00000086820; ENSMUSG00000068227.
ENSMUST00000163494; ENSMUSP00000127006; ENSMUSG00000068227.
GeneIDi16185.
KEGGimmu:16185.
UCSCiuc007wpk.2. mouse.

Organism-specific databases

CTDi3560.
MGIiMGI:96550. Il2rb.

Phylogenomic databases

eggNOGiENOG410II5H. Eukaryota.
ENOG410YXT9. LUCA.
GeneTreeiENSGT00510000049239.
HOGENOMiHOG000038003.
HOVERGENiHBG052110.
InParanoidiP16297.
KOiK05069.
OMAiACQVYFT.
OrthoDBiEOG091G046N.
PhylomeDBiP16297.
TreeFamiTF337874.

Enzyme and pathway databases

ReactomeiR-MMU-114604. GPVI-mediated activation cascade.
R-MMU-392451. G beta:gamma signalling through PI3Kgamma.
R-MMU-449147. Signaling by Interleukins.
R-MMU-451927. Interleukin-2 signaling.
R-MMU-5673001. RAF/MAP kinase cascade.
R-MMU-912526. Interleukin receptor SHC signaling.

Miscellaneous databases

PROiP16297.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000068227.
CleanExiMM_IL2RB.
GenevisibleiP16297. MM.

Family and domain databases

CDDicd00063. FN3. 1 hit.
Gene3Di2.60.40.10. 1 hit.
InterProiIPR003961. FN3_dom.
IPR003531. Hempt_rcpt_S_F1_CS.
IPR013783. Ig-like_fold.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 2 hits.
PROSITEiPS50853. FN3. 1 hit.
PS01355. HEMATOPO_REC_S_F1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIL2RB_MOUSE
AccessioniPrimary (citable) accession number: P16297
Secondary accession number(s): Q3TZT2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: November 30, 2016
This is version 148 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.