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P16290

- PGAM2_RAT

UniProt

P16290 - PGAM2_RAT

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Protein
Phosphoglycerate mutase 2
Gene
Pgam2
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Interconversion of 3- and 2-phosphoglycerate with 2,3-bisphosphoglycerate as the primer of the reaction. Can also catalyze the reaction of EC 5.4.2.4 (synthase) and EC 3.1.3.13 (phosphatase), but with a reduced activity.UniRule annotation

Catalytic activityi

2-phospho-D-glycerate = 3-phospho-D-glycerate.UniRule annotation
3-phospho-D-glyceroyl phosphate = 2,3-bisphospho-D-glycerate.UniRule annotation
2,3-bisphospho-D-glycerate + H2O = 3-phospho-D-glycerate + phosphate.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei11 – 111Tele-phosphohistidine intermediate
Sitei62 – 621Interaction with carboxyl group of phosphoglycerates
Active sitei186 – 1861

GO - Molecular functioni

  1. 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity Source: RGD
  2. bisphosphoglycerate 2-phosphatase activity Source: UniProtKB-EC
  3. bisphosphoglycerate mutase activity Source: UniProtKB-EC
  4. cofactor binding Source: RGD
  5. phosphoglycerate mutase activity Source: RGD

GO - Biological processi

  1. gluconeogenesis Source: RGD
  2. glycolytic process Source: UniProtKB-KW
  3. response to inorganic substance Source: RGD
  4. response to mercury ion Source: RGD
  5. spermatogenesis Source: RGD
  6. striated muscle contraction Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Isomerase

Keywords - Biological processi

Glycolysis

Enzyme and pathway databases

ReactomeiREACT_217998. Gluconeogenesis.
REACT_225694. Glycolysis.
SABIO-RKP16290.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoglycerate mutase 2 (EC:3.1.3.13, EC:5.4.2.11, EC:5.4.2.4)
Alternative name(s):
BPG-dependent PGAM 2
Muscle-specific phosphoglycerate mutase
Phosphoglycerate mutase isozyme M
Short name:
PGAM-M
Gene namesi
Name:Pgam2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 14

Organism-specific databases

RGDi3313. Pgam2.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: RGD
  2. nucleus Source: RGD
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 253253Phosphoglycerate mutase 2UniRule annotation
PRO_0000179831Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki179 – 179Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) By similarity
Cross-linki195 – 195Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) By similarity

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

PaxDbiP16290.
PRIDEiP16290.

PTM databases

PhosphoSiteiP16290.

Expressioni

Tissue specificityi

In mammalian tissues there are two types of phosphoglycerate mutase isozymes: type-M in muscles and type-B in other tissues.

Gene expression databases

GenevestigatoriP16290.

Interactioni

Subunit structurei

Homodimer.

Protein-protein interaction databases

IntActiP16290. 7 interactions.
MINTiMINT-4588391.
STRINGi10116.ENSRNOP00000018227.

Structurei

3D structure databases

ProteinModelPortaliP16290.
SMRiP16290. Positions 2-246.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi122 – 1254Poly-ProUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0588.
GeneTreeiENSGT00390000016700.
HOGENOMiHOG000221682.
HOVERGENiHBG027528.
InParanoidiP16290.
KOiK01834.
OMAiWTILEGT.
OrthoDBiEOG7XM2ZV.
PhylomeDBiP16290.
TreeFamiTF300007.

Family and domain databases

Gene3Di3.40.50.1240. 1 hit.
HAMAPiMF_01039. PGAM_GpmA.
InterProiIPR013078. His_Pase_superF_clade-1.
IPR029033. His_PPase_superfam.
IPR001345. PG/BPGM_mutase_AS.
IPR005952. Phosphogly_mut1.
[Graphical view]
PANTHERiPTHR11931. PTHR11931. 1 hit.
PfamiPF00300. His_Phos_1. 1 hit.
[Graphical view]
SMARTiSM00855. PGAM. 1 hit.
[Graphical view]
SUPFAMiSSF53254. SSF53254. 1 hit.
TIGRFAMsiTIGR01258. pgm_1. 1 hit.
PROSITEiPS00175. PG_MUTASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P16290-1 [UniParc]FASTAAdd to Basket

« Hide

MATHRLVMVR HGESSWNQEN RFCGWFDAEL SEKGAEEAKR GATAIKDAKI    50
EFDICYTSVL KRAIRTLWTI LDVTDQMWVP VVRTWRLNER HYGGLTGLNK 100
AETAAKHGEE QVKIWRRSFD TPPPPMDEKH NYYASISKDR RYAGLKPEEL 150
PTCESLKDTI ARALPFWNEE IAPKIKAGKR VLIAAHGNSL RGIVKHLEGM 200
SDQAIMELNL PTGIPIVYEL NQELKPTKPM RFLGDEETVR KAMEAVAAQG 250
KAK 253
Length:253
Mass (Da):28,755
Last modified:January 23, 2007 - v2
Checksum:i73F6118A1C73D545
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M31835 mRNA. Translation: AAA41835.1.
Z17319 Genomic DNA. Translation: CAA78967.1.
PIRiA33793. PMRTYM.
RefSeqiNP_059024.1. NM_017328.2.
UniGeneiRn.9738.

Genome annotation databases

EnsembliENSRNOT00000018227; ENSRNOP00000018227; ENSRNOG00000013532.
GeneIDi24959.
KEGGirno:24959.
UCSCiRGD:3313. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M31835 mRNA. Translation: AAA41835.1 .
Z17319 Genomic DNA. Translation: CAA78967.1 .
PIRi A33793. PMRTYM.
RefSeqi NP_059024.1. NM_017328.2.
UniGenei Rn.9738.

3D structure databases

ProteinModelPortali P16290.
SMRi P16290. Positions 2-246.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P16290. 7 interactions.
MINTi MINT-4588391.
STRINGi 10116.ENSRNOP00000018227.

PTM databases

PhosphoSitei P16290.

Proteomic databases

PaxDbi P16290.
PRIDEi P16290.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000018227 ; ENSRNOP00000018227 ; ENSRNOG00000013532 .
GeneIDi 24959.
KEGGi rno:24959.
UCSCi RGD:3313. rat.

Organism-specific databases

CTDi 5224.
RGDi 3313. Pgam2.

Phylogenomic databases

eggNOGi COG0588.
GeneTreei ENSGT00390000016700.
HOGENOMi HOG000221682.
HOVERGENi HBG027528.
InParanoidi P16290.
KOi K01834.
OMAi WTILEGT.
OrthoDBi EOG7XM2ZV.
PhylomeDBi P16290.
TreeFami TF300007.

Enzyme and pathway databases

Reactomei REACT_217998. Gluconeogenesis.
REACT_225694. Glycolysis.
SABIO-RK P16290.

Miscellaneous databases

NextBioi 604991.
PROi P16290.

Gene expression databases

Genevestigatori P16290.

Family and domain databases

Gene3Di 3.40.50.1240. 1 hit.
HAMAPi MF_01039. PGAM_GpmA.
InterProi IPR013078. His_Pase_superF_clade-1.
IPR029033. His_PPase_superfam.
IPR001345. PG/BPGM_mutase_AS.
IPR005952. Phosphogly_mut1.
[Graphical view ]
PANTHERi PTHR11931. PTHR11931. 1 hit.
Pfami PF00300. His_Phos_1. 1 hit.
[Graphical view ]
SMARTi SM00855. PGAM. 1 hit.
[Graphical view ]
SUPFAMi SSF53254. SSF53254. 1 hit.
TIGRFAMsi TIGR01258. pgm_1. 1 hit.
PROSITEi PS00175. PG_MUTASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Skeletal muscle.
  2. "The gene encoding rat phosphoglycerate mutase subunit M: cloning and promoter analysis in skeletal muscle cells."
    Ruiz-Lozano P., de Lecea L., Buesa C., Perez de la Osa P., Lepage D., Gualberto A., Walsh K., Pons G.
    Gene 147:243-248(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiPGAM2_RAT
AccessioniPrimary (citable) accession number: P16290
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: January 23, 2007
Last modified: September 3, 2014
This is version 124 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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