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P16290

- PGAM2_RAT

UniProt

P16290 - PGAM2_RAT

Protein

Phosphoglycerate mutase 2

Gene

Pgam2

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 125 (01 Oct 2014)
      Sequence version 2 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Interconversion of 3- and 2-phosphoglycerate with 2,3-bisphosphoglycerate as the primer of the reaction. Can also catalyze the reaction of EC 5.4.2.4 (synthase) and EC 3.1.3.13 (phosphatase), but with a reduced activity.

    Catalytic activityi

    2-phospho-D-glycerate = 3-phospho-D-glycerate.
    3-phospho-D-glyceroyl phosphate = 2,3-bisphospho-D-glycerate.
    2,3-bisphospho-D-glycerate + H2O = 3-phospho-D-glycerate + phosphate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei11 – 111Tele-phosphohistidine intermediate
    Sitei62 – 621Interaction with carboxyl group of phosphoglycerates
    Active sitei186 – 1861

    GO - Molecular functioni

    1. 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity Source: RGD
    2. bisphosphoglycerate 2-phosphatase activity Source: UniProtKB-EC
    3. bisphosphoglycerate mutase activity Source: UniProtKB-EC
    4. cofactor binding Source: RGD
    5. phosphoglycerate mutase activity Source: RGD

    GO - Biological processi

    1. gluconeogenesis Source: RGD
    2. glycolytic process Source: UniProtKB-KW
    3. response to inorganic substance Source: RGD
    4. response to mercury ion Source: RGD
    5. spermatogenesis Source: RGD
    6. striated muscle contraction Source: Ensembl

    Keywords - Molecular functioni

    Hydrolase, Isomerase

    Keywords - Biological processi

    Glycolysis

    Enzyme and pathway databases

    ReactomeiREACT_217998. Gluconeogenesis.
    REACT_225694. Glycolysis.
    SABIO-RKP16290.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphoglycerate mutase 2 (EC:3.1.3.13, EC:5.4.2.11, EC:5.4.2.4)
    Alternative name(s):
    BPG-dependent PGAM 2
    Muscle-specific phosphoglycerate mutase
    Phosphoglycerate mutase isozyme M
    Short name:
    PGAM-M
    Gene namesi
    Name:Pgam2
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 14

    Organism-specific databases

    RGDi3313. Pgam2.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: RGD
    2. nucleus Source: RGD

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 253253Phosphoglycerate mutase 2PRO_0000179831Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Cross-linki179 – 179Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
    Cross-linki195 – 195Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity

    Keywords - PTMi

    Isopeptide bond, Ubl conjugation

    Proteomic databases

    PaxDbiP16290.
    PRIDEiP16290.

    PTM databases

    PhosphoSiteiP16290.

    Expressioni

    Tissue specificityi

    In mammalian tissues there are two types of phosphoglycerate mutase isozymes: type-M in muscles and type-B in other tissues.

    Gene expression databases

    GenevestigatoriP16290.

    Interactioni

    Subunit structurei

    Homodimer.

    Protein-protein interaction databases

    IntActiP16290. 7 interactions.
    MINTiMINT-4588391.
    STRINGi10116.ENSRNOP00000018227.

    Structurei

    3D structure databases

    ProteinModelPortaliP16290.
    SMRiP16290. Positions 2-246.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi122 – 1254Poly-Pro

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0588.
    GeneTreeiENSGT00390000016700.
    HOGENOMiHOG000221682.
    HOVERGENiHBG027528.
    InParanoidiP16290.
    KOiK01834.
    OMAiWTILEGT.
    OrthoDBiEOG7XM2ZV.
    PhylomeDBiP16290.
    TreeFamiTF300007.

    Family and domain databases

    Gene3Di3.40.50.1240. 1 hit.
    HAMAPiMF_01039. PGAM_GpmA.
    InterProiIPR013078. His_Pase_superF_clade-1.
    IPR029033. His_PPase_superfam.
    IPR001345. PG/BPGM_mutase_AS.
    IPR005952. Phosphogly_mut1.
    [Graphical view]
    PANTHERiPTHR11931. PTHR11931. 1 hit.
    PfamiPF00300. His_Phos_1. 1 hit.
    [Graphical view]
    SMARTiSM00855. PGAM. 1 hit.
    [Graphical view]
    SUPFAMiSSF53254. SSF53254. 1 hit.
    TIGRFAMsiTIGR01258. pgm_1. 1 hit.
    PROSITEiPS00175. PG_MUTASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P16290-1 [UniParc]FASTAAdd to Basket

    « Hide

    MATHRLVMVR HGESSWNQEN RFCGWFDAEL SEKGAEEAKR GATAIKDAKI    50
    EFDICYTSVL KRAIRTLWTI LDVTDQMWVP VVRTWRLNER HYGGLTGLNK 100
    AETAAKHGEE QVKIWRRSFD TPPPPMDEKH NYYASISKDR RYAGLKPEEL 150
    PTCESLKDTI ARALPFWNEE IAPKIKAGKR VLIAAHGNSL RGIVKHLEGM 200
    SDQAIMELNL PTGIPIVYEL NQELKPTKPM RFLGDEETVR KAMEAVAAQG 250
    KAK 253
    Length:253
    Mass (Da):28,755
    Last modified:January 23, 2007 - v2
    Checksum:i73F6118A1C73D545
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M31835 mRNA. Translation: AAA41835.1.
    Z17319 Genomic DNA. Translation: CAA78967.1.
    PIRiA33793. PMRTYM.
    RefSeqiNP_059024.1. NM_017328.2.
    UniGeneiRn.9738.

    Genome annotation databases

    EnsembliENSRNOT00000018227; ENSRNOP00000018227; ENSRNOG00000013532.
    GeneIDi24959.
    KEGGirno:24959.
    UCSCiRGD:3313. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M31835 mRNA. Translation: AAA41835.1 .
    Z17319 Genomic DNA. Translation: CAA78967.1 .
    PIRi A33793. PMRTYM.
    RefSeqi NP_059024.1. NM_017328.2.
    UniGenei Rn.9738.

    3D structure databases

    ProteinModelPortali P16290.
    SMRi P16290. Positions 2-246.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P16290. 7 interactions.
    MINTi MINT-4588391.
    STRINGi 10116.ENSRNOP00000018227.

    PTM databases

    PhosphoSitei P16290.

    Proteomic databases

    PaxDbi P16290.
    PRIDEi P16290.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000018227 ; ENSRNOP00000018227 ; ENSRNOG00000013532 .
    GeneIDi 24959.
    KEGGi rno:24959.
    UCSCi RGD:3313. rat.

    Organism-specific databases

    CTDi 5224.
    RGDi 3313. Pgam2.

    Phylogenomic databases

    eggNOGi COG0588.
    GeneTreei ENSGT00390000016700.
    HOGENOMi HOG000221682.
    HOVERGENi HBG027528.
    InParanoidi P16290.
    KOi K01834.
    OMAi WTILEGT.
    OrthoDBi EOG7XM2ZV.
    PhylomeDBi P16290.
    TreeFami TF300007.

    Enzyme and pathway databases

    Reactomei REACT_217998. Gluconeogenesis.
    REACT_225694. Glycolysis.
    SABIO-RK P16290.

    Miscellaneous databases

    NextBioi 604991.
    PROi P16290.

    Gene expression databases

    Genevestigatori P16290.

    Family and domain databases

    Gene3Di 3.40.50.1240. 1 hit.
    HAMAPi MF_01039. PGAM_GpmA.
    InterProi IPR013078. His_Pase_superF_clade-1.
    IPR029033. His_PPase_superfam.
    IPR001345. PG/BPGM_mutase_AS.
    IPR005952. Phosphogly_mut1.
    [Graphical view ]
    PANTHERi PTHR11931. PTHR11931. 1 hit.
    Pfami PF00300. His_Phos_1. 1 hit.
    [Graphical view ]
    SMARTi SM00855. PGAM. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53254. SSF53254. 1 hit.
    TIGRFAMsi TIGR01258. pgm_1. 1 hit.
    PROSITEi PS00175. PG_MUTASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Skeletal muscle.
    2. "The gene encoding rat phosphoglycerate mutase subunit M: cloning and promoter analysis in skeletal muscle cells."
      Ruiz-Lozano P., de Lecea L., Buesa C., Perez de la Osa P., Lepage D., Gualberto A., Walsh K., Pons G.
      Gene 147:243-248(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiPGAM2_RAT
    AccessioniPrimary (citable) accession number: P16290
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1990
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 125 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3