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Protein

Matrix protein

Gene

M

Organism
Rabies virus (strain SAD B19) (RABV)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a major role in assembly and budding of virion. Completely covers the ribonucleoprotein coil and keep it in condensed bullet-shaped form. Inhibits viral transcription and stimulates replication. Plays a major role in early induction of TRAIL-mediated apoptosis in infected neurons.2 Publications

Miscellaneous

Most abundant protein in the virion.By similarity

GO - Molecular functioni

GO - Biological processi

  • negative regulation of viral transcription Source: CACAO
  • viral budding via host ESCRT complex Source: UniProtKB-KW
  • viral release from host cell Source: UniProtKB-KW

Keywordsi

Biological processApoptosis, Host-virus interaction, Viral budding, Viral budding via the host ESCRT complexes, Virus exit from host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Matrix protein
Alternative name(s):
Phosphoprotein M2
Gene namesi
Name:M
OrganismiRabies virus (strain SAD B19) (RABV)
Taxonomic identifieri11300 [NCBI]
Taxonomic lineageiVirusesssRNA virusesssRNA negative-strand virusesMononegaviralesRhabdoviridaeLyssavirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Mammalia [TaxID: 40674]
Proteomesi
  • UP000175378 Componenti: Genome
  • UP000151156 Componenti: Genome
  • UP000167748 Componenti: Genome
  • UP000172072 Componenti: Genome
  • UP000107382 Componenti: Genome
  • UP000132522 Componenti: Genome
  • UP000118099 Componenti: Genome
  • UP000006363 Componenti: Genome
  • UP000007308 Componenti: Genome
  • UP000115894 Componenti: Genome
  • UP000123862 Componenti: Genome
  • UP000142143 Componenti: Genome
  • UP000100286 Componenti: Genome
  • UP000174835 Componenti: Genome
  • UP000133682 Componenti: Genome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Host membrane, Membrane, Viral envelope protein, Viral matrix protein, Virion

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi38Y → A: Complete loss of interaction with WW domain in vitro. 1 Publication1
Mutagenesisi58R → G: Complete loss of viral transcription inhibition. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002228511 – 202Matrix proteinAdd BLAST202

Interactioni

Subunit structurei

Homomultimer. Interacts with nucleoprotein and with the cytoplasmic domain of glycoprotein.1 Publication

Structurei

3D structure databases

ProteinModelPortaliP16287.
SMRiP16287.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni115 – 151Essential for glycoprotein bindingBy similarityAdd BLAST37

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi35 – 38PPXY motifSequence analysis4

Domaini

Late-budding domains (L domains) are short sequence motifs essential for viral particle budding. They recruit proteins of the host ESCRT machinery (Endosomal Sorting Complex Required for Transport) or ESCRT-associated proteins. Matrix protein contains one L domain: a PPXY motif which potentially interacts with the WW domain 3 of NEDD4 E3 ubiquitin ligase (Potential).Curated

Sequence similaritiesi

Belongs to the lyssavirus matrix protein family.Curated

Phylogenomic databases

OrthoDBiVOG090000TW.

Family and domain databases

InterProiView protein in InterPro
IPR006870. Rhabdo_M2.
PfamiView protein in Pfam
PF04785. Rhabdo_M2. 1 hit.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD009661. Rhabdo_M2. 1 hit.

Sequencei

Sequence statusi: Complete.

P16287-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNLLRKIVKN RRDEDTQKSS PASAPLDDDD LWLPPPEYVP LKELTGKKNM
60 70 80 90 100
RNFCINGRVK VCSPNGYSFR ILRHILKSFD EIYSGNHRMI GLVKVVIGLA
110 120 130 140 150
LSGSPVPEGL NWVYKLRRTF IFQWADSRGP LEGEELEYSQ EITWDDDTEF
160 170 180 190 200
VGLQIRVIAK QCHIQGRVWC INMNPRACQL WSDMSLQTQR SEEDKDSSLL

LE
Length:202
Mass (Da):23,341
Last modified:August 1, 1990 - v1
Checksum:i012A1C6C25237628
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti2N → D in strain: Isolate SAD1-3670 var 1 and Isolate SAD1-3670 var 2. 1
Natural varianti11R → C in strain: Isolate SAD1-3670 var 1 and Isolate SAD1-3670 var 2. 1
Natural varianti19S → P in strain: Isolate SAD1-3670 var 1 and Isolate SAD1-3670 var 2. 1
Natural varianti22A → V in strain: Isolate SAD1-3670 var 1 and Isolate SAD1-3670 var 2. 1
Natural varianti46G → S in strain: Isolate SAD1-3670 var 1 and Isolate SAD1-3670 var 2. 1
Natural varianti58R → G in strain: Isolate SAD1-3670 var 1 and Isolate SAD1-3670 var 2. 1
Natural varianti110L → M in strain: Isolate SAD1-3670 var 1 and Isolate SAD1-3670 var 2. 1
Natural varianti120F → L in strain: Isolate SAD1-3670 var 1 and Isolate SAD1-3670 var 2. 1
Natural varianti158I → S in strain: Isolate SAD1-3670 var 1 and Isolate SAD1-3670 var 2. 1
Natural varianti168V → I in strain: Isolate SAD1-3670 var 1 and Isolate SAD1-3670 var 2. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M31046 Genomic RNA. Translation: AAA47201.1.
AF499686 Genomic RNA. Translation: AAT48625.1.
EF206708 Genomic RNA. Translation: ABN11298.1.
EF206709 Genomic RNA. Translation: ABN11303.1.
EF206710 Genomic RNA. Translation: ABN11308.1.
EF206711 Genomic RNA. Translation: ABN11313.1.
EF206712 Genomic RNA. Translation: ABN11318.1.
EF206713 Genomic RNA. Translation: ABN11323.1.
EF206714 Genomic RNA. Translation: ABN11328.1.
EF206715 Genomic RNA. Translation: ABN11333.1.
EF206716 Genomic RNA. Translation: ABN11338.1.
EF206717 Genomic RNA. Translation: ABN11343.1.
EF206718 Genomic RNA. Translation: ABN11348.1.
EF206719 Genomic RNA. Translation: ABN11353.1.
EF206720 Genomic RNA. Translation: ABN11358.1.
PIRiC34746. MFVNSB.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M31046 Genomic RNA. Translation: AAA47201.1.
AF499686 Genomic RNA. Translation: AAT48625.1.
EF206708 Genomic RNA. Translation: ABN11298.1.
EF206709 Genomic RNA. Translation: ABN11303.1.
EF206710 Genomic RNA. Translation: ABN11308.1.
EF206711 Genomic RNA. Translation: ABN11313.1.
EF206712 Genomic RNA. Translation: ABN11318.1.
EF206713 Genomic RNA. Translation: ABN11323.1.
EF206714 Genomic RNA. Translation: ABN11328.1.
EF206715 Genomic RNA. Translation: ABN11333.1.
EF206716 Genomic RNA. Translation: ABN11338.1.
EF206717 Genomic RNA. Translation: ABN11343.1.
EF206718 Genomic RNA. Translation: ABN11348.1.
EF206719 Genomic RNA. Translation: ABN11353.1.
EF206720 Genomic RNA. Translation: ABN11358.1.
PIRiC34746. MFVNSB.

3D structure databases

ProteinModelPortaliP16287.
SMRiP16287.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

OrthoDBiVOG090000TW.

Family and domain databases

InterProiView protein in InterPro
IPR006870. Rhabdo_M2.
PfamiView protein in Pfam
PF04785. Rhabdo_M2. 1 hit.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD009661. Rhabdo_M2. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMATRX_RABVS
AccessioniPrimary (citable) accession number: P16287
Secondary accession number(s): A3F5L7
, A3F5R7, A3F5T2, P13616, Q6HA96
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: May 10, 2017
This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.