Reviewed, UniProtKB/Swiss-Prot P16284 (PECA1_HUMAN)

Names and origin

Protein names

Recommended name:
    Platelet endothelial cell adhesion molecule
Alternative name(s):
    PECAM-1
    EndoCAM
    GPIIA'
    CD_antigen=CD31

Gene names

Name:

PECAM1

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	738 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	This protein is a cell adhesion molecule expressed on platelets and at endothelial cell intercellular junctions.
Subcellular location	Membrane; Single-pass type I membrane protein.
Tissue specificity	Long isoform predominates all tissues examined, isoform Delta12 was detected only in trachea and isoform Delta14-15 only in lung, isoform Delta14 was detected in all tissues examined with the strongest expression in heart. Ref.11
Post-translational modification	Phosphorylated on Ser and Tyr residues after cellular activation. Ref.10 Ref.12 Ref.13 Ref.14 Ref.15
Sequence similarities	Contains 6 Ig-like C2-type (immunoglobulin-like) domains.

Ontologies

Keywords
Biological process	Cell adhesion
Cellular component	Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Immunoglobulin domain Repeat Signal Transmembrane
PTM	Disulfide bond Glycoprotein Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cell adhesion Inferred from electronic annotation. Source: UniProtKB-KW cell recognition Ref.3 Traceable author statement. Source: ProtInc signal transduction Ref.5 Traceable author statement. Source: ProtInc
Cellular component	extracellular space Inferred from direct assay. Source: UniProtKB integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Ref.3 Inferred from Experiment. Source: Reactome platelet alpha granule membrane Inferred from Experiment. Source: Reactome
Molecular function	protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
JUP	P14923	3	EBI-716404,EBI-702484
PRKCE	Q02156	1	EBI-716404,EBI-706254
SRC	P12931	1	EBI-716404,EBI-621482

Alternative products

This entry describes 6 isoforms produced by alternative splicing. [Align] [Select]

Isoform Long (identifier: P16284-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform Delta12 (identifier: P16284-2)

The sequence of this isoform differs from the canonical sequence as follows:
     664-681: Missing.

Isoform Delta13 (identifier: P16284-3)

The sequence of this isoform differs from the canonical sequence as follows:
     682-702: Missing.

Isoform Delta14 (identifier: P16284-4)

The sequence of this isoform differs from the canonical sequence as follows:
     703-721: Missing.

Isoform Delta14-15 (identifier: P16284-5)

The sequence of this isoform differs from the canonical sequence as follows:
     703-729: Missing.
     730-738: RTEGSLDGT → ENGRLP

Isoform Delta15 (identifier: P16284-6)

The sequence of this isoform differs from the canonical sequence as follows:
     722-729: Missing.
     730-738: RTEGSLDGT → ENGRLP

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 27	27
	Chain	28 – 738	711	Platelet endothelial cell adhesion molecule		PRO_0000014895
Regions
	Topological domain	28 – 601	574	Extracellular Potential
	Transmembrane	602 – 620	19	Potential
	Topological domain	621 – 738	118	Cytoplasmic Potential
	Domain	35 – 121	87	Ig-like C2-type 1
	Domain	145 – 233	89	Ig-like C2-type 2
	Domain	236 – 315	80	Ig-like C2-type 3
	Domain	328 – 401	74	Ig-like C2-type 4
	Domain	424 – 493	70	Ig-like C2-type 5
	Domain	499 – 591	93	Ig-like C2-type 6
Amino acid modifications
	Modified residue	290	1	Phosphotyrosine Ref.14
	Modified residue	713	1	Phosphotyrosine Ref.10 Ref.12 Ref.13 Ref.15
	Glycosylation	52	1	N-linked (GlcNAc...) Potential
	Glycosylation	84	1	N-linked (GlcNAc...) Ref.17
	Glycosylation	151	1	N-linked (GlcNAc...) Ref.16
	Glycosylation	301	1	N-linked (GlcNAc...) Potential
	Glycosylation	320	1	N-linked (GlcNAc...) Ref.17 Ref.16
	Glycosylation	344	1	N-linked (GlcNAc...) Potential
	Glycosylation	356	1	N-linked (GlcNAc...) Potential
	Glycosylation	453	1	N-linked (GlcNAc...) Ref.16
	Glycosylation	551	1	N-linked (GlcNAc...) Ref.17
	Disulfide bond	57 ↔ 109		Potential
	Disulfide bond	152 ↔ 206		Potential
	Disulfide bond	256 ↔ 304		Potential
	Disulfide bond	347 ↔ 386		Potential
	Disulfide bond	431 ↔ 476		Potential
	Disulfide bond	523 ↔ 572		Potential
Natural variations
	Alternative sequence	664 – 681	18	Missing in isoform Delta12.		VSP_011806
	Alternative sequence	682 – 702	21	Missing in isoform Delta13.		VSP_011807
	Alternative sequence	703 – 729	27	Missing in isoform Delta14-15.		VSP_011808
	Alternative sequence	703 – 721	19	Missing in isoform Delta14.		VSP_011809
	Alternative sequence	722 – 729	8	Missing in isoform Delta15.		VSP_011810
	Alternative sequence	730 – 738	9	RTEGSLDGT → ENGRLP in isoform Delta14-15 and isoform Delta15.		VSP_011811
	Natural variant	125	1	L → V: dbSNP rs668. Ref.2 Ref.7 Ref.8 Ref.18 Ref.19		VAR_013145
	Natural variant	304	1	C → Y: dbSNP rs7209607.		VAR_059402
	Natural variant	563	1	S → I: dbSNP rs12953.		VAR_059403
	Natural variant	563	1	S → N: dbSNP rs12953. Ref.2 Ref.7 Ref.8 Ref.5		VAR_059404
	Natural variant	670	1	R → G: dbSNP rs1131012. Ref.2 Ref.7 Ref.8		VAR_059405
Experimental info
	Sequence conflict	8 – 12	5	GATMW → ADV Ref.1
	Sequence conflict	80	1	V → M in AAK84009. Ref.8
	Sequence conflict	97	1	P → L in AAK84011. Ref.8
	Sequence conflict	329	1	E → K in AAF91460. Ref.8
	Sequence conflict	430	1	R → H in AAF91451. Ref.8

Sequences

	Sequence		Length	Mass (Da)
	Isoform Long [UniParc]. Last modified April 1, 1990. Version 1. Checksum: C57BBFA200A407A6	FASTA	738	82,536
	10 20 30 40 50 60 MQPRWAQGAT MWLGVLLTLL LCSSLEGQEN SFTINSVDMK SLPDWTVQNG KNLTLQCFAD 70 80 90 100 110 120 VSTTSHVKPQ HQMLFYKDDV LFYNISSMKS TESYFIPEVR IYDSGTYKCT VIVNNKEKTT 130 140 150 160 170 180 AEYQLLVEGV PSPRVTLDKK EAIQGGIVRV NCSVPEEKAP IHFTIEKLEL NEKMVKLKRE 190 200 210 220 230 240 KNSRDQNFVI LEFPVEEQDR VLSFRCQARI ISGIHMQTSE STKSELVTVT ESFSTPKFHI 250 260 270 280 290 300 SPTGMIMEGA QLHIKCTIQV THLAQEFPEI IIQKDKAIVA HNRHGNKAVY SVMAMVEHSG 310 320 330 340 350 360 NYTCKVESSR ISKVSSIVVN ITELFSKPEL ESSFTHLDQG ERLNLSCSIP GAPPANFTIQ 370 380 390 400 410 420 KEDTIVSQTQ DFTKIASKSD SGTYICTAGI DKVVKKSNTV QIVVCEMLSQ PRISYDAQFE 430 440 450 460 470 480 VIKGQTIEVR CESISGTLPI SYQLLKTSKV LENSTKNSND PAVFKDNPTE DVEYQCVADN 490 500 510 520 530 540 CHSHAKMLSE VLRVKVIAPV DEVQISILSS KVVESGEDIV LQCAVNEGSG PITYKFYREK 550 560 570 580 590 600 EGKPFYQMTS NATQAFWTKQ KASKEQEGEY YCTAFNRANH ASSVPRSKIL TVRVILAPWK 610 620 630 640 650 660 KGLIAVVIIG VIIALLIIAA KCYFLRKAKA KQMPVEMSRP AVPLLNSNNE KMSDPNMEAN 670 680 690 700 710 720 SHYGHNDDVR NHAMKPINDN KEPLNSDVQY TEVQVSSAES HKDLGKKDTE TVYSEVRKAV 730 PDAVESRYSR TEGSLDGT
	Isoform Delta12. Checksum: AAD7D2166EE7137B	FASTA	720	80,479
	10 20 30 40 50 60 MQPRWAQGAT MWLGVLLTLL LCSSLEGQEN SFTINSVDMK SLPDWTVQNG KNLTLQCFAD 70 80 90 100 110 120 VSTTSHVKPQ HQMLFYKDDV LFYNISSMKS TESYFIPEVR IYDSGTYKCT VIVNNKEKTT 130 140 150 160 170 180 AEYQLLVEGV PSPRVTLDKK EAIQGGIVRV NCSVPEEKAP IHFTIEKLEL NEKMVKLKRE 190 200 210 220 230 240 KNSRDQNFVI LEFPVEEQDR VLSFRCQARI ISGIHMQTSE STKSELVTVT ESFSTPKFHI 250 260 270 280 290 300 SPTGMIMEGA QLHIKCTIQV THLAQEFPEI IIQKDKAIVA HNRHGNKAVY SVMAMVEHSG 310 320 330 340 350 360 NYTCKVESSR ISKVSSIVVN ITELFSKPEL ESSFTHLDQG ERLNLSCSIP GAPPANFTIQ 370 380 390 400 410 420 KEDTIVSQTQ DFTKIASKSD SGTYICTAGI DKVVKKSNTV QIVVCEMLSQ PRISYDAQFE 430 440 450 460 470 480 VIKGQTIEVR CESISGTLPI SYQLLKTSKV LENSTKNSND PAVFKDNPTE DVEYQCVADN 490 500 510 520 530 540 CHSHAKMLSE VLRVKVIAPV DEVQISILSS KVVESGEDIV LQCAVNEGSG PITYKFYREK 550 560 570 580 590 600 EGKPFYQMTS NATQAFWTKQ KASKEQEGEY YCTAFNRANH ASSVPRSKIL TVRVILAPWK 610 620 630 640 650 660 KGLIAVVIIG VIIALLIIAA KCYFLRKAKA KQMPVEMSRP AVPLLNSNNE KMSDPNMEAN 670 680 690 700 710 720 SHYEPLNSDV QYTEVQVSSA ESHKDLGKKD TETVYSEVRK AVPDAVESRY SRTEGSLDGT
	Isoform Delta13. Checksum: 84A04E34A9EF7619	FASTA	717	80,207
	10 20 30 40 50 60 MQPRWAQGAT MWLGVLLTLL LCSSLEGQEN SFTINSVDMK SLPDWTVQNG KNLTLQCFAD 70 80 90 100 110 120 VSTTSHVKPQ HQMLFYKDDV LFYNISSMKS TESYFIPEVR IYDSGTYKCT VIVNNKEKTT 130 140 150 160 170 180 AEYQLLVEGV PSPRVTLDKK EAIQGGIVRV NCSVPEEKAP IHFTIEKLEL NEKMVKLKRE 190 200 210 220 230 240 KNSRDQNFVI LEFPVEEQDR VLSFRCQARI ISGIHMQTSE STKSELVTVT ESFSTPKFHI 250 260 270 280 290 300 SPTGMIMEGA QLHIKCTIQV THLAQEFPEI IIQKDKAIVA HNRHGNKAVY SVMAMVEHSG 310 320 330 340 350 360 NYTCKVESSR ISKVSSIVVN ITELFSKPEL ESSFTHLDQG ERLNLSCSIP GAPPANFTIQ 370 380 390 400 410 420 KEDTIVSQTQ DFTKIASKSD SGTYICTAGI DKVVKKSNTV QIVVCEMLSQ PRISYDAQFE 430 440 450 460 470 480 VIKGQTIEVR CESISGTLPI SYQLLKTSKV LENSTKNSND PAVFKDNPTE DVEYQCVADN 490 500 510 520 530 540 CHSHAKMLSE VLRVKVIAPV DEVQISILSS KVVESGEDIV LQCAVNEGSG PITYKFYREK 550 560 570 580 590 600 EGKPFYQMTS NATQAFWTKQ KASKEQEGEY YCTAFNRANH ASSVPRSKIL TVRVILAPWK 610 620 630 640 650 660 KGLIAVVIIG VIIALLIIAA KCYFLRKAKA KQMPVEMSRP AVPLLNSNNE KMSDPNMEAN 670 680 690 700 710 SHYGHNDDVR NHAMKPINDN KDLGKKDTET VYSEVRKAVP DAVESRYSRT EGSLDGT
	Isoform Delta14. Checksum: 41B823F2ACEEE3AB	FASTA	719	80,419
	10 20 30 40 50 60 MQPRWAQGAT MWLGVLLTLL LCSSLEGQEN SFTINSVDMK SLPDWTVQNG KNLTLQCFAD 70 80 90 100 110 120 VSTTSHVKPQ HQMLFYKDDV LFYNISSMKS TESYFIPEVR IYDSGTYKCT VIVNNKEKTT 130 140 150 160 170 180 AEYQLLVEGV PSPRVTLDKK EAIQGGIVRV NCSVPEEKAP IHFTIEKLEL NEKMVKLKRE 190 200 210 220 230 240 KNSRDQNFVI LEFPVEEQDR VLSFRCQARI ISGIHMQTSE STKSELVTVT ESFSTPKFHI 250 260 270 280 290 300 SPTGMIMEGA QLHIKCTIQV THLAQEFPEI IIQKDKAIVA HNRHGNKAVY SVMAMVEHSG 310 320 330 340 350 360 NYTCKVESSR ISKVSSIVVN ITELFSKPEL ESSFTHLDQG ERLNLSCSIP GAPPANFTIQ 370 380 390 400 410 420 KEDTIVSQTQ DFTKIASKSD SGTYICTAGI DKVVKKSNTV QIVVCEMLSQ PRISYDAQFE 430 440 450 460 470 480 VIKGQTIEVR CESISGTLPI SYQLLKTSKV LENSTKNSND PAVFKDNPTE DVEYQCVADN 490 500 510 520 530 540 CHSHAKMLSE VLRVKVIAPV DEVQISILSS KVVESGEDIV LQCAVNEGSG PITYKFYREK 550 560 570 580 590 600 EGKPFYQMTS NATQAFWTKQ KASKEQEGEY YCTAFNRANH ASSVPRSKIL TVRVILAPWK 610 620 630 640 650 660 KGLIAVVIIG VIIALLIIAA KCYFLRKAKA KQMPVEMSRP AVPLLNSNNE KMSDPNMEAN 670 680 690 700 710 SHYGHNDDVR NHAMKPINDN KEPLNSDVQY TEVQVSSAES HKDAVESRYS RTEGSLDGT
	Isoform Delta14-15. Checksum: 9245FAAEFDFCF5E2	FASTA	708	79,261
	10 20 30 40 50 60 MQPRWAQGAT MWLGVLLTLL LCSSLEGQEN SFTINSVDMK SLPDWTVQNG KNLTLQCFAD 70 80 90 100 110 120 VSTTSHVKPQ HQMLFYKDDV LFYNISSMKS TESYFIPEVR IYDSGTYKCT VIVNNKEKTT 130 140 150 160 170 180 AEYQLLVEGV PSPRVTLDKK EAIQGGIVRV NCSVPEEKAP IHFTIEKLEL NEKMVKLKRE 190 200 210 220 230 240 KNSRDQNFVI LEFPVEEQDR VLSFRCQARI ISGIHMQTSE STKSELVTVT ESFSTPKFHI 250 260 270 280 290 300 SPTGMIMEGA QLHIKCTIQV THLAQEFPEI IIQKDKAIVA HNRHGNKAVY SVMAMVEHSG 310 320 330 340 350 360 NYTCKVESSR ISKVSSIVVN ITELFSKPEL ESSFTHLDQG ERLNLSCSIP GAPPANFTIQ 370 380 390 400 410 420 KEDTIVSQTQ DFTKIASKSD SGTYICTAGI DKVVKKSNTV QIVVCEMLSQ PRISYDAQFE 430 440 450 460 470 480 VIKGQTIEVR CESISGTLPI SYQLLKTSKV LENSTKNSND PAVFKDNPTE DVEYQCVADN 490 500 510 520 530 540 CHSHAKMLSE VLRVKVIAPV DEVQISILSS KVVESGEDIV LQCAVNEGSG PITYKFYREK 550 560 570 580 590 600 EGKPFYQMTS NATQAFWTKQ KASKEQEGEY YCTAFNRANH ASSVPRSKIL TVRVILAPWK 610 620 630 640 650 660 KGLIAVVIIG VIIALLIIAA KCYFLRKAKA KQMPVEMSRP AVPLLNSNNE KMSDPNMEAN 670 680 690 700 SHYGHNDDVR NHAMKPINDN KEPLNSDVQY TEVQVSSAES HKENGRLP
	Isoform Delta15. Checksum: 50DEEBC45F1864E9	FASTA	727	81,378
	10 20 30 40 50 60 MQPRWAQGAT MWLGVLLTLL LCSSLEGQEN SFTINSVDMK SLPDWTVQNG KNLTLQCFAD 70 80 90 100 110 120 VSTTSHVKPQ HQMLFYKDDV LFYNISSMKS TESYFIPEVR IYDSGTYKCT VIVNNKEKTT 130 140 150 160 170 180 AEYQLLVEGV PSPRVTLDKK EAIQGGIVRV NCSVPEEKAP IHFTIEKLEL NEKMVKLKRE 190 200 210 220 230 240 KNSRDQNFVI LEFPVEEQDR VLSFRCQARI ISGIHMQTSE STKSELVTVT ESFSTPKFHI 250 260 270 280 290 300 SPTGMIMEGA QLHIKCTIQV THLAQEFPEI IIQKDKAIVA HNRHGNKAVY SVMAMVEHSG 310 320 330 340 350 360 NYTCKVESSR ISKVSSIVVN ITELFSKPEL ESSFTHLDQG ERLNLSCSIP GAPPANFTIQ 370 380 390 400 410 420 KEDTIVSQTQ DFTKIASKSD SGTYICTAGI DKVVKKSNTV QIVVCEMLSQ PRISYDAQFE 430 440 450 460 470 480 VIKGQTIEVR CESISGTLPI SYQLLKTSKV LENSTKNSND PAVFKDNPTE DVEYQCVADN 490 500 510 520 530 540 CHSHAKMLSE VLRVKVIAPV DEVQISILSS KVVESGEDIV LQCAVNEGSG PITYKFYREK 550 560 570 580 590 600 EGKPFYQMTS NATQAFWTKQ KASKEQEGEY YCTAFNRANH ASSVPRSKIL TVRVILAPWK 610 620 630 640 650 660 KGLIAVVIIG VIIALLIIAA KCYFLRKAKA KQMPVEMSRP AVPLLNSNNE KMSDPNMEAN 670 680 690 700 710 720 SHYGHNDDVR NHAMKPINDN KEPLNSDVQY TEVQVSSAES HKDLGKKDTE TVYSEVRKAV PENGRLP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning of CD31, a putative intercellular adhesion molecule closely related to carcinoembryonic antigen." Simmons D.L., Walker C., Power C., Pigott R. J. Exp. Med. 171:2147-2152(1990) [PubMed: 2351935] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LONG).
[2]	"Molecular characterization and functional analysis of the leukocyte surface protein CD31." Stockinger H., Gadd S.J., Eher R., Majdic O., Kasinrek W., Schreiber W., Strass B., Schnabl E., Knapp W. J. Immunol. 145:3889-3897(1990) [PubMed: 1700999] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LONG), VARIANTS VAL-125; ASN-563 AND GLY-670.
[3]	"PECAM-1 (CD31) cloning and relation to adhesion molecules of the immunoglobulin gene superfamily." Newman P.J., Berndt M.C., Gorski J., White J.C. II, Lyman S., Paddock C., Muller W.A. Science 247:1219-1222(1990) [PubMed: 1690453] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LONG).
[4]	"Molecular and cellular properties of PECAM-1 (endoCAM/CD31): a novel vascular cell-cell adhesion molecule." Albelda S.M., Muller W.A., Buck C.A., Newman P.J. J. Cell Biol. 114:1059-1068(1991) [PubMed: 1874786] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LONG).
[5]	"Organization of the gene for human platelet/endothelial cell adhesion molecule-1 shows alternatively spliced isoforms and a functionally complex cytoplasmic domain." Kirschbaum N.E., Gumina R.J., Newman P.J. Blood 84:4028-4037(1994) [PubMed: 7994021] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM LONG), VARIANT ASN-563.
[6]	"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L. , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C. Nature 440:1045-1049(2006) [PubMed: 16625196] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM LONG), VARIANTS VAL-125; ASN-563 AND GLY-670. Tissue: Brain.
[8]	Robbins F.-M.Y., Yao H., Hurley C.K., Hartzman R.J. Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-734 (ISOFORM LONG), VARIANTS VAL-125; ASN-563 AND GLY-670.
[9]	"Identification of PECAM-1 in solid tumor cells and its potential involvement in tumor cell adhesion to endothelium." Tang D.G., Chen Y.Q., Newman P.J., Shi L., Gao X., Diglio C.A., Honn K.V. J. Biol. Chem. 268:22883-22894(1993) [PubMed: 8226797] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 507-584.
[10]	"Tyrosine residue in exon 14 of the cytoplasmic domain of platelet endothelial cell adhesion molecule-1 (PECAM-1/CD31) regulates ligand binding specificity." Famiglietti J., Sun J., DeLisser H.M., Albelda S.M. J. Cell Biol. 138:1425-1435(1997) [PubMed: 9298995] [Abstract] Cited for: PHOSPHORYLATION AT TYR-713.
[11]	"Tissue-specific distributions of alternatively spliced human PECAM-1 isoforms." Wang Y., Su X., Sorenson C.M., Sheibani N. Am. J. Physiol. 284:H1008-H1017(2003) [PubMed: 12433657] [Abstract] Cited for: ALTERNATIVE SPLICING, TISSUE SPECIFICITY.
[12]	"Immunoaffinity profiling of tyrosine phosphorylation in cancer cells." Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H., Zha X.-M., Polakiewicz R.D., Comb M.J. Nat. Biotechnol. 23:94-101(2005) [PubMed: 15592455] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-713, MASS SPECTROMETRY.
[13]	"Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer." Rikova K., Guo A., Zeng Q., Possemato A., Yu J., Haack H., Nardone J., Lee K., Reeves C., Li Y., Hu Y., Tan Z., Stokes M., Sullivan L., Mitchell J., Wetzel R., Macneill J., Ren J.M. , Yuan J., Bakalarski C.E., Villen J., Kornhauser J.M., Smith B., Li D., Zhou X., Gygi S.P., Gu T.-L., Polakiewicz R.D., Rush J., Comb M.J. Cell 131:1190-1203(2007) [PubMed: 18083107] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-713, MASS SPECTROMETRY.
[14]	"Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column." Imami K., Sugiyama N., Kyono Y., Tomita M., Ishihama Y. Anal. Sci. 24:161-166(2008) [PubMed: 18187866] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-290, MASS SPECTROMETRY.
[15]	"Phosphoproteome of resting human platelets." Zahedi R.P., Lewandrowski U., Wiesner J., Wortelkamp S., Moebius J., Schuetz C., Walter U., Gambaryan S., Sickmann A. J. Proteome Res. 7:526-534(2008) [PubMed: 18088087] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-713, MASS SPECTROMETRY. Tissue: Platelet.
[16]	"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry." Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H. J. Proteome Res. 8:651-661(2009) [PubMed: 19159218] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-151; ASN-320 AND ASN-453, MASS SPECTROMETRY. Tissue: Liver.
[17]	"Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins." Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D. Nat. Biotechnol. 27:378-386(2009) [PubMed: 19349973] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-84; ASN-320 AND ASN-551, MASS SPECTROMETRY.
[18]	"Polymorphism of adhesion molecule CD31 and its role in acute graft-versus-host disease." Behar E., Chao N.J., Hiraki D.D., Krishnaswamy S., Brown B.W., Zehnder J.L., Grumet F.C. N. Engl. J. Med. 334:286-291(1996) [PubMed: 8532023] [Abstract] Cited for: VARIANT VAL-125.
[19]	"Codon 125 polymorphism of CD31 and susceptibility to malaria." Casals-Pascual C., Allen S., Allen A., Kai O., Lowe B., Pain A., Roberts D.J. Am. J. Trop. Med. Hyg. 65:736-737(2001) [PubMed: 11791967] [Abstract] Cited for: VARIANT VAL-125.
+	Additional computationally mapped references.

Web resources

SHMPD

The Singapore human mutation and polymorphism database

Wikipedia

CD31 entry

Functional Glycomics Gateway - Glycan Binding

PECAM-1

Cross-references

Sequence databases
EMBLGenBankDDBJ	M37780 mRNA. Translation: AAA36186.1. M28526 mRNA. Translation: AAA36429.1. L34657 , L34631, L34637, L34638, L34639, L34640, L34641, L34642, L34644, L34645, L34649, L34655 Genomic DNA. Translation: AAA60057.1. AC016489 Genomic DNA. No translation available. AC138744 Genomic DNA. No translation available. BC022512 mRNA. Translation: AAH22512.1. BC051822 mRNA. Translation: AAH51822.1. AF281287 mRNA. Translation: AAF91446.1. AF281288 mRNA. Translation: AAF91447.1. AF281289 mRNA. Translation: AAF91448.1. AF281290 mRNA. Translation: AAF91449.1. AF281291 mRNA. Translation: AAF91450.1. AF281292 mRNA. Translation: AAF91451.1. AF281293 mRNA. Translation: AAF91452.1. AF281294 mRNA. Translation: AAF91453.1. AF281295 mRNA. Translation: AAF91454.1. AF281296 mRNA. Translation: AAF91455.1. AF281297 mRNA. Translation: AAF91456.1. AF281298 mRNA. Translation: AAF91457.1. AF281299 mRNA. Translation: AAF91458.1. AF281300 mRNA. Translation: AAF91459.1. AF281301 mRNA. Translation: AAF91460.1. AF393676 mRNA. Translation: AAK84009.1. AF393677 mRNA. Translation: AAK84010.1. AF393678 mRNA. Translation: AAK84011.1. S66450 mRNA. Translation: AAB28645.1.
IPI	IPI00295618. IPI00470719. IPI00470720. IPI00470722. IPI00871352. IPI00914041.
PIR	A40096.
RefSeq	NP_000433.3.
UniGene	Hs.514412 Hs.709189
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	P16284. 7 interactions.
STRING	P16284.
PTM databases
PhosphoSite	P16284.
Proteomic databases
PRIDE	P16284.
Genome annotation databases
Ensembl	ENST00000361649; ENSP00000354973; ENSG00000198802; Homo sapiens. [Genome view] ENST00000397738; ENSP00000380846; ENSG00000198802; Homo sapiens. [Genome view] ENST00000397739; ENSP00000380847; ENSG00000198802; Homo sapiens. [Genome view] ENST00000397740; ENSP00000380848; ENSG00000198802; Homo sapiens. [Genome view] ENST00000397741; ENSP00000380849; ENSG00000198802; Homo sapiens. [Genome view] ENST00000397744; ENSP00000380852; ENSG00000198802; Homo sapiens. [Genome view] ENST00000401822; ENSP00000384220; ENSG00000198802; Homo sapiens. [Genome view]
GeneID	5175.
KEGG	hsa:5175.
UCSC	uc002jeg.1. human.
Organism-specific databases
CTD	5175.
GeneCards	GC17M059754.
H-InvDB	HIX0021820. HIX0059654.
HGNC	HGNC:8823. PECAM1.
HPA	CAB000017. HPA004690.
MIM	173445. gene.
PharmGKB	PA33167.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	P16284.
Enzyme and pathway databases
Reactome	REACT_13552. Integrin cell surface interactions. REACT_604. Hemostasis. REACT_6900. Signaling in Immune system.
Gene expression databases
ArrayExpress	P16284.
Genevestigator	P16284.
GermOnline	ENSG00000198802. Homo sapiens.
Family and domain databases
InterPro	IPR013151. Ig. IPR007110. Ig-like. IPR013783. Ig-like_fold. IPR003599. Ig_sub. IPR013106. Ig_V-set. [Graphical view]
Gene3D	G3DSA:2.60.40.10. Ig-like_fold. 2 hits.
Pfam	PF00047. ig. 2 hits. PF07686. V-set. 2 hits. [Graphical view]
SMART	SM00409. IG. 3 hits. [Graphical view]
PROSITE	PS50835. IG_LIKE. 4 hits. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	20032.
PMAP-CutDB	P16284.
SOURCE	Search...

Entry information

Entry name

PECA1_HUMAN

Accession

Primary (citable) accession number: P16284
Secondary accession number(s): Q6LDA9 , Q8TBH1, Q96RF5, Q96RF6, Q9NP65, Q9NPB7, Q9NPG9, Q9NQS9, Q9NQT0, Q9NQT1, Q9NQT2

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 1, 1990
Last sequence update:	April 1, 1990
Last modified:	October 13, 2009
This is version 122 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.