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P16283

- B3A3_MOUSE

UniProt

P16283 - B3A3_MOUSE

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Protein

Anion exchange protein 3

Gene
Slc4a3, Ae3
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Plasma membrane anion exchange protein.

GO - Molecular functioni

  1. anion:anion antiporter activity Source: MGI
  2. inorganic anion exchanger activity Source: InterPro

GO - Biological processi

  1. regulation of intracellular pH Source: MGI
Complete GO annotation...

Keywords - Biological processi

Anion exchange, Antiport, Ion transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Anion exchange protein 3
Short name:
AE 3
Short name:
Anion exchanger 3
Alternative name(s):
Neuronal band 3-like protein
Solute carrier family 4 member 3
Gene namesi
Name:Slc4a3
Synonyms:Ae3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 1

Organism-specific databases

MGIiMGI:109350. Slc4a3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 707707CytoplasmicAdd
BLAST
Transmembranei708 – 73023Helical; Reviewed predictionAdd
BLAST
Transmembranei736 – 77338Helical; Reviewed predictionAdd
BLAST
Transmembranei793 – 81523Helical; Reviewed predictionAdd
BLAST
Transmembranei825 – 84622Helical; Reviewed predictionAdd
BLAST
Transmembranei888 – 90518Helical; Reviewed predictionAdd
BLAST
Topological domaini906 – 92015Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei921 – 94121Helical; Reviewed predictionAdd
BLAST
Transmembranei975 – 99723Helical; Reviewed predictionAdd
BLAST
Transmembranei1023 – 104422Helical; Reviewed predictionAdd
BLAST
Transmembranei1078 – 112346Helical; Reviewed predictionAdd
BLAST
Transmembranei1150 – 118637Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12271227Anion exchange protein 3PRO_0000079220Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi868 – 8681N-linked (GlcNAc...) Reviewed prediction
Lipidationi1160 – 11601S-palmitoyl cysteine By similarity

Keywords - PTMi

Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiP16283.
PRIDEiP16283.

PTM databases

PhosphoSiteiP16283.

Expressioni

Tissue specificityi

Neuronal.

Gene expression databases

ArrayExpressiP16283.
BgeeiP16283.
GenevestigatoriP16283.

Interactioni

Protein-protein interaction databases

IntActiP16283. 1 interaction.
MINTiMINT-4996490.

Structurei

3D structure databases

ProteinModelPortaliP16283.
SMRiP16283. Positions 319-637, 691-732.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni708 – 1227520Membrane (anion exchange)Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi135 – 14511Poly-GluAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG268067.
GeneTreeiENSGT00560000076933.
HOGENOMiHOG000280683.
HOVERGENiHBG004326.
KOiK13856.
OMAiGDSHRGK.
OrthoDBiEOG7TMZR0.
PhylomeDBiP16283.
TreeFamiTF313630.

Family and domain databases

Gene3Di3.40.1100.10. 1 hit.
InterProiIPR001717. Anion_exchange.
IPR002979. Anion_exchange_3.
IPR018241. Anion_exchange_CS.
IPR013769. Band3_cytoplasmic_dom.
IPR011531. HCO3_transpt_C.
IPR003020. HCO3_transpt_euk.
IPR016152. PTrfase/Anion_transptr.
[Graphical view]
PANTHERiPTHR11453. PTHR11453. 1 hit.
PTHR11453:SF15. PTHR11453:SF15. 1 hit.
PfamiPF07565. Band_3_cyto. 1 hit.
PF00955. HCO3_cotransp. 2 hits.
[Graphical view]
PRINTSiPR00165. ANIONEXCHNGR.
PR01189. ANIONEXHNGR3.
PR01231. HCO3TRNSPORT.
SUPFAMiSSF55804. SSF55804. 2 hits.
TIGRFAMsiTIGR00834. ae. 1 hit.
PROSITEiPS00219. ANION_EXCHANGER_1. 1 hit.
PS00220. ANION_EXCHANGER_2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform FL-AE3 (identifier: P16283-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MANGVIPPPG GASPLPQVRV PLEEPPLGPD VEEEDDDLGK TLAVSRFGDL     50
ISKTPAWDPE KPSRSYSERD FEFHRHTSHH THHPLSARLP PPHKLRRPPP 100
TSARHTRRKR KKEKTSAPPS EGTPPIQEEG GAGAEEEEEE EEEEEGESEA 150
EPVEPLPPGP PQKAKFSIGS DEDDSPGLPV KAPCAKALPS VGLQSDQSPQ 200
RSGSSPSPRA RASRISTEKS RPWSPSASYD LRERLCPGSA LGNPGPEQRV 250
PTDEAEAQML GSADLDDMKS HRLEDNPGVR RHLVKKPSRI QGGRGSPSGL 300
APILRRKKKK KKLDRRPHEV FVELNELMLD RSQEPHWRET ARWIKFEEDV 350
EEETERWGKP HVASLSFRSL LELRRTIAQG AALLDLEQTT LPGIAHLVVE 400
TMIVSDQIRP EDRASVLRTL LLKHSHPNDD KDSGFFPRNP SSSSVNSVLG 450
NHHPTPSHGP DGAVPTMADD QGEPAPLWPH DPDAKEKPLH MPGGDGHRGK 500
SLKLLEKIPE DAEATVVLVG CVPFLEQPAA AFVRLSEAVL LESVLEVPVP 550
VRFLFVMLGP SHTSTDYHEL GRSIATLMSD KLFHEAAYQA DDRQDLLGAI 600
SEFLDGSIVI PPSEVEGRDL LRSVAAFQRE LLRKRREREQ TKVEMTTRGG 650
YAAPGKELSL EMGGSEATSE DDPLQRTGSV FGGLVRDVKR RYPHYPSDLR 700
DALHSQCVAA VLFIYFAALS PAITFGGLLG EKTEGLMGVS ELIVSTAVLG 750
VLFSLLGAQP LLVVGFSGPL LVFEEAFFKF CRAQDLEYLT GRVWVGLWLV 800
VFVLALVAAE GSFLVRYISP FTQEIFAFLI SLIFIYETFH KLYKVFTEHP 850
LLPFYPPDEA LETGLELNSS ALPPTEGPPG PRNQPNTALL SLILMLGTFL 900
IAFFLRKFRN SRFLGGKARR IIGDFGIPIS ILVMVLVDYS ITDTYTQKLT 950
VPTGLSVTSP HKRTWFIPPL GSARPFPPWM MVAAAVPALL VLILIFMETQ 1000
ITALIVSQKA RRLLKGSGFH LDLLLIGSLG GLCGLFGLPW LTAATVRSVT 1050
HVNALTVMRT AIAPGDKPQI QEVREQRVTG VLIASLVGLS IVMGAVLRRI 1100
PLAVLFGIFL YMGVTSLSGI QLSQRLLLIF MPAKHHPEQP YVTKVKTWRM 1150
HLFTCIQLGC IALLWVVKST AASLAFPFLL LLTVPLRRCL LPRLFQDREL 1200
QALDSEDAEP NFDEDGQDEY NELHMPV 1227
Length:1,227
Mass (Da):135,373
Last modified:July 27, 2011 - v2
Checksum:i68BC64B72E5FDC55
GO
Isoform 311-AE3 (identifier: P16283-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     381-391: AALLDLEQTTL → RAFWAGNESLL
     392-1227: Missing.

Show »
Length:391
Mass (Da):43,470
Checksum:i3489399BE07290D5
GO
Isoform 14-AE3 (identifier: P16283-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     487-503: KPLHMPGGDGHRGKSLK → FCVLRSPSPCLGETVTEGKA
     504-1227: Missing.

Show »
Length:506
Mass (Da):55,695
Checksum:iB9749CF90C91B695
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei381 – 39111AALLDLEQTTL → RAFWAGNESLL in isoform 311-AE3. VSP_000464Add
BLAST
Alternative sequencei392 – 1227836Missing in isoform 311-AE3. VSP_000465Add
BLAST
Alternative sequencei487 – 50317KPLHM…GKSLK → FCVLRSPSPCLGETVTEGKA in isoform 14-AE3. VSP_000466Add
BLAST
Alternative sequencei504 – 1227724Missing in isoform 14-AE3. VSP_000467Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti530 – 5301A → G in AAA37184. 1 Publication
Sequence conflicti812 – 8121S → T in AAA37184. 1 Publication
Sequence conflicti1150 – 11512MH → ID in AAA37184. 1 Publication
Sequence conflicti1187 – 11882RR → SG in AAA37184. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M28383 mRNA. Translation: AAA37184.1.
S69314 mRNA. Translation: AAB30140.1.
AF294651 Genomic DNA. Translation: AAG25582.1.
CH466548 Genomic DNA. Translation: EDL00426.1.
CCDSiCCDS15080.1. [P16283-1]
PIRiA33638.
RefSeqiNP_033234.2. NM_009208.3. [P16283-1]
XP_006496512.1. XM_006496449.1. [P16283-1]
XP_006496513.1. XM_006496450.1. [P16283-1]
XP_006496514.1. XM_006496451.1. [P16283-1]
XP_006496515.1. XM_006496452.1. [P16283-1]
XP_006496516.1. XM_006496453.1. [P16283-1]
UniGeneiMm.5053.

Genome annotation databases

EnsembliENSMUST00000124341; ENSMUSP00000116747; ENSMUSG00000006576. [P16283-1]
GeneIDi20536.
KEGGimmu:20536.
UCSCiuc007bpv.2. mouse. [P16283-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M28383 mRNA. Translation: AAA37184.1 .
S69314 mRNA. Translation: AAB30140.1 .
AF294651 Genomic DNA. Translation: AAG25582.1 .
CH466548 Genomic DNA. Translation: EDL00426.1 .
CCDSi CCDS15080.1. [P16283-1 ]
PIRi A33638.
RefSeqi NP_033234.2. NM_009208.3. [P16283-1 ]
XP_006496512.1. XM_006496449.1. [P16283-1 ]
XP_006496513.1. XM_006496450.1. [P16283-1 ]
XP_006496514.1. XM_006496451.1. [P16283-1 ]
XP_006496515.1. XM_006496452.1. [P16283-1 ]
XP_006496516.1. XM_006496453.1. [P16283-1 ]
UniGenei Mm.5053.

3D structure databases

ProteinModelPortali P16283.
SMRi P16283. Positions 319-637, 691-732.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P16283. 1 interaction.
MINTi MINT-4996490.

PTM databases

PhosphoSitei P16283.

Proteomic databases

PaxDbi P16283.
PRIDEi P16283.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000124341 ; ENSMUSP00000116747 ; ENSMUSG00000006576 . [P16283-1 ]
GeneIDi 20536.
KEGGi mmu:20536.
UCSCi uc007bpv.2. mouse. [P16283-1 ]

Organism-specific databases

CTDi 6508.
MGIi MGI:109350. Slc4a3.

Phylogenomic databases

eggNOGi NOG268067.
GeneTreei ENSGT00560000076933.
HOGENOMi HOG000280683.
HOVERGENi HBG004326.
KOi K13856.
OMAi GDSHRGK.
OrthoDBi EOG7TMZR0.
PhylomeDBi P16283.
TreeFami TF313630.

Miscellaneous databases

NextBioi 298807.
PROi P16283.
SOURCEi Search...

Gene expression databases

ArrayExpressi P16283.
Bgeei P16283.
Genevestigatori P16283.

Family and domain databases

Gene3Di 3.40.1100.10. 1 hit.
InterProi IPR001717. Anion_exchange.
IPR002979. Anion_exchange_3.
IPR018241. Anion_exchange_CS.
IPR013769. Band3_cytoplasmic_dom.
IPR011531. HCO3_transpt_C.
IPR003020. HCO3_transpt_euk.
IPR016152. PTrfase/Anion_transptr.
[Graphical view ]
PANTHERi PTHR11453. PTHR11453. 1 hit.
PTHR11453:SF15. PTHR11453:SF15. 1 hit.
Pfami PF07565. Band_3_cyto. 1 hit.
PF00955. HCO3_cotransp. 2 hits.
[Graphical view ]
PRINTSi PR00165. ANIONEXCHNGR.
PR01189. ANIONEXHNGR3.
PR01231. HCO3TRNSPORT.
SUPFAMi SSF55804. SSF55804. 2 hits.
TIGRFAMsi TIGR00834. ae. 1 hit.
PROSITEi PS00219. ANION_EXCHANGER_1. 1 hit.
PS00220. ANION_EXCHANGER_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Regulation of intracellular pH by a neuronal homolog of the erythrocyte anion exchanger."
    Kopito R.R., Lee B.S., Simmons D.M., Lindsey A.E., Morgans C.W., Schneider K.
    Cell 59:927-937(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Generation of truncated brain AE3 isoforms by alternate mRNA processing."
    Morgans C.W., Kopito R.R.
    J. Cell Sci. 106:1275-1282(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], ALTERNATIVE SPLICING.
  3. "Genomic cloning and promoter analysis of a mouse anion exchanger 3 (AE3) gene."
    Iwaasa M., Tatewaki H., Ohno T., Okubo K., Hamasaki N., Kang D.
    DNA Seq. 13:251-255(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/Sv.
  4. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations."
    Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F., Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D., Gerrits B., Panse C., Schlapbach R., Mansuy I.M.
    Mol. Cell. Proteomics 6:283-293(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain cortex.

Entry informationi

Entry nameiB3A3_MOUSE
AccessioniPrimary (citable) accession number: P16283
Secondary accession number(s): Q9ERP5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: July 27, 2011
Last modified: July 9, 2014
This is version 125 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi