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P16262

- COX1_BACP3

UniProt

P16262 - COX1_BACP3

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Protein

Cytochrome c oxidase subunit 1

Gene
ctaD, caaB, coi
Organism
Bacillus sp. (strain PS3)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Co I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme a of subunit 1 to the bimetallic center formed by heme a3 and copper B. This cytochrome c oxidase shows proton pump activity across the membrane in addition to the electron transfer.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactori

Binds 1 copper B ion per subunit.
Binds 2 heme groups per subunit.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi72 – 721Iron (heme A axial ligand) Inferred
Metal bindingi249 – 2491Copper B Inferred
Metal bindingi253 – 2531Copper B Inferred
Metal bindingi298 – 2981Copper B Inferred
Metal bindingi299 – 2991Copper B Inferred
Metal bindingi384 – 3841Iron (heme A3/O axial ligand) Inferred
Metal bindingi386 – 3861Iron (heme A axial ligand) Inferred

GO - Molecular functioni

  1. copper ion binding Source: InterPro
  2. cytochrome-c oxidase activity Source: UniProtKB-EC
  3. heme binding Source: InterPro
  4. iron ion binding Source: InterPro

GO - Biological processi

  1. aerobic respiration Source: InterPro
  2. electron transport chain Source: InterPro
  3. oxidative phosphorylation Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Heme, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00705.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 1 (EC:1.9.3.1)
Alternative name(s):
Cytochrome aa3 subunit 1
Cytochrome c oxidase polypeptide I
Gene namesi
Name:ctaD
Synonyms:caaB, coi
OrganismiBacillus sp. (strain PS3)
Taxonomic identifieri2334 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei28 – 4821Helical; Reviewed predictionAdd
BLAST
Transmembranei75 – 9521Helical; Reviewed predictionAdd
BLAST
Transmembranei102 – 12221Helical; Reviewed predictionAdd
BLAST
Transmembranei158 – 17821Helical; Reviewed predictionAdd
BLAST
Transmembranei198 – 21821Helical; Reviewed predictionAdd
BLAST
Transmembranei243 – 26321Helical; Reviewed predictionAdd
BLAST
Transmembranei275 – 29521Helical; Reviewed predictionAdd
BLAST
Transmembranei303 – 32321Helical; Reviewed predictionAdd
BLAST
Transmembranei349 – 36921Helical; Reviewed predictionAdd
BLAST
Transmembranei380 – 40021Helical; Reviewed predictionAdd
BLAST
Transmembranei420 – 44021Helical; Reviewed predictionAdd
BLAST
Transmembranei463 – 48321Helical; Reviewed predictionAdd
BLAST
Transmembranei553 – 57321Helical; Reviewed predictionAdd
BLAST
Transmembranei577 – 59721Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
  3. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed2 Publications
Chaini2 – 616615Cytochrome c oxidase subunit 1PRO_0000183435Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki249 ↔ 2531'-histidyl-3'-tyrosine (His-Tyr) By similarity

Structurei

3D structure databases

ProteinModelPortaliP16262.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
IPR014241. Cyt_c_oxidase_su1_bac.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
TIGRFAMsiTIGR02891. CtaD_CoxA. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P16262-1 [UniParc]FASTAAdd to Basket

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MSTIARKKGV GAVLWDYLTT VDHKKIAHLY LISGGFFFLL GGLEALFIRI    50
QLAKPNNDFL VGGLYNEVLT MHGTTMIFLA AMPLVFAFMN AVVPLQIGAR 100
DVAFPFLNAL GFWMFFFGGL FLNCSWFLGG APDAGWTSYA SLSLDSKAHH 150
GIDFYTLGLQ ISGFGTIMGA INFLVTIINM RAPGMTFMRM PMFTWATFVT 200
SALILFAFPP LTVGLIFMMM DRLFGGNFFN PAAGGNTIIW EHLFWVFGHP 250
EVYILVLPAF GIFSEIFATF SRKRLFGYSS MVFATVLIAF LGFMVWAHHM 300
FTVGMGPIAN AIFAVATMTI AVPTGVKIFN WLFTMWGGSI KFTTPMHYAV 350
AFIPSFVMGG VTGVMLASAA ADYQYHDSYF VVAHFHYVIV GGVVFALLAG 400
THYWWPKMFG RMLNETLGKI TFWLFFIGFH LTFFIQHFLG LTGMPRRVFT 450
YLPHQGWETG NLISTIGAFF IAAATVILLI NIVVTTAKGE KVPGDAWGDG 500
RTLEWAIASP PPVYNFAQTP LVRGLDAFWL EKMEGKKELT PAEPLGDIHM 550
PNSSFLPFVI AFGLFVAAFG FTYHNDAGWG LPVAILGLLI TLGSMFLRSV 600
IDDHGFHIHK EEVLEL 616
Length:616
Mass (Da):68,294
Last modified:January 23, 2007 - v3
Checksum:i17DF1E3325014B96
GO

Sequence cautioni

The sequence BAA01793.1 differs from that shown. Reason: Frameshift at positions 520 and 540.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti448 – 4481V → W in BAA01793. 1 Publication
Sequence conflicti470 – 4701F → I in BAA01793. 1 Publication
Sequence conflicti506 – 5083AIA → RS in BAA01793. 1 Publication
Sequence conflicti525 – 5262LD → WT AA sequence 1 Publication
Sequence conflicti549 – 5491Missing AA sequence 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D13955 Genomic DNA. Translation: BAA03046.1.
D11038 Genomic DNA. Translation: BAA01793.1. Frameshift.
PIRiJX0140.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D13955 Genomic DNA. Translation: BAA03046.1 .
D11038 Genomic DNA. Translation: BAA01793.1 . Frameshift.
PIRi JX0140.

3D structure databases

ProteinModelPortali P16262.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00705 .

Family and domain databases

Gene3Di 1.20.210.10. 1 hit.
InterProi IPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
IPR014241. Cyt_c_oxidase_su1_bac.
[Graphical view ]
PANTHERi PTHR10422. PTHR10422. 1 hit.
Pfami PF00115. COX1. 1 hit.
[Graphical view ]
PRINTSi PR01165. CYCOXIDASEI.
SUPFAMi SSF81442. SSF81442. 1 hit.
TIGRFAMsi TIGR02891. CtaD_CoxA. 1 hit.
PROSITEi PS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Nucleotide sequence of the gene coding for four subunits of cytochrome c oxidase from the thermophilic bacterium PS3."
    Ishizuka M., Machida K., Shimada S., Mogi A., Tsuchiya T., Ohmori T., Souma Y., Gonda M., Sone N.
    J. Biochem. 108:866-873(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 2-31.
  2. "Nucleotide sequence of the gene coding for cytochrome oxidase subunit I from the thermophilic bacterium PS3."
    Sone N., Yokoi F., Fu T., Ohta S., Metso T., Raitio M., Saraste M.
    J. Biochem. 103:606-610(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-552, PROTEIN SEQUENCE OF 2-15.
  3. "Haem O2 can replace haem A in the active site of cytochrome c oxidase from thermophilic bacterium PS3."
    Sone N., Fujiwara Y.
    FEBS Lett. 288:154-158(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.

Entry informationi

Entry nameiCOX1_BACP3
AccessioniPrimary (citable) accession number: P16262
Secondary accession number(s): Q56248
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: January 23, 2007
Last modified: September 3, 2014
This is version 108 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Under slightly air-limited conditions, the cytochrome a3 center of the enzyme is replaced by cytochrome o.
This cytochrome c oxidase shows clear proton pump activity in addition to electron transfer across the membrane.

Keywords - Technical termi

Direct protein sequencing

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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