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Protein

Graves disease carrier protein

Gene

Slc25a16

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Graves disease carrier protein
Short name:
GDC
Alternative name(s):
Mitochondrial solute carrier protein homolog
Solute carrier family 25 member 16
Gene namesi
Name:Slc25a16
Synonyms:Gda
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1311311. Slc25a16.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – ›322›322Graves disease carrier proteinPRO_0000090618Add
BLAST

Proteomic databases

PaxDbiP16261.
PeptideAtlasiP16261.
PRIDEiP16261.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000052899.

Structurei

3D structure databases

ProteinModelPortaliP16261.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati34 – 12087Solcar 1Add
BLAST
Repeati128 – 21992Solcar 2Add
BLAST
Repeati241 – ›322›82Solcar 3Add
BLAST

Sequence similaritiesi

Contains 3 Solcar repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane

Phylogenomic databases

eggNOGiKOG0752. Eukaryota.
ENOG410ZRF1. LUCA.
HOVERGENiHBG104402.
InParanoidiP16261.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR002167. Graves_DC.
IPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00928. GRAVESDC.
PR00926. MITOCARRIER.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

P16261-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAALVAAAAL AAAEPPPAVP AAAGSGGPTS RRDFYWLRSF LAGSIAGCCA
60 70 80 90 100
KTTVAPLDRV KVLLQAHNHH YKHLGVLSPL RAVPQKEGYL GLYKGNGAMM
110 120 130 140 150
IRIFPYGAIQ FMAFEHYKTF ITTKLGVSGH VHRLMAGSMA GKMSMTAVIC
160 170 180 190 200
TYPLDVVRVR LAFQVKGEHT YSGIIHAFKT IYAKEGGFLG FYRGLMPTIL
210 220 230 240 250
GMAPYASVSF FTFGTLKSVG LSYAPTLLGR PSSDNPNVLV LKTHINLLCG
260 270 280 290 300
GVARAIAQTI SYPFDVTRRR MQLGAVLPEF EKCLTMRETM KYVYGHHGIR
310 320
RGLYRGLSLN YIRCIPSQAV AF
Length:322
Mass (Da):35,056
Last modified:August 1, 1990 - v1
Checksum:iF78CBDA36CA9DC9A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei322 – 3221

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M32973 mRNA. Translation: AAA41639.1.
UniGeneiRn.21448.

Genome annotation databases

UCSCiRGD:1311311. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M32973 mRNA. Translation: AAA41639.1.
UniGeneiRn.21448.

3D structure databases

ProteinModelPortaliP16261.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000052899.

Proteomic databases

PaxDbiP16261.
PeptideAtlasiP16261.
PRIDEiP16261.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiRGD:1311311. rat.

Organism-specific databases

RGDi1311311. Slc25a16.

Phylogenomic databases

eggNOGiKOG0752. Eukaryota.
ENOG410ZRF1. LUCA.
HOVERGENiHBG104402.
InParanoidiP16261.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR002167. Graves_DC.
IPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00928. GRAVESDC.
PR00926. MITOCARRIER.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Sequence and chromosomal assignment of a novel cDNA identified by immunoscreening of a thyroid expression library: similarity to a family of mitochondrial solute carrier proteins."
    Zarrilli R., Oates E.L., McBride O.W., Lerman M.I., Chan J.Y., Santisteban P., Ursini M.V., Notkins A.L., Kohn L.D.
    Mol. Endocrinol. 3:1498-1505(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Thyroid.

Entry informationi

Entry nameiGDC_RAT
AccessioniPrimary (citable) accession number: P16261
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: July 6, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.