ID   GDC_HUMAN               Reviewed;         332 AA.
AC   P16260; Q8N2U1;
DT   01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
DT   25-NOV-2008, sequence version 3.
DT   27-MAR-2024, entry version 198.
DE   RecName: Full=Solute carrier family 25 member 16;
DE   AltName: Full=Graves disease autoantigen;
DE            Short=GDA;
DE   AltName: Full=Graves disease carrier protein {ECO:0000250|UniProtKB:Q01888};
DE            Short=GDC {ECO:0000250|UniProtKB:Q01888};
DE   AltName: Full=Graves' didease protein {ECO:0000303|PubMed:2575220};
DE            Short=hGP {ECO:0000303|PubMed:11158296};
DE   AltName: Full=Mitochondrial solute carrier protein homolog;
GN   Name=SLC25A16 {ECO:0000312|HGNC:HGNC:10986}; Synonyms=GDA;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Thyroid;
RX   PubMed=2575220; DOI=10.1210/mend-3-9-1498;
RA   Zarrilli R., Oates E.L., McBride O.W., Lerman M.I., Chan J.Y.,
RA   Santisteban P., Ursini M.V., Notkins A.L., Kohn L.D.;
RT   "Sequence and chromosomal assignment of a novel cDNA identified by
RT   immunoscreening of a thyroid expression library: similarity to a family of
RT   mitochondrial solute carrier proteins.";
RL   Mol. Endocrinol. 3:1498-1505(1989).
RN   [2]
RP   SEQUENCE REVISION TO C-TERMINUS.
RX   PubMed=1457817; DOI=10.3109/10425179209033999;
RA   Fiermonte G., Runswick M.J., Walker J.E., Palmieri F.;
RT   "Sequence and pattern of expression of a bovine homologue of a human
RT   mitochondrial transport protein associated with Grave's disease.";
RL   DNA Seq. 3:71-78(1992).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Colon;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15164054; DOI=10.1038/nature02462;
RA   Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
RA   Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
RA   Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
RA   Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
RA   Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y.,
RA   Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P.,
RA   Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N.,
RA   Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A.,
RA   Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C.,
RA   Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D.,
RA   Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C.,
RA   Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K.,
RA   Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A.,
RA   Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S.,
RA   McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S.,
RA   Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V.,
RA   Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A.,
RA   Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
RA   Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A.,
RA   Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P.,
RA   Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y.,
RA   Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D.,
RA   Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
RT   "The DNA sequence and comparative analysis of human chromosome 10.";
RL   Nature 429:375-381(2004).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [6]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [7]
RP   FUNCTION, AND SUBCELLULAR LOCATION.
RX   PubMed=11158296; DOI=10.1128/mcb.21.4.1089-1097.2001;
RA   Prohl C., Pelzer W., Diekert K., Kmita H., Bedekovics T., Kispal G.,
RA   Lill R.;
RT   "The yeast mitochondrial carrier Leu5p and its human homologue Graves'
RT   disease protein are required for accumulation of coenzyme A in the
RT   matrix.";
RL   Mol. Cell. Biol. 21:1089-1097(2001).
RN   [8]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Cervix carcinoma;
RX   PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA   Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA   Elledge S.J., Gygi S.P.;
RT   "A quantitative atlas of mitotic phosphorylation.";
RL   Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
CC   -!- FUNCTION: May be involved in the transport of coenzyme A in the
CC       mitochondrial matrix (PubMed:11158296). Very little is known about the
CC       physiological function of this carrier (PubMed:11158296).
CC       {ECO:0000269|PubMed:11158296}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC       {ECO:0000305|PubMed:11158296}; Multi-pass membrane protein
CC       {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAA36329.1; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; M31659; AAA36329.1; ALT_FRAME; mRNA.
DR   EMBL; AK290255; BAF82944.1; -; mRNA.
DR   EMBL; AL713888; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471083; EAW54298.1; -; Genomic_DNA.
DR   EMBL; BC030266; AAH30266.1; -; mRNA.
DR   CCDS; CCDS7280.1; -.
DR   PIR; A40141; A40141.
DR   RefSeq; NP_689920.1; NM_152707.3.
DR   RefSeq; XP_011538513.1; XM_011540211.2.
DR   AlphaFoldDB; P16260; -.
DR   SMR; P16260; -.
DR   BioGRID; 113727; 38.
DR   IntAct; P16260; 13.
DR   STRING; 9606.ENSP00000476815; -.
DR   TCDB; 2.A.29.12.3; the mitochondrial carrier (mc) family.
DR   GlyCosmos; P16260; 3 sites, 1 glycan.
DR   GlyGen; P16260; 3 sites, 1 O-linked glycan (3 sites).
DR   iPTMnet; P16260; -.
DR   PhosphoSitePlus; P16260; -.
DR   SwissPalm; P16260; -.
DR   BioMuta; SLC25A16; -.
DR   DMDM; 215274156; -.
DR   EPD; P16260; -.
DR   jPOST; P16260; -.
DR   MassIVE; P16260; -.
DR   MaxQB; P16260; -.
DR   PaxDb; 9606-ENSP00000476815; -.
DR   PeptideAtlas; P16260; -.
DR   ProteomicsDB; 53331; -.
DR   Pumba; P16260; -.
DR   Antibodypedia; 28525; 79 antibodies from 18 providers.
DR   DNASU; 8034; -.
DR   Ensembl; ENST00000609923.6; ENSP00000476815.1; ENSG00000122912.15.
DR   GeneID; 8034; -.
DR   KEGG; hsa:8034; -.
DR   MANE-Select; ENST00000609923.6; ENSP00000476815.1; NM_152707.4; NP_689920.1.
DR   UCSC; uc001joi.4; human.
DR   AGR; HGNC:10986; -.
DR   CTD; 8034; -.
DR   DisGeNET; 8034; -.
DR   GeneCards; SLC25A16; -.
DR   HGNC; HGNC:10986; SLC25A16.
DR   HPA; ENSG00000122912; Low tissue specificity.
DR   MalaCards; SLC25A16; -.
DR   MIM; 139080; gene.
DR   neXtProt; NX_P16260; -.
DR   OpenTargets; ENSG00000122912; -.
DR   PharmGKB; PA35862; -.
DR   VEuPathDB; HostDB:ENSG00000122912; -.
DR   eggNOG; KOG0752; Eukaryota.
DR   GeneTree; ENSGT00940000157520; -.
DR   HOGENOM; CLU_015166_10_1_1; -.
DR   InParanoid; P16260; -.
DR   OMA; YKMSVPK; -.
DR   OrthoDB; 1330359at2759; -.
DR   PhylomeDB; P16260; -.
DR   TreeFam; TF314806; -.
DR   PathwayCommons; P16260; -.
DR   Reactome; R-HSA-199220; Vitamin B5 (pantothenate) metabolism.
DR   SignaLink; P16260; -.
DR   BioGRID-ORCS; 8034; 13 hits in 1162 CRISPR screens.
DR   ChiTaRS; SLC25A16; human.
DR   GenomeRNAi; 8034; -.
DR   Pharos; P16260; Tbio.
DR   PRO; PR:P16260; -.
DR   Proteomes; UP000005640; Chromosome 10.
DR   RNAct; P16260; Protein.
DR   Bgee; ENSG00000122912; Expressed in jejunal mucosa and 184 other cell types or tissues.
DR   ExpressionAtlas; P16260; baseline and differential.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IBA:GO_Central.
DR   GO; GO:0005739; C:mitochondrion; IDA:HPA.
DR   GO; GO:0015297; F:antiporter activity; NAS:UniProtKB.
DR   GO; GO:0015228; F:coenzyme A transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:1990559; P:mitochondrial coenzyme A transmembrane transport; IBA:GO_Central.
DR   GO; GO:0006839; P:mitochondrial transport; NAS:UniProtKB.
DR   GO; GO:0015939; P:pantothenate metabolic process; TAS:Reactome.
DR   Gene3D; 1.50.40.10; Mitochondrial carrier domain; 1.
DR   InterPro; IPR002167; GDC-like.
DR   InterPro; IPR002067; Mit_carrier.
DR   InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR   InterPro; IPR023395; Mt_carrier_dom_sf.
DR   PANTHER; PTHR24089:SF705; GRAVES DISEASE CARRIER PROTEIN; 1.
DR   PANTHER; PTHR24089; SOLUTE CARRIER FAMILY 25; 1.
DR   Pfam; PF00153; Mito_carr; 3.
DR   PRINTS; PR00928; GRAVESDC.
DR   PRINTS; PR00926; MITOCARRIER.
DR   SUPFAM; SSF103506; Mitochondrial carrier; 1.
DR   PROSITE; PS50920; SOLCAR; 3.
DR   Genevisible; P16260; HS.
PE   1: Evidence at protein level;
KW   Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW   Repeat; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..332
FT                   /note="Solute carrier family 25 member 16"
FT                   /id="PRO_0000090616"
FT   TRANSMEM        37..57
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        88..108
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        134..154
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        191..211
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        244..264
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        299..319
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   REPEAT          34..120
FT                   /note="Solcar 1"
FT   REPEAT          128..216
FT                   /note="Solcar 2"
FT   REPEAT          238..328
FT                   /note="Solcar 3"
FT   CONFLICT        21
FT                   /note="Q -> G (in Ref. 1; AAA36329)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        44
FT                   /note="G -> S (in Ref. 1; AAA36329)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        149..151
FT                   /note="YPL -> DPV (in Ref. 1; AAA36329)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        167
FT                   /note="S -> R (in Ref. 1; AAA36329)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        227
FT                   /note="R -> S (in Ref. 1; AAA36329)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        251
FT                   /note="G -> R (in Ref. 1; AAA36329)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        290
FT                   /note="V -> D (in Ref. 1; AAA36329)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   332 AA;  36224 MW;  71C2C3D413F80246 CRC64;
     MAAATAAAAL AAADPPPAMP QAAGAGGPTT RRDFYWLRSF LAGGIAGCCA KTTVAPLDRV
     KVLLQAHNHH YKHLGVFSAL RAVPQKEGFL GLYKGNGAMM IRIFPYGAIQ FMAFEHYKTL
     ITTKLGISGH VHRLMAGSMA GMTAVICTYP LDMVRVRLAF QVKGEHSYTG IIHAFKTIYA
     KEGGFFGFYR GLMPTILGMA PYAGVSFFTF GTLKSVGLSH APTLLGRPSS DNPNVLVLKT
     HVNLLCGGVA GAIAQTISYP FDVTRRRMQL GTVLPEFEKC LTMRDTMKYV YGHHGIRKGL
     YRGLSLNYIR CIPSQAVAFT TYELMKQFFH LN
//