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Protein

Graves disease carrier protein

Gene

SLC25A16

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Required for the accumulation of coenzyme A in the mitochondrial matrix.1 Publication

GO - Molecular functioni

  • antiporter activity Source: UniProtKB
  • secondary active transmembrane transporter activity Source: Reactome

GO - Biological processi

  • coenzyme biosynthetic process Source: Reactome
  • transport Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciZFISH:ENSG00000122912-MONOMER.
ReactomeiR-HSA-196783. Coenzyme A biosynthesis.

Protein family/group databases

TCDBi2.A.29.12.3. the mitochondrial carrier (mc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Graves disease carrier protein
Short name:
GDC
Alternative name(s):
Graves disease autoantigen
Short name:
GDA
Mitochondrial solute carrier protein homolog
Solute carrier family 25 member 16
Gene namesi
Name:SLC25A16
Synonyms:GDA
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:10986. SLC25A16.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei37 – 57Helical; Name=1Sequence analysisAdd BLAST21
Transmembranei88 – 108Helical; Name=2Sequence analysisAdd BLAST21
Transmembranei134 – 154Helical; Name=3Sequence analysisAdd BLAST21
Transmembranei191 – 211Helical; Name=4Sequence analysisAdd BLAST21
Transmembranei244 – 264Helical; Name=5Sequence analysisAdd BLAST21
Transmembranei299 – 319Helical; Name=6Sequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi8034.
OpenTargetsiENSG00000122912.
PharmGKBiPA35862.

Polymorphism and mutation databases

BioMutaiSLC25A16.
DMDMi215274156.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000906161 – 332Graves disease carrier proteinAdd BLAST332

Proteomic databases

EPDiP16260.
MaxQBiP16260.
PaxDbiP16260.
PeptideAtlasiP16260.
PRIDEiP16260.

PTM databases

iPTMnetiP16260.
PhosphoSitePlusiP16260.

Expressioni

Gene expression databases

BgeeiENSG00000122912.
CleanExiHS_GDA.
HS_SLC25A16.
ExpressionAtlasiP16260. baseline and differential.
GenevisibleiP16260. HS.

Organism-specific databases

HPAiHPA044580.

Interactioni

Protein-protein interaction databases

BioGridi113727. 20 interactors.
STRINGi9606.ENSP00000265870.

Structurei

3D structure databases

ProteinModelPortaliP16260.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati34 – 120Solcar 1Add BLAST87
Repeati128 – 216Solcar 2Add BLAST89
Repeati238 – 328Solcar 3Add BLAST91

Sequence similaritiesi

Contains 3 Solcar repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0752. Eukaryota.
ENOG410ZRF1. LUCA.
GeneTreeiENSGT00760000119245.
HOGENOMiHOG000165726.
HOVERGENiHBG104402.
InParanoidiP16260.
KOiK15084.
OMAiHHYKHLE.
OrthoDBiEOG091G0C8S.
PhylomeDBiP16260.
TreeFamiTF314806.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR002167. Graves_DC.
IPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00928. GRAVESDC.
PR00926. MITOCARRIER.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P16260-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAATAAAAL AAADPPPAMP QAAGAGGPTT RRDFYWLRSF LAGGIAGCCA
60 70 80 90 100
KTTVAPLDRV KVLLQAHNHH YKHLGVFSAL RAVPQKEGFL GLYKGNGAMM
110 120 130 140 150
IRIFPYGAIQ FMAFEHYKTL ITTKLGISGH VHRLMAGSMA GMTAVICTYP
160 170 180 190 200
LDMVRVRLAF QVKGEHSYTG IIHAFKTIYA KEGGFFGFYR GLMPTILGMA
210 220 230 240 250
PYAGVSFFTF GTLKSVGLSH APTLLGRPSS DNPNVLVLKT HVNLLCGGVA
260 270 280 290 300
GAIAQTISYP FDVTRRRMQL GTVLPEFEKC LTMRDTMKYV YGHHGIRKGL
310 320 330
YRGLSLNYIR CIPSQAVAFT TYELMKQFFH LN
Length:332
Mass (Da):36,224
Last modified:November 25, 2008 - v3
Checksum:i71C2C3D413F80246
GO

Sequence cautioni

The sequence AAA36329 differs from that shown. Reason: Frameshift at position 320.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti21Q → G in AAA36329 (PubMed:2575220).Curated1
Sequence conflicti44G → S in AAA36329 (PubMed:2575220).Curated1
Sequence conflicti149 – 151YPL → DPV in AAA36329 (PubMed:2575220).Curated3
Sequence conflicti167S → R in AAA36329 (PubMed:2575220).Curated1
Sequence conflicti227R → S in AAA36329 (PubMed:2575220).Curated1
Sequence conflicti251G → R in AAA36329 (PubMed:2575220).Curated1
Sequence conflicti290V → D in AAA36329 (PubMed:2575220).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M31659 mRNA. Translation: AAA36329.1. Frameshift.
AK290255 mRNA. Translation: BAF82944.1.
AL713888 Genomic DNA. Translation: CAI15116.1.
CH471083 Genomic DNA. Translation: EAW54298.1.
BC030266 mRNA. Translation: AAH30266.1.
CCDSiCCDS7280.1.
PIRiA40141.
RefSeqiNP_689920.1. NM_152707.3.
XP_011538513.1. XM_011540211.2.
UniGeneiHs.180408.

Genome annotation databases

EnsembliENST00000609923; ENSP00000476815; ENSG00000122912.
GeneIDi8034.
KEGGihsa:8034.
UCSCiuc001joi.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M31659 mRNA. Translation: AAA36329.1. Frameshift.
AK290255 mRNA. Translation: BAF82944.1.
AL713888 Genomic DNA. Translation: CAI15116.1.
CH471083 Genomic DNA. Translation: EAW54298.1.
BC030266 mRNA. Translation: AAH30266.1.
CCDSiCCDS7280.1.
PIRiA40141.
RefSeqiNP_689920.1. NM_152707.3.
XP_011538513.1. XM_011540211.2.
UniGeneiHs.180408.

3D structure databases

ProteinModelPortaliP16260.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113727. 20 interactors.
STRINGi9606.ENSP00000265870.

Protein family/group databases

TCDBi2.A.29.12.3. the mitochondrial carrier (mc) family.

PTM databases

iPTMnetiP16260.
PhosphoSitePlusiP16260.

Polymorphism and mutation databases

BioMutaiSLC25A16.
DMDMi215274156.

Proteomic databases

EPDiP16260.
MaxQBiP16260.
PaxDbiP16260.
PeptideAtlasiP16260.
PRIDEiP16260.

Protocols and materials databases

DNASUi8034.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000609923; ENSP00000476815; ENSG00000122912.
GeneIDi8034.
KEGGihsa:8034.
UCSCiuc001joi.4. human.

Organism-specific databases

CTDi8034.
DisGeNETi8034.
GeneCardsiSLC25A16.
HGNCiHGNC:10986. SLC25A16.
HPAiHPA044580.
MIMi139080. gene.
neXtProtiNX_P16260.
OpenTargetsiENSG00000122912.
PharmGKBiPA35862.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0752. Eukaryota.
ENOG410ZRF1. LUCA.
GeneTreeiENSGT00760000119245.
HOGENOMiHOG000165726.
HOVERGENiHBG104402.
InParanoidiP16260.
KOiK15084.
OMAiHHYKHLE.
OrthoDBiEOG091G0C8S.
PhylomeDBiP16260.
TreeFamiTF314806.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000122912-MONOMER.
ReactomeiR-HSA-196783. Coenzyme A biosynthesis.

Miscellaneous databases

GenomeRNAii8034.
PROiP16260.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000122912.
CleanExiHS_GDA.
HS_SLC25A16.
ExpressionAtlasiP16260. baseline and differential.
GenevisibleiP16260. HS.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR002167. Graves_DC.
IPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00928. GRAVESDC.
PR00926. MITOCARRIER.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGDC_HUMAN
AccessioniPrimary (citable) accession number: P16260
Secondary accession number(s): Q8N2U1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: November 25, 2008
Last modified: November 30, 2016
This is version 156 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.