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P16260 (GDC_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 134. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Graves disease carrier protein

Short name=GDC
Alternative name(s):
Graves disease autoantigen
Short name=GDA
Mitochondrial solute carrier protein homolog
Solute carrier family 25 member 16
Gene names
Name:SLC25A16
Synonyms:GDA
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length332 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Required for the accumulation of coenzyme A in the mitochondrial matrix. Ref.7

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein Ref.7.

Sequence similarities

Belongs to the mitochondrial carrier (TC 2.A.29) family. [View classification]

Contains 3 Solcar repeats.

Sequence caution

The sequence AAA36329.1 differs from that shown. Reason: Frameshift at position 320.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 332332Graves disease carrier protein
PRO_0000090616

Regions

Transmembrane37 – 5721Helical; Name=1; Potential
Transmembrane88 – 10821Helical; Name=2; Potential
Transmembrane134 – 15421Helical; Name=3; Potential
Transmembrane191 – 21121Helical; Name=4; Potential
Transmembrane244 – 26421Helical; Name=5; Potential
Transmembrane299 – 31921Helical; Name=6; Potential
Repeat34 – 12087Solcar 1
Repeat128 – 21689Solcar 2
Repeat238 – 32891Solcar 3

Experimental info

Sequence conflict211Q → G in AAA36329. Ref.1
Sequence conflict441G → S in AAA36329. Ref.1
Sequence conflict149 – 1513YPL → DPV in AAA36329. Ref.1
Sequence conflict1671S → R in AAA36329. Ref.1
Sequence conflict2271R → S in AAA36329. Ref.1
Sequence conflict2511G → R in AAA36329. Ref.1
Sequence conflict2901V → D in AAA36329. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P16260 [UniParc].

Last modified November 25, 2008. Version 3.
Checksum: 71C2C3D413F80246

FASTA33236,224
        10         20         30         40         50         60 
MAAATAAAAL AAADPPPAMP QAAGAGGPTT RRDFYWLRSF LAGGIAGCCA KTTVAPLDRV 

        70         80         90        100        110        120 
KVLLQAHNHH YKHLGVFSAL RAVPQKEGFL GLYKGNGAMM IRIFPYGAIQ FMAFEHYKTL 

       130        140        150        160        170        180 
ITTKLGISGH VHRLMAGSMA GMTAVICTYP LDMVRVRLAF QVKGEHSYTG IIHAFKTIYA 

       190        200        210        220        230        240 
KEGGFFGFYR GLMPTILGMA PYAGVSFFTF GTLKSVGLSH APTLLGRPSS DNPNVLVLKT 

       250        260        270        280        290        300 
HVNLLCGGVA GAIAQTISYP FDVTRRRMQL GTVLPEFEKC LTMRDTMKYV YGHHGIRKGL 

       310        320        330 
YRGLSLNYIR CIPSQAVAFT TYELMKQFFH LN 

« Hide

References

« Hide 'large scale' references
[1]"Sequence and chromosomal assignment of a novel cDNA identified by immunoscreening of a thyroid expression library: similarity to a family of mitochondrial solute carrier proteins."
Zarrilli R., Oates E.L., McBride O.W., Lerman M.I., Chan J.Y., Santisteban P., Ursini M.V., Notkins A.L., Kohn L.D.
Mol. Endocrinol. 3:1498-1505(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Thyroid.
[2]"Sequence and pattern of expression of a bovine homologue of a human mitochondrial transport protein associated with Grave's disease."
Fiermonte G., Runswick M.J., Walker J.E., Palmieri F.
DNA Seq. 3:71-78(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: SEQUENCE REVISION TO C-TERMINUS.
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Colon.
[4]"The DNA sequence and comparative analysis of human chromosome 10."
Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. expand/collapse author list , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[7]"The yeast mitochondrial carrier Leu5p and its human homologue Graves' disease protein are required for accumulation of coenzyme A in the matrix."
Prohl C., Pelzer W., Diekert K., Kmita H., Bedekovics T., Kispal G., Lill R.
Mol. Cell. Biol. 21:1089-1097(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION.
[8]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M31659 mRNA. Translation: AAA36329.1. Frameshift.
AK290255 mRNA. Translation: BAF82944.1.
AL713888 Genomic DNA. Translation: CAI15116.1.
CH471083 Genomic DNA. Translation: EAW54298.1.
BC030266 mRNA. Translation: AAH30266.1.
PIRA40141.
RefSeqNP_689920.1. NM_152707.3.
UniGeneHs.180408.

3D structure databases

ProteinModelPortalP16260.
SMRP16260. Positions 32-330.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000265870.

Protein family/group databases

TCDB2.A.29.12.3. the mitochondrial carrier (mc) family.

PTM databases

PhosphoSiteP16260.

Polymorphism databases

DMDM215274156.

Proteomic databases

PaxDbP16260.
PRIDEP16260.

Protocols and materials databases

DNASU8034.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000609923; ENSP00000476815; ENSG00000122912.
GeneID8034.
KEGGhsa:8034.
UCSCuc001joi.3. human.

Organism-specific databases

CTD8034.
GeneCardsGC10M070242.
HGNCHGNC:10986. SLC25A16.
HPAHPA044580.
MIM139080. gene.
neXtProtNX_P16260.
PharmGKBPA35862.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG274055.
HOGENOMHOG000165726.
HOVERGENHBG104402.
InParanoidP16260.
KOK15084.
OMAKTHVNLL.
OrthoDBEOG7HXCR5.
PhylomeDBP16260.
TreeFamTF314806.

Enzyme and pathway databases

ReactomeREACT_111217. Metabolism.
REACT_116125. Disease.

Gene expression databases

ArrayExpressP16260.
BgeeP16260.
CleanExHS_GDA.
HS_SLC25A16.
GenevestigatorP16260.

Family and domain databases

Gene3D1.50.40.10. 1 hit.
InterProIPR002167. Graves_DC.
IPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSPR00928. GRAVESDC.
PR00926. MITOCARRIER.
SUPFAMSSF103506. SSF103506. 1 hit.
PROSITEPS50920. SOLCAR. 3 hits.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi8034.
NextBio30619.
PROP16260.
SOURCESearch...

Entry information

Entry nameGDC_HUMAN
AccessionPrimary (citable) accession number: P16260
Secondary accession number(s): Q8N2U1
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: November 25, 2008
Last modified: April 16, 2014
This is version 134 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 10

Human chromosome 10: entries, gene names and cross-references to MIM