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P16260

- GDC_HUMAN

UniProt

P16260 - GDC_HUMAN

Protein

Graves disease carrier protein

Gene

SLC25A16

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 139 (01 Oct 2014)
      Sequence version 3 (25 Nov 2008)
      Previous versions | rss
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    Functioni

    Required for the accumulation of coenzyme A in the mitochondrial matrix.1 Publication

    GO - Molecular functioni

    1. antiporter activity Source: UniProtKB

    GO - Biological processi

    1. coenzyme biosynthetic process Source: Reactome
    2. pantothenate metabolic process Source: Reactome
    3. small molecule metabolic process Source: Reactome
    4. transport Source: UniProtKB
    5. vitamin metabolic process Source: Reactome
    6. water-soluble vitamin metabolic process Source: Reactome

    Keywords - Biological processi

    Transport

    Enzyme and pathway databases

    ReactomeiREACT_11218. Coenzyme A biosynthesis.

    Protein family/group databases

    TCDBi2.A.29.12.3. the mitochondrial carrier (mc) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Graves disease carrier protein
    Short name:
    GDC
    Alternative name(s):
    Graves disease autoantigen
    Short name:
    GDA
    Mitochondrial solute carrier protein homolog
    Solute carrier family 25 member 16
    Gene namesi
    Name:SLC25A16
    Synonyms:GDA
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 10

    Organism-specific databases

    HGNCiHGNC:10986. SLC25A16.

    Subcellular locationi

    Mitochondrion inner membrane 1 Publication; Multi-pass membrane protein 1 Publication

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial inner membrane Source: Reactome

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA35862.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 332332Graves disease carrier proteinPRO_0000090616Add
    BLAST

    Proteomic databases

    MaxQBiP16260.
    PaxDbiP16260.
    PRIDEiP16260.

    PTM databases

    PhosphoSiteiP16260.

    Expressioni

    Gene expression databases

    ArrayExpressiP16260.
    BgeeiP16260.
    CleanExiHS_GDA.
    HS_SLC25A16.
    GenevestigatoriP16260.

    Organism-specific databases

    HPAiHPA044580.

    Interactioni

    Protein-protein interaction databases

    BioGridi113727. 1 interaction.
    STRINGi9606.ENSP00000265870.

    Structurei

    3D structure databases

    ProteinModelPortaliP16260.
    SMRiP16260. Positions 36-317.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei37 – 5721Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei88 – 10821Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei134 – 15421Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei191 – 21121Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei244 – 26421Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei299 – 31921Helical; Name=6Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati34 – 12087Solcar 1Add
    BLAST
    Repeati128 – 21689Solcar 2Add
    BLAST
    Repeati238 – 32891Solcar 3Add
    BLAST

    Sequence similaritiesi

    Contains 3 Solcar repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG274055.
    HOGENOMiHOG000165726.
    HOVERGENiHBG104402.
    InParanoidiP16260.
    KOiK15084.
    OMAiHHYKHLE.
    OrthoDBiEOG7HXCR5.
    PhylomeDBiP16260.
    TreeFamiTF314806.

    Family and domain databases

    Gene3Di1.50.40.10. 1 hit.
    InterProiIPR002167. Graves_DC.
    IPR002067. Mit_carrier.
    IPR018108. Mitochondrial_sb/sol_carrier.
    IPR023395. Mt_carrier_dom.
    [Graphical view]
    PfamiPF00153. Mito_carr. 3 hits.
    [Graphical view]
    PRINTSiPR00928. GRAVESDC.
    PR00926. MITOCARRIER.
    SUPFAMiSSF103506. SSF103506. 1 hit.
    PROSITEiPS50920. SOLCAR. 3 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P16260-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAAATAAAAL AAADPPPAMP QAAGAGGPTT RRDFYWLRSF LAGGIAGCCA    50
    KTTVAPLDRV KVLLQAHNHH YKHLGVFSAL RAVPQKEGFL GLYKGNGAMM 100
    IRIFPYGAIQ FMAFEHYKTL ITTKLGISGH VHRLMAGSMA GMTAVICTYP 150
    LDMVRVRLAF QVKGEHSYTG IIHAFKTIYA KEGGFFGFYR GLMPTILGMA 200
    PYAGVSFFTF GTLKSVGLSH APTLLGRPSS DNPNVLVLKT HVNLLCGGVA 250
    GAIAQTISYP FDVTRRRMQL GTVLPEFEKC LTMRDTMKYV YGHHGIRKGL 300
    YRGLSLNYIR CIPSQAVAFT TYELMKQFFH LN 332
    Length:332
    Mass (Da):36,224
    Last modified:November 25, 2008 - v3
    Checksum:i71C2C3D413F80246
    GO

    Sequence cautioni

    The sequence AAA36329.1 differs from that shown. Reason: Frameshift at position 320.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti21 – 211Q → G in AAA36329. (PubMed:2575220)Curated
    Sequence conflicti44 – 441G → S in AAA36329. (PubMed:2575220)Curated
    Sequence conflicti149 – 1513YPL → DPV in AAA36329. (PubMed:2575220)Curated
    Sequence conflicti167 – 1671S → R in AAA36329. (PubMed:2575220)Curated
    Sequence conflicti227 – 2271R → S in AAA36329. (PubMed:2575220)Curated
    Sequence conflicti251 – 2511G → R in AAA36329. (PubMed:2575220)Curated
    Sequence conflicti290 – 2901V → D in AAA36329. (PubMed:2575220)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M31659 mRNA. Translation: AAA36329.1. Frameshift.
    AK290255 mRNA. Translation: BAF82944.1.
    AL713888 Genomic DNA. Translation: CAI15116.1.
    CH471083 Genomic DNA. Translation: EAW54298.1.
    BC030266 mRNA. Translation: AAH30266.1.
    CCDSiCCDS7280.1.
    PIRiA40141.
    RefSeqiNP_689920.1. NM_152707.3.
    UniGeneiHs.180408.

    Genome annotation databases

    EnsembliENST00000609923; ENSP00000476815; ENSG00000122912.
    GeneIDi8034.
    KEGGihsa:8034.
    UCSCiuc001joi.3. human.

    Polymorphism databases

    DMDMi215274156.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M31659 mRNA. Translation: AAA36329.1 . Frameshift.
    AK290255 mRNA. Translation: BAF82944.1 .
    AL713888 Genomic DNA. Translation: CAI15116.1 .
    CH471083 Genomic DNA. Translation: EAW54298.1 .
    BC030266 mRNA. Translation: AAH30266.1 .
    CCDSi CCDS7280.1.
    PIRi A40141.
    RefSeqi NP_689920.1. NM_152707.3.
    UniGenei Hs.180408.

    3D structure databases

    ProteinModelPortali P16260.
    SMRi P16260. Positions 36-317.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 113727. 1 interaction.
    STRINGi 9606.ENSP00000265870.

    Protein family/group databases

    TCDBi 2.A.29.12.3. the mitochondrial carrier (mc) family.

    PTM databases

    PhosphoSitei P16260.

    Polymorphism databases

    DMDMi 215274156.

    Proteomic databases

    MaxQBi P16260.
    PaxDbi P16260.
    PRIDEi P16260.

    Protocols and materials databases

    DNASUi 8034.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000609923 ; ENSP00000476815 ; ENSG00000122912 .
    GeneIDi 8034.
    KEGGi hsa:8034.
    UCSCi uc001joi.3. human.

    Organism-specific databases

    CTDi 8034.
    GeneCardsi GC10M070242.
    HGNCi HGNC:10986. SLC25A16.
    HPAi HPA044580.
    MIMi 139080. gene.
    neXtProti NX_P16260.
    PharmGKBi PA35862.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG274055.
    HOGENOMi HOG000165726.
    HOVERGENi HBG104402.
    InParanoidi P16260.
    KOi K15084.
    OMAi HHYKHLE.
    OrthoDBi EOG7HXCR5.
    PhylomeDBi P16260.
    TreeFami TF314806.

    Enzyme and pathway databases

    Reactomei REACT_11218. Coenzyme A biosynthesis.

    Miscellaneous databases

    GenomeRNAii 8034.
    NextBioi 30619.
    PROi P16260.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P16260.
    Bgeei P16260.
    CleanExi HS_GDA.
    HS_SLC25A16.
    Genevestigatori P16260.

    Family and domain databases

    Gene3Di 1.50.40.10. 1 hit.
    InterProi IPR002167. Graves_DC.
    IPR002067. Mit_carrier.
    IPR018108. Mitochondrial_sb/sol_carrier.
    IPR023395. Mt_carrier_dom.
    [Graphical view ]
    Pfami PF00153. Mito_carr. 3 hits.
    [Graphical view ]
    PRINTSi PR00928. GRAVESDC.
    PR00926. MITOCARRIER.
    SUPFAMi SSF103506. SSF103506. 1 hit.
    PROSITEi PS50920. SOLCAR. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence and chromosomal assignment of a novel cDNA identified by immunoscreening of a thyroid expression library: similarity to a family of mitochondrial solute carrier proteins."
      Zarrilli R., Oates E.L., McBride O.W., Lerman M.I., Chan J.Y., Santisteban P., Ursini M.V., Notkins A.L., Kohn L.D.
      Mol. Endocrinol. 3:1498-1505(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Thyroid.
    2. "Sequence and pattern of expression of a bovine homologue of a human mitochondrial transport protein associated with Grave's disease."
      Fiermonte G., Runswick M.J., Walker J.E., Palmieri F.
      DNA Seq. 3:71-78(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: SEQUENCE REVISION TO C-TERMINUS.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Colon.
    4. "The DNA sequence and comparative analysis of human chromosome 10."
      Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
      , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
      Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    7. "The yeast mitochondrial carrier Leu5p and its human homologue Graves' disease protein are required for accumulation of coenzyme A in the matrix."
      Prohl C., Pelzer W., Diekert K., Kmita H., Bedekovics T., Kispal G., Lill R.
      Mol. Cell. Biol. 21:1089-1097(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION.
    8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.

    Entry informationi

    Entry nameiGDC_HUMAN
    AccessioniPrimary (citable) accession number: P16260
    Secondary accession number(s): Q8N2U1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1990
    Last sequence update: November 25, 2008
    Last modified: October 1, 2014
    This is version 139 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 10
      Human chromosome 10: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3