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Protein

Graves disease carrier protein

Gene

SLC25A16

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Required for the accumulation of coenzyme A in the mitochondrial matrix.1 Publication

GO - Molecular functioni

  1. antiporter activity Source: UniProtKB

GO - Biological processi

  1. coenzyme biosynthetic process Source: Reactome
  2. pantothenate metabolic process Source: Reactome
  3. small molecule metabolic process Source: Reactome
  4. transport Source: UniProtKB
  5. vitamin metabolic process Source: Reactome
  6. water-soluble vitamin metabolic process Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

ReactomeiREACT_11218. Coenzyme A biosynthesis.

Protein family/group databases

TCDBi2.A.29.12.3. the mitochondrial carrier (mc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Graves disease carrier protein
Short name:
GDC
Alternative name(s):
Graves disease autoantigen
Short name:
GDA
Mitochondrial solute carrier protein homolog
Solute carrier family 25 member 16
Gene namesi
Name:SLC25A16
Synonyms:GDA
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 10

Organism-specific databases

HGNCiHGNC:10986. SLC25A16.

Subcellular locationi

Mitochondrion inner membrane 1 Publication; Multi-pass membrane protein 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei37 – 5721Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei88 – 10821Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei134 – 15421Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei191 – 21121Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei244 – 26421Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei299 – 31921Helical; Name=6Sequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35862.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 332332Graves disease carrier proteinPRO_0000090616Add
BLAST

Proteomic databases

MaxQBiP16260.
PaxDbiP16260.
PRIDEiP16260.

PTM databases

PhosphoSiteiP16260.

Expressioni

Gene expression databases

BgeeiP16260.
CleanExiHS_GDA.
HS_SLC25A16.
ExpressionAtlasiP16260. baseline and differential.
GenevestigatoriP16260.

Organism-specific databases

HPAiHPA044580.

Interactioni

Protein-protein interaction databases

BioGridi113727. 12 interactions.
STRINGi9606.ENSP00000265870.

Structurei

3D structure databases

ProteinModelPortaliP16260.
SMRiP16260. Positions 36-317.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati34 – 12087Solcar 1Add
BLAST
Repeati128 – 21689Solcar 2Add
BLAST
Repeati238 – 32891Solcar 3Add
BLAST

Sequence similaritiesi

Contains 3 Solcar repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG274055.
GeneTreeiENSGT00760000119245.
HOGENOMiHOG000165726.
HOVERGENiHBG104402.
InParanoidiP16260.
KOiK15084.
OMAiEKCLTMW.
OrthoDBiEOG7HXCR5.
PhylomeDBiP16260.
TreeFamiTF314806.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR002167. Graves_DC.
IPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00928. GRAVESDC.
PR00926. MITOCARRIER.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P16260-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAATAAAAL AAADPPPAMP QAAGAGGPTT RRDFYWLRSF LAGGIAGCCA
60 70 80 90 100
KTTVAPLDRV KVLLQAHNHH YKHLGVFSAL RAVPQKEGFL GLYKGNGAMM
110 120 130 140 150
IRIFPYGAIQ FMAFEHYKTL ITTKLGISGH VHRLMAGSMA GMTAVICTYP
160 170 180 190 200
LDMVRVRLAF QVKGEHSYTG IIHAFKTIYA KEGGFFGFYR GLMPTILGMA
210 220 230 240 250
PYAGVSFFTF GTLKSVGLSH APTLLGRPSS DNPNVLVLKT HVNLLCGGVA
260 270 280 290 300
GAIAQTISYP FDVTRRRMQL GTVLPEFEKC LTMRDTMKYV YGHHGIRKGL
310 320 330
YRGLSLNYIR CIPSQAVAFT TYELMKQFFH LN
Length:332
Mass (Da):36,224
Last modified:November 25, 2008 - v3
Checksum:i71C2C3D413F80246
GO

Sequence cautioni

The sequence AAA36329.1 differs from that shown. Reason: Frameshift at position 320. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti21 – 211Q → G in AAA36329 (PubMed:2575220).Curated
Sequence conflicti44 – 441G → S in AAA36329 (PubMed:2575220).Curated
Sequence conflicti149 – 1513YPL → DPV in AAA36329 (PubMed:2575220).Curated
Sequence conflicti167 – 1671S → R in AAA36329 (PubMed:2575220).Curated
Sequence conflicti227 – 2271R → S in AAA36329 (PubMed:2575220).Curated
Sequence conflicti251 – 2511G → R in AAA36329 (PubMed:2575220).Curated
Sequence conflicti290 – 2901V → D in AAA36329 (PubMed:2575220).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M31659 mRNA. Translation: AAA36329.1. Frameshift.
AK290255 mRNA. Translation: BAF82944.1.
AL713888 Genomic DNA. Translation: CAI15116.1.
CH471083 Genomic DNA. Translation: EAW54298.1.
BC030266 mRNA. Translation: AAH30266.1.
CCDSiCCDS7280.1.
PIRiA40141.
RefSeqiNP_689920.1. NM_152707.3.
UniGeneiHs.180408.

Genome annotation databases

EnsembliENST00000609923; ENSP00000476815; ENSG00000122912.
GeneIDi8034.
KEGGihsa:8034.
UCSCiuc001joi.3. human.

Polymorphism databases

DMDMi215274156.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M31659 mRNA. Translation: AAA36329.1. Frameshift.
AK290255 mRNA. Translation: BAF82944.1.
AL713888 Genomic DNA. Translation: CAI15116.1.
CH471083 Genomic DNA. Translation: EAW54298.1.
BC030266 mRNA. Translation: AAH30266.1.
CCDSiCCDS7280.1.
PIRiA40141.
RefSeqiNP_689920.1. NM_152707.3.
UniGeneiHs.180408.

3D structure databases

ProteinModelPortaliP16260.
SMRiP16260. Positions 36-317.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113727. 12 interactions.
STRINGi9606.ENSP00000265870.

Protein family/group databases

TCDBi2.A.29.12.3. the mitochondrial carrier (mc) family.

PTM databases

PhosphoSiteiP16260.

Polymorphism databases

DMDMi215274156.

Proteomic databases

MaxQBiP16260.
PaxDbiP16260.
PRIDEiP16260.

Protocols and materials databases

DNASUi8034.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000609923; ENSP00000476815; ENSG00000122912.
GeneIDi8034.
KEGGihsa:8034.
UCSCiuc001joi.3. human.

Organism-specific databases

CTDi8034.
GeneCardsiGC10M070242.
HGNCiHGNC:10986. SLC25A16.
HPAiHPA044580.
MIMi139080. gene.
neXtProtiNX_P16260.
PharmGKBiPA35862.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG274055.
GeneTreeiENSGT00760000119245.
HOGENOMiHOG000165726.
HOVERGENiHBG104402.
InParanoidiP16260.
KOiK15084.
OMAiEKCLTMW.
OrthoDBiEOG7HXCR5.
PhylomeDBiP16260.
TreeFamiTF314806.

Enzyme and pathway databases

ReactomeiREACT_11218. Coenzyme A biosynthesis.

Miscellaneous databases

GenomeRNAii8034.
NextBioi30619.
PROiP16260.
SOURCEiSearch...

Gene expression databases

BgeeiP16260.
CleanExiHS_GDA.
HS_SLC25A16.
ExpressionAtlasiP16260. baseline and differential.
GenevestigatoriP16260.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR002167. Graves_DC.
IPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00928. GRAVESDC.
PR00926. MITOCARRIER.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence and chromosomal assignment of a novel cDNA identified by immunoscreening of a thyroid expression library: similarity to a family of mitochondrial solute carrier proteins."
    Zarrilli R., Oates E.L., McBride O.W., Lerman M.I., Chan J.Y., Santisteban P., Ursini M.V., Notkins A.L., Kohn L.D.
    Mol. Endocrinol. 3:1498-1505(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Thyroid.
  2. "Sequence and pattern of expression of a bovine homologue of a human mitochondrial transport protein associated with Grave's disease."
    Fiermonte G., Runswick M.J., Walker J.E., Palmieri F.
    DNA Seq. 3:71-78(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: SEQUENCE REVISION TO C-TERMINUS.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Colon.
  4. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  7. "The yeast mitochondrial carrier Leu5p and its human homologue Graves' disease protein are required for accumulation of coenzyme A in the matrix."
    Prohl C., Pelzer W., Diekert K., Kmita H., Bedekovics T., Kispal G., Lill R.
    Mol. Cell. Biol. 21:1089-1097(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.

Entry informationi

Entry nameiGDC_HUMAN
AccessioniPrimary (citable) accession number: P16260
Secondary accession number(s): Q8N2U1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: November 25, 2008
Last modified: January 7, 2015
This is version 141 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.