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Protein

Sodium/pantothenate symporter

Gene

panF

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the sodium-dependent uptake of extracellular pantothenate.

GO - Molecular functioni

  • pantothenate transmembrane transporter activity Source: EcoCyc
  • sodium ion binding Source: InterPro
  • sodium ion transmembrane transporter activity Source: InterPro
  • symporter activity Source: EcoCyc

GO - Biological processi

  • pantothenate transmembrane transport Source: EcoCyc
  • sodium ion export Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Ion transport, Sodium transport, Symport, Transport

Keywords - Ligandi

Sodium

Enzyme and pathway databases

BioCyciEcoCyc:PANF-MONOMER.
ECOL316407:JW3226-MONOMER.
MetaCyc:PANF-MONOMER.

Protein family/group databases

TCDBi2.A.21.1.1. the solute:sodium symporter (sss) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/pantothenate symporter
Alternative name(s):
Pantothenate permease
Gene namesi
Name:panF
Ordered Locus Names:b3258, JW3226
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10685. panF.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 2CytoplasmicSequence analysis2
Transmembranei3 – 23HelicalSequence analysisAdd BLAST21
Topological domaini24 – 42PeriplasmicSequence analysisAdd BLAST19
Transmembranei43 – 63HelicalSequence analysisAdd BLAST21
Topological domaini64 – 73CytoplasmicSequence analysis10
Transmembranei74 – 94HelicalSequence analysisAdd BLAST21
Topological domaini95 – 123PeriplasmicSequence analysisAdd BLAST29
Transmembranei124 – 144HelicalSequence analysisAdd BLAST21
Topological domaini145 – 161CytoplasmicSequence analysisAdd BLAST17
Transmembranei162 – 182HelicalSequence analysisAdd BLAST21
Topological domaini183 – 232PeriplasmicSequence analysisAdd BLAST50
Transmembranei233 – 253HelicalSequence analysisAdd BLAST21
Topological domaini254 – 272CytoplasmicSequence analysisAdd BLAST19
Transmembranei273 – 293HelicalSequence analysisAdd BLAST21
Topological domaini294 – 305PeriplasmicSequence analysisAdd BLAST12
Transmembranei306 – 326HelicalSequence analysisAdd BLAST21
Topological domaini327 – 368CytoplasmicSequence analysisAdd BLAST42
Transmembranei369 – 389HelicalSequence analysisAdd BLAST21
Topological domaini390 – 391PeriplasmicSequence analysis2
Transmembranei392 – 412HelicalSequence analysisAdd BLAST21
Topological domaini413 – 423CytoplasmicSequence analysisAdd BLAST11
Transmembranei424 – 444HelicalSequence analysisAdd BLAST21
Topological domaini445PeriplasmicSequence analysis1
Transmembranei446 – 466HelicalSequence analysisAdd BLAST21
Topological domaini467 – 483CytoplasmicSequence analysisAdd BLAST17

GO - Cellular componenti

  • integral component of plasma membrane Source: GO_Central
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001054021 – 483Sodium/pantothenate symporterAdd BLAST483

Proteomic databases

PaxDbiP16256.
PRIDEiP16256.

Interactioni

Protein-protein interaction databases

BioGridi4262451. 166 interactors.
DIPiDIP-10439N.
STRINGi511145.b3258.

Structurei

3D structure databases

ProteinModelPortaliP16256.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4108IA2. Bacteria.
COG4145. LUCA.
HOGENOMiHOG000281958.
InParanoidiP16256.
KOiK14392.
OMAiMMATYGS.
PhylomeDBiP16256.

Family and domain databases

CDDicd10327. SLC5sbd_PanF. 1 hit.
InterProiIPR011849. Na/pantothenate_symporter.
IPR001734. Na/solute_symporter.
IPR018212. Na/solute_symporter_CS.
[Graphical view]
PANTHERiPTHR11819. PTHR11819. 1 hit.
PfamiPF00474. SSF. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02119. panF. 1 hit.
TIGR00813. sss. 1 hit.
PROSITEiPS00456. NA_SOLUT_SYMP_1. 1 hit.
PS00457. NA_SOLUT_SYMP_2. 1 hit.
PS50283. NA_SOLUT_SYMP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P16256-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQLEVILPLV AYLVVVFGIS VYAMRKRSTG TFLNEYFLGS RSMGGIVLAM
60 70 80 90 100
TLTATYISAS SFIGGPGAAY KYGLGWVLLA MIQLPAVWLS LGILGKKFAI
110 120 130 140 150
LARRYNAVTL NDMLFARYQS RLLVWLASLS LLVAFVGAMT VQFIGGARLL
160 170 180 190 200
ETAAGIPYET GLLIFGISIA LYTAFGGFRA SVLNDTMQGL VMLIGTVVLL
210 220 230 240 250
IGVVHAAGGL SNAVQTLQTI DPQLVTPQGA DDILSPAFMT SFWVLVCFGV
260 270 280 290 300
IGLPHTAVRC ISYKDSKAVH RGIIIGTIVV AILMFGMHLA GALGRAVIPD
310 320 330 340 350
LTVPDLVIPT LMVKVLPPFA AGIFLAAPMA AIMSTINAQL LQSSATIIKD
360 370 380 390 400
LYLNIRPDQM QNETRLKRMS AVITLVLGAL LLLAAWKPPE MIIWLNLLAF
410 420 430 440 450
GGLEAVFLWP LVLGLYWERA NAKGALSAMI VGGVLYAVLA TLNIQYLGFH
460 470 480
PIVPSLLLSL LAFLVGNRFG TSVPQATVLT TDK
Length:483
Mass (Da):51,717
Last modified:November 1, 1995 - v2
Checksum:i5F607C043ECAB1F8
GO

Sequence cautioni

The sequence AAA23747 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence AAA58061 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti179 – 206RASVL…GVVHA → APAAERHHARACDADWHRCA AYWRSTC in AAA24276 (PubMed:2193919).CuratedAdd BLAST28
Sequence conflicti254P → A in AAA24276 (PubMed:2193919).Curated1
Sequence conflicti302T → H in AAA24276 (PubMed:2193919).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M30953 Genomic DNA. Translation: AAA24276.1.
U18997 Genomic DNA. Translation: AAA58061.1. Different initiation.
U00096 Genomic DNA. Translation: AAC76290.2.
AP009048 Genomic DNA. Translation: BAE77299.1.
M83198 Genomic DNA. Translation: AAA23747.1. Different initiation.
S67010 Genomic DNA. Translation: AAB28768.1.
RefSeqiNP_417724.4. NC_000913.3.
WP_001175728.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC76290; AAC76290; b3258.
BAE77299; BAE77299; BAE77299.
GeneIDi947752.
KEGGiecj:JW3226.
eco:b3258.
PATRICi32121946. VBIEscCol129921_3357.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M30953 Genomic DNA. Translation: AAA24276.1.
U18997 Genomic DNA. Translation: AAA58061.1. Different initiation.
U00096 Genomic DNA. Translation: AAC76290.2.
AP009048 Genomic DNA. Translation: BAE77299.1.
M83198 Genomic DNA. Translation: AAA23747.1. Different initiation.
S67010 Genomic DNA. Translation: AAB28768.1.
RefSeqiNP_417724.4. NC_000913.3.
WP_001175728.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP16256.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4262451. 166 interactors.
DIPiDIP-10439N.
STRINGi511145.b3258.

Protein family/group databases

TCDBi2.A.21.1.1. the solute:sodium symporter (sss) family.

Proteomic databases

PaxDbiP16256.
PRIDEiP16256.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC76290; AAC76290; b3258.
BAE77299; BAE77299; BAE77299.
GeneIDi947752.
KEGGiecj:JW3226.
eco:b3258.
PATRICi32121946. VBIEscCol129921_3357.

Organism-specific databases

EchoBASEiEB0679.
EcoGeneiEG10685. panF.

Phylogenomic databases

eggNOGiENOG4108IA2. Bacteria.
COG4145. LUCA.
HOGENOMiHOG000281958.
InParanoidiP16256.
KOiK14392.
OMAiMMATYGS.
PhylomeDBiP16256.

Enzyme and pathway databases

BioCyciEcoCyc:PANF-MONOMER.
ECOL316407:JW3226-MONOMER.
MetaCyc:PANF-MONOMER.

Miscellaneous databases

PROiP16256.

Family and domain databases

CDDicd10327. SLC5sbd_PanF. 1 hit.
InterProiIPR011849. Na/pantothenate_symporter.
IPR001734. Na/solute_symporter.
IPR018212. Na/solute_symporter_CS.
[Graphical view]
PANTHERiPTHR11819. PTHR11819. 1 hit.
PfamiPF00474. SSF. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02119. panF. 1 hit.
TIGR00813. sss. 1 hit.
PROSITEiPS00456. NA_SOLUT_SYMP_1. 1 hit.
PS00457. NA_SOLUT_SYMP_2. 1 hit.
PS50283. NA_SOLUT_SYMP_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPANF_ECOLI
AccessioniPrimary (citable) accession number: P16256
Secondary accession number(s): P76679, Q2M8V7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: November 1, 1995
Last modified: November 2, 2016
This is version 140 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.