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Protein

Histidinol-phosphate aminotransferase

Gene

hisC

Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

L-histidinol phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate.

Cofactori

Pathwayi: L-histidine biosynthesis

This protein is involved in step 7 of the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate.
Proteins known to be involved in the 9 steps of the subpathway in this organism are:
  1. ATP phosphoribosyltransferase (hisG)
  2. Phosphoribosyl-ATP pyrophosphatase (hisE)
  3. Phosphoribosyl-AMP cyclohydrolase (hisI)
  4. Phosphoribosyl isomerase A (priA)
  5. Imidazole glycerol phosphate synthase subunit HisF (hisF), Imidazole glycerol phosphate synthase subunit HisH (hisH)
  6. Imidazoleglycerol-phosphate dehydratase (hisB)
  7. Histidinol-phosphate aminotransferase (hisC)
  8. Histidinol-phosphatase (hisN)
  9. Histidinol dehydrogenase (hisD)
This subpathway is part of the pathway L-histidine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate, the pathway L-histidine biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminotransferase, Transferase
Biological processAmino-acid biosynthesis, Histidine biosynthesis
LigandPyridoxal phosphate

Enzyme and pathway databases

UniPathwayiUPA00031; UER00012.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol-phosphate aminotransferase (EC:2.6.1.9)
Alternative name(s):
Imidazole acetol-phosphate transaminase
Gene namesi
Name:hisC
Ordered Locus Names:SCO2053
ORF Names:SC4G6.22c
OrganismiStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Taxonomic identifieri100226 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomycesStreptomyces albidoflavus group
Proteomesi
  • UP000001973 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001534631 – 369Histidinol-phosphate aminotransferaseAdd BLAST369

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei230N6-(pyridoxal phosphate)lysineBy similarity1

Proteomic databases

PRIDEiP16246.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi100226.SCO2053.

Structurei

3D structure databases

ProteinModelPortaliP16246.
SMRiP16246.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105CIH. Bacteria.
COG0079. LUCA.
HOGENOMiHOG000288510.
InParanoidiP16246.
KOiK00817.
OMAiTYGMYKV.
OrthoDBiPOG091H05S1.
PhylomeDBiP16246.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPiMF_01023. HisC_aminotrans_2. 1 hit.
InterProiView protein in InterPro
IPR001917. Aminotrans_II_pyridoxalP_BS.
IPR004839. Aminotransferase_I/II.
IPR005861. HisP_aminotrans.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_sub2.
PfamiView protein in Pfam
PF00155. Aminotran_1_2. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01141. hisC. 1 hit.
PROSITEiView protein in PROSITE
PS00599. AA_TRANSFER_CLASS_2. 1 hit.

Sequencei

Sequence statusi: Complete.

P16246-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTFGIDDLPV RDELRGKSPY GAPQLDVPVR LNTNENPYPL PEALVERIAE
60 70 80 90 100
RVREAARDLN RYPDRDAVEL RTQLARYLTD TSGHPLDVSN VWAANGSNEV
110 120 130 140 150
IQQLLQTFGG PGRTAIGFEP SYSMHGLIAR GTGTGWISGP RHEDFTIDVP
160 170 180 190 200
AATRAIDEHR PDVVFITTPN NPTGTAVPAE TVLALYEAAQ AAKPSMVVVD
210 220 230 240 250
EAYIEFSHGA SLLPLLDGRP NLVVSRTMSK AFGAAGLRLG YLAAHPAVVD
260 270 280 290 300
AVQLVRLPYH LSAVTQATAL AALEHTDTLL KYVEQLKTER DRLVAELRAI
310 320 330 340 350
GYAVTESDAN FVQFGRFADS HATWRKILDR GVLVRDNGVP GWLRVTAGTP
360
EENDAFLDAV REVKKEQHT
Length:369
Mass (Da):40,388
Last modified:August 1, 1990 - v1
Checksum:iAA572A9BB0C93E08
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M31628 Genomic DNA. Translation: AAA26756.1.
AL939111 Genomic DNA. Translation: CAB51445.1.
PIRiJQ0637.
RefSeqiNP_626313.1. NC_003888.3.
WP_003976762.1. NC_003888.3.

Genome annotation databases

EnsemblBacteriaiCAB51445; CAB51445; CAB51445.
GeneIDi1097487.
29661923.
KEGGisco:SCO2053.
PATRICifig|100226.15.peg.2085.

Similar proteinsi

Entry informationi

Entry nameiHIS8_STRCO
AccessioniPrimary (citable) accession number: P16246
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: June 7, 2017
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families