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Protein

Histidinol dehydrogenase

Gene

hisD

Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.By similarity

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei240 – 2401SubstrateBy similarity
Metal bindingi262 – 2621ZincBy similarity
Binding sitei262 – 2621SubstrateBy similarity
Metal bindingi265 – 2651ZincBy similarity
Binding sitei265 – 2651SubstrateBy similarity
Active sitei332 – 3321Proton acceptorBy similarity
Active sitei333 – 3331Proton acceptorBy similarity
Binding sitei333 – 3331SubstrateBy similarity
Metal bindingi366 – 3661ZincBy similarity
Binding sitei366 – 3661SubstrateBy similarity
Binding sitei420 – 4201SubstrateBy similarity
Metal bindingi425 – 4251ZincBy similarity
Binding sitei425 – 4251SubstrateBy similarity

GO - Molecular functioni

  1. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
  2. NAD binding Source: InterPro
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenase (EC:1.1.1.23)
Short name:
HDH
Gene namesi
Name:hisD
Ordered Locus Names:SCO2054
ORF Names:SC4G6.23c
OrganismiStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Taxonomic identifieri100226 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomycesStreptomyces albidoflavus group
ProteomesiUP000001973 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 441441Histidinol dehydrogenasePRO_0000135860Add
BLAST

Proteomic databases

PRIDEiP16245.

Interactioni

Protein-protein interaction databases

STRINGi100226.SCO2054.

Structurei

3D structure databases

ProteinModelPortaliP16245.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histidinol dehydrogenase family.Curated

Phylogenomic databases

eggNOGiCOG0141.
HOGENOMiHOG000243914.
InParanoidiP16245.
KOiK00013.
OMAiLSVQSFL.
OrthoDBiEOG6CVVCR.
PhylomeDBiP16245.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P16245-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MISRIDLRGD ALPEGPALRD LLPRADFDVS VALEKVRPIC EAVHHRGDAA
60 70 80 90 100
LIDFTEQFDG VRLERVRVPA EELTRALEGL DPEVRAALEE SIRRARLVHR
110 120 130 140 150
EQRRATHTTQ VVPGGSVTEK WVPVERVGLY VPGGRSVYPS SVVMNVVPAQ
160 170 180 190 200
EAGVGSIALA SPAQAEFGGI PHPTILAACA LLGVDEVYAA GGATAVAMFA
210 220 230 240 250
YGTESCPPAN MVTGPGNIWV AAAKRFFTGK IGIDAEAGPT EIAVLADSTA
260 270 280 290 300
DPVHVASDLI SQAEHDPLAA AVLVTDSAEL ADAVEKELQP QVEATKHIED
310 320 330 340 350
RIRPALAGRQ SAIVLVDGLD EGLRVVDAYG AEHLEIQTAD AAAVADRVKN
360 370 380 390 400
AGAIFVGPWA PVSLGDYAAG SNHVLPTGGC ACHSSGLSVQ SFLRGIHIVD
410 420 430 440
YTRDALAEVA RHVVTLAEAE DLPAHGAAIK ARFEWKVPES K
Length:441
Mass (Da):46,493
Last modified:November 30, 2000 - v3
Checksum:i3B0B26BA17F91743
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti262 – 2621Q → L in CAA45767 (PubMed:1488552).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL939111 Genomic DNA. Translation: CAB51446.1.
X64420 Genomic DNA. Translation: CAA45767.1.
M31628 Genomic DNA. Translation: AAA26755.1.
PIRiT35083.
RefSeqiNP_626314.1. NC_003888.3.

Genome annotation databases

GeneIDi1097488.
KEGGisco:SCO2054.
PATRICi23733754. VBIStrCoe124346_2086.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL939111 Genomic DNA. Translation: CAB51446.1.
X64420 Genomic DNA. Translation: CAA45767.1.
M31628 Genomic DNA. Translation: AAA26755.1.
PIRiT35083.
RefSeqiNP_626314.1. NC_003888.3.

3D structure databases

ProteinModelPortaliP16245.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi100226.SCO2054.

Proteomic databases

PRIDEiP16245.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi1097488.
KEGGisco:SCO2054.
PATRICi23733754. VBIStrCoe124346_2086.

Phylogenomic databases

eggNOGiCOG0141.
HOGENOMiHOG000243914.
InParanoidiP16245.
KOiK00013.
OMAiLSVQSFL.
OrthoDBiEOG6CVVCR.
PhylomeDBiP16245.

Enzyme and pathway databases

UniPathwayiUPA00031; UER00014.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-471 / A3(2) / M145.
  2. "Further characterization of the histidine gene cluster of Streptomyces coelicolor A3(2): nucleotide sequence and transcriptional analysis of hisD."
    Limauro D., Avitabile A., Puglia A.M., Bruni C.B.
    Res. Microbiol. 143:683-693(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-288.
    Strain: A3(2) / NRRL B-16638.
  3. "Cloning and characterization of the histidine biosynthetic gene cluster of Streptomyces coelicolor A3(2)."
    Limauro D., Avitabile A., Cappellano M., Puglia A.M., Bruni C.B.
    Gene 90:31-41(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 287-441.
    Strain: A3(2) / NRRL B-16638.

Entry informationi

Entry nameiHISX_STRCO
AccessioniPrimary (citable) accession number: P16245
Secondary accession number(s): Q59834, Q9S2T5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 31, 1990
Last sequence update: November 30, 2000
Last modified: March 31, 2015
This is version 119 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.