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P16245

- HISX_STRCO

UniProt

P16245 - HISX_STRCO

Protein

Histidinol dehydrogenase

Gene

hisD

Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 113 (01 Oct 2014)
      Sequence version 3 (01 Dec 2000)
      Previous versions | rss
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    Functioni

    Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.By similarity

    Catalytic activityi

    L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.

    Cofactori

    Binds 1 zinc ion per subunit.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei240 – 2401SubstrateBy similarity
    Metal bindingi262 – 2621ZincBy similarity
    Binding sitei262 – 2621SubstrateBy similarity
    Metal bindingi265 – 2651ZincBy similarity
    Binding sitei265 – 2651SubstrateBy similarity
    Active sitei332 – 3321Proton acceptorBy similarity
    Active sitei333 – 3331Proton acceptorBy similarity
    Binding sitei333 – 3331SubstrateBy similarity
    Metal bindingi366 – 3661ZincBy similarity
    Binding sitei366 – 3661SubstrateBy similarity
    Binding sitei420 – 4201SubstrateBy similarity
    Metal bindingi425 – 4251ZincBy similarity
    Binding sitei425 – 4251SubstrateBy similarity

    GO - Molecular functioni

    1. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
    2. NAD binding Source: InterPro
    3. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. histidine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Amino-acid biosynthesis, Histidine biosynthesis

    Keywords - Ligandi

    Metal-binding, NAD, Zinc

    Enzyme and pathway databases

    UniPathwayiUPA00031; UER00014.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histidinol dehydrogenase (EC:1.1.1.23)
    Short name:
    HDH
    Gene namesi
    Name:hisD
    Ordered Locus Names:SCO2054
    ORF Names:SC4G6.23c
    OrganismiStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
    Taxonomic identifieri100226 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomycesStreptomyces albidoflavus group
    ProteomesiUP000001973: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 441441Histidinol dehydrogenasePRO_0000135860Add
    BLAST

    Proteomic databases

    PRIDEiP16245.

    Interactioni

    Protein-protein interaction databases

    STRINGi100226.SCO2054.

    Structurei

    3D structure databases

    ProteinModelPortaliP16245.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the histidinol dehydrogenase family.Curated

    Phylogenomic databases

    eggNOGiCOG0141.
    HOGENOMiHOG000243914.
    KOiK00013.
    OMAiYAAKLCG.
    OrthoDBiEOG6CVVCR.
    PhylomeDBiP16245.

    Family and domain databases

    HAMAPiMF_01024. HisD.
    InterProiIPR016161. Ald_DH/histidinol_DH.
    IPR001692. Histidinol_DH_CS.
    IPR022695. Histidinol_DH_monofunct.
    IPR012131. Hstdl_DH.
    [Graphical view]
    PfamiPF00815. Histidinol_dh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
    PRINTSiPR00083. HOLDHDRGNASE.
    SUPFAMiSSF53720. SSF53720. 1 hit.
    TIGRFAMsiTIGR00069. hisD. 1 hit.
    PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P16245-1 [UniParc]FASTAAdd to Basket

    « Hide

    MISRIDLRGD ALPEGPALRD LLPRADFDVS VALEKVRPIC EAVHHRGDAA    50
    LIDFTEQFDG VRLERVRVPA EELTRALEGL DPEVRAALEE SIRRARLVHR 100
    EQRRATHTTQ VVPGGSVTEK WVPVERVGLY VPGGRSVYPS SVVMNVVPAQ 150
    EAGVGSIALA SPAQAEFGGI PHPTILAACA LLGVDEVYAA GGATAVAMFA 200
    YGTESCPPAN MVTGPGNIWV AAAKRFFTGK IGIDAEAGPT EIAVLADSTA 250
    DPVHVASDLI SQAEHDPLAA AVLVTDSAEL ADAVEKELQP QVEATKHIED 300
    RIRPALAGRQ SAIVLVDGLD EGLRVVDAYG AEHLEIQTAD AAAVADRVKN 350
    AGAIFVGPWA PVSLGDYAAG SNHVLPTGGC ACHSSGLSVQ SFLRGIHIVD 400
    YTRDALAEVA RHVVTLAEAE DLPAHGAAIK ARFEWKVPES K 441
    Length:441
    Mass (Da):46,493
    Last modified:December 1, 2000 - v3
    Checksum:i3B0B26BA17F91743
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti262 – 2621Q → L in CAA45767. (PubMed:1488552)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL939111 Genomic DNA. Translation: CAB51446.1.
    X64420 Genomic DNA. Translation: CAA45767.1.
    M31628 Genomic DNA. Translation: AAA26755.1.
    PIRiT35083.
    RefSeqiNP_626314.1. NC_003888.3.

    Genome annotation databases

    EnsemblBacteriaiCAB51446; CAB51446; CAB51446.
    GeneIDi1097488.
    KEGGisco:SCO2054.
    PATRICi23733754. VBIStrCoe124346_2086.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL939111 Genomic DNA. Translation: CAB51446.1 .
    X64420 Genomic DNA. Translation: CAA45767.1 .
    M31628 Genomic DNA. Translation: AAA26755.1 .
    PIRi T35083.
    RefSeqi NP_626314.1. NC_003888.3.

    3D structure databases

    ProteinModelPortali P16245.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 100226.SCO2054.

    Proteomic databases

    PRIDEi P16245.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAB51446 ; CAB51446 ; CAB51446 .
    GeneIDi 1097488.
    KEGGi sco:SCO2054.
    PATRICi 23733754. VBIStrCoe124346_2086.

    Phylogenomic databases

    eggNOGi COG0141.
    HOGENOMi HOG000243914.
    KOi K00013.
    OMAi YAAKLCG.
    OrthoDBi EOG6CVVCR.
    PhylomeDBi P16245.

    Enzyme and pathway databases

    UniPathwayi UPA00031 ; UER00014 .

    Family and domain databases

    HAMAPi MF_01024. HisD.
    InterProi IPR016161. Ald_DH/histidinol_DH.
    IPR001692. Histidinol_DH_CS.
    IPR022695. Histidinol_DH_monofunct.
    IPR012131. Hstdl_DH.
    [Graphical view ]
    Pfami PF00815. Histidinol_dh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
    PRINTSi PR00083. HOLDHDRGNASE.
    SUPFAMi SSF53720. SSF53720. 1 hit.
    TIGRFAMsi TIGR00069. hisD. 1 hit.
    PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-471 / A3(2) / M145.
    2. "Further characterization of the histidine gene cluster of Streptomyces coelicolor A3(2): nucleotide sequence and transcriptional analysis of hisD."
      Limauro D., Avitabile A., Puglia A.M., Bruni C.B.
      Res. Microbiol. 143:683-693(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-288.
      Strain: A3(2) / NRRL B-16638.
    3. "Cloning and characterization of the histidine biosynthetic gene cluster of Streptomyces coelicolor A3(2)."
      Limauro D., Avitabile A., Cappellano M., Puglia A.M., Bruni C.B.
      Gene 90:31-41(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 287-441.
      Strain: A3(2) / NRRL B-16638.

    Entry informationi

    Entry nameiHISX_STRCO
    AccessioniPrimary (citable) accession number: P16245
    Secondary accession number(s): Q59834, Q9S2T5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1990
    Last sequence update: December 1, 2000
    Last modified: October 1, 2014
    This is version 113 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3