ID CF1A_DROME Reviewed; 427 AA. AC P16241; Q24460; Q86P26; Q9VRY9; DT 01-APR-1990, integrated into UniProtKB/Swiss-Prot. DT 10-JAN-2003, sequence version 5. DT 27-MAR-2024, entry version 210. DE RecName: Full=POU domain protein CF1A; DE AltName: Full=Chorion factor 1A; DE Short=CF1-A; DE AltName: Full=Protein drifter; DE AltName: Full=Ventral veins lacking protein; GN Name=vvl; Synonyms=Cf1a; ORFNames=CG10037; OS Drosophila melanogaster (Fruit fly). OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; OC Drosophilidae; Drosophila; Sophophora. OX NCBI_TaxID=7227; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY. RX PubMed=1673230; DOI=10.1038/350577a0; RA Treacy M.N., He X., Rosenfeld M.G.; RT "I-POU: a POU-domain protein that inhibits neuron-specific gene RT activation."; RL Nature 350:577-584(1991). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, AND DEVELOPMENTAL RP STAGE. RC STRAIN=Oregon-R; TISSUE=Embryo; RX PubMed=1680380; DOI=10.1016/0925-4773(91)90045-8; RA Billin A.N., Cockerill K.A., Poole S.J.; RT "Isolation of a family of Drosophila POU domain genes expressed in early RT development."; RL Mech. Dev. 34:75-84(1991). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley; RX PubMed=10731132; DOI=10.1126/science.287.5461.2185; RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C., RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., RA Venter J.C.; RT "The genome sequence of Drosophila melanogaster."; RL Science 287:2185-2195(2000). RN [4] RP GENOME REANNOTATION. RC STRAIN=Berkeley; RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083; RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A., RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.; RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic RT review."; RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002). RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC STRAIN=Berkeley; TISSUE=Embryo; RA Stapleton M., Brokstein P., Hong L., Agbayani A., Carlson J.W., Champe M., RA Chavez C., Dorsett V., Dresnek D., Farfan D., Frise E., George R.A., RA Gonzalez M., Guarin H., Kronmiller B., Li P.W., Liao G., Miranda A., RA Mungall C.J., Nunoo J., Pacleb J.M., Paragas V., Park S., Patel S., RA Phouanenavong S., Wan K.H., Yu C., Lewis S.E., Rubin G.M., Celniker S.E.; RL Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases. RN [6] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 83-427, FUNCTION, AND TISSUE RP SPECIFICITY. RX PubMed=1967821; DOI=10.1038/343467a0; RA Johnson W.A., Hirsh J.; RT "Binding of a Drosophila POU-domain protein to a sequence element RT regulating gene expression in specific dopaminergic neurons."; RL Nature 343:467-470(1990). RN [7] RP SHOWS THAT CF1A DOES NOT ASSOCIATE WITH ACJ6. RX PubMed=8986770; DOI=10.1073/pnas.93.26.15097; RA Turner E.E.; RT "Similar DNA recognition properties of alternatively spliced Drosophila POU RT factors."; RL Proc. Natl. Acad. Sci. U.S.A. 93:15097-15101(1996). CC -!- FUNCTION: Binds to a DNA sequence element required for the expression CC of the dopa decarboxylase gene (Ddc) in specific dopaminergic neurons. CC Could also play an early role in specific ectodermal cells, and a CC subsequent role in the embryonic nervous system. CC {ECO:0000269|PubMed:1680380, ECO:0000269|PubMed:1967821}. CC -!- SUBCELLULAR LOCATION: Nucleus. CC -!- TISSUE SPECIFICITY: Coexpressed with acj6 in overlapping subsets of CC neurons in the embryonic epidermis and central nervous system. First CC detected in the precursor of the tracheal pits and the stomodeal CC invagination and later in the peripheral nervous system. CC {ECO:0000269|PubMed:1673230, ECO:0000269|PubMed:1680380, CC ECO:0000269|PubMed:1967821}. CC -!- DEVELOPMENTAL STAGE: Expressed at maximal levels in early embryos (6-12 CC hours). Expressed at lower levels during development. CC {ECO:0000269|PubMed:1680380}. CC -!- SIMILARITY: Belongs to the POU transcription factor family. Class-3 CC subfamily. {ECO:0000305}. CC -!- CAUTION: Was originally thought to interact with acj6. CC {ECO:0000305|PubMed:1673230}. CC -!- SEQUENCE CAUTION: CC Sequence=CAA41341.1; Type=Frameshift; Evidence={ECO:0000305}; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; X58435; CAA41341.1; ALT_FRAME; mRNA. DR EMBL; M81959; AAA28831.1; -; mRNA. DR EMBL; AE014296; AAF50641.3; -; Genomic_DNA. DR EMBL; BT003517; AAO39521.1; -; mRNA. DR EMBL; X52252; CAA36496.1; -; Genomic_DNA. DR PIR; S19095; S19095. DR RefSeq; NP_001286957.1; NM_001300028.1. DR RefSeq; NP_523948.1; NM_079224.5. DR AlphaFoldDB; P16241; -. DR SMR; P16241; -. DR BioGRID; 64202; 19. DR DIP; DIP-17200N; -. DR IntAct; P16241; 7. DR STRING; 7227.FBpp0312431; -. DR PaxDb; 7227-FBpp0076653; -. DR DNASU; 38752; -. DR EnsemblMetazoa; FBtr0076944; FBpp0076653; FBgn0086680. DR EnsemblMetazoa; FBtr0345911; FBpp0311831; FBgn0086680. DR GeneID; 38752; -. DR KEGG; dme:Dmel_CG10037; -. DR AGR; FB:FBgn0086680; -. DR CTD; 38752; -. DR FlyBase; FBgn0086680; vvl. DR VEuPathDB; VectorBase:FBgn0086680; -. DR eggNOG; KOG3802; Eukaryota. DR GeneTree; ENSGT00940000171806; -. DR HOGENOM; CLU_404003_0_0_1; -. DR InParanoid; P16241; -. DR OMA; VASRFEW; -. DR SignaLink; P16241; -. DR BioGRID-ORCS; 38752; 0 hits in 3 CRISPR screens. DR ChiTaRS; vvl; fly. DR GenomeRNAi; 38752; -. DR PRO; PR:P16241; -. DR Proteomes; UP000000803; Chromosome 3L. DR Bgee; FBgn0086680; Expressed in wing disc and 37 other cell types or tissues. DR ExpressionAtlas; P16241; baseline and differential. DR GO; GO:0005634; C:nucleus; IDA:FlyBase. DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IDA:FlyBase. DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central. DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IDA:FlyBase. DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IDA:FlyBase. DR GO; GO:0007420; P:brain development; IMP:FlyBase. DR GO; GO:0035284; P:brain segmentation; IMP:FlyBase. DR GO; GO:0048813; P:dendrite morphogenesis; TAS:FlyBase. DR GO; GO:0008045; P:motor neuron axon guidance; IMP:FlyBase. DR GO; GO:0007422; P:peripheral nervous system development; IMP:FlyBase. DR GO; GO:0002807; P:positive regulation of antimicrobial peptide biosynthetic process; IDA:FlyBase. DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:FlyBase. DR GO; GO:0048814; P:regulation of dendrite morphogenesis; IMP:FlyBase. DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central. DR CDD; cd00086; homeodomain; 1. DR Gene3D; 1.10.10.60; Homeodomain-like; 1. DR Gene3D; 1.10.260.40; lambda repressor-like DNA-binding domains; 1. DR InterPro; IPR009057; Homeobox-like_sf. DR InterPro; IPR017970; Homeobox_CS. DR InterPro; IPR001356; Homeobox_dom. DR InterPro; IPR010982; Lambda_DNA-bd_dom_sf. DR InterPro; IPR013847; POU. DR InterPro; IPR000327; POU_dom. DR InterPro; IPR016362; TF_POU_3. DR PANTHER; PTHR11636; POU DOMAIN; 1. DR PANTHER; PTHR11636:SF89; POU DOMAIN PROTEIN 2, ISOFORM B-RELATED; 1. DR Pfam; PF00046; Homeodomain; 1. DR Pfam; PF00157; Pou; 1. DR PIRSF; PIRSF002629; Transcription_factor_POU; 1. DR PRINTS; PR00028; POUDOMAIN. DR SMART; SM00389; HOX; 1. DR SMART; SM00352; POU; 1. DR SUPFAM; SSF46689; Homeodomain-like; 1. DR SUPFAM; SSF47413; lambda repressor-like DNA-binding domains; 1. DR PROSITE; PS00027; HOMEOBOX_1; 1. DR PROSITE; PS50071; HOMEOBOX_2; 1. DR PROSITE; PS00035; POU_1; 1. DR PROSITE; PS00465; POU_2; 1. DR PROSITE; PS51179; POU_3; 1. DR Genevisible; P16241; DM. PE 2: Evidence at transcript level; KW Activator; DNA-binding; Homeobox; Nucleus; Reference proteome; KW Transcription; Transcription regulation. FT CHAIN 1..427 FT /note="POU domain protein CF1A" FT /id="PRO_0000100774" FT DOMAIN 212..286 FT /note="POU-specific" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00530" FT DNA_BIND 304..363 FT /note="Homeobox" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108" FT REGION 39..77 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 196..217 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 288..309 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 390..427 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 58..72 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 196..211 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 398..420 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT CONFLICT 83..102 FT /note="SWSALHPDPWMQTHHTHHLP -> LMECPPSGSVDANPSYAPSA (in FT Ref. 6; CAA36496)" FT /evidence="ECO:0000305" FT CONFLICT 130..140 FT /note="GMASPHAAWHA -> ACLAPCRLAC (in Ref. 6; CAA36496)" FT /evidence="ECO:0000305" FT CONFLICT 147 FT /note="A -> G (in Ref. 6; CAA36496)" FT /evidence="ECO:0000305" FT CONFLICT 169 FT /note="H -> N (in Ref. 5; AAO39521)" FT /evidence="ECO:0000305" FT CONFLICT 364..375 FT /note="PPNTLGGDMMDG -> AKYARRRHDGR (in Ref. 6; CAA36496)" FT /evidence="ECO:0000305" SQ SEQUENCE 427 AA; 45927 MW; 161F40CF3DBB8BF7 CRC64; MAATSYMTPP SGDLDMALGG GGYHTSSPRS AADAGEMKYM QHHHHHHAAA AAAAHHQLPS SPSPNGQGNG GGLGLGSGSG LGSWSALHPD PWMQTHHTHH LPAAAAVASA ADTVKQEMSH LSQQTRIQQG MASPHAAWHA PHAGHYAPTG GSPLQYHHAM NGMLHHPAHA VAAAHHQSVA PLHHTLRGES PQLHIHHHMG GGDRDAISGG EEDTPTSDDL EAFAKQFKQR RIKLGFTQAD VGLALGTLYG NVFSQTTICR FEALQLSFKN MCKLKPLLQK WLEEADSTTG SPTSIDKIAA QGRKRKKRTS IEVSVKGALE QHFHKQPKPS AQEITSLADS LQLEKEVVRV WFCNRRQKEK RMTPPNTLGG DMMDGMPPGH MHHGGYHPHH DMHGSPMGTH SHSHSPPMLS PQNMQSSAVA AHQLAAH //