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P16241

- CF1A_DROME

UniProt

P16241 - CF1A_DROME

Protein

POU domain protein CF1A

Gene

vvl

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 148 (01 Oct 2014)
      Sequence version 5 (10 Jan 2003)
      Previous versions | rss
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    Functioni

    Binds to a DNA sequence element required for the expression of the dopa decarboxylase gene (Ddc) in specific dopaminergic neurons. Could also play an early role in specific ectodermal cells, and a subsequent role in the embryonic nervous system.2 Publications

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi304 – 36360HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: FlyBase
    2. RNA polymerase II distal enhancer sequence-specific DNA binding Source: FlyBase
    3. RNA polymerase II regulatory region sequence-specific DNA binding Source: FlyBase
    4. RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: FlyBase
    5. sequence-specific DNA binding transcription factor activity Source: FlyBase

    GO - Biological processi

    1. brain development Source: FlyBase
    2. brain segmentation Source: FlyBase
    3. dendrite morphogenesis Source: FlyBase
    4. epithelial cell fate determination, open tracheal system Source: FlyBase
    5. motor neuron axon guidance Source: FlyBase
    6. peripheral nervous system development Source: FlyBase
    7. positive regulation of antimicrobial peptide biosynthetic process Source: FlyBase
    8. positive regulation of transcription from RNA polymerase II promoter Source: FlyBase
    9. regulation of dendrite morphogenesis Source: FlyBase

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Enzyme and pathway databases

    SignaLinkiP16241.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    POU domain protein CF1A
    Alternative name(s):
    Chorion factor 1A
    Short name:
    CF1-A
    Protein drifter
    Ventral veins lacking protein
    Gene namesi
    Name:vvl
    Synonyms:Cf1a
    ORF Names:CG10037
    OrganismiDrosophila melanogaster (Fruit fly)
    Taxonomic identifieri7227 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
    ProteomesiUP000000803: Chromosome 3L

    Organism-specific databases

    FlyBaseiFBgn0086680. vvl.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: FlyBase

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 427427POU domain protein CF1APRO_0000100774Add
    BLAST

    Proteomic databases

    PaxDbiP16241.

    Expressioni

    Tissue specificityi

    Coexpressed with acj6 in overlapping subsets of neurons in the embryonic epidermis and central nervous system. First detected in the precursor of the tracheal pits and the stomodeal invagination and later in the peripheral nervous system.3 Publications

    Developmental stagei

    Expressed at maximal levels in early embryos (6-12 hours). Expressed at lower levels during development.1 Publication

    Gene expression databases

    BgeeiP16241.

    Interactioni

    Protein-protein interaction databases

    BioGridi64202. 7 interactions.
    DIPiDIP-17200N.
    MINTiMINT-1699542.

    Structurei

    3D structure databases

    ProteinModelPortaliP16241.
    SMRiP16241. Positions 215-364.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini212 – 28675POU-specificPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi19 – 224Poly-Gly
    Compositional biasi42 – 198157His-richAdd
    BLAST
    Compositional biasi48 – 547Poly-Ala
    Compositional biasi103 – 1119Poly-Ala
    Compositional biasi380 – 40425His-richAdd
    BLAST

    Sequence similaritiesi

    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation
    Contains 1 POU-specific domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG261729.
    GeneTreeiENSGT00730000110809.
    InParanoidiP16241.
    KOiK09365.
    OrthoDBiEOG7DJSMG.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    1.10.260.40. 1 hit.
    InterProiIPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR010982. Lambda_DNA-bd_dom.
    IPR013847. POU.
    IPR000327. POU_specific.
    IPR016362. Transcription_factor_POU.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    PF00157. Pou. 1 hit.
    [Graphical view]
    PIRSFiPIRSF002629. Transcription_factor_POU. 1 hit.
    PRINTSiPR00028. POUDOMAIN.
    SMARTiSM00389. HOX. 1 hit.
    SM00352. POU. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    SSF47413. SSF47413. 1 hit.
    PROSITEiPS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    PS00035. POU_1. 1 hit.
    PS00465. POU_2. 1 hit.
    PS51179. POU_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P16241-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAATSYMTPP SGDLDMALGG GGYHTSSPRS AADAGEMKYM QHHHHHHAAA    50
    AAAAHHQLPS SPSPNGQGNG GGLGLGSGSG LGSWSALHPD PWMQTHHTHH 100
    LPAAAAVASA ADTVKQEMSH LSQQTRIQQG MASPHAAWHA PHAGHYAPTG 150
    GSPLQYHHAM NGMLHHPAHA VAAAHHQSVA PLHHTLRGES PQLHIHHHMG 200
    GGDRDAISGG EEDTPTSDDL EAFAKQFKQR RIKLGFTQAD VGLALGTLYG 250
    NVFSQTTICR FEALQLSFKN MCKLKPLLQK WLEEADSTTG SPTSIDKIAA 300
    QGRKRKKRTS IEVSVKGALE QHFHKQPKPS AQEITSLADS LQLEKEVVRV 350
    WFCNRRQKEK RMTPPNTLGG DMMDGMPPGH MHHGGYHPHH DMHGSPMGTH 400
    SHSHSPPMLS PQNMQSSAVA AHQLAAH 427
    Length:427
    Mass (Da):45,927
    Last modified:January 10, 2003 - v5
    Checksum:i161F40CF3DBB8BF7
    GO

    Sequence cautioni

    The sequence CAA41341.1 differs from that shown. Reason: Frameshift at positions 9, 52, 102 and 420.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti83 – 10220SWSAL…THHLP → LMECPPSGSVDANPSYAPSA in CAA36496. (PubMed:1967821)CuratedAdd
    BLAST
    Sequence conflicti130 – 14011GMASPHAAWHA → ACLAPCRLAC in CAA36496. (PubMed:1967821)CuratedAdd
    BLAST
    Sequence conflicti147 – 1471A → G in CAA36496. (PubMed:1967821)Curated
    Sequence conflicti169 – 1691H → N in AAO39521. 1 PublicationCurated
    Sequence conflicti364 – 37512PPNTL…DMMDG → AKYARRRHDGR in CAA36496. (PubMed:1967821)CuratedAdd
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X58435 mRNA. Translation: CAA41341.1. Frameshift.
    M81959 mRNA. Translation: AAA28831.1.
    AE014296 Genomic DNA. Translation: AAF50641.3.
    BT003517 mRNA. Translation: AAO39521.1.
    X52252 Genomic DNA. Translation: CAA36496.1.
    PIRiS19095.
    RefSeqiNP_523948.1. NM_079224.5.
    UniGeneiDm.2556.

    Genome annotation databases

    EnsemblMetazoaiFBtr0076944; FBpp0076653; FBgn0086680.
    GeneIDi38752.
    KEGGidme:Dmel_CG10037.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X58435 mRNA. Translation: CAA41341.1 . Frameshift.
    M81959 mRNA. Translation: AAA28831.1 .
    AE014296 Genomic DNA. Translation: AAF50641.3 .
    BT003517 mRNA. Translation: AAO39521.1 .
    X52252 Genomic DNA. Translation: CAA36496.1 .
    PIRi S19095.
    RefSeqi NP_523948.1. NM_079224.5.
    UniGenei Dm.2556.

    3D structure databases

    ProteinModelPortali P16241.
    SMRi P16241. Positions 215-364.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 64202. 7 interactions.
    DIPi DIP-17200N.
    MINTi MINT-1699542.

    Proteomic databases

    PaxDbi P16241.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai FBtr0076944 ; FBpp0076653 ; FBgn0086680 .
    GeneIDi 38752.
    KEGGi dme:Dmel_CG10037.

    Organism-specific databases

    CTDi 38752.
    FlyBasei FBgn0086680. vvl.

    Phylogenomic databases

    eggNOGi NOG261729.
    GeneTreei ENSGT00730000110809.
    InParanoidi P16241.
    KOi K09365.
    OrthoDBi EOG7DJSMG.

    Enzyme and pathway databases

    SignaLinki P16241.

    Miscellaneous databases

    GenomeRNAii 38752.
    NextBioi 810212.

    Gene expression databases

    Bgeei P16241.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    1.10.260.40. 1 hit.
    InterProi IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR010982. Lambda_DNA-bd_dom.
    IPR013847. POU.
    IPR000327. POU_specific.
    IPR016362. Transcription_factor_POU.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    PF00157. Pou. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF002629. Transcription_factor_POU. 1 hit.
    PRINTSi PR00028. POUDOMAIN.
    SMARTi SM00389. HOX. 1 hit.
    SM00352. POU. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    SSF47413. SSF47413. 1 hit.
    PROSITEi PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    PS00035. POU_1. 1 hit.
    PS00465. POU_2. 1 hit.
    PS51179. POU_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "I-POU: a POU-domain protein that inhibits neuron-specific gene activation."
      Treacy M.N., He X., Rosenfeld M.G.
      Nature 350:577-584(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    2. "Isolation of a family of Drosophila POU domain genes expressed in early development."
      Billin A.N., Cockerill K.A., Poole S.J.
      Mech. Dev. 34:75-84(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
      Strain: Oregon-R.
      Tissue: Embryo.
    3. "The genome sequence of Drosophila melanogaster."
      Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
      , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
      Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Berkeley.
    4. Cited for: GENOME REANNOTATION.
      Strain: Berkeley.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Berkeley.
      Tissue: Embryo.
    6. "Binding of a Drosophila POU-domain protein to a sequence element regulating gene expression in specific dopaminergic neurons."
      Johnson W.A., Hirsh J.
      Nature 343:467-470(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 83-427, FUNCTION, TISSUE SPECIFICITY.
    7. "Similar DNA recognition properties of alternatively spliced Drosophila POU factors."
      Turner E.E.
      Proc. Natl. Acad. Sci. U.S.A. 93:15097-15101(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: SHOWS THAT CF1A DOES NOT ASSOCIATE WITH ACJ6.

    Entry informationi

    Entry nameiCF1A_DROME
    AccessioniPrimary (citable) accession number: P16241
    Secondary accession number(s): Q24460, Q86P26, Q9VRY9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1990
    Last sequence update: January 10, 2003
    Last modified: October 1, 2014
    This is version 148 of the entry and version 5 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programDrosophila annotation project

    Miscellaneousi

    Caution

    Was originally thought to interact with acj6.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Drosophila
      Drosophila: entries, gene names and cross-references to FlyBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3