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P16241

- CF1A_DROME

UniProt

P16241 - CF1A_DROME

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Protein

POU domain protein CF1A

Gene
vvl, Cf1a, CG10037
Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Binds to a DNA sequence element required for the expression of the dopa decarboxylase gene (Ddc) in specific dopaminergic neurons. Could also play an early role in specific ectodermal cells, and a subsequent role in the embryonic nervous system.2 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi304 – 36360HomeoboxAdd
BLAST

GO - Molecular functioni

  1. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: FlyBase
  2. RNA polymerase II distal enhancer sequence-specific DNA binding Source: FlyBase
  3. RNA polymerase II regulatory region sequence-specific DNA binding Source: FlyBase
  4. RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: FlyBase
  5. sequence-specific DNA binding transcription factor activity Source: FlyBase

GO - Biological processi

  1. brain development Source: FlyBase
  2. brain segmentation Source: FlyBase
  3. dendrite morphogenesis Source: FlyBase
  4. epithelial cell fate determination, open tracheal system Source: FlyBase
  5. motor neuron axon guidance Source: FlyBase
  6. peripheral nervous system development Source: FlyBase
  7. positive regulation of antimicrobial peptide biosynthetic process Source: FlyBase
  8. positive regulation of transcription from RNA polymerase II promoter Source: FlyBase
  9. regulation of dendrite morphogenesis Source: FlyBase
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

SignaLinkiP16241.

Names & Taxonomyi

Protein namesi
Recommended name:
POU domain protein CF1A
Alternative name(s):
Chorion factor 1A
Short name:
CF1-A
Protein drifter
Ventral veins lacking protein
Gene namesi
Name:vvl
Synonyms:Cf1a
ORF Names:CG10037
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000000803: Chromosome 3L

Organism-specific databases

FlyBaseiFBgn0086680. vvl.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: FlyBase
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 427427POU domain protein CF1APRO_0000100774Add
BLAST

Proteomic databases

PaxDbiP16241.

Expressioni

Tissue specificityi

Coexpressed with acj6 in overlapping subsets of neurons in the embryonic epidermis and central nervous system. First detected in the precursor of the tracheal pits and the stomodeal invagination and later in the peripheral nervous system.3 Publications

Developmental stagei

Expressed at maximal levels in early embryos (6-12 hours). Expressed at lower levels during development.1 Publication

Gene expression databases

BgeeiP16241.

Interactioni

Protein-protein interaction databases

BioGridi64202. 7 interactions.
DIPiDIP-17200N.
MINTiMINT-1699542.

Structurei

3D structure databases

ProteinModelPortaliP16241.
SMRiP16241. Positions 215-364.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini212 – 28675POU-specificAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi19 – 224Poly-Gly
Compositional biasi42 – 198157His-richAdd
BLAST
Compositional biasi48 – 547Poly-Ala
Compositional biasi103 – 1119Poly-Ala
Compositional biasi380 – 40425His-richAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG261729.
GeneTreeiENSGT00730000110809.
InParanoidiP16241.
KOiK09365.
OrthoDBiEOG7DJSMG.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
1.10.260.40. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
IPR013847. POU.
IPR000327. POU_specific.
IPR016362. Transcription_factor_POU.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF00157. Pou. 1 hit.
[Graphical view]
PIRSFiPIRSF002629. Transcription_factor_POU. 1 hit.
PRINTSiPR00028. POUDOMAIN.
SMARTiSM00389. HOX. 1 hit.
SM00352. POU. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00035. POU_1. 1 hit.
PS00465. POU_2. 1 hit.
PS51179. POU_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P16241-1 [UniParc]FASTAAdd to Basket

« Hide

MAATSYMTPP SGDLDMALGG GGYHTSSPRS AADAGEMKYM QHHHHHHAAA    50
AAAAHHQLPS SPSPNGQGNG GGLGLGSGSG LGSWSALHPD PWMQTHHTHH 100
LPAAAAVASA ADTVKQEMSH LSQQTRIQQG MASPHAAWHA PHAGHYAPTG 150
GSPLQYHHAM NGMLHHPAHA VAAAHHQSVA PLHHTLRGES PQLHIHHHMG 200
GGDRDAISGG EEDTPTSDDL EAFAKQFKQR RIKLGFTQAD VGLALGTLYG 250
NVFSQTTICR FEALQLSFKN MCKLKPLLQK WLEEADSTTG SPTSIDKIAA 300
QGRKRKKRTS IEVSVKGALE QHFHKQPKPS AQEITSLADS LQLEKEVVRV 350
WFCNRRQKEK RMTPPNTLGG DMMDGMPPGH MHHGGYHPHH DMHGSPMGTH 400
SHSHSPPMLS PQNMQSSAVA AHQLAAH 427
Length:427
Mass (Da):45,927
Last modified:January 10, 2003 - v5
Checksum:i161F40CF3DBB8BF7
GO

Sequence cautioni

The sequence CAA41341.1 differs from that shown. Reason: Frameshift at positions 9, 52, 102 and 420.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti83 – 10220SWSAL…THHLP → LMECPPSGSVDANPSYAPSA in CAA36496. 1 PublicationAdd
BLAST
Sequence conflicti130 – 14011GMASPHAAWHA → ACLAPCRLAC in CAA36496. 1 PublicationAdd
BLAST
Sequence conflicti147 – 1471A → G in CAA36496. 1 Publication
Sequence conflicti169 – 1691H → N in AAO39521. 1 Publication
Sequence conflicti364 – 37512PPNTL…DMMDG → AKYARRRHDGR in CAA36496. 1 PublicationAdd
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X58435 mRNA. Translation: CAA41341.1. Frameshift.
M81959 mRNA. Translation: AAA28831.1.
AE014296 Genomic DNA. Translation: AAF50641.3.
BT003517 mRNA. Translation: AAO39521.1.
X52252 Genomic DNA. Translation: CAA36496.1.
PIRiS19095.
RefSeqiNP_523948.1. NM_079224.5.
UniGeneiDm.2556.

Genome annotation databases

EnsemblMetazoaiFBtr0076944; FBpp0076653; FBgn0086680.
GeneIDi38752.
KEGGidme:Dmel_CG10037.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X58435 mRNA. Translation: CAA41341.1 . Frameshift.
M81959 mRNA. Translation: AAA28831.1 .
AE014296 Genomic DNA. Translation: AAF50641.3 .
BT003517 mRNA. Translation: AAO39521.1 .
X52252 Genomic DNA. Translation: CAA36496.1 .
PIRi S19095.
RefSeqi NP_523948.1. NM_079224.5.
UniGenei Dm.2556.

3D structure databases

ProteinModelPortali P16241.
SMRi P16241. Positions 215-364.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 64202. 7 interactions.
DIPi DIP-17200N.
MINTi MINT-1699542.

Proteomic databases

PaxDbi P16241.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0076944 ; FBpp0076653 ; FBgn0086680 .
GeneIDi 38752.
KEGGi dme:Dmel_CG10037.

Organism-specific databases

CTDi 38752.
FlyBasei FBgn0086680. vvl.

Phylogenomic databases

eggNOGi NOG261729.
GeneTreei ENSGT00730000110809.
InParanoidi P16241.
KOi K09365.
OrthoDBi EOG7DJSMG.

Enzyme and pathway databases

SignaLinki P16241.

Miscellaneous databases

GenomeRNAii 38752.
NextBioi 810212.

Gene expression databases

Bgeei P16241.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
1.10.260.40. 1 hit.
InterProi IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
IPR013847. POU.
IPR000327. POU_specific.
IPR016362. Transcription_factor_POU.
[Graphical view ]
Pfami PF00046. Homeobox. 1 hit.
PF00157. Pou. 1 hit.
[Graphical view ]
PIRSFi PIRSF002629. Transcription_factor_POU. 1 hit.
PRINTSi PR00028. POUDOMAIN.
SMARTi SM00389. HOX. 1 hit.
SM00352. POU. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEi PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00035. POU_1. 1 hit.
PS00465. POU_2. 1 hit.
PS51179. POU_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "I-POU: a POU-domain protein that inhibits neuron-specific gene activation."
    Treacy M.N., He X., Rosenfeld M.G.
    Nature 350:577-584(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
  2. "Isolation of a family of Drosophila POU domain genes expressed in early development."
    Billin A.N., Cockerill K.A., Poole S.J.
    Mech. Dev. 34:75-84(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    Strain: Oregon-R.
    Tissue: Embryo.
  3. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  4. Cited for: GENOME REANNOTATION.
    Strain: Berkeley.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Berkeley.
    Tissue: Embryo.
  6. "Binding of a Drosophila POU-domain protein to a sequence element regulating gene expression in specific dopaminergic neurons."
    Johnson W.A., Hirsh J.
    Nature 343:467-470(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 83-427, FUNCTION, TISSUE SPECIFICITY.
  7. "Similar DNA recognition properties of alternatively spliced Drosophila POU factors."
    Turner E.E.
    Proc. Natl. Acad. Sci. U.S.A. 93:15097-15101(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: SHOWS THAT CF1A DOES NOT ASSOCIATE WITH ACJ6.

Entry informationi

Entry nameiCF1A_DROME
AccessioniPrimary (citable) accession number: P16241
Secondary accession number(s): Q24460, Q86P26, Q9VRY9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: January 10, 2003
Last modified: July 9, 2014
This is version 147 of the entry and version 5 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Caution

Was originally (1 Publication) thought to interact with acj6.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi