P16240 (CION_CIOIN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Cionin
Organism	Ciona intestinalis (Transparent sea squirt) (Ascidia intestinalis)
Taxonomic identifier	7719 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Chordata › Urochordata › Ascidiacea › Enterogona › Phlebobranchia › Cionidae › Ciona

Protein attributes

Sequence length	128 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Secreted.
Tissue specificity	Expressed in both the gut and the neural ganglion.
Sequence similarities	Belongs to the gastrin/cholecystokinin family.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Molecular function	Hormone Neuropeptide
PTM	Amidation Cleavage on pair of basic residues Sulfation
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological process	neuropeptide signaling pathway Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	hormone activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 22	22	Potential
	Propeptide	23 – 108	86			PRO_0000010671
	Peptide	109 – 116	8	Cionin Ref.2		PRO_0000010672
	Propeptide	120 – 128	9			PRO_0000010673
Amino acid modifications
	Modified residue	110	1	Sulfotyrosine
	Modified residue	111	1	Sulfotyrosine
	Modified residue	116	1	Phenylalanine amide

Sequences

	Sequence		Length	Mass (Da)
	P16240 [UniParc]. Last modified June 1, 1994. Version 2. Checksum: BF1DE73438E66609	FASTA	128	14,820
	10 20 30 40 50 60 MGSNIVIYFS IIVIVTLNVN GVPASDLFKS VSQYHIPRSK VINKETVTKP LQFQRAICRL 70 80 90 100 110 120 LQKLGEETFA RLSQSELEAK QLDLIKTCYQ ANSFGDNENQ GHMQRMDRNY YGWMDFGKRA IEDVDYEY

References

[1]	"cDNA deduced procionin. Structure and expression in protochordates resemble that of procholecystokinin in mammals." Monstein H.J., Thorup J.U., Folkesson R., Johnsen A.H., Rehfeld J.F. FEBS Lett. 331:60-64(1993) [PubMed: 8405412] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Cionin: a disulfotyrosyl hybrid of cholecystokinin and gastrin from the neural ganglion of the protochordate Ciona intestinalis." Johnsen A.H., Rehfeld J.F. J. Biol. Chem. 265:3054-3058(1990) [PubMed: 2303439] [Abstract] Cited for: PROTEIN SEQUENCE OF 109-116. Tissue: Neural ganglion.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X69130 mRNA. Translation: CAA48884.1.
PIR	S36901.
RefSeq	NP_001027711.1. NM_001032539.1.
UniGene	Cin.14237.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	445737.
KEGG	cin:445737.
Family and domain databases
InterPro	IPR001651. Gastrin. IPR013152. Gastrin/cholecystokinin_CS. [Graphical view]
Pfam	PF00918. Gastrin. 1 hit. [Graphical view]
SMART	SM00029. GASTRIN. 1 hit. [Graphical view]
PROSITE	PS00259. GASTRIN. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CION_CIOIN

Accession

Primary (citable) accession number: P16240

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 1, 1990
Last sequence update:	June 1, 1994
Last modified:	September 21, 2011
This is version 65 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program