P16235 (LSHR_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Lutropin-choriogonadotropic hormone receptor
Short name=LH/CG-R

Alternative name(s):
Luteinizing hormone receptor
Short name=LSH-R

Gene names

Name:

Lhcgr

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	700 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase.
Subcellular location	Cell membrane; Multi-pass membrane protein. Secreted. Note: Some isoforms may be secreted.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. Contains 6 LRR (leucine-rich) repeats.

Ontologies

Keywords
Cellular component	Cell membrane Membrane Secreted
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Leucine-rich repeat Repeat Signal Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein Lipoprotein Palmitate
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	activation of adenylate cyclase activity Inferred from direct assay PubMed 8440169. Source: RGD adenylate cyclase-modulating G-protein coupled receptor signaling pathway Inferred from direct assay Ref.1. Source: RGD arachidonic acid secretion Inferred from direct assay PubMed 9291830. Source: RGD central nervous system development Inferred from expression pattern PubMed 14581462. Source: RGD hormone-mediated signaling pathway Inferred from direct assay Ref.1. Source: RGD luteinizing hormone signaling pathway Inferred from direct assay PubMed 3030841. Source: RGD phospholipase C-activating G-protein coupled receptor signaling pathway Inferred from direct assay PubMed 3026357. Source: RGD positive regulation of calcium-mediated signaling Inferred from direct assay PubMed 8187959. Source: RGD positive regulation of hormone biosynthetic process Inferred from direct assay PubMed 3026357. Source: RGD positive regulation of release of sequestered calcium ion into cytosol Inferred from direct assay PubMed 8187959. Source: RGD protein targeting to lysosome Inferred from mutant phenotype PubMed 10847593. Source: RGD regulation of steroid biosynthetic process Inferred from expression pattern PubMed 17241129. Source: RGD response to drug Inferred from expression pattern PubMed 9653071. Source: RGD
Cellular_component	endoplasmic reticulum Inferred from direct assay PubMed 16495341. Source: RGD endosome Inferred from direct assay PubMed 10847593. Source: RGD extracellular space Inferred from direct assay Ref.7. Source: RGD integral to plasma membrane Inferred from direct assay PubMed 1695568. Source: RGD intrinsic to external side of plasma membrane Inferred from direct assay PubMed 15901736. Source: RGD lysosome Inferred from direct assay PubMed 10847593. Source: RGD nucleus Inferred from direct assay PubMed 12816543. Source: RGD receptor complex Inferred from direct assay PubMed 11266505. Source: RGD
Molecular_function	G-protein coupled peptide receptor activity Inferred from direct assay Ref.1. Source: RGD luteinizing hormone receptor activity Inferred from electronic annotation. Source: InterPro peptide hormone binding Inferred from direct assay PubMed 15901736. Source: RGD protein homodimerization activity Inferred from direct assay Ref.8. Source: RGD
Complete GO annotation...

Alternative products

This entry describes 11 isoforms produced by alternative splicing. [Align] [Select]

Note: Additional isoforms seem to exist.

Isoform 1 (identifier: P16235-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 1759 (identifier: P16235-2)

The sequence of this isoform differs from the canonical sequence as follows:
     133-157: Missing.
     321-342: YSAIFEENELSGWDYDYGFCSP → LHGALPAAHCLRGLPNKRPVL
     343-700: Missing.

Isoform 1834 (identifier: P16235-3)

The sequence of this isoform differs from the canonical sequence as follows:
     321-342: YSAIFEENELSGWDYDYGFCSP → LHGALPAAHCLRGLPNKRPVL
     343-700: Missing.

Isoform 1950 (identifier: P16235-4)

The sequence of this isoform differs from the canonical sequence as follows:
     83-132: Missing.

Isoform 2075 (identifier: P16235-5)

The sequence of this isoform differs from the canonical sequence as follows:
     232-251: DISSTKLQALPSHGLESIQT → PCRATGWSPFRRSSPCLPTH
     252-700: Missing.

Isoform C1 (identifier: P16235-6)

The sequence of this isoform differs from the canonical sequence as follows:
     294-294: Q → P
     295-700: Missing.

Isoform C2 (identifier: P16235-7)

The sequence of this isoform differs from the canonical sequence as follows:
     184-700: Missing.

Isoform EA2 (identifier: P16235-8)

The sequence of this isoform differs from the canonical sequence as follows:
     232-293: Missing.

Isoform EB (identifier: P16235-9)

The sequence of this isoform differs from the canonical sequence as follows:
     232-293: Missing.
     321-342: YSAIFEENELSGWDYDYGFCSP → LHGALPAAHCLRGLPNKRPVL
     343-700: Missing.

Isoform B1 (identifier: P16235-10)

The sequence of this isoform differs from the canonical sequence as follows:
     232-293: Missing.
     294-367: QNFSFSIFEN...EDIMGYAFLR → IFHFPFLKTS...ILWAMPSLGS
     368-700: Missing.

Isoform B3 (identifier: P16235-11)

The sequence of this isoform differs from the canonical sequence as follows:
     294-367: QNFSFSIFEN...EDIMGYAFLR → IFHFPFLKTS...ILWAMPSLGS
     368-700: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 26	26	Ref.8 Ref.9
	Chain	27 – 700	674	Lutropin-choriogonadotropic hormone receptor		PRO_0000012783
Regions
	Topological domain	27 – 362	336	Extracellular Potential
	Transmembrane	363 – 390	28	Helical; Name=1; Potential
	Topological domain	391 – 399	9	Cytoplasmic Potential
	Transmembrane	400 – 422	23	Helical; Name=2; Potential
	Topological domain	423 – 443	21	Extracellular Potential
	Transmembrane	444 – 466	23	Helical; Name=3; Potential
	Topological domain	467 – 486	20	Cytoplasmic Potential
	Transmembrane	487 – 509	23	Helical; Name=4; Potential
	Topological domain	510 – 529	20	Extracellular Potential
	Transmembrane	530 – 551	22	Helical; Name=5; Potential
	Topological domain	552 – 574	23	Cytoplasmic Potential
	Transmembrane	575 – 598	24	Helical; Name=6; Potential
	Topological domain	599 – 609	11	Extracellular Potential
	Transmembrane	610 – 631	22	Helical; Name=7; Potential
	Topological domain	632 – 700	69	Cytoplasmic Potential
	Repeat	126 – 150	25	LRR 1
	Repeat	152 – 175	24	LRR 2
	Repeat	176 – 200	25	LRR 3
	Repeat	202 – 224	23	LRR 4
	Repeat	225 – 248	24	LRR 5
	Repeat	250 – 271	22	LRR 6
Amino acid modifications
	Lipidation	647	1	S-palmitoyl cysteine Probable
	Lipidation	648	1	S-palmitoyl cysteine Probable
	Glycosylation	103	1	N-linked (GlcNAc...) Potential
	Glycosylation	178	1	N-linked (GlcNAc...) Potential
	Glycosylation	199	1	N-linked (GlcNAc...) Potential
	Glycosylation	295	1	N-linked (GlcNAc...) Potential
	Glycosylation	303	1	N-linked (GlcNAc...) Potential
	Glycosylation	317	1	N-linked (GlcNAc...) Potential
	Disulfide bond	443 ↔ 518		By similarity
Natural variations
	Alternative sequence	83 – 132	50	Missing in isoform 1950.		VSP_001968
	Alternative sequence	133 – 157	25	Missing in isoform 1759.		VSP_001969
	Alternative sequence	184 – 700	517	Missing in isoform C2.		VSP_001970
	Alternative sequence	232 – 293	62	Missing in isoform EA2, isoform EB and isoform B1.		VSP_001972
	Alternative sequence	232 – 251	20	DISST…ESIQT → PCRATGWSPFRRSSPCLPTH in isoform 2075.		VSP_001971
	Alternative sequence	252 – 700	449	Missing in isoform 2075.		VSP_001973
	Alternative sequence	294 – 367	74	QNFSF…YAFLR → IFHFPFLKTSPNNAKAQLEK QITRRFIPPSLRRMNSVAGI MIMASVHPRHSNVLQNQMLS TPVKILWAMPSLGS in isoform B1 and isoform B3.		VSP_001974
	Alternative sequence	294	1	Q → P in isoform C1.		VSP_001975
	Alternative sequence	295 – 700	406	Missing in isoform C1.		VSP_001976
	Alternative sequence	321 – 342	22	YSAIF…GFCSP → LHGALPAAHCLRGLPNKRPV L in isoform 1834, isoform 1759 and isoform EB.		VSP_001977
	Alternative sequence	343 – 700	358	Missing in isoform 1834, isoform 1759 and isoform EB.		VSP_001978
	Alternative sequence	368 – 700	333	Missing in isoform B1 and isoform B3.		VSP_001979
	Natural variant	82	1	I → M in isoform 1950.
	Natural variant	179	1	E → G in isoform 1759.
	Natural variant	233	1	I → T in isoform 1950.
	Natural variant	646	1	G → S in isoform 1950.
Experimental info
	Mutagenesis	409	1	D → N: Significant reduction of binding. Ref.10
	Mutagenesis	436	1	D → N: No change in binding or cAMP production. Ref.10
	Mutagenesis	455	1	E → Q: No change in binding or cAMP production. Ref.10
	Mutagenesis	582	1	D → N: No change in binding or cAMP production. Ref.10
	Mutagenesis	647	1	C → A: Trapped intracellularly and does not appear to become mature; when associated with A-648. Ref.11
	Mutagenesis	648	1	C → A: Trapped intracellularly and does not appear to become mature; when associated with A-647. Ref.11
	Sequence conflict	33	1	R → L AA sequence Ref.9

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified April 1, 1990. Version 1. Checksum: 31807E73BAC94F1F	FASTA	700	78,036
	10 20 30 40 50 60 MGRRVPALRQ LLVLAVLLLK PSQLQSRELS GSRCPEPCDC APDGALRCPG PRAGLARLSL 70 80 90 100 110 120 TYLPVKVIPS QAFRGLNEVV KIEISQSDSL ERIEANAFDN LLNLSELLIQ NTKNLLYIEP 130 140 150 160 170 180 GAFTNLPRLK YLSICNTGIR TLPDVTKISS SEFNFILEIC DNLHITTIPG NAFQGMNNES 190 200 210 220 230 240 VTLKLYGNGF EEVQSHAFNG TTLISLELKE NIYLEKMHSG AFQGATGPSI LDISSTKLQA 250 260 270 280 290 300 LPSHGLESIQ TLIALSSYSL KTLPSKEKFT SLLVATLTYP SHCCAFRNLP KKEQNFSFSI 310 320 330 340 350 360 FENFSKQCES TVRKADNETL YSAIFEENEL SGWDYDYGFC SPKTLQCAPE PDAFNPCEDI 370 380 390 400 410 420 MGYAFLRVLI WLINILAIFG NLTVLFVLLT SRYKLTVPRF LMCNLSFADF CMGLYLLLIA 430 440 450 460 470 480 SVDSQTKGQY YNHAIDWQTG SGCGAAGFFT VFASELSVYT LTVITLERWH TITYAVQLDQ 490 500 510 520 530 540 KLRLRHAIPI MLGGWLFSTL IATMPLVGIS NYMKVSICLP MDVESTLSQV YILSILILNV 550 560 570 580 590 600 VAFVVICACY IRIYFAVQNP ELTAPNKDTK IAKKMAILIF TDFTCMAPIS FFAISAAFKV 610 620 630 640 650 660 PLITVTNSKI LLVLFYPVNS CANPFLYAIF TKAFQRDFLL LLSRFGCCKR RAELYRRKEF 670 680 690 700 SAYTSNCKNG FPGASKPSQA TLKLSTVHCQ QPIPPRALTH
	Isoform 1759 [UniParc]. Checksum: 7B2268943600064C	FASTA	316	34,776
	10 20 30 40 50 60 MGRRVPALRQ LLVLAVLLLK PSQLQSRELS GSRCPEPCDC APDGALRCPG PRAGLARLSL 70 80 90 100 110 120 TYLPVKVIPS QAFRGLNEVV KIEISQSDSL ERIEANAFDN LLNLSELLIQ NTKNLLYIEP 130 140 150 160 170 180 GAFTNLPRLK YLEICDNLHI TTIPGNAFQG MNNESVTLKL YGNGFEEVQS HAFNGTTLIS 190 200 210 220 230 240 LELKENIYLE KMHSGAFQGA TGPSILDISS TKLQALPSHG LESIQTLIAL SSYSLKTLPS 250 260 270 280 290 300 KEKFTSLLVA TLTYPSHCCA FRNLPKKEQN FSFSIFENFS KQCESTVRKA DNETLLHGAL 310 PAAHCLRGLP NKRPVL
	Isoform 1834 [UniParc]. Checksum: F07ADCB07BB0A074	FASTA	341	37,514
	10 20 30 40 50 60 MGRRVPALRQ LLVLAVLLLK PSQLQSRELS GSRCPEPCDC APDGALRCPG PRAGLARLSL 70 80 90 100 110 120 TYLPVKVIPS QAFRGLNEVV KIEISQSDSL ERIEANAFDN LLNLSELLIQ NTKNLLYIEP 130 140 150 160 170 180 GAFTNLPRLK YLSICNTGIR TLPDVTKISS SEFNFILEIC DNLHITTIPG NAFQGMNNES 190 200 210 220 230 240 VTLKLYGNGF EEVQSHAFNG TTLISLELKE NIYLEKMHSG AFQGATGPSI LDISSTKLQA 250 260 270 280 290 300 LPSHGLESIQ TLIALSSYSL KTLPSKEKFT SLLVATLTYP SHCCAFRNLP KKEQNFSFSI 310 320 330 340 FENFSKQCES TVRKADNETL LHGALPAAHC LRGLPNKRPV L
	Isoform 1950 [UniParc]. Checksum: 9674879D3BB793AD	FASTA	650	72,318
	10 20 30 40 50 60 MGRRVPALRQ LLVLAVLLLK PSQLQSRELS GSRCPEPCDC APDGALRCPG PRAGLARLSL 70 80 90 100 110 120 TYLPVKVIPS QAFRGLNEVV KISICNTGIR TLPDVTKISS SEFNFILEIC DNLHITTIPG 130 140 150 160 170 180 NAFQGMNNES VTLKLYGNGF EEVQSHAFNG TTLISLELKE NIYLEKMHSG AFQGATGPSI 190 200 210 220 230 240 LDISSTKLQA LPSHGLESIQ TLIALSSYSL KTLPSKEKFT SLLVATLTYP SHCCAFRNLP 250 260 270 280 290 300 KKEQNFSFSI FENFSKQCES TVRKADNETL YSAIFEENEL SGWDYDYGFC SPKTLQCAPE 310 320 330 340 350 360 PDAFNPCEDI MGYAFLRVLI WLINILAIFG NLTVLFVLLT SRYKLTVPRF LMCNLSFADF 370 380 390 400 410 420 CMGLYLLLIA SVDSQTKGQY YNHAIDWQTG SGCGAAGFFT VFASELSVYT LTVITLERWH 430 440 450 460 470 480 TITYAVQLDQ KLRLRHAIPI MLGGWLFSTL IATMPLVGIS NYMKVSICLP MDVESTLSQV 490 500 510 520 530 540 YILSILILNV VAFVVICACY IRIYFAVQNP ELTAPNKDTK IAKKMAILIF TDFTCMAPIS 550 560 570 580 590 600 FFAISAAFKV PLITVTNSKI LLVLFYPVNS CANPFLYAIF TKAFQRDFLL LLSRFGCCKR 610 620 630 640 650 RAELYRRKEF SAYTSNCKNG FPGASKPSQA TLKLSTVHCQ QPIPPRALTH
	Isoform 2075 [UniParc]. Checksum: 0CF9CC2BA3EEBD33	FASTA	251	27,595
	10 20 30 40 50 60 MGRRVPALRQ LLVLAVLLLK PSQLQSRELS GSRCPEPCDC APDGALRCPG PRAGLARLSL 70 80 90 100 110 120 TYLPVKVIPS QAFRGLNEVV KIEISQSDSL ERIEANAFDN LLNLSELLIQ NTKNLLYIEP 130 140 150 160 170 180 GAFTNLPRLK YLSICNTGIR TLPDVTKISS SEFNFILEIC DNLHITTIPG NAFQGMNNES 190 200 210 220 230 240 VTLKLYGNGF EEVQSHAFNG TTLISLELKE NIYLEKMHSG AFQGATGPSI LPCRATGWSP 250 FRRSSPCLPT H
	Isoform C1 [UniParc]. Checksum: 6BCDFA656F66B8F3	FASTA	294	32,243
	10 20 30 40 50 60 MGRRVPALRQ LLVLAVLLLK PSQLQSRELS GSRCPEPCDC APDGALRCPG PRAGLARLSL 70 80 90 100 110 120 TYLPVKVIPS QAFRGLNEVV KIEISQSDSL ERIEANAFDN LLNLSELLIQ NTKNLLYIEP 130 140 150 160 170 180 GAFTNLPRLK YLSICNTGIR TLPDVTKISS SEFNFILEIC DNLHITTIPG NAFQGMNNES 190 200 210 220 230 240 VTLKLYGNGF EEVQSHAFNG TTLISLELKE NIYLEKMHSG AFQGATGPSI LDISSTKLQA 250 260 270 280 290 LPSHGLESIQ TLIALSSYSL KTLPSKEKFT SLLVATLTYP SHCCAFRNLP KKEP
	Isoform C2 [UniParc]. Checksum: 0F4579BC254CAF7F	FASTA	183	20,132
	10 20 30 40 50 60 MGRRVPALRQ LLVLAVLLLK PSQLQSRELS GSRCPEPCDC APDGALRCPG PRAGLARLSL 70 80 90 100 110 120 TYLPVKVIPS QAFRGLNEVV KIEISQSDSL ERIEANAFDN LLNLSELLIQ NTKNLLYIEP 130 140 150 160 170 180 GAFTNLPRLK YLSICNTGIR TLPDVTKISS SEFNFILEIC DNLHITTIPG NAFQGMNNES VTL
	Isoform EA2 [UniParc]. Checksum: 2A51B16A0ABAABA5	FASTA	638	71,246
	10 20 30 40 50 60 MGRRVPALRQ LLVLAVLLLK PSQLQSRELS GSRCPEPCDC APDGALRCPG PRAGLARLSL 70 80 90 100 110 120 TYLPVKVIPS QAFRGLNEVV KIEISQSDSL ERIEANAFDN LLNLSELLIQ NTKNLLYIEP 130 140 150 160 170 180 GAFTNLPRLK YLSICNTGIR TLPDVTKISS SEFNFILEIC DNLHITTIPG NAFQGMNNES 190 200 210 220 230 240 VTLKLYGNGF EEVQSHAFNG TTLISLELKE NIYLEKMHSG AFQGATGPSI LQNFSFSIFE 250 260 270 280 290 300 NFSKQCESTV RKADNETLYS AIFEENELSG WDYDYGFCSP KTLQCAPEPD AFNPCEDIMG 310 320 330 340 350 360 YAFLRVLIWL INILAIFGNL TVLFVLLTSR YKLTVPRFLM CNLSFADFCM GLYLLLIASV 370 380 390 400 410 420 DSQTKGQYYN HAIDWQTGSG CGAAGFFTVF ASELSVYTLT VITLERWHTI TYAVQLDQKL 430 440 450 460 470 480 RLRHAIPIML GGWLFSTLIA TMPLVGISNY MKVSICLPMD VESTLSQVYI LSILILNVVA 490 500 510 520 530 540 FVVICACYIR IYFAVQNPEL TAPNKDTKIA KKMAILIFTD FTCMAPISFF AISAAFKVPL 550 560 570 580 590 600 ITVTNSKILL VLFYPVNSCA NPFLYAIFTK AFQRDFLLLL SRFGCCKRRA ELYRRKEFSA 610 620 630 YTSNCKNGFP GASKPSQATL KLSTVHCQQP IPPRALTH
	Isoform EB [UniParc]. Checksum: C20FE7913916C1EC	FASTA	279	30,724
	10 20 30 40 50 60 MGRRVPALRQ LLVLAVLLLK PSQLQSRELS GSRCPEPCDC APDGALRCPG PRAGLARLSL 70 80 90 100 110 120 TYLPVKVIPS QAFRGLNEVV KIEISQSDSL ERIEANAFDN LLNLSELLIQ NTKNLLYIEP 130 140 150 160 170 180 GAFTNLPRLK YLSICNTGIR TLPDVTKISS SEFNFILEIC DNLHITTIPG NAFQGMNNES 190 200 210 220 230 240 VTLKLYGNGF EEVQSHAFNG TTLISLELKE NIYLEKMHSG AFQGATGPSI LQNFSFSIFE 250 260 270 NFSKQCESTV RKADNETLLH GALPAAHCLR GLPNKRPVL
	Isoform B1 [UniParc]. Checksum: A6F021436A24B636	FASTA	305	33,721
	10 20 30 40 50 60 MGRRVPALRQ LLVLAVLLLK PSQLQSRELS GSRCPEPCDC APDGALRCPG PRAGLARLSL 70 80 90 100 110 120 TYLPVKVIPS QAFRGLNEVV KIEISQSDSL ERIEANAFDN LLNLSELLIQ NTKNLLYIEP 130 140 150 160 170 180 GAFTNLPRLK YLSICNTGIR TLPDVTKISS SEFNFILEIC DNLHITTIPG NAFQGMNNES 190 200 210 220 230 240 VTLKLYGNGF EEVQSHAFNG TTLISLELKE NIYLEKMHSG AFQGATGPSI LIFHFPFLKT 250 260 270 280 290 300 SPNNAKAQLE KQITRRFIPP SLRRMNSVAG IMIMASVHPR HSNVLQNQML STPVKILWAM PSLGS
	Isoform B3 [UniParc]. Checksum: 49B1FC6213C166FE	FASTA	367	40,511
	10 20 30 40 50 60 MGRRVPALRQ LLVLAVLLLK PSQLQSRELS GSRCPEPCDC APDGALRCPG PRAGLARLSL 70 80 90 100 110 120 TYLPVKVIPS QAFRGLNEVV KIEISQSDSL ERIEANAFDN LLNLSELLIQ NTKNLLYIEP 130 140 150 160 170 180 GAFTNLPRLK YLSICNTGIR TLPDVTKISS SEFNFILEIC DNLHITTIPG NAFQGMNNES 190 200 210 220 230 240 VTLKLYGNGF EEVQSHAFNG TTLISLELKE NIYLEKMHSG AFQGATGPSI LDISSTKLQA 250 260 270 280 290 300 LPSHGLESIQ TLIALSSYSL KTLPSKEKFT SLLVATLTYP SHCCAFRNLP KKEIFHFPFL 310 320 330 340 350 360 KTSPNNAKAQ LEKQITRRFI PPSLRRMNSV AGIMIMASVH PRHSNVLQNQ MLSTPVKILW AMPSLGS

References

[1]	"Lutropin-choriogonadotropin receptor: an unusual member of the G protein-coupled receptor family." McFarland K.C., Sprengel R., Phillips H.S., Koehler M., Rosemblit N., Nikolics K., Segaloff D.L., Seeburg P.H. Science 245:494-499(1989) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Expression of the LH/CG receptor gene in rat ovarian tissue is regulated by an extensive alternative splicing of the primary transcript." Aatsinki J.T., Pietila E.M., Lakkakorpi J.T., Rajaniemi H.J. Mol. Cell. Endocrinol. 84:127-135(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE, ALTERNATIVE SPLICING. Strain: Sprague-Dawley. Tissue: Ovary.
[3]	"Structure of the luteinizing hormone receptor gene and multiple exons of the coding sequence." Koo Y.B., Slaughter R.G., Ji T.H. Endocrinology 128:2297-2308(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]	"Cloning of rat lutropin (LH) receptor analogs lacking the soybean lectin domain." Bernard M.P., Myers R.V., Moyle W.R. Mol. Cell. Endocrinol. 71:R19-R23(1990) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE, ALTERNATIVE SPLICING.
[5]	"Structure of the lutropin/choriogonadotropin receptor." Segaloff D.L., Sprengel R., Nikolics K., Ascoli M. Recent Prog. Horm. Res. 46:261-301(1990) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE, ALTERNATIVE SPLICING.
[6]	"Structural organization of the rat luteinizing hormone (LH) receptor gene." Tsai-Morris C.H., Buczko E., Wang W., Xie X.-Z., Dufau M.L. J. Biol. Chem. 266:11355-11359(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-320. Tissue: Liver.
[7]	"Intronic nature of the rat luteinizing hormone receptor gene defines a soluble receptor subspecies with hormone binding activity." Tsai-Morris C.H., Buczko E., Wang W., Dufau M.L. J. Biol. Chem. 265:19385-19388(1990) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 295-700.
[8]	"Characterization and structure of ovarian and testicular LH/hCG receptors." Dufau M.L., Minegishi T., Buczko E.S., Delgado C.J., Zhang R. J. Steroid Biochem. 33:715-720(1989) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 27-44.
[9]	"Purification, characterization, and amino-terminal sequence of rat ovarian receptor for luteinizing hormone/human choriogonadotropin." Roche P.C., Ryan R.J. J. Biol. Chem. 264:4636-4641(1989) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 27-37.
[10]	"Asp383 in the second transmembrane domain of the lutropin receptor is important for high affinity hormone binding and cAMP production." Ji I., Ji T.H. J. Biol. Chem. 266:14953-14957(1991) [PubMed] [Europe PMC] [Abstract] Cited for: MUTAGENESIS OF ASP-409; ASP-436; GLU-455 AND ASP-582.
[11]	"The lutropin/choriogonadotropin receptor is palmitoylated at intracellular cysteine residues." Zhu H., Wang H., Ascoli M. Mol. Endocrinol. 9:141-150(1995) [PubMed] [Europe PMC] [Abstract] Cited for: PALMITOYLATION AT CYS-647 AND CYS-648, MUTAGENESIS OF CYS-647 AND CYS-648.
+	Additional computationally mapped references.

Web resources

GRIS

Glycoprotein-hormone Receptors Information System

Sequence-structure-function-analysis of glycoprotein hormone receptors

Cross-references

Sequence databases
EMBL GenBank DDBJ	M26199 mRNA. Translation: AAA41528.1. M61212, M61211 Genomic DNA. Translation: AAA41527.1. S40803 , S40787, S40903, S40904, S40905, S40907, S40909, S40918, S40920, S40795, S40798 Genomic DNA. Translation: AAB22680.1. S40795 , S40787, S40903, S40904, S40905, S40907, S40909, S40918, S40920 Genomic DNA. Translation: AAB22681.1. S40803 , S40787, S40903, S40907, S40909, S40918, S40920, S40795, S40798 Genomic DNA. Translation: AAB22682.2. S40803 , S40787, S40903, S40904, S40905, S40907, S40909, S40918, S40920, S40795, S40798 Genomic DNA. Translation: AAB22683.1. S40803 , S40787, S40903, S40904, S40905, S40909, S40918, S40920, S40795, S40798 Genomic DNA. Translation: AAB22684.2. M68928 , M68917, M68918, M68919, M68920, M68921, M68922, M68923, M68925, M68926, M68927 Genomic DNA. Translation: AAA41529.1. AH004953 Genomic DNA. Translation: AAB42193.1.
IPI	IPI00211097. IPI00230821. IPI00230822. IPI00230823. IPI00230824. IPI00230825. IPI00230826. IPI00230827. IPI00230828. IPI00230894. IPI00230895.
PIR	A49744. I57668. I77461.
RefSeq	NP_037110.1. NM_012978.1.
UniGene	Rn.11216.
3D structure databases
ProteinModelPortal	P16235.
ModBase	Search...
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	P16235.
Proteomic databases
PaxDb	P16235.
PRIDE	P16235.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	25477.
KEGG	rno:25477.
UCSC	RGD:3007. rat.
Organism-specific databases
CTD	3973.
RGD	3007. Lhcgr.
Phylogenomic databases
eggNOG	NOG285844.
HOGENOM	HOG000045902.
HOVERGEN	HBG003521.
KO	K04248.
OrthoDB	EOG4K9BC3.
Gene expression databases
ArrayExpress	P16235.
Genevestigator	P16235.
GermOnline	ENSRNOG00000016712. Rattus norvegicus.
Family and domain databases
InterPro	IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. IPR002131. Gphrmn_rcpt. IPR000372. LRR-contain_N. IPR026906. LRR_5. IPR002273. LSH_rcpt. [Graphical view]
PANTHER	PTHR24372:SF1. PTHR24372:SF1. 1 hit.
Pfam	PF00001. 7tm_1. 1 hit. PF13306. LRR_5. 2 hits. [Graphical view]
PRINTS	PR00373. GLYCHORMONER. PR00237. GPCRRHODOPSN. PR01144. LSHRECEPTOR.
SMART	SM00013. LRRNT. 1 hit. [Graphical view]
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChEMBL	CHEMBL2456.
NextBio	606797.

Entry information

Entry name

LSHR_RAT

Accession

Primary (citable) accession number: P16235
Secondary accession number(s): P70646 , Q63807, Q63808, Q63809, Q6LDI7

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 1, 1990
Last sequence update:	April 1, 1990
Last modified:	April 3, 2013
This is version 133 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program