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Protein

Lutropin-choriogonadotropic hormone receptor

Gene

Lhcgr

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase.By similarity

GO - Molecular functioni

  • follicle-stimulating hormone receptor activity Source: GO_Central
  • G-protein coupled peptide receptor activity Source: RGD
  • identical protein binding Source: RGD
  • luteinizing hormone receptor activity Source: UniProtKB
  • peptide hormone binding Source: RGD
  • protein homodimerization activity Source: RGD

GO - Biological processi

  • activation of adenylate cyclase activity Source: RGD
  • adenylate cyclase-activating G-protein coupled receptor signaling pathway Source: GO_Central
  • adenylate cyclase-modulating G-protein coupled receptor signaling pathway Source: RGD
  • arachidonic acid secretion Source: RGD
  • cellular response to luteinizing hormone stimulus Source: UniProtKB
  • central nervous system development Source: RGD
  • follicle-stimulating hormone signaling pathway Source: GO_Central
  • hormone-mediated signaling pathway Source: RGD
  • luteinizing hormone signaling pathway Source: RGD
  • phospholipase C-activating G-protein coupled receptor signaling pathway Source: RGD
  • positive regulation of calcium ion transport into cytosol Source: RGD
  • positive regulation of calcium-mediated signaling Source: RGD
  • positive regulation of hormone biosynthetic process Source: RGD
  • positive regulation of release of sequestered calcium ion into cytosol Source: RGD
  • primary ovarian follicle growth Source: GO_Central
  • protein targeting to lysosome Source: RGD
  • regulation of osteoclast differentiation Source: GO_Central
  • regulation of steroid biosynthetic process Source: RGD
  • response to drug Source: RGD
  • response to luteinizing hormone Source: CAFA

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Lutropin-choriogonadotropic hormone receptor
Short name:
LH/CG-R
Alternative name(s):
Luteinizing hormone receptor
Short name:
LSH-R
Gene namesi
Name:Lhcgr
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi3007 Lhcgr

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini27 – 362ExtracellularSequence analysisAdd BLAST336
Transmembranei363 – 390Helical; Name=1Sequence analysisAdd BLAST28
Topological domaini391 – 399CytoplasmicSequence analysis9
Transmembranei400 – 422Helical; Name=2Sequence analysisAdd BLAST23
Topological domaini423 – 443ExtracellularSequence analysisAdd BLAST21
Transmembranei444 – 466Helical; Name=3Sequence analysisAdd BLAST23
Topological domaini467 – 486CytoplasmicSequence analysisAdd BLAST20
Transmembranei487 – 509Helical; Name=4Sequence analysisAdd BLAST23
Topological domaini510 – 529ExtracellularSequence analysisAdd BLAST20
Transmembranei530 – 551Helical; Name=5Sequence analysisAdd BLAST22
Topological domaini552 – 574CytoplasmicSequence analysisAdd BLAST23
Transmembranei575 – 598Helical; Name=6Sequence analysisAdd BLAST24
Topological domaini599 – 609ExtracellularSequence analysisAdd BLAST11
Transmembranei610 – 631Helical; Name=7Sequence analysisAdd BLAST22
Topological domaini632 – 700CytoplasmicSequence analysisAdd BLAST69

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi409D → N: Significant reduction of binding. 1 Publication1
Mutagenesisi436D → N: No change in binding or cAMP production. 1 Publication1
Mutagenesisi455E → Q: No change in binding or cAMP production. 1 Publication1
Mutagenesisi582D → N: No change in binding or cAMP production. 1 Publication1
Mutagenesisi647C → A: Trapped intracellularly and does not appear to become mature; when associated with A-648. 1 Publication1
Mutagenesisi648C → A: Trapped intracellularly and does not appear to become mature; when associated with A-647. 1 Publication1

Chemistry databases

ChEMBLiCHEMBL2456

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 262 PublicationsAdd BLAST26
ChainiPRO_000001278327 – 700Lutropin-choriogonadotropic hormone receptorAdd BLAST674

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi103N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi178N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi199N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi295N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi303N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi317N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei335SulfotyrosineBy similarity1
Disulfide bondi443 ↔ 518PROSITE-ProRule annotation
Lipidationi647S-palmitoyl cysteine1 Publication1
Lipidationi648S-palmitoyl cysteine1 Publication1

Post-translational modificationi

Sulfated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Sulfation

Proteomic databases

PaxDbiP16235
PRIDEiP16235

PTM databases

iPTMnetiP16235
PhosphoSitePlusiP16235
SwissPalmiP16235

Interactioni

GO - Molecular functioni

  • identical protein binding Source: RGD
  • protein homodimerization activity Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000022481

Chemistry databases

BindingDBiP16235

Structurei

3D structure databases

ProteinModelPortaliP16235
SMRiP16235
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati126 – 150LRR 1Add BLAST25
Repeati152 – 175LRR 2Add BLAST24
Repeati176 – 200LRR 3Add BLAST25
Repeati202 – 224LRR 4Add BLAST23
Repeati225 – 248LRR 5Add BLAST24
Repeati250 – 271LRR 6Add BLAST22

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2087 Eukaryota
ENOG410XR1T LUCA
HOGENOMiHOG000045902
HOVERGENiHBG003521
InParanoidiP16235
KOiK04248
PhylomeDBiP16235

Family and domain databases

Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR002131 Gphrmn_rcpt_fam
IPR026906 LRR_5
IPR032675 LRR_dom_sf
IPR002273 LSH_rcpt
IPR034298 TSHR/LHCGR/FSHR
PANTHERiPTHR24372 PTHR24372, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PF13306 LRR_5, 2 hits
PRINTSiPR00373 GLYCHORMONER
PR00237 GPCRRHODOPSN
PR01144 LSHRECEPTOR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequences (11)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 11 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Additional isoforms seem to exist.
Isoform 1 (identifier: P16235-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGRRVPALRQ LLVLAVLLLK PSQLQSRELS GSRCPEPCDC APDGALRCPG
60 70 80 90 100
PRAGLARLSL TYLPVKVIPS QAFRGLNEVV KIEISQSDSL ERIEANAFDN
110 120 130 140 150
LLNLSELLIQ NTKNLLYIEP GAFTNLPRLK YLSICNTGIR TLPDVTKISS
160 170 180 190 200
SEFNFILEIC DNLHITTIPG NAFQGMNNES VTLKLYGNGF EEVQSHAFNG
210 220 230 240 250
TTLISLELKE NIYLEKMHSG AFQGATGPSI LDISSTKLQA LPSHGLESIQ
260 270 280 290 300
TLIALSSYSL KTLPSKEKFT SLLVATLTYP SHCCAFRNLP KKEQNFSFSI
310 320 330 340 350
FENFSKQCES TVRKADNETL YSAIFEENEL SGWDYDYGFC SPKTLQCAPE
360 370 380 390 400
PDAFNPCEDI MGYAFLRVLI WLINILAIFG NLTVLFVLLT SRYKLTVPRF
410 420 430 440 450
LMCNLSFADF CMGLYLLLIA SVDSQTKGQY YNHAIDWQTG SGCGAAGFFT
460 470 480 490 500
VFASELSVYT LTVITLERWH TITYAVQLDQ KLRLRHAIPI MLGGWLFSTL
510 520 530 540 550
IATMPLVGIS NYMKVSICLP MDVESTLSQV YILSILILNV VAFVVICACY
560 570 580 590 600
IRIYFAVQNP ELTAPNKDTK IAKKMAILIF TDFTCMAPIS FFAISAAFKV
610 620 630 640 650
PLITVTNSKI LLVLFYPVNS CANPFLYAIF TKAFQRDFLL LLSRFGCCKR
660 670 680 690 700
RAELYRRKEF SAYTSNCKNG FPGASKPSQA TLKLSTVHCQ QPIPPRALTH
Length:700
Mass (Da):78,036
Last modified:April 1, 1990 - v1
Checksum:i31807E73BAC94F1F
GO
Isoform 1759 (identifier: P16235-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     133-157: Missing.
     321-342: YSAIFEENELSGWDYDYGFCSP → LHGALPAAHCLRGLPNKRPVL
     343-700: Missing.

Show »
Length:316
Mass (Da):34,776
Checksum:i7B2268943600064C
GO
Isoform 1834 (identifier: P16235-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     321-342: YSAIFEENELSGWDYDYGFCSP → LHGALPAAHCLRGLPNKRPVL
     343-700: Missing.

Show »
Length:341
Mass (Da):37,514
Checksum:iF07ADCB07BB0A074
GO
Isoform 1950 (identifier: P16235-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     83-132: Missing.

Show »
Length:650
Mass (Da):72,318
Checksum:i9674879D3BB793AD
GO
Isoform 2075 (identifier: P16235-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     232-251: DISSTKLQALPSHGLESIQT → PCRATGWSPFRRSSPCLPTH
     252-700: Missing.

Show »
Length:251
Mass (Da):27,595
Checksum:i0CF9CC2BA3EEBD33
GO
Isoform C1 (identifier: P16235-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     294-294: Q → P
     295-700: Missing.

Show »
Length:294
Mass (Da):32,243
Checksum:i6BCDFA656F66B8F3
GO
Isoform C2 (identifier: P16235-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     184-700: Missing.

Show »
Length:183
Mass (Da):20,132
Checksum:i0F4579BC254CAF7F
GO
Isoform EA2 (identifier: P16235-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     232-293: Missing.

Show »
Length:638
Mass (Da):71,246
Checksum:i2A51B16A0ABAABA5
GO
Isoform EB (identifier: P16235-9) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     232-293: Missing.
     321-342: YSAIFEENELSGWDYDYGFCSP → LHGALPAAHCLRGLPNKRPVL
     343-700: Missing.

Show »
Length:279
Mass (Da):30,724
Checksum:iC20FE7913916C1EC
GO
Isoform B1 (identifier: P16235-10) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     232-293: Missing.
     294-367: QNFSFSIFEN...EDIMGYAFLR → IFHFPFLKTS...ILWAMPSLGS
     368-700: Missing.

Show »
Length:305
Mass (Da):33,721
Checksum:iA6F021436A24B636
GO
Isoform B3 (identifier: P16235-11) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     294-367: QNFSFSIFEN...EDIMGYAFLR → IFHFPFLKTS...ILWAMPSLGS
     368-700: Missing.

Show »
Length:367
Mass (Da):40,511
Checksum:i49B1FC6213C166FE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti33R → L AA sequence (PubMed:2925659).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti82I → M in isoform 1950. 1
Natural varianti179E → G in isoform 1759. 1
Natural varianti233I → T in isoform 1950. 1
Natural varianti646G → S in isoform 1950. 1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00196883 – 132Missing in isoform 1950. CuratedAdd BLAST50
Alternative sequenceiVSP_001969133 – 157Missing in isoform 1759. CuratedAdd BLAST25
Alternative sequenceiVSP_001970184 – 700Missing in isoform C2. CuratedAdd BLAST517
Alternative sequenceiVSP_001972232 – 293Missing in isoform EA2, isoform EB and isoform B1. CuratedAdd BLAST62
Alternative sequenceiVSP_001971232 – 251DISST…ESIQT → PCRATGWSPFRRSSPCLPTH in isoform 2075. CuratedAdd BLAST20
Alternative sequenceiVSP_001973252 – 700Missing in isoform 2075. CuratedAdd BLAST449
Alternative sequenceiVSP_001974294 – 367QNFSF…YAFLR → IFHFPFLKTSPNNAKAQLEK QITRRFIPPSLRRMNSVAGI MIMASVHPRHSNVLQNQMLS TPVKILWAMPSLGS in isoform B1 and isoform B3. CuratedAdd BLAST74
Alternative sequenceiVSP_001975294Q → P in isoform C1. Curated1
Alternative sequenceiVSP_001976295 – 700Missing in isoform C1. CuratedAdd BLAST406
Alternative sequenceiVSP_001977321 – 342YSAIF…GFCSP → LHGALPAAHCLRGLPNKRPV L in isoform 1834, isoform 1759 and isoform EB. CuratedAdd BLAST22
Alternative sequenceiVSP_001978343 – 700Missing in isoform 1834, isoform 1759 and isoform EB. CuratedAdd BLAST358
Alternative sequenceiVSP_001979368 – 700Missing in isoform B1 and isoform B3. CuratedAdd BLAST333

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M26199 mRNA Translation: AAA41528.1
M61212, M61211 Genomic DNA Translation: AAA41527.1
S40803
, S40787, S40903, S40904, S40905, S40907, S40909, S40918, S40920, S40795, S40798 Genomic DNA Translation: AAB22680.1
S40795
, S40787, S40903, S40904, S40905, S40907, S40909, S40918, S40920 Genomic DNA Translation: AAB22681.1
S40803
, S40787, S40903, S40907, S40909, S40918, S40920, S40795, S40798 Genomic DNA Translation: AAB22682.2
S40803
, S40787, S40903, S40904, S40905, S40907, S40909, S40918, S40920, S40795, S40798 Genomic DNA Translation: AAB22683.1
S40803
, S40787, S40903, S40904, S40905, S40909, S40918, S40920, S40795, S40798 Genomic DNA Translation: AAB22684.2
M68928
, M68917, M68918, M68919, M68920, M68921, M68922, M68923, M68925, M68926, M68927 Genomic DNA Translation: AAA41529.1
AH004953 Genomic DNA Translation: AAB42193.1
PIRiA49744
I57668
I77461
RefSeqiNP_037110.1, NM_012978.1 [P16235-1]
UniGeneiRn.11216

Genome annotation databases

GeneIDi25477
KEGGirno:25477
UCSCiRGD:3007 rat [P16235-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiLSHR_RAT
AccessioniPrimary (citable) accession number: P16235
Secondary accession number(s): P70646
, Q63807, Q63808, Q63809, Q6LDI7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: May 23, 2018
This is version 167 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health