Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Lutropin-choriogonadotropic hormone receptor

Gene

Lhcgr

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase.

GO - Molecular functioni

  • ATPase binding Source: RGD
  • G-protein coupled peptide receptor activity Source: RGD
  • identical protein binding Source: RGD
  • luteinizing hormone receptor activity Source: GO_Central
  • peptide hormone binding Source: RGD
  • protein homodimerization activity Source: RGD

GO - Biological processi

  • activation of adenylate cyclase activity Source: RGD
  • adenylate cyclase-activating G-protein coupled receptor signaling pathway Source: GO_Central
  • adenylate cyclase-modulating G-protein coupled receptor signaling pathway Source: RGD
  • arachidonic acid secretion Source: RGD
  • central nervous system development Source: RGD
  • development of primary male sexual characteristics Source: GO_Central
  • hormone-mediated signaling pathway Source: RGD
  • luteinizing hormone signaling pathway Source: RGD
  • ovulation cycle process Source: GO_Central
  • phospholipase C-activating G-protein coupled receptor signaling pathway Source: RGD
  • positive regulation of calcium ion transport into cytosol Source: RGD
  • positive regulation of calcium-mediated signaling Source: RGD
  • positive regulation of hormone biosynthetic process Source: RGD
  • positive regulation of release of sequestered calcium ion into cytosol Source: RGD
  • protein targeting to lysosome Source: RGD
  • regulation of steroid biosynthetic process Source: RGD
  • response to drug Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Lutropin-choriogonadotropic hormone receptor
Short name:
LH/CG-R
Alternative name(s):
Luteinizing hormone receptor
Short name:
LSH-R
Gene namesi
Name:Lhcgr
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi3007. Lhcgr.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini27 – 362ExtracellularSequence analysisAdd BLAST336
Transmembranei363 – 390Helical; Name=1Sequence analysisAdd BLAST28
Topological domaini391 – 399CytoplasmicSequence analysis9
Transmembranei400 – 422Helical; Name=2Sequence analysisAdd BLAST23
Topological domaini423 – 443ExtracellularSequence analysisAdd BLAST21
Transmembranei444 – 466Helical; Name=3Sequence analysisAdd BLAST23
Topological domaini467 – 486CytoplasmicSequence analysisAdd BLAST20
Transmembranei487 – 509Helical; Name=4Sequence analysisAdd BLAST23
Topological domaini510 – 529ExtracellularSequence analysisAdd BLAST20
Transmembranei530 – 551Helical; Name=5Sequence analysisAdd BLAST22
Topological domaini552 – 574CytoplasmicSequence analysisAdd BLAST23
Transmembranei575 – 598Helical; Name=6Sequence analysisAdd BLAST24
Topological domaini599 – 609ExtracellularSequence analysisAdd BLAST11
Transmembranei610 – 631Helical; Name=7Sequence analysisAdd BLAST22
Topological domaini632 – 700CytoplasmicSequence analysisAdd BLAST69

GO - Cellular componenti

  • cytoplasm Source: RGD
  • endoplasmic reticulum Source: RGD
  • endosome Source: RGD
  • extracellular space Source: RGD
  • integral component of plasma membrane Source: RGD
  • intrinsic component of external side of plasma membrane Source: RGD
  • lysosome Source: RGD
  • nucleus Source: RGD
  • plasma membrane Source: RGD
  • receptor complex Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi409D → N: Significant reduction of binding. 1 Publication1
Mutagenesisi436D → N: No change in binding or cAMP production. 1 Publication1
Mutagenesisi455E → Q: No change in binding or cAMP production. 1 Publication1
Mutagenesisi582D → N: No change in binding or cAMP production. 1 Publication1
Mutagenesisi647C → A: Trapped intracellularly and does not appear to become mature; when associated with A-648. 1 Publication1
Mutagenesisi648C → A: Trapped intracellularly and does not appear to become mature; when associated with A-647. 1 Publication1

Chemistry databases

ChEMBLiCHEMBL2456.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 262 PublicationsAdd BLAST26
ChainiPRO_000001278327 – 700Lutropin-choriogonadotropic hormone receptorAdd BLAST674

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi103N-linked (GlcNAc...)Sequence analysis1
Glycosylationi178N-linked (GlcNAc...)Sequence analysis1
Glycosylationi199N-linked (GlcNAc...)Sequence analysis1
Glycosylationi295N-linked (GlcNAc...)Sequence analysis1
Glycosylationi303N-linked (GlcNAc...)Sequence analysis1
Glycosylationi317N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi443 ↔ 518PROSITE-ProRule annotation
Lipidationi647S-palmitoyl cysteine1 Publication1
Lipidationi648S-palmitoyl cysteine1 Publication1

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiP16235.
PRIDEiP16235.

PTM databases

iPTMnetiP16235.
PhosphoSitePlusiP16235.
SwissPalmiP16235.

Interactioni

GO - Molecular functioni

  • ATPase binding Source: RGD
  • identical protein binding Source: RGD
  • protein homodimerization activity Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000022481.

Chemistry databases

BindingDBiP16235.

Structurei

3D structure databases

ProteinModelPortaliP16235.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati126 – 150LRR 1Add BLAST25
Repeati152 – 175LRR 2Add BLAST24
Repeati176 – 200LRR 3Add BLAST25
Repeati202 – 224LRR 4Add BLAST23
Repeati225 – 248LRR 5Add BLAST24
Repeati250 – 271LRR 6Add BLAST22

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.PROSITE-ProRule annotation
Contains 6 LRR (leucine-rich) repeats.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2087. Eukaryota.
ENOG410XR1T. LUCA.
HOGENOMiHOG000045902.
HOVERGENiHBG003521.
InParanoidiP16235.
KOiK04248.
PhylomeDBiP16235.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR002131. Gphrmn_rcpt_fam.
IPR032675. L_dom-like.
IPR026906. LRR_5.
IPR002273. LSH_rcpt.
[Graphical view]
PANTHERiPTHR24372. PTHR24372. 1 hit.
PTHR24372:SF1. PTHR24372:SF1. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
PF13306. LRR_5. 2 hits.
[Graphical view]
PRINTSiPR00373. GLYCHORMONER.
PR00237. GPCRRHODOPSN.
PR01144. LSHRECEPTOR.
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequences (11)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 11 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Additional isoforms seem to exist.
Isoform 1 (identifier: P16235-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGRRVPALRQ LLVLAVLLLK PSQLQSRELS GSRCPEPCDC APDGALRCPG
60 70 80 90 100
PRAGLARLSL TYLPVKVIPS QAFRGLNEVV KIEISQSDSL ERIEANAFDN
110 120 130 140 150
LLNLSELLIQ NTKNLLYIEP GAFTNLPRLK YLSICNTGIR TLPDVTKISS
160 170 180 190 200
SEFNFILEIC DNLHITTIPG NAFQGMNNES VTLKLYGNGF EEVQSHAFNG
210 220 230 240 250
TTLISLELKE NIYLEKMHSG AFQGATGPSI LDISSTKLQA LPSHGLESIQ
260 270 280 290 300
TLIALSSYSL KTLPSKEKFT SLLVATLTYP SHCCAFRNLP KKEQNFSFSI
310 320 330 340 350
FENFSKQCES TVRKADNETL YSAIFEENEL SGWDYDYGFC SPKTLQCAPE
360 370 380 390 400
PDAFNPCEDI MGYAFLRVLI WLINILAIFG NLTVLFVLLT SRYKLTVPRF
410 420 430 440 450
LMCNLSFADF CMGLYLLLIA SVDSQTKGQY YNHAIDWQTG SGCGAAGFFT
460 470 480 490 500
VFASELSVYT LTVITLERWH TITYAVQLDQ KLRLRHAIPI MLGGWLFSTL
510 520 530 540 550
IATMPLVGIS NYMKVSICLP MDVESTLSQV YILSILILNV VAFVVICACY
560 570 580 590 600
IRIYFAVQNP ELTAPNKDTK IAKKMAILIF TDFTCMAPIS FFAISAAFKV
610 620 630 640 650
PLITVTNSKI LLVLFYPVNS CANPFLYAIF TKAFQRDFLL LLSRFGCCKR
660 670 680 690 700
RAELYRRKEF SAYTSNCKNG FPGASKPSQA TLKLSTVHCQ QPIPPRALTH
Length:700
Mass (Da):78,036
Last modified:April 1, 1990 - v1
Checksum:i31807E73BAC94F1F
GO
Isoform 1759 (identifier: P16235-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     133-157: Missing.
     321-342: YSAIFEENELSGWDYDYGFCSP → LHGALPAAHCLRGLPNKRPVL
     343-700: Missing.

Show »
Length:316
Mass (Da):34,776
Checksum:i7B2268943600064C
GO
Isoform 1834 (identifier: P16235-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     321-342: YSAIFEENELSGWDYDYGFCSP → LHGALPAAHCLRGLPNKRPVL
     343-700: Missing.

Show »
Length:341
Mass (Da):37,514
Checksum:iF07ADCB07BB0A074
GO
Isoform 1950 (identifier: P16235-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     83-132: Missing.

Show »
Length:650
Mass (Da):72,318
Checksum:i9674879D3BB793AD
GO
Isoform 2075 (identifier: P16235-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     232-251: DISSTKLQALPSHGLESIQT → PCRATGWSPFRRSSPCLPTH
     252-700: Missing.

Show »
Length:251
Mass (Da):27,595
Checksum:i0CF9CC2BA3EEBD33
GO
Isoform C1 (identifier: P16235-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     294-294: Q → P
     295-700: Missing.

Show »
Length:294
Mass (Da):32,243
Checksum:i6BCDFA656F66B8F3
GO
Isoform C2 (identifier: P16235-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     184-700: Missing.

Show »
Length:183
Mass (Da):20,132
Checksum:i0F4579BC254CAF7F
GO
Isoform EA2 (identifier: P16235-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     232-293: Missing.

Show »
Length:638
Mass (Da):71,246
Checksum:i2A51B16A0ABAABA5
GO
Isoform EB (identifier: P16235-9) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     232-293: Missing.
     321-342: YSAIFEENELSGWDYDYGFCSP → LHGALPAAHCLRGLPNKRPVL
     343-700: Missing.

Show »
Length:279
Mass (Da):30,724
Checksum:iC20FE7913916C1EC
GO
Isoform B1 (identifier: P16235-10) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     232-293: Missing.
     294-367: QNFSFSIFEN...EDIMGYAFLR → IFHFPFLKTS...ILWAMPSLGS
     368-700: Missing.

Show »
Length:305
Mass (Da):33,721
Checksum:iA6F021436A24B636
GO
Isoform B3 (identifier: P16235-11) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     294-367: QNFSFSIFEN...EDIMGYAFLR → IFHFPFLKTS...ILWAMPSLGS
     368-700: Missing.

Show »
Length:367
Mass (Da):40,511
Checksum:i49B1FC6213C166FE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti33R → L AA sequence (PubMed:2925659).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti82I → M in isoform 1950. 1
Natural varianti179E → G in isoform 1759. 1
Natural varianti233I → T in isoform 1950. 1
Natural varianti646G → S in isoform 1950. 1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00196883 – 132Missing in isoform 1950. CuratedAdd BLAST50
Alternative sequenceiVSP_001969133 – 157Missing in isoform 1759. CuratedAdd BLAST25
Alternative sequenceiVSP_001970184 – 700Missing in isoform C2. CuratedAdd BLAST517
Alternative sequenceiVSP_001972232 – 293Missing in isoform EA2, isoform EB and isoform B1. CuratedAdd BLAST62
Alternative sequenceiVSP_001971232 – 251DISST…ESIQT → PCRATGWSPFRRSSPCLPTH in isoform 2075. CuratedAdd BLAST20
Alternative sequenceiVSP_001973252 – 700Missing in isoform 2075. CuratedAdd BLAST449
Alternative sequenceiVSP_001974294 – 367QNFSF…YAFLR → IFHFPFLKTSPNNAKAQLEK QITRRFIPPSLRRMNSVAGI MIMASVHPRHSNVLQNQMLS TPVKILWAMPSLGS in isoform B1 and isoform B3. CuratedAdd BLAST74
Alternative sequenceiVSP_001975294Q → P in isoform C1. Curated1
Alternative sequenceiVSP_001976295 – 700Missing in isoform C1. CuratedAdd BLAST406
Alternative sequenceiVSP_001977321 – 342YSAIF…GFCSP → LHGALPAAHCLRGLPNKRPV L in isoform 1834, isoform 1759 and isoform EB. CuratedAdd BLAST22
Alternative sequenceiVSP_001978343 – 700Missing in isoform 1834, isoform 1759 and isoform EB. CuratedAdd BLAST358
Alternative sequenceiVSP_001979368 – 700Missing in isoform B1 and isoform B3. CuratedAdd BLAST333

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M26199 mRNA. Translation: AAA41528.1.
M61212, M61211 Genomic DNA. Translation: AAA41527.1.
S40803
, S40787, S40903, S40904, S40905, S40907, S40909, S40918, S40920, S40795, S40798 Genomic DNA. Translation: AAB22680.1.
S40795
, S40787, S40903, S40904, S40905, S40907, S40909, S40918, S40920 Genomic DNA. Translation: AAB22681.1.
S40803
, S40787, S40903, S40907, S40909, S40918, S40920, S40795, S40798 Genomic DNA. Translation: AAB22682.2.
S40803
, S40787, S40903, S40904, S40905, S40907, S40909, S40918, S40920, S40795, S40798 Genomic DNA. Translation: AAB22683.1.
S40803
, S40787, S40903, S40904, S40905, S40909, S40918, S40920, S40795, S40798 Genomic DNA. Translation: AAB22684.2.
M68928
, M68917, M68918, M68919, M68920, M68921, M68922, M68923, M68925, M68926, M68927 Genomic DNA. Translation: AAA41529.1.
AH004953 Genomic DNA. Translation: AAB42193.1.
PIRiA49744.
I57668.
I77461.
RefSeqiNP_037110.1. NM_012978.1. [P16235-1]
UniGeneiRn.11216.

Genome annotation databases

GeneIDi25477.
KEGGirno:25477.
UCSCiRGD:3007. rat. [P16235-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Sequence-structure-function-analysis of glycoprotein hormone receptors

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M26199 mRNA. Translation: AAA41528.1.
M61212, M61211 Genomic DNA. Translation: AAA41527.1.
S40803
, S40787, S40903, S40904, S40905, S40907, S40909, S40918, S40920, S40795, S40798 Genomic DNA. Translation: AAB22680.1.
S40795
, S40787, S40903, S40904, S40905, S40907, S40909, S40918, S40920 Genomic DNA. Translation: AAB22681.1.
S40803
, S40787, S40903, S40907, S40909, S40918, S40920, S40795, S40798 Genomic DNA. Translation: AAB22682.2.
S40803
, S40787, S40903, S40904, S40905, S40907, S40909, S40918, S40920, S40795, S40798 Genomic DNA. Translation: AAB22683.1.
S40803
, S40787, S40903, S40904, S40905, S40909, S40918, S40920, S40795, S40798 Genomic DNA. Translation: AAB22684.2.
M68928
, M68917, M68918, M68919, M68920, M68921, M68922, M68923, M68925, M68926, M68927 Genomic DNA. Translation: AAA41529.1.
AH004953 Genomic DNA. Translation: AAB42193.1.
PIRiA49744.
I57668.
I77461.
RefSeqiNP_037110.1. NM_012978.1. [P16235-1]
UniGeneiRn.11216.

3D structure databases

ProteinModelPortaliP16235.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000022481.

Chemistry databases

BindingDBiP16235.
ChEMBLiCHEMBL2456.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiP16235.
PhosphoSitePlusiP16235.
SwissPalmiP16235.

Proteomic databases

PaxDbiP16235.
PRIDEiP16235.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi25477.
KEGGirno:25477.
UCSCiRGD:3007. rat. [P16235-1]

Organism-specific databases

CTDi3973.
RGDi3007. Lhcgr.

Phylogenomic databases

eggNOGiKOG2087. Eukaryota.
ENOG410XR1T. LUCA.
HOGENOMiHOG000045902.
HOVERGENiHBG003521.
InParanoidiP16235.
KOiK04248.
PhylomeDBiP16235.

Miscellaneous databases

PROiP16235.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR002131. Gphrmn_rcpt_fam.
IPR032675. L_dom-like.
IPR026906. LRR_5.
IPR002273. LSH_rcpt.
[Graphical view]
PANTHERiPTHR24372. PTHR24372. 1 hit.
PTHR24372:SF1. PTHR24372:SF1. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
PF13306. LRR_5. 2 hits.
[Graphical view]
PRINTSiPR00373. GLYCHORMONER.
PR00237. GPCRRHODOPSN.
PR01144. LSHRECEPTOR.
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLSHR_RAT
AccessioniPrimary (citable) accession number: P16235
Secondary accession number(s): P70646
, Q63807, Q63808, Q63809, Q6LDI7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: November 2, 2016
This is version 158 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.