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Protein

Lutropin-choriogonadotropic hormone receptor

Gene

Lhcgr

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase.

GO - Molecular functioni

  • ATPase binding Source: RGD
  • G-protein coupled peptide receptor activity Source: RGD
  • identical protein binding Source: RGD
  • luteinizing hormone receptor activity Source: GO_Central
  • peptide hormone binding Source: RGD
  • protein homodimerization activity Source: RGD

GO - Biological processi

  • activation of adenylate cyclase activity Source: RGD
  • adenylate cyclase-activating G-protein coupled receptor signaling pathway Source: GO_Central
  • adenylate cyclase-modulating G-protein coupled receptor signaling pathway Source: RGD
  • arachidonic acid secretion Source: RGD
  • central nervous system development Source: RGD
  • development of primary male sexual characteristics Source: GO_Central
  • hormone-mediated signaling pathway Source: RGD
  • luteinizing hormone signaling pathway Source: RGD
  • ovulation cycle process Source: GO_Central
  • phospholipase C-activating G-protein coupled receptor signaling pathway Source: RGD
  • positive regulation of calcium ion transport into cytosol Source: RGD
  • positive regulation of calcium-mediated signaling Source: RGD
  • positive regulation of hormone biosynthetic process Source: RGD
  • positive regulation of release of sequestered calcium ion into cytosol Source: RGD
  • protein targeting to lysosome Source: RGD
  • regulation of steroid biosynthetic process Source: RGD
  • response to drug Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Lutropin-choriogonadotropic hormone receptor
Short name:
LH/CG-R
Alternative name(s):
Luteinizing hormone receptor
Short name:
LSH-R
Gene namesi
Name:Lhcgr
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi3007. Lhcgr.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini27 – 362336ExtracellularSequence analysisAdd
BLAST
Transmembranei363 – 39028Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini391 – 3999CytoplasmicSequence analysis
Transmembranei400 – 42223Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini423 – 44321ExtracellularSequence analysisAdd
BLAST
Transmembranei444 – 46623Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini467 – 48620CytoplasmicSequence analysisAdd
BLAST
Transmembranei487 – 50923Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini510 – 52920ExtracellularSequence analysisAdd
BLAST
Transmembranei530 – 55122Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini552 – 57423CytoplasmicSequence analysisAdd
BLAST
Transmembranei575 – 59824Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini599 – 60911ExtracellularSequence analysisAdd
BLAST
Transmembranei610 – 63122Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini632 – 70069CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • cytoplasm Source: RGD
  • endoplasmic reticulum Source: RGD
  • endosome Source: RGD
  • extracellular space Source: RGD
  • integral component of plasma membrane Source: RGD
  • intrinsic component of external side of plasma membrane Source: RGD
  • lysosome Source: RGD
  • nucleus Source: RGD
  • plasma membrane Source: RGD
  • receptor complex Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi409 – 4091D → N: Significant reduction of binding. 1 Publication
Mutagenesisi436 – 4361D → N: No change in binding or cAMP production. 1 Publication
Mutagenesisi455 – 4551E → Q: No change in binding or cAMP production. 1 Publication
Mutagenesisi582 – 5821D → N: No change in binding or cAMP production. 1 Publication
Mutagenesisi647 – 6471C → A: Trapped intracellularly and does not appear to become mature; when associated with A-648. 1 Publication
Mutagenesisi648 – 6481C → A: Trapped intracellularly and does not appear to become mature; when associated with A-647. 1 Publication

Chemistry

ChEMBLiCHEMBL2456.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 26262 PublicationsAdd
BLAST
Chaini27 – 700674Lutropin-choriogonadotropic hormone receptorPRO_0000012783Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi103 – 1031N-linked (GlcNAc...)Sequence analysis
Glycosylationi178 – 1781N-linked (GlcNAc...)Sequence analysis
Glycosylationi199 – 1991N-linked (GlcNAc...)Sequence analysis
Glycosylationi295 – 2951N-linked (GlcNAc...)Sequence analysis
Glycosylationi303 – 3031N-linked (GlcNAc...)Sequence analysis
Glycosylationi317 – 3171N-linked (GlcNAc...)Sequence analysis
Disulfide bondi443 ↔ 518PROSITE-ProRule annotation
Lipidationi647 – 6471S-palmitoyl cysteine1 Publication
Lipidationi648 – 6481S-palmitoyl cysteine1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiP16235.
PRIDEiP16235.

PTM databases

iPTMnetiP16235.
PhosphoSiteiP16235.
SwissPalmiP16235.

Interactioni

GO - Molecular functioni

  • ATPase binding Source: RGD
  • identical protein binding Source: RGD
  • protein homodimerization activity Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000022481.

Chemistry

BindingDBiP16235.

Structurei

3D structure databases

ProteinModelPortaliP16235.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati126 – 15025LRR 1Add
BLAST
Repeati152 – 17524LRR 2Add
BLAST
Repeati176 – 20025LRR 3Add
BLAST
Repeati202 – 22423LRR 4Add
BLAST
Repeati225 – 24824LRR 5Add
BLAST
Repeati250 – 27122LRR 6Add
BLAST

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.PROSITE-ProRule annotation
Contains 6 LRR (leucine-rich) repeats.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2087. Eukaryota.
ENOG410XR1T. LUCA.
HOGENOMiHOG000045902.
HOVERGENiHBG003521.
InParanoidiP16235.
KOiK04248.
PhylomeDBiP16235.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR002131. Gphrmn_rcpt_fam.
IPR032675. L_dom-like.
IPR026906. LRR_5.
IPR002273. LSH_rcpt.
[Graphical view]
PANTHERiPTHR24372. PTHR24372. 1 hit.
PTHR24372:SF1. PTHR24372:SF1. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
PF13306. LRR_5. 2 hits.
[Graphical view]
PRINTSiPR00373. GLYCHORMONER.
PR00237. GPCRRHODOPSN.
PR01144. LSHRECEPTOR.
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequences (11)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 11 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Additional isoforms seem to exist.
Isoform 1 (identifier: P16235-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGRRVPALRQ LLVLAVLLLK PSQLQSRELS GSRCPEPCDC APDGALRCPG
60 70 80 90 100
PRAGLARLSL TYLPVKVIPS QAFRGLNEVV KIEISQSDSL ERIEANAFDN
110 120 130 140 150
LLNLSELLIQ NTKNLLYIEP GAFTNLPRLK YLSICNTGIR TLPDVTKISS
160 170 180 190 200
SEFNFILEIC DNLHITTIPG NAFQGMNNES VTLKLYGNGF EEVQSHAFNG
210 220 230 240 250
TTLISLELKE NIYLEKMHSG AFQGATGPSI LDISSTKLQA LPSHGLESIQ
260 270 280 290 300
TLIALSSYSL KTLPSKEKFT SLLVATLTYP SHCCAFRNLP KKEQNFSFSI
310 320 330 340 350
FENFSKQCES TVRKADNETL YSAIFEENEL SGWDYDYGFC SPKTLQCAPE
360 370 380 390 400
PDAFNPCEDI MGYAFLRVLI WLINILAIFG NLTVLFVLLT SRYKLTVPRF
410 420 430 440 450
LMCNLSFADF CMGLYLLLIA SVDSQTKGQY YNHAIDWQTG SGCGAAGFFT
460 470 480 490 500
VFASELSVYT LTVITLERWH TITYAVQLDQ KLRLRHAIPI MLGGWLFSTL
510 520 530 540 550
IATMPLVGIS NYMKVSICLP MDVESTLSQV YILSILILNV VAFVVICACY
560 570 580 590 600
IRIYFAVQNP ELTAPNKDTK IAKKMAILIF TDFTCMAPIS FFAISAAFKV
610 620 630 640 650
PLITVTNSKI LLVLFYPVNS CANPFLYAIF TKAFQRDFLL LLSRFGCCKR
660 670 680 690 700
RAELYRRKEF SAYTSNCKNG FPGASKPSQA TLKLSTVHCQ QPIPPRALTH
Length:700
Mass (Da):78,036
Last modified:April 1, 1990 - v1
Checksum:i31807E73BAC94F1F
GO
Isoform 1759 (identifier: P16235-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     133-157: Missing.
     321-342: YSAIFEENELSGWDYDYGFCSP → LHGALPAAHCLRGLPNKRPVL
     343-700: Missing.

Show »
Length:316
Mass (Da):34,776
Checksum:i7B2268943600064C
GO
Isoform 1834 (identifier: P16235-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     321-342: YSAIFEENELSGWDYDYGFCSP → LHGALPAAHCLRGLPNKRPVL
     343-700: Missing.

Show »
Length:341
Mass (Da):37,514
Checksum:iF07ADCB07BB0A074
GO
Isoform 1950 (identifier: P16235-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     83-132: Missing.

Show »
Length:650
Mass (Da):72,318
Checksum:i9674879D3BB793AD
GO
Isoform 2075 (identifier: P16235-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     232-251: DISSTKLQALPSHGLESIQT → PCRATGWSPFRRSSPCLPTH
     252-700: Missing.

Show »
Length:251
Mass (Da):27,595
Checksum:i0CF9CC2BA3EEBD33
GO
Isoform C1 (identifier: P16235-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     294-294: Q → P
     295-700: Missing.

Show »
Length:294
Mass (Da):32,243
Checksum:i6BCDFA656F66B8F3
GO
Isoform C2 (identifier: P16235-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     184-700: Missing.

Show »
Length:183
Mass (Da):20,132
Checksum:i0F4579BC254CAF7F
GO
Isoform EA2 (identifier: P16235-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     232-293: Missing.

Show »
Length:638
Mass (Da):71,246
Checksum:i2A51B16A0ABAABA5
GO
Isoform EB (identifier: P16235-9) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     232-293: Missing.
     321-342: YSAIFEENELSGWDYDYGFCSP → LHGALPAAHCLRGLPNKRPVL
     343-700: Missing.

Show »
Length:279
Mass (Da):30,724
Checksum:iC20FE7913916C1EC
GO
Isoform B1 (identifier: P16235-10) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     232-293: Missing.
     294-367: QNFSFSIFEN...EDIMGYAFLR → IFHFPFLKTS...ILWAMPSLGS
     368-700: Missing.

Show »
Length:305
Mass (Da):33,721
Checksum:iA6F021436A24B636
GO
Isoform B3 (identifier: P16235-11) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     294-367: QNFSFSIFEN...EDIMGYAFLR → IFHFPFLKTS...ILWAMPSLGS
     368-700: Missing.

Show »
Length:367
Mass (Da):40,511
Checksum:i49B1FC6213C166FE
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti33 – 331R → L AA sequence (PubMed:2925659).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti82 – 821I → M in isoform 1950.
Natural varianti179 – 1791E → G in isoform 1759.
Natural varianti233 – 2331I → T in isoform 1950.
Natural varianti646 – 6461G → S in isoform 1950.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei83 – 13250Missing in isoform 1950. CuratedVSP_001968Add
BLAST
Alternative sequencei133 – 15725Missing in isoform 1759. CuratedVSP_001969Add
BLAST
Alternative sequencei184 – 700517Missing in isoform C2. CuratedVSP_001970Add
BLAST
Alternative sequencei232 – 29362Missing in isoform EA2, isoform EB and isoform B1. CuratedVSP_001972Add
BLAST
Alternative sequencei232 – 25120DISST…ESIQT → PCRATGWSPFRRSSPCLPTH in isoform 2075. CuratedVSP_001971Add
BLAST
Alternative sequencei252 – 700449Missing in isoform 2075. CuratedVSP_001973Add
BLAST
Alternative sequencei294 – 36774QNFSF…YAFLR → IFHFPFLKTSPNNAKAQLEK QITRRFIPPSLRRMNSVAGI MIMASVHPRHSNVLQNQMLS TPVKILWAMPSLGS in isoform B1 and isoform B3. CuratedVSP_001974Add
BLAST
Alternative sequencei294 – 2941Q → P in isoform C1. CuratedVSP_001975
Alternative sequencei295 – 700406Missing in isoform C1. CuratedVSP_001976Add
BLAST
Alternative sequencei321 – 34222YSAIF…GFCSP → LHGALPAAHCLRGLPNKRPV L in isoform 1834, isoform 1759 and isoform EB. CuratedVSP_001977Add
BLAST
Alternative sequencei343 – 700358Missing in isoform 1834, isoform 1759 and isoform EB. CuratedVSP_001978Add
BLAST
Alternative sequencei368 – 700333Missing in isoform B1 and isoform B3. CuratedVSP_001979Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M26199 mRNA. Translation: AAA41528.1.
M61212, M61211 Genomic DNA. Translation: AAA41527.1.
S40803
, S40787, S40903, S40904, S40905, S40907, S40909, S40918, S40920, S40795, S40798 Genomic DNA. Translation: AAB22680.1.
S40795
, S40787, S40903, S40904, S40905, S40907, S40909, S40918, S40920 Genomic DNA. Translation: AAB22681.1.
S40803
, S40787, S40903, S40907, S40909, S40918, S40920, S40795, S40798 Genomic DNA. Translation: AAB22682.2.
S40803
, S40787, S40903, S40904, S40905, S40907, S40909, S40918, S40920, S40795, S40798 Genomic DNA. Translation: AAB22683.1.
S40803
, S40787, S40903, S40904, S40905, S40909, S40918, S40920, S40795, S40798 Genomic DNA. Translation: AAB22684.2.
M68928
, M68917, M68918, M68919, M68920, M68921, M68922, M68923, M68925, M68926, M68927 Genomic DNA. Translation: AAA41529.1.
AH004953 Genomic DNA. Translation: AAB42193.1.
PIRiA49744.
I57668.
I77461.
RefSeqiNP_037110.1. NM_012978.1. [P16235-1]
UniGeneiRn.11216.

Genome annotation databases

GeneIDi25477.
KEGGirno:25477.
UCSCiRGD:3007. rat. [P16235-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Sequence-structure-function-analysis of glycoprotein hormone receptors

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M26199 mRNA. Translation: AAA41528.1.
M61212, M61211 Genomic DNA. Translation: AAA41527.1.
S40803
, S40787, S40903, S40904, S40905, S40907, S40909, S40918, S40920, S40795, S40798 Genomic DNA. Translation: AAB22680.1.
S40795
, S40787, S40903, S40904, S40905, S40907, S40909, S40918, S40920 Genomic DNA. Translation: AAB22681.1.
S40803
, S40787, S40903, S40907, S40909, S40918, S40920, S40795, S40798 Genomic DNA. Translation: AAB22682.2.
S40803
, S40787, S40903, S40904, S40905, S40907, S40909, S40918, S40920, S40795, S40798 Genomic DNA. Translation: AAB22683.1.
S40803
, S40787, S40903, S40904, S40905, S40909, S40918, S40920, S40795, S40798 Genomic DNA. Translation: AAB22684.2.
M68928
, M68917, M68918, M68919, M68920, M68921, M68922, M68923, M68925, M68926, M68927 Genomic DNA. Translation: AAA41529.1.
AH004953 Genomic DNA. Translation: AAB42193.1.
PIRiA49744.
I57668.
I77461.
RefSeqiNP_037110.1. NM_012978.1. [P16235-1]
UniGeneiRn.11216.

3D structure databases

ProteinModelPortaliP16235.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000022481.

Chemistry

BindingDBiP16235.
ChEMBLiCHEMBL2456.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiP16235.
PhosphoSiteiP16235.
SwissPalmiP16235.

Proteomic databases

PaxDbiP16235.
PRIDEiP16235.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi25477.
KEGGirno:25477.
UCSCiRGD:3007. rat. [P16235-1]

Organism-specific databases

CTDi3973.
RGDi3007. Lhcgr.

Phylogenomic databases

eggNOGiKOG2087. Eukaryota.
ENOG410XR1T. LUCA.
HOGENOMiHOG000045902.
HOVERGENiHBG003521.
InParanoidiP16235.
KOiK04248.
PhylomeDBiP16235.

Miscellaneous databases

PROiP16235.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR002131. Gphrmn_rcpt_fam.
IPR032675. L_dom-like.
IPR026906. LRR_5.
IPR002273. LSH_rcpt.
[Graphical view]
PANTHERiPTHR24372. PTHR24372. 1 hit.
PTHR24372:SF1. PTHR24372:SF1. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
PF13306. LRR_5. 2 hits.
[Graphical view]
PRINTSiPR00373. GLYCHORMONER.
PR00237. GPCRRHODOPSN.
PR01144. LSHRECEPTOR.
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLSHR_RAT
AccessioniPrimary (citable) accession number: P16235
Secondary accession number(s): P70646
, Q63807, Q63808, Q63809, Q6LDI7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: July 6, 2016
This is version 157 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.