ID   PGDS_HUMAN     STANDARD;      PRT;  1089 AA.
AC   P16234;
DT   01-APR-1990 (REL. 14, CREATED)
DT   01-APR-1990 (REL. 14, LAST SEQUENCE UPDATE)
DT   01-NOV-1997 (REL. 35, LAST ANNOTATION UPDATE)
DE   ALPHA PLATELET-DERIVED GROWTH FACTOR RECEPTOR PRECURSOR (EC 2.7.1.112)
DE   (PDGF-R-ALPHA) (CD140A ANTIGEN).
GN   PDGFRA.
OS   HOMO SAPIENS (HUMAN).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; MAMMALIA; EUTHERIA;
OC   PRIMATES; CATARRHINI; HOMINIDAE; HOMO.
RN   [1]
RP   SEQUENCE FROM N.A.
RX   MEDLINE; 89130149.
RA   MATSUI T., HEIDARAN M., MIKI T., POPESCU N., LA ROCHELLE W.,
RA   KRAUS M., PIERCE J., AARONSON S.;
RT   "Isolation of a novel receptor cDNA establishes the existence of two
RT   PDGF receptor genes.";
RL   SCIENCE 243:800-804(1989).
RN   [2]
RP   SEQUENCE FROM N.A.
RX   MEDLINE; 89296915.
RA   CLAESSON-WELSH L., ERIKSSON A., WESTERMARK B., HELDIN C.H.;
RT   "cDNA cloning and expression of the human A-type platelet-derived
RT   growth factor (PDGF) receptor establishes structural similarity to
RT   the B-type PDGF receptor.";
RL   PROC. NATL. ACAD. SCI. U.S.A. 86:4917-4921(1989).
CC   -!- FUNCTION: THIS RECEPTOR BINDS PLATELET-DERIVED GROWTH FACTOR AND
CC       HAS A TYROSINE-PROTEIN KINASE ACTIVITY. THIS RECEPTOR CAN BIND
CC       EITHER PDGF-A OR PDGF-B.
CC   -!- SUBUNIT: DIMER OF EITHER ALPHA-ALPHA, BETA-BETA OR ALPHA-BETA
CC       SUBUNITS.
CC   -!- SUBCELLULAR LOCATION: TYPE I MEMBRANE PROTEIN.
CC   -!- SIMILARITY: BELONGS TO THE CSF-1/PDGF RECEPTOR FAMILY OF TYROSINE-
CC       PROTEIN KINASES.
CC   -!- SIMILARITY: BELONGS TO THE IMMUNOGLOBULIN SUPERFAMILY. THE
CC       EXTRACELLULAR DOMAIN CONTAINS FIVE IG-FOLD DOMAINS.
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DR   EMBL; M21574; G189734; -.
DR   EMBL; M22734; G189726; -.
DR   PIR; A40162; PFHUGA.
DR   MIM; 173490; -.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
DR   PROSITE; PS00240; RECEPTOR_TYR_KIN_III; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PFAM; PF00047; ig; 2.
DR   PFAM; PF00069; pkinase; 2.
DR   HSSP; P11362; 1AGW.
KW   TYROSINE-PROTEIN KINASE; RECEPTOR; TRANSMEMBRANE; GLYCOPROTEIN;
KW   TRANSFERASE; PHOSPHORYLATION; ATP-BINDING; IMMUNOGLOBULIN FOLD;
KW   SIGNAL.
FT   SIGNAL        1     23
FT   CHAIN        24   1089       ALPHA PLATELET-DERIVED GROWTH FACTOR
FT                                RECEPTOR.
FT   DOMAIN       24    524       EXTRACELLULAR (POTENTIAL).
FT   TRANSMEM    525    549       POTENTIAL.
FT   DOMAIN      550   1089       CYTOPLASMIC (POTENTIAL).
FT   DOMAIN      593    954       PROTEIN KINASE.
FT   DOMAIN     1041   1087       SER-RICH.
FT   NP_BIND     599    607       ATP (BY SIMILARITY).
FT   BINDING     627    627       ATP (BY SIMILARITY).
FT   ACT_SITE    818    818       BY SIMILARITY.
FT   MOD_RES     849    849       PHOSPHORYLATION (AUTO-) (BY SIMILARITY).
FT   CARBOHYD     42     42       POTENTIAL.
FT   CARBOHYD     76     76       POTENTIAL.
FT   CARBOHYD    103    103       POTENTIAL.
FT   CARBOHYD    179    179       POTENTIAL.
FT   CARBOHYD    353    353       POTENTIAL.
FT   CARBOHYD    359    359       POTENTIAL.
FT   CARBOHYD    458    458       POTENTIAL.
FT   CARBOHYD    468    468       POTENTIAL.
SQ   SEQUENCE   1089 AA;  122669 MW;  43E6902A CRC32;
     MGTSHPAFLV LGCLLTGLSL ILCQLSLPSI LPNENEKVVQ LNSSFSLRCF GESEVSWQYP
     MSEEESSDVE IRNEENNSGL FVTVLEVSSA SAAHTGLYTC YYNHTQTEEN ELEGRHIYIY
     VPDPDVAFVP LGMTDYLVIV EDDDSAIIPC RTTDPETPVT LHNSEGVVPA SYDSRQGFNG
     TFTVGPYICE ATVKGKKFQT IPFNVYALKA TSELDLEMEA LKTVYKSGET IVVTCAVFNN
     EVVDLQWTYP GEVKGKGITM LEEIKVPSIK LVYTLTVPEA TVKDSGDYEC AARQATREVK
     EMKKVTISVH EKGFIEIKPT FSQLEAVNLH EVKHFVVEVR AYPPPRISWL KNNLTLIENL
     TEITTDVEKI QEIRYRSKLK LIRAKEEDSG HYTIVAQNED AVKSYTFELL TQVPSSILDL
     VDDHHGSTGG QTVRCTAEGT PLPDIEWMIC KDIKKCNNET SWTILANNVS NIITEIHSRD
     RSTVEGRVTF AKVEETIAVR CLAKNLLGAE NRELKLVAPT LRSELTVAAA VLVLLVIVII
     SLIVLVVIWK QKPRYEIRWR VIESISPDGH EYIYVDPMQL PYDSRWEFPR DGLVLGRVLG
     SGAFGKVVEG TAYGLSRSQP VMKVAVKMLK PTARSSEKQA LMSELKIMTH LGPHLNIVNL
     LGACTKSGPI YIITEYCFYG DLVNYLHKNR DSFLSHHPEK PKKELDIFGL NPADESTRSY
     VILSFENNGD YMDMKQADTT QYVPMLERKE VSKYSDIQRS LYDRPASYKK KSMLDSEVKN
     LLSDDNSEGL TLLDLLSFTY QVARGMEFLA SKNCVHRDLA ARNVLLAQGK IVKICDFGLA
     RDIMHDSNYV SKGSTFLPVK WMAPESIFDN LYTTLSDVWS YGILLWEIFS LGGTPYPGMM
     VDSTFYNKIK SGYRMAKPDH ATSEVYEIMV KCWNSEPEKR PSFYHLSEIV ENLLPGQYKK
     SYEKIHLDFL KSDHPAVARM RVDSDNAYIG VTYKNEEDKL KDWEGGLDEQ RLSADSGYII
     PLPDIDPVPE EEDLGKRNRH SSQTSEESAI ETGSSSSTFI KREDETIEDI DMMDDIGIDS
     SDLVEDSFL
//