ID   PGDS$HUMAN     STANDARD;      PRT;  1089 AA.
AC   P16234;
DT   01-APR-1990  (REL. 14, CREATED)
DT   01-APR-1990  (REL. 14, LAST SEQUENCE UPDATE)
DT   01-APR-1990  (REL. 14, LAST ANNOTATION UPDATE)
DE   PLATELET-DERIVED GROWTH FACTOR RECEPTOR BETA PRECURSOR (EC 2.7.1.112).
OS   HUMAN (HOMO SAPIENS).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; MAMMALIA;
OC   EUTHERIA; PRIMATES.
RN   [1] (SEQUENCE FROM N.A.)
RA   MATSUI T., HEIDARAN M., MIKI T., POPESCU N., LA ROCHELLE W.,
RA   KRAUS M., PIERCE J., AARONSON S.;
RL   SCIENCE 243:800-804(1989).
CC   -!- FUNCTION: THIS RECEPTOR BINDS PLATELET-DERIVED GROWTH FACTOR AND
CC       HAS A TYROSINE-PROTEIN KINASE ACTIVITY.
CC   -!- SIMILARITY: BELONGS TO THE CSF-1/PDGF RECEPTOR FAMILY OF TYROSINE-
CC       PROTEIN KINASES.
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DR   EMBL; M21574; M21574.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP.
DR   PROSITE; PS00109; PROTEIN_KINASE_TYR.
DR   PROSITE; PS00240; RECEPTOR_TYR_KIN_III.
KW   TYROSINE-PROTEIN KINASE; RECEPTOR; TRANSMEMBRANE; GLYCOPROTEIN;
KW   TRANSFERASE; PHOSPHORYLATION; ATP-BINDING; SIGNAL.
FT   SIGNAL        1     24
FT   CHAIN        25   1089       PDGF RECEPTOR.
FT   DOMAIN       25    526       EXTRACELLULAR (PUTATIVE).
FT   TRANSMEM    527    549       PUTATIVE.
FT   DOMAIN      550   1089       CYTOPLASMIC (CATALYTIC).
FT   NP_BIND     599    607       ATP (BY SIMILARITY).
FT   BINDING     627    627       ATP (BY SIMILARITY).
FT   MOD_RES     849    849       PHOSPHORYLATION (AUTO-) (BY SIMILARITY).
FT   CARBOHYD     42     42       POTENTIAL.
FT   CARBOHYD     76     76       POTENTIAL.
FT   CARBOHYD    103    103       POTENTIAL.
FT   CARBOHYD    179    179       POTENTIAL.
FT   CARBOHYD    353    353       POTENTIAL.
FT   CARBOHYD    359    359       POTENTIAL.
FT   CARBOHYD    458    458       POTENTIAL.
FT   CARBOHYD    468    468       POTENTIAL.
SQ   SEQUENCE   1089 AA;  122668 MW;  6396990 CN;
     MGTSHPAFLV LGCLLTGLSL ILCQLSLPSI LPNENEKVVQ LNSSFSLRCF GESEVSWQYP
     MSEEESSDVE IRNEENNSGL FVTVLEVSSA SAAHTGLYTC YYNHTQTEEN ELEGRHIYIY
     VPDPDVAFVP LGMTDYLVIV EDDDSAIIPC RTTDPETPVT LHNSEGVVPA SYDSRQGFNG
     TFTVGPYICE ATVKGKKFQT IPFNVYALKA TSELDLEMEA LKTVYKSGET IVVTCAVFNN
     EVVDLQWTYP GEVKGKGITM LEEIKVPSIK LVYTLTVPEA TVKDSGDYEC AARQATREVK
     EMKKVTISVH EKGFIEIKPT FSQLEAVNLH EVKHFVVEVR AYPPPRISWL KNNLTLIENL
     TEITTDVEKI QEIRYRSKLK LIRAKEEDSG HYTIVAQNED AVKSYTFELL TQVPSSILDL
     VDDHHGSTGG QTVRCTAEGT PLPDIEWMIC KDIKKCNNET SWTILANNVS NIITEIHSRD
     RSTVEGRVTF AKVEETIAVR CLAKNLLGAE NRELKLVAPT LRSELTVAAA VLVLLVIVII
     SLIVLVVIWK QKPRYEIRWR VIESISPDGH EYIYVDPMQL PYDSRWEFPR DGLVLGRVLG
     SGAFGKVVEG TAYGLSRSQP VMKVAVKMLK PTARSSEKQA LMSELKIMTH LGPHLNIVNL
     LGACTKSGPI YIITEYCFYG DLVNYLHKNR DSFLSHHPEK PKKELDIFGL NPADESTRSY
     VILSFENNGD YMDMKQADTT QYVPMLERKE VSKYSDIQRS LYDRPASYKK KSMLDSEVKN
     LLSDDNSEGL TLLDLLSFTY QVARGMEFLA SKNCVHRDLA ARNVLLAQGK IVKICDFGLA
     RDIMHDSNYV SKGSTFLPVK WMAPESIFDN LYTTLSDVWS YGILLWEIFS LGGTPYPGMM
     VDSTFYNKIK SGYRMAKPDH ATSEVYEIMV KCWNSEPEKR PSFYHLSEIV ENLLPGQYKK
     SYEKIHLDFL KSDHPAVARM RVDSDNAYIG VTYKNEEDKL KDWEGGLDEQ RLSADSGYII
     PLPDIDPVPE EEDLGKRNRH SSQTSEESAI ETGSSSSTFI KREDETIEDI DMMDDIGIDS
     SDLVEDSFL
//