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Protein

Pancreatic triacylglycerol lipase

Gene

PNLIP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Triacylglycerol + H2O = diacylglycerol + a carboxylate.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei169Nucleophile1
Active sitei193Charge relay system1
Metal bindingi204Calcium; via carbonyl oxygen1
Metal bindingi207Calcium; via carbonyl oxygen1
Metal bindingi209Calcium1
Metal bindingi212Calcium1
Active sitei280Charge relay system1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid degradation, Lipid metabolism

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

BioCyciMetaCyc:HS10947-MONOMER.
ZFISH:HS10947-MONOMER.
ReactomeiR-HSA-192456. Digestion of dietary lipid.
R-HSA-975634. Retinoid metabolism and transport.
SABIO-RKP16233.

Protein family/group databases

ESTHERihuman-PNLIP. Pancreatic_lipase.

Chemistry databases

SwissLipidsiSLP:000000529.

Names & Taxonomyi

Protein namesi
Recommended name:
Pancreatic triacylglycerol lipase (EC:3.1.1.3)
Short name:
PL
Short name:
PTL
Short name:
Pancreatic lipase
Gene namesi
Name:PNLIP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:9155. PNLIP.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi5406.
MalaCardsiPNLIP.
MIMi246600. gene+phenotype.
OpenTargetsiENSG00000175535.
PharmGKBiPA33478.

Chemistry databases

ChEMBLiCHEMBL1812.
DrugBankiDB08909. Glycerol Phenylbutyrate.
DB01083. Orlistat.
GuidetoPHARMACOLOGYi2590.

Polymorphism and mutation databases

BioMutaiPNLIP.
DMDMi126318.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16Add BLAST16
ChainiPRO_000001778517 – 465Pancreatic triacylglycerol lipaseAdd BLAST449

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi20 ↔ 26
Disulfide bondi107 ↔ 118
Glycosylationi183N-linked (GlcNAc...)1
Disulfide bondi254 ↔ 278
Disulfide bondi302 ↔ 313
Disulfide bondi316 ↔ 321
Disulfide bondi449 ↔ 465

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP16233.
PeptideAtlasiP16233.
PRIDEiP16233.

PTM databases

iPTMnetiP16233.
PhosphoSitePlusiP16233.

Expressioni

Inductioni

By colipase/CLPS in the presence of bile salts.

Gene expression databases

BgeeiENSG00000175535.
CleanExiHS_PNLIP.
GenevisibleiP16233. HS.

Organism-specific databases

HPAiHPA062430.
HPA062494.

Interactioni

Protein-protein interaction databases

BioGridi111407. 10 interactors.
IntActiP16233. 1 interactor.
MINTiMINT-1179407.
STRINGi9606.ENSP00000358223.

Chemistry databases

BindingDBiP16233.

Structurei

Secondary structure

1465
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi18 – 21Combined sources4
Turni22 – 24Combined sources3
Beta strandi25 – 28Combined sources4
Turni31 – 33Combined sources3
Beta strandi34 – 38Combined sources5
Helixi48 – 51Combined sources4
Beta strandi54 – 58Combined sources5
Beta strandi60 – 65Combined sources6
Beta strandi67 – 69Combined sources3
Helixi73 – 78Combined sources6
Beta strandi87 – 91Combined sources5
Helixi101 – 110Combined sources10
Turni111 – 113Combined sources3
Beta strandi117 – 122Combined sources6
Helixi124 – 127Combined sources4
Helixi131 – 156Combined sources26
Helixi160 – 162Combined sources3
Beta strandi163 – 168Combined sources6
Helixi170 – 180Combined sources11
Turni181 – 184Combined sources4
Beta strandi186 – 193Combined sources8
Turni197 – 201Combined sources5
Turni204 – 206Combined sources3
Helixi210 – 212Combined sources3
Beta strandi216 – 219Combined sources4
Turni227 – 229Combined sources3
Beta strandi239 – 245Combined sources7
Beta strandi248 – 250Combined sources3
Helixi258 – 262Combined sources5
Helixi268 – 291Combined sources24
Turni294 – 297Combined sources4
Helixi305 – 309Combined sources5
Beta strandi323 – 325Combined sources3
Helixi328 – 330Combined sources3
Turni332 – 335Combined sources4
Beta strandi336 – 344Combined sources9
Beta strandi348 – 351Combined sources4
Beta strandi355 – 365Combined sources11
Beta strandi368 – 378Combined sources11
Beta strandi386 – 393Combined sources8
Beta strandi398 – 407Combined sources10
Beta strandi411 – 420Combined sources10
Beta strandi431 – 440Combined sources10
Beta strandi445 – 449Combined sources5
Beta strandi460 – 464Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1LPAX-ray3.04B17-465[»]
1LPBX-ray2.46B17-465[»]
1N8SX-ray3.04A17-465[»]
ProteinModelPortaliP16233.
SMRiP16233.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP16233.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini355 – 465PLATPROSITE-ProRule annotationAdd BLAST111

Sequence similaritiesi

Belongs to the AB hydrolase superfamily. Lipase family.Curated
Contains 1 PLAT domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IHRX. Eukaryota.
ENOG410Y92X. LUCA.
GeneTreeiENSGT00760000119069.
HOGENOMiHOG000038552.
HOVERGENiHBG003243.
InParanoidiP16233.
KOiK14073.
OMAiNPNNFQE.
OrthoDBiEOG091G0DJ5.
PhylomeDBiP16233.
TreeFamiTF324997.

Family and domain databases

CDDicd00707. Pancreat_lipase_like. 1 hit.
Gene3Di2.60.60.20. 1 hit.
3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR013818. Lipase/vitellogenin.
IPR016272. Lipase_LIPH.
IPR033906. Lipase_N.
IPR002331. Lipase_panc.
IPR001024. PLAT/LH2_dom.
IPR000734. TAG_lipase.
[Graphical view]
PANTHERiPTHR11610. PTHR11610. 1 hit.
PfamiPF00151. Lipase. 1 hit.
PF01477. PLAT. 1 hit.
[Graphical view]
PIRSFiPIRSF000865. Lipoprotein_lipase_LIPH. 1 hit.
PRINTSiPR00823. PANCLIPASE.
PR00821. TAGLIPASE.
SMARTiSM00308. LH2. 1 hit.
[Graphical view]
SUPFAMiSSF49723. SSF49723. 1 hit.
SSF53474. SSF53474. 1 hit.
PROSITEiPS00120. LIPASE_SER. 1 hit.
PS50095. PLAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P16233-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLPLWTLSLL LGAVAGKEVC YERLGCFSDD SPWSGITERP LHILPWSPKD
60 70 80 90 100
VNTRFLLYTN ENPNNFQEVA ADSSSISGSN FKTNRKTRFI IHGFIDKGEE
110 120 130 140 150
NWLANVCKNL FKVESVNCIC VDWKGGSRTG YTQASQNIRI VGAEVAYFVE
160 170 180 190 200
FLQSAFGYSP SNVHVIGHSL GAHAAGEAGR RTNGTIGRIT GLDPAEPCFQ
210 220 230 240 250
GTPELVRLDP SDAKFVDVIH TDGAPIVPNL GFGMSQVVGH LDFFPNGGVE
260 270 280 290 300
MPGCKKNILS QIVDIDGIWE GTRDFAACNH LRSYKYYTDS IVNPDGFAGF
310 320 330 340 350
PCASYNVFTA NKCFPCPSGG CPQMGHYADR YPGKTNDVGQ KFYLDTGDAS
360 370 380 390 400
NFARWRYKVS VTLSGKKVTG HILVSLFGNK GNSKQYEIFK GTLKPDSTHS
410 420 430 440 450
NEFDSDVDVG DLQMVKFIWY NNVINPTLPR VGASKIIVET NVGKQFNFCS
460
PETVREEVLL TLTPC
Length:465
Mass (Da):51,157
Last modified:April 1, 1990 - v1
Checksum:i2BC49CC7F0E2DF52
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05125 mRNA. Translation: AAA36740.1.
M93285 mRNA. Translation: AAA60129.1.
L24529
, L11242, L24502, L24522, L24523, L24525, L24526, L24527, L24528 Genomic DNA. Translation: AAA99053.1.
AK313941 mRNA. Translation: BAG36659.1.
AL731653 Genomic DNA. Translation: CAH72667.1.
CH471066 Genomic DNA. Translation: EAW49451.1.
BC014309 mRNA. Translation: AAH14309.1.
CCDSiCCDS7594.1.
PIRiC43357.
RefSeqiNP_000927.1. NM_000936.3.
UniGeneiHs.501135.

Genome annotation databases

EnsembliENST00000369221; ENSP00000358223; ENSG00000175535.
GeneIDi5406.
KEGGihsa:5406.
UCSCiuc001lcm.4. human.

Cross-referencesi

Web resourcesi

Wikipedia

Pancreatic lipase entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05125 mRNA. Translation: AAA36740.1.
M93285 mRNA. Translation: AAA60129.1.
L24529
, L11242, L24502, L24522, L24523, L24525, L24526, L24527, L24528 Genomic DNA. Translation: AAA99053.1.
AK313941 mRNA. Translation: BAG36659.1.
AL731653 Genomic DNA. Translation: CAH72667.1.
CH471066 Genomic DNA. Translation: EAW49451.1.
BC014309 mRNA. Translation: AAH14309.1.
CCDSiCCDS7594.1.
PIRiC43357.
RefSeqiNP_000927.1. NM_000936.3.
UniGeneiHs.501135.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1LPAX-ray3.04B17-465[»]
1LPBX-ray2.46B17-465[»]
1N8SX-ray3.04A17-465[»]
ProteinModelPortaliP16233.
SMRiP16233.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111407. 10 interactors.
IntActiP16233. 1 interactor.
MINTiMINT-1179407.
STRINGi9606.ENSP00000358223.

Chemistry databases

BindingDBiP16233.
ChEMBLiCHEMBL1812.
DrugBankiDB08909. Glycerol Phenylbutyrate.
DB01083. Orlistat.
GuidetoPHARMACOLOGYi2590.
SwissLipidsiSLP:000000529.

Protein family/group databases

ESTHERihuman-PNLIP. Pancreatic_lipase.

PTM databases

iPTMnetiP16233.
PhosphoSitePlusiP16233.

Polymorphism and mutation databases

BioMutaiPNLIP.
DMDMi126318.

Proteomic databases

PaxDbiP16233.
PeptideAtlasiP16233.
PRIDEiP16233.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000369221; ENSP00000358223; ENSG00000175535.
GeneIDi5406.
KEGGihsa:5406.
UCSCiuc001lcm.4. human.

Organism-specific databases

CTDi5406.
DisGeNETi5406.
GeneCardsiPNLIP.
HGNCiHGNC:9155. PNLIP.
HPAiHPA062430.
HPA062494.
MalaCardsiPNLIP.
MIMi246600. gene+phenotype.
neXtProtiNX_P16233.
OpenTargetsiENSG00000175535.
PharmGKBiPA33478.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IHRX. Eukaryota.
ENOG410Y92X. LUCA.
GeneTreeiENSGT00760000119069.
HOGENOMiHOG000038552.
HOVERGENiHBG003243.
InParanoidiP16233.
KOiK14073.
OMAiNPNNFQE.
OrthoDBiEOG091G0DJ5.
PhylomeDBiP16233.
TreeFamiTF324997.

Enzyme and pathway databases

BioCyciMetaCyc:HS10947-MONOMER.
ZFISH:HS10947-MONOMER.
ReactomeiR-HSA-192456. Digestion of dietary lipid.
R-HSA-975634. Retinoid metabolism and transport.
SABIO-RKP16233.

Miscellaneous databases

ChiTaRSiPNLIP. human.
EvolutionaryTraceiP16233.
GeneWikiiPancreatic_lipase.
GenomeRNAii5406.
PROiP16233.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000175535.
CleanExiHS_PNLIP.
GenevisibleiP16233. HS.

Family and domain databases

CDDicd00707. Pancreat_lipase_like. 1 hit.
Gene3Di2.60.60.20. 1 hit.
3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR013818. Lipase/vitellogenin.
IPR016272. Lipase_LIPH.
IPR033906. Lipase_N.
IPR002331. Lipase_panc.
IPR001024. PLAT/LH2_dom.
IPR000734. TAG_lipase.
[Graphical view]
PANTHERiPTHR11610. PTHR11610. 1 hit.
PfamiPF00151. Lipase. 1 hit.
PF01477. PLAT. 1 hit.
[Graphical view]
PIRSFiPIRSF000865. Lipoprotein_lipase_LIPH. 1 hit.
PRINTSiPR00823. PANCLIPASE.
PR00821. TAGLIPASE.
SMARTiSM00308. LH2. 1 hit.
[Graphical view]
SUPFAMiSSF49723. SSF49723. 1 hit.
SSF53474. SSF53474. 1 hit.
PROSITEiPS00120. LIPASE_SER. 1 hit.
PS50095. PLAT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLIPP_HUMAN
AccessioniPrimary (citable) accession number: P16233
Secondary accession number(s): Q5VSQ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: November 30, 2016
This is version 176 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.