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P16220

- CREB1_HUMAN

UniProt

P16220 - CREB1_HUMAN

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Protein
Cyclic AMP-responsive element-binding protein 1
Gene
CREB1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-133 phosphorylation. Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei314 – 3141Required for binding TORCs

GO - Molecular functioni

  1. RNA polymerase II activating transcription factor binding Source: BHF-UCL
  2. RNA polymerase II distal enhancer sequence-specific DNA binding Source: BHF-UCL
  3. RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity Source: BHF-UCL
  4. RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription Source: BHF-UCL
  5. cAMP response element binding Source: BHF-UCL
  6. enzyme binding Source: UniProt
  7. protein binding Source: UniProtKB
  8. sequence-specific DNA binding transcription factor activity Source: MGI
  9. transcription cofactor activity Source: ProtInc

GO - Biological processi

  1. Fc-epsilon receptor signaling pathway Source: Reactome
  2. MyD88-dependent toll-like receptor signaling pathway Source: Reactome
  3. MyD88-independent toll-like receptor signaling pathway Source: Reactome
  4. Notch signaling pathway Source: Reactome
  5. TRIF-dependent toll-like receptor signaling pathway Source: Reactome
  6. Type I pneumocyte differentiation Source: Ensembl
  7. activation of phospholipase C activity Source: Reactome
  8. axon guidance Source: Reactome
  9. circadian rhythm Source: UniProtKB
  10. epidermal growth factor receptor signaling pathway Source: Reactome
  11. fibroblast growth factor receptor signaling pathway Source: Reactome
  12. innate immune response Source: Reactome
  13. lactation Source: Ensembl
  14. lung saccule development Source: Ensembl
  15. negative regulation of transcription by competitive promoter binding Source: BHF-UCL
  16. neurotrophin TRK receptor signaling pathway Source: Reactome
  17. phosphatidylinositol-mediated signaling Source: Reactome
  18. pituitary gland development Source: Ensembl
  19. positive regulation of fat cell differentiation Source: UniProtKB
  20. positive regulation of hormone secretion Source: Ensembl
  21. positive regulation of lipid biosynthetic process Source: UniProtKB
  22. positive regulation of multicellular organism growth Source: Ensembl
  23. positive regulation of osteoclast differentiation Source: Ensembl
  24. positive regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  25. positive regulation of transcription, DNA-templated Source: UniProtKB
  26. protein phosphorylation Source: MGI
  27. protein stabilization Source: UniProtKB
  28. regulation of cell size Source: Ensembl
  29. response to drug Source: Ensembl
  30. response to glucagon Source: UniProtKB
  31. response to organic substance Source: MGI
  32. secretory granule organization Source: Ensembl
  33. signal transduction Source: Reactome
  34. stress-activated MAPK cascade Source: Reactome
  35. synaptic transmission Source: Reactome
  36. toll-like receptor 10 signaling pathway Source: Reactome
  37. toll-like receptor 2 signaling pathway Source: Reactome
  38. toll-like receptor 3 signaling pathway Source: Reactome
  39. toll-like receptor 4 signaling pathway Source: Reactome
  40. toll-like receptor 5 signaling pathway Source: Reactome
  41. toll-like receptor 9 signaling pathway Source: Reactome
  42. toll-like receptor TLR1:TLR2 signaling pathway Source: Reactome
  43. toll-like receptor TLR6:TLR2 signaling pathway Source: Reactome
  44. toll-like receptor signaling pathway Source: Reactome
  45. transcription from RNA polymerase II promoter Source: GOC
  46. viral process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Biological rhythms, Differentiation, Host-virus interaction, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiREACT_120966. Gastrin-CREB signalling pathway via PKC and MAPK.
REACT_12442. AKT phosphorylates targets in the nucleus.
REACT_12524. CREB phosphorylation.
REACT_147727. Constitutive PI3K/AKT Signaling in Cancer.
REACT_15497. PKA-mediated phosphorylation of CREB.
REACT_15502. CaMK IV-mediated phosphorylation of CREB.
REACT_163910. NOTCH2 intracellular domain regulates transcription.
REACT_18334. NCAM signaling for neurite out-growth.
REACT_200608. Transcriptional activation of mitochondrial biogenesis.
REACT_20568. CREB phosphorylation through the activation of Ras.
REACT_20625. CREB phosphorylation through the activation of Adenylate Cyclase.
REACT_20642. CREB phosphorylation through the activation of CaMKII.
REACT_20661. CREB phosphorylation through the activation of CaMKK.
REACT_24941. Circadian Clock.
SignaLinkiP16220.

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclic AMP-responsive element-binding protein 1
Short name:
CREB-1
Short name:
cAMP-responsive element-binding protein 1
Gene namesi
Name:CREB1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:2345. CREB1.

Subcellular locationi

Nucleus 1 Publication

GO - Cellular componenti

  1. nuclear euchromatin Source: BHF-UCL
  2. nucleoplasm Source: Reactome
  3. nucleus Source: HPA
  4. transcription factor complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

Angiomatoid fibrous histiocytoma (AFH) [MIM:612160]: A distinct variant of malignant fibrous histiocytoma that typically occurs in children and adolescents and is manifest by nodular subcutaneous growth. Characteristic microscopic features include lobulated sheets of histiocyte-like cells intimately associated with areas of hemorrhage and cystic pseudovascular spaces, as well as a striking cuffing of inflammatory cells, mimicking a lymph node metastasis.
Note: The gene represented in this entry may be involved in disease pathogenesis. A chromosomal aberration involving CREB1 is found in a patient with angiomatoid fibrous histiocytoma. Translocation t(2;22)(q33;q12) with CREB1 generates a EWSR1/CREB1 fusion gene that is most common genetic abnormality in this tumor type.
A CREB1 mutation has been found in a patient with multiple congenital anomalies consisting of agenesis of the corpus callosum, cerebellar hypoplasia, severe neonatal respiratory distress refractory to surfactant, thymus hypoplasia, and thyroid follicular hypoplasia (1 Publication).

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi133 – 1331S → A: Does not interact with TOX3 and inhibits induction of transcription by TOX3. Loss of phosphorylation by CaMK4. 2 Publications
Mutagenesisi155 – 1551K → R: No effect on sumoylation. 1 Publication
Mutagenesisi271 – 2711S → A: Impaired phosphorylation by HIPK2 and subsequent transactivation. 1 Publication
Mutagenesisi271 – 2711S → E: Potentiated transactivation. 1 Publication
Mutagenesisi285 – 2851K → R: Decreased sumoylation, in vivo and in vitro. 1 Publication
Mutagenesisi304 – 3041K → R: Decreased sumoylation, in vivo and in vitro. Loss of nuclear localization. 1 Publication

Organism-specific databases

MIMi612160. phenotype.
Orphaneti97338. Melanoma of soft parts.
PharmGKBiPA26864.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 341341Cyclic AMP-responsive element-binding protein 1
PRO_0000076597Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei133 – 1331Phosphoserine; by CaMK1, CaMK2, CaMK4, PKB/AKT1 or PKB/AKT2, RPS6KA3, RPS6KA4, RPS6KA5 and SGK15 Publications
Modified residuei142 – 1421Phosphoserine; by CaMK2 By similarity
Modified residuei271 – 2711Phosphoserine; by HIPK21 Publication
Cross-linki285 – 285Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)1 Publication
Cross-linki304 – 304Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)1 Publication

Post-translational modificationi

Stimulated by phosphorylation. Phosphorylation of both Ser-133 and Ser-142 in the SCN regulates the activity of CREB and participates in circadian rhythm generation. Phosphorylation of Ser-133 allows CREBBP binding. In liver, phosphorylation is induced by fasting or glucagon in a circadian fashion By similarity. CREBL2 positively regulates phosphorylation at Ser-133 thereby stimulating CREB1 transcriptional activity By similarity. Phosphorylated upon calcium influx by CaMK4 and CaMK2 on Ser-133. CaMK4 is much more potent than CaMK2 in activating CREB. Phosphorylated by CaMK2 on Ser-142. Phosphorylation of Ser-142 blocks CREB-mediated transcription even when Ser-133 is phosphorylated. Phosphorylated by CaMK1 By similarity. Phosphorylation of Ser-271 by HIPK2 in response to genotoxic stress promotes CREB1 activity, facilitating the recruitment of the coactivator CBP. Phosphorylated at Ser-133 by RPS6KA3, RPS6KA4 and RPS6KA5 in response to mitogenic or stress stimuli.6 Publications
Sumoylated with SUMO1. Sumoylation on Lys-304, but not on Lys-285, is required for nuclear localization of this protein. Sumoylation is enhanced under hypoxia, promoting nuclear localization and stabilization.1 Publication

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiP16220.
PaxDbiP16220.
PRIDEiP16220.

PTM databases

PhosphoSiteiP16220.

Miscellaneous databases

PMAP-CutDBP16220.

Expressioni

Gene expression databases

ArrayExpressiP16220.
BgeeiP16220.
CleanExiHS_CREB1.
GenevestigatoriP16220.

Organism-specific databases

HPAiCAB003803.
HPA019150.

Interactioni

Subunit structurei

Interacts with PPRC1. Binds DNA as a dimer. This dimer is stabilized by magnesium ions. Interacts, through the bZIP domain, with the coactivators TORC1/CRTC1, TORC2/CRTC2 and TORC3/CRTC3. When phosphorylated on Ser-133, binds CREBBP By similarity. Interacts with CREBL2; regulates CREB1 phosphorylation, stability and transcriptional activity By similarity. Interacts (phosphorylated form) with TOX3. Interacts with ARRB1. Binds to HIPK2. Interacts with SGK1.10 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
P03259-22EBI-711855,EBI-7225021From a different organism.
CREBBPQ927932EBI-711855,EBI-81215
EP300Q094722EBI-711855,EBI-447295
MEIS1O004709EBI-711855,EBI-1210694
PASKQ96RG22EBI-711855,EBI-1042651
TSSK4Q6SA085EBI-711855,EBI-1202583

Protein-protein interaction databases

BioGridi107775. 91 interactions.
DIPiDIP-765N.
IntActiP16220. 36 interactions.
MINTiMINT-1338714.
STRINGi9606.ENSP00000387699.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi120 – 1289
Helixi132 – 14211

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2LXTNMR-C116-149[»]
ProteinModelPortaliP16220.
SMRiP16220. Positions 116-149, 285-339.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini101 – 16060KID
Add
BLAST
Domaini283 – 34159bZIP
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni284 – 30926Basic motif By similarity
Add
BLAST
Regioni311 – 33222Leucine-zipper By similarity
Add
BLAST

Sequence similaritiesi

Belongs to the bZIP family.

Phylogenomic databases

eggNOGiNOG300199.
HOGENOMiHOG000007365.
HOVERGENiHBG011077.
InParanoidiP16220.
KOiK05870.
OMAiQXISTIA.
OrthoDBiEOG72G18D.
PhylomeDBiP16220.
TreeFamiTF106464.

Family and domain databases

InterProiIPR004827. bZIP.
IPR003102. Coactivator_CBP_pKID.
IPR001630. Leuzip_CREB.
[Graphical view]
PfamiPF00170. bZIP_1. 1 hit.
PF02173. pKID. 1 hit.
[Graphical view]
PRINTSiPR00041. LEUZIPPRCREB.
SMARTiSM00338. BRLZ. 1 hit.
[Graphical view]
PROSITEiPS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
PS50953. KID. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform CREB-A (identifier: P16220-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MTMESGAENQ QSGDAAVTEA ENQQMTVQAQ PQIATLAQVS MPAAHATSSA    50
PTVTLVQLPN GQTVQVHGVI QAAQPSVIQS PQVQTVQSSC KDLKRLFSGT 100
QISTIAESED SQESVDSVTD SQKRREILSR RPSYRKILND LSSDAPGVPR 150
IEEEKSEEET SAPAITTVTV PTPIYQTSSG QYIAITQGGA IQLANNGTDG 200
VQGLQTLTMT NAAATQPGTT ILQYAQTTDG QQILVPSNQV VVQAASGDVQ 250
TYQIRTAPTS TIAPGVVMAS SPALPTQPAE EAARKREVRL MKNREAAREC 300
RRKKKEYVKC LENRVAVLEN QNKTLIEELK ALKDLYCHKS D 341
Length:341
Mass (Da):36,688
Last modified:May 1, 1992 - v2
Checksum:iD5E989AE40BF69AF
GO
Isoform CREB-B (identifier: P16220-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     88-101: Missing.

Show »
Length:327
Mass (Da):35,136
Checksum:iF5BA8200EE5184B7
GO
Isoform 3 (identifier: P16220-3) [UniParc]FASTAAdd to Basket

Also known as: htCREB

The sequence of this isoform differs from the canonical sequence as follows:
     162-272: Missing.

Note: Highly expressed in adult testis and sperm.

Show »
Length:230
Mass (Da):25,445
Checksum:i9FD8CA28F7632FBD
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti116 – 1161D → G Found in a patient with multiple congenital anomalies; does not affect CREB1 phosphorylation at S-133; fails to interact with CREBBP. 1 Publication
VAR_068077

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei88 – 10114Missing in isoform CREB-B.
VSP_000596Add
BLAST
Alternative sequencei162 – 272111Missing in isoform 3.
VSP_043914Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti4 – 41E → D in CAA42620. 1 Publication
Sequence conflicti8 – 81E → D in CAA42620. 1 Publication
Sequence conflicti160 – 1601T → A in CAA42620. 1 Publication
Sequence conflicti167 – 1671T → A in CAA42620. 1 Publication
Sequence conflicti169 – 1691T → A in CAA42620. 1 Publication
Sequence conflicti176 – 1761Q → R in CAA42620. 1 Publication
Sequence conflicti184 – 1841A → T in CAA42620. 1 Publication
Sequence conflicti188 – 1881G → R in CAA42620. 1 Publication
Sequence conflicti195 – 1951N → S in CAA42620. 1 Publication
Sequence conflicti210 – 2101T → A in CAA42620. 1 Publication
Sequence conflicti292 – 2921K → E in AAQ24858. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S72459 Genomic DNA. Translation: AAB20597.1.
X55545 mRNA. Translation: CAA39151.1.
M34356 mRNA. Translation: AAA35717.1.
M34356 mRNA. Translation: AAA35716.1.
M27691 mRNA. Translation: AAA35715.1.
X60003 mRNA. Translation: CAA42620.1.
AY347527 mRNA. Translation: AAQ24858.1.
BC010636 mRNA. Translation: AAH10636.1.
S53724 Genomic DNA. Translation: AAD13869.1.
CCDSiCCDS2374.1. [P16220-2]
CCDS2375.1. [P16220-1]
PIRiA37340. A35769.
B37340. B35769.
S22298.
RefSeqiNP_004370.1. NM_004379.3. [P16220-2]
NP_604391.1. NM_134442.3. [P16220-1]
UniGeneiHs.516646.

Genome annotation databases

EnsembliENST00000353267; ENSP00000236995; ENSG00000118260. [P16220-2]
ENST00000374397; ENSP00000363518; ENSG00000118260. [P16220-3]
ENST00000430624; ENSP00000405539; ENSG00000118260. [P16220-2]
ENST00000432329; ENSP00000387699; ENSG00000118260. [P16220-1]
GeneIDi1385.
KEGGihsa:1385.
UCSCiuc002vcc.3. human. [P16220-1]

Polymorphism databases

DMDMi117434.

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S72459 Genomic DNA. Translation: AAB20597.1 .
X55545 mRNA. Translation: CAA39151.1 .
M34356 mRNA. Translation: AAA35717.1 .
M34356 mRNA. Translation: AAA35716.1 .
M27691 mRNA. Translation: AAA35715.1 .
X60003 mRNA. Translation: CAA42620.1 .
AY347527 mRNA. Translation: AAQ24858.1 .
BC010636 mRNA. Translation: AAH10636.1 .
S53724 Genomic DNA. Translation: AAD13869.1 .
CCDSi CCDS2374.1. [P16220-2 ]
CCDS2375.1. [P16220-1 ]
PIRi A37340. A35769.
B37340. B35769.
S22298.
RefSeqi NP_004370.1. NM_004379.3. [P16220-2 ]
NP_604391.1. NM_134442.3. [P16220-1 ]
UniGenei Hs.516646.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2LXT NMR - C 116-149 [» ]
ProteinModelPortali P16220.
SMRi P16220. Positions 116-149, 285-339.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 107775. 91 interactions.
DIPi DIP-765N.
IntActi P16220. 36 interactions.
MINTi MINT-1338714.
STRINGi 9606.ENSP00000387699.

Chemistry

ChEMBLi CHEMBL5587.
DrugBanki DB00131. Adenosine monophosphate.
DB01200. Bromocriptine.
DB01183. Naloxone.

PTM databases

PhosphoSitei P16220.

Polymorphism databases

DMDMi 117434.

Proteomic databases

MaxQBi P16220.
PaxDbi P16220.
PRIDEi P16220.

Protocols and materials databases

DNASUi 1385.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000353267 ; ENSP00000236995 ; ENSG00000118260 . [P16220-2 ]
ENST00000374397 ; ENSP00000363518 ; ENSG00000118260 . [P16220-3 ]
ENST00000430624 ; ENSP00000405539 ; ENSG00000118260 . [P16220-2 ]
ENST00000432329 ; ENSP00000387699 ; ENSG00000118260 . [P16220-1 ]
GeneIDi 1385.
KEGGi hsa:1385.
UCSCi uc002vcc.3. human. [P16220-1 ]

Organism-specific databases

CTDi 1385.
GeneCardsi GC02P208394.
HGNCi HGNC:2345. CREB1.
HPAi CAB003803.
HPA019150.
MIMi 123810. gene.
612160. phenotype.
neXtProti NX_P16220.
Orphaneti 97338. Melanoma of soft parts.
PharmGKBi PA26864.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG300199.
HOGENOMi HOG000007365.
HOVERGENi HBG011077.
InParanoidi P16220.
KOi K05870.
OMAi QXISTIA.
OrthoDBi EOG72G18D.
PhylomeDBi P16220.
TreeFami TF106464.

Enzyme and pathway databases

Reactomei REACT_120966. Gastrin-CREB signalling pathway via PKC and MAPK.
REACT_12442. AKT phosphorylates targets in the nucleus.
REACT_12524. CREB phosphorylation.
REACT_147727. Constitutive PI3K/AKT Signaling in Cancer.
REACT_15497. PKA-mediated phosphorylation of CREB.
REACT_15502. CaMK IV-mediated phosphorylation of CREB.
REACT_163910. NOTCH2 intracellular domain regulates transcription.
REACT_18334. NCAM signaling for neurite out-growth.
REACT_200608. Transcriptional activation of mitochondrial biogenesis.
REACT_20568. CREB phosphorylation through the activation of Ras.
REACT_20625. CREB phosphorylation through the activation of Adenylate Cyclase.
REACT_20642. CREB phosphorylation through the activation of CaMKII.
REACT_20661. CREB phosphorylation through the activation of CaMKK.
REACT_24941. Circadian Clock.
SignaLinki P16220.

Miscellaneous databases

GeneWikii CREB1.
GenomeRNAii 1385.
NextBioi 5625.
PMAP-CutDB P16220.
PROi P16220.
SOURCEi Search...

Gene expression databases

ArrayExpressi P16220.
Bgeei P16220.
CleanExi HS_CREB1.
Genevestigatori P16220.

Family and domain databases

InterProi IPR004827. bZIP.
IPR003102. Coactivator_CBP_pKID.
IPR001630. Leuzip_CREB.
[Graphical view ]
Pfami PF00170. bZIP_1. 1 hit.
PF02173. pKID. 1 hit.
[Graphical view ]
PRINTSi PR00041. LEUZIPPRCREB.
SMARTi SM00338. BRLZ. 1 hit.
[Graphical view ]
PROSITEi PS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
PS50953. KID. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Two distinct forms of active transcription factor CREB (cAMP response element binding protein)."
    Berkowitz L.A., Gilman M.Z.
    Proc. Natl. Acad. Sci. U.S.A. 87:5258-5262(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM CREB-A).
  2. "Multiple cDNA clones encoding nuclear proteins that bind to the tax-dependent enhancer of HTLV-1: all contain a leucine zipper structure and basic amino acid domain."
    Yoshimura T., Fujisawa J., Yoshida M.
    EMBO J. 9:2537-2542(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM CREB-A).
  3. "Diversification of cyclic AMP-responsive enhancer binding proteins-generated by alternative exon splicing."
    Waeber G., Meyer T.E., Hoeffler J.P., Habener J.F.
    Trans. Assoc. Am. Physicians 103:28-37(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM CREB-A).
  4. "Cyclic AMP-responsive DNA-binding protein: structure based on a cloned placental cDNA."
    Hoeffler J.P., Meyer T.E., Yun Y., Jameson J.L., Habener J.F.
    Science 242:1430-1433(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM CREB-B).
  5. "Nucleotide and derived amino-acid sequences of the CRE-binding proteins from rat C6 glioma and HeLa cells."
    Short M.L., Manohar C.F., Furtado M.R., Ghadge G.D., Wolinsky S.M., Thimmapaya B., Jungmann R.A.
    Nucleic Acids Res. 19:4290-4290(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM CREB-B).
  6. "Cloning and expression of a novel CREB mRNA splice variant in human testis."
    Huang X., Zhang J., Lu L., Yin L., Xu M., Wang Y., Zhou Z., Sha J.
    Reproduction 128:775-782(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
    Tissue: Testis.
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM CREB-A).
    Tissue: Eye.
  8. "The promoter of the gene encoding 3',5'-cyclic adenosine monophosphate (cAMP) response element binding protein contains cAMP response elements: evidence for positive autoregulation of gene transcription."
    Meyer T.E., Waeber G., Lin J., Beckmann W., Habener J.F.
    Endocrinology 132:770-780(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-8.
  9. "HBV X protein alters the DNA binding specificity of CREB and ATF-2 by protein-protein interactions."
    Maguire H.F., Hoeffler J.P., Siddiqui A.
    Science 252:842-844(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH HBV PROTEIN X.
  10. "Human T-cell lymphotropic virus type I (HTLV-I) transcriptional activator, Tax, enhances CREB binding to HTLV-I 21-base-pair repeats by protein-protein interaction."
    Zhao L.J., Giam C.-Z.
    Proc. Natl. Acad. Sci. U.S.A. 89:7070-7074(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH HTLV-1 TAX-1.
  11. "Calcium/calmodulin-dependent protein kinase types II and IV differentially regulate CREB-dependent gene expression."
    Matthews R.P., Guthrie C.R., Wailes L.M., Zhao X., Means A.R., McKnight G.S.
    Mol. Cell. Biol. 14:6107-6116(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION AT SER-133, MUTAGENESIS OF SER-133.
  12. "Transcriptional activation of egr-1 by granulocyte-macrophage colony-stimulating factor but not interleukin 3 requires phosphorylation of cAMP response element-binding protein (CREB) on serine 133."
    Lee H.-J.J., Mignacca R.C., Sakamoto K.M.
    J. Biol. Chem. 270:15979-15983(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION AT SER-133.
  13. "CREB is a regulatory target for the protein kinase Akt/PKB."
    Du K., Montminy M.
    J. Biol. Chem. 273:32377-32379(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION AT SER-133.
  14. "Rsk-2 activity is necessary for epidermal growth factor-induced phosphorylation of CREB protein and transcription of c-fos gene."
    De Cesare D., Jacquot S., Hanauer A., Sassone-Corsi P.
    Proc. Natl. Acad. Sci. U.S.A. 95:12202-12207(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION AT SER-133.
  15. Cited for: INTERACTION WITH CRTC1.
  16. "Small ubiquitin-related modifier-1 modification mediates resolution of CREB-dependent responses to hypoxia."
    Comerford K.M., Leonard M.O., Karhausen J., Carey R., Colgan S.P., Taylor C.T.
    Proc. Natl. Acad. Sci. U.S.A. 100:986-991(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUMOYLATION AT LYS-285 AND LYS-304, SUBCELLULAR LOCATION, MUTAGENESIS OF LYS-155; LYS-285 AND LYS-304.
  17. "Identification of a family of cAMP response element-binding protein coactivators by genome-scale functional analysis in mammalian cells."
    Iourgenko V., Zhang W., Mickanin C., Daly I., Jiang C., Hexham J.M., Orth A.P., Miraglia L., Meltzer J., Garza D., Chirn G.-W., McWhinnie E., Cohen D., Skelton J., Terry R., Yu Y., Bodian D., Buxton F.P.
    , Zhu J., Song C., Labow M.A.
    Proc. Natl. Acad. Sci. U.S.A. 100:12147-12152(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CRTC3.
  18. "The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector."
    Screaton R.A., Conkright M.D., Katoh Y., Best J.L., Canettieri G., Jeffries S., Guzman E., Niessen S., Yates J.R. III, Takemori H., Okamoto M., Montminy M.
    Cell 119:61-74(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CRTC2.
  19. "A nuclear function of beta-arrestin1 in GPCR signaling: regulation of histone acetylation and gene transcription."
    Kang J., Shi Y., Xiang B., Qu B., Su W., Zhu M., Zhang M., Bao G., Wang F., Zhang X., Yang R., Fan F., Chen X., Pei G., Ma L.
    Cell 123:833-847(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH ARRB1.
  20. "Serum/glucocorticoid-inducible kinase can phosphorylate the cyclic AMP response element binding protein, CREB."
    David S., Kalb R.G.
    FEBS Lett. 579:1534-1538(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION AT SER-133 BY SGK1, INTERACTION WITH SGK1.
  21. "PGC-1-related coactivator: immediate early expression and characterization of a CREB/NRF-1 binding domain associated with cytochrome c promoter occupancy and respiratory growth."
    Vercauteren K., Pasko R.A., Gleyzer N., Marino V.M., Scarpulla R.C.
    Mol. Cell. Biol. 26:7409-7419(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH PPRC1.
  22. "EWSR1-CREB1 is the predominant gene fusion in angiomatoid fibrous histiocytoma."
    Antonescu C.R., Dal Cin P., Nafa K., Teot L.A., Surti U., Fletcher C.D., Ladanyi M.
    Genes Chromosomes Cancer 46:1051-1060(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHROMOSOMAL TRANSLOCATION WITH EWSR1, ASSOCIATION WITH ANGIOMATOID FIBROUS HISTIOCYTOMA.
  23. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic kidney.
  24. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  25. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  26. "Regulation of genotoxic stress response by homeodomain-interacting protein kinase 2 through phosphorylation of cyclic AMP response element-binding protein at serine 271."
    Sakamoto K., Huang B.-W., Iwasaki K., Hailemariam K., Ninomiya-Tsuji J., Tsuji Y.
    Mol. Biol. Cell 21:2966-2974(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION AT SER-271 BY HIPK2, MUTAGENESIS OF SER-271, INTERACTION WITH HIPK2.
  27. "TOX3 is a neuronal survival factor that induces transcription depending on the presence of CITED1 or phosphorylated CREB in the transcriptionally active complex."
    Dittmer S., Kovacs Z., Yuan S.H., Siszler G., Kogl M., Summer H., Geerts A., Golz S., Shioda T., Methner A.
    J. Cell Sci. 124:252-260(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH TOX3, MUTAGENESIS OF SER-133.
  28. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  29. "A p.D116G mutation in CREB1 leads to novel multiple malformation syndrome resembling CrebA knockout mouse."
    Kitazawa S., Kondo T., Mori K., Yokoyama N., Matsuo M., Kitazawa R.
    Hum. Mutat. 33:651-654(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: POSSIBLE INVOLVEMENT IN MULTIPLE CONGENITAL ANOMALIES, VARIANT GLY-116, CHARACTERIZATION OF VARIANT GLY-116.

Entry informationi

Entry nameiCREB1_HUMAN
AccessioniPrimary (citable) accession number: P16220
Secondary accession number(s): P21934, Q6V963, Q9UMA7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: May 1, 1992
Last modified: September 3, 2014
This is version 179 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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