Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

HLA class I histocompatibility antigen, A-33 alpha chain

Gene

HLA-A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the presentation of foreign antigens to the immune system.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Host-virus interaction, Immunity

Enzyme and pathway databases

ReactomeiR-HSA-1236974. ER-Phagosome pathway.
R-HSA-1236977. Endosomal/Vacuolar pathway.
R-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
R-HSA-877300. Interferon gamma signaling.
R-HSA-909733. Interferon alpha/beta signaling.
R-HSA-983170. Antigen Presentation: Folding, assembly and peptide loading of class I MHC.

Names & Taxonomyi

Protein namesi
Recommended name:
HLA class I histocompatibility antigen, A-33 alpha chain
Alternative name(s):
Aw-19
Aw-33
MHC class I antigen A*33
Gene namesi
Name:HLA-A
Synonyms:HLAA
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:4931. HLA-A.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini25 – 308284ExtracellularSequence analysisAdd
BLAST
Transmembranei309 – 33224HelicalSequence analysisAdd
BLAST
Topological domaini333 – 36533CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, MHC I

Pathology & Biotechi

Organism-specific databases

MalaCardsiHLA-A.

Polymorphism and mutation databases

DMDMi2851527.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Add
BLAST
Chaini25 – 365341HLA class I histocompatibility antigen, A-33 alpha chainPRO_0000018825Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi110 – 1101N-linked (GlcNAc...)By similarity
Disulfide bondi125 ↔ 188PROSITE-ProRule annotation
Disulfide bondi227 ↔ 283PROSITE-ProRule annotation
Modified residuei343 – 3431PhosphoserineCombined sources
Modified residuei344 – 3441PhosphotyrosineCombined sources
Modified residuei345 – 3451PhosphoserineCombined sources
Modified residuei349 – 3491PhosphoserineCombined sources
Modified residuei350 – 3501PhosphoserineCombined sources
Modified residuei352 – 3521PhosphoserineCombined sources
Modified residuei356 – 3561PhosphoserineCombined sources
Modified residuei359 – 3591PhosphoserineCombined sources

Post-translational modificationi

Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system (By similarity).By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP16190.
PRIDEiP16190.

PTM databases

iPTMnetiP16190.
SwissPalmiP16190.

Expressioni

Gene expression databases

CleanExiHS_HLA-A.

Interactioni

Subunit structurei

Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8 MIR1 protein (By similarity).By similarity

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliP16190.
SMRiP16190. Positions 25-294.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini209 – 29587Ig-like C1-typeAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni25 – 11490Alpha-1Add
BLAST
Regioni115 – 20692Alpha-2Add
BLAST
Regioni207 – 29892Alpha-3Add
BLAST
Regioni299 – 30810Connecting peptide

Sequence similaritiesi

Belongs to the MHC class I family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG016709.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR027648. MHC_I_a.
IPR001039. MHC_I_a_a1/a2.
IPR010579. MHC_I_a_C.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
PF06623. MHC_I_C. 1 hit.
[Graphical view]
PRINTSiPR01638. MHCCLASSI.
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P16190-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVMAPRTLL LLLLGALALT QTWAGSHSMR YFTTSVSRPG RGEPRFIAVG
60 70 80 90 100
YVDDTQFVRF DSDAASQRME PRAPWIEQEG PEYWDRNTRN VKAHSQIDRV
110 120 130 140 150
DLGTLRGYYN QSEAGSHTIQ MMYGCDVGSD GRFLRGYQQD AYDGKDYIAL
160 170 180 190 200
NEDLRSWTAA DMAAQITQRK WEAARVAEQL RAYLEGTCVE WLRRHLENGK
210 220 230 240 250
ETLQRTDPPK THMTHHAVSD HEATLRCWAL SFYPAEITLT WQRDGEDQTQ
260 270 280 290 300
DTELVETRPA GDGTFQKWAS VVVPSGQEQR YTCHVQHEGL PKPLTLRWEP
310 320 330 340 350
SSQPTIPIVG IIAGLVLFGA VFAGAVVAAV RWRRKSSDRK GGSYSQAASS
360
DSAQGSDMSL TACKV
Length:365
Mass (Da):40,892
Last modified:July 15, 1998 - v3
Checksum:i060AE508EADEB328
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti210 – 2101K → R in AAB53374 (Ref. 3) Curated

Polymorphismi

The following alleles of A-33 are known: A*33:01 (Aw-33.1), A*33:02 and A*33:03. The sequence shown is that of A*33:01.Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti41 – 411R → S in allele A*33:02. 1 Publication
VAR_004375
Natural varianti151 – 1511N → K.
Corresponds to variant rs1059509 [ dbSNP | Ensembl ].
VAR_056286
Natural varianti166 – 1661I → T.
Corresponds to variant rs1059516 [ dbSNP | Ensembl ].
VAR_056287
Natural varianti195 – 1951H → Y in allele A*33:02 and allele A*33:03. 4 Publications
VAR_004376
Natural varianti217 – 2182AV → PI in allele A*33:02. 1 Publication
VAR_004377
Natural varianti358 – 3581M → V in allele A*33:02. Combined sources1 Publication
VAR_004378

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M30580 Genomic DNA. Translation: AAB47870.1.
U83416 mRNA. Translation: AAB53374.1.
L06440 mRNA. Translation: AAA71914.1.
U09740 mRNA. Translation: AAA79865.1.
X83004 Genomic DNA. Translation: CAA58125.1.
X83005 Genomic DNA. Translation: CAA58126.1.
X83002 Genomic DNA. Translation: CAA58123.1.
X83003 Genomic DNA. Translation: CAA58124.1.
AH005379 Genomic DNA. Translation: AAB60652.1.
AH005380 Genomic DNA. Translation: AAB60653.1.
PIRiI38610.
S51099.
S51100.
UniGeneiHs.181244.
Hs.713441.

Genome annotation databases

EnsembliENST00000456012; ENSP00000408986; ENSG00000231834.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M30580 Genomic DNA. Translation: AAB47870.1.
U83416 mRNA. Translation: AAB53374.1.
L06440 mRNA. Translation: AAA71914.1.
U09740 mRNA. Translation: AAA79865.1.
X83004 Genomic DNA. Translation: CAA58125.1.
X83005 Genomic DNA. Translation: CAA58126.1.
X83002 Genomic DNA. Translation: CAA58123.1.
X83003 Genomic DNA. Translation: CAA58124.1.
AH005379 Genomic DNA. Translation: AAB60652.1.
AH005380 Genomic DNA. Translation: AAB60653.1.
PIRiI38610.
S51099.
S51100.
UniGeneiHs.181244.
Hs.713441.

3D structure databases

ProteinModelPortaliP16190.
SMRiP16190. Positions 25-294.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiP16190.
SwissPalmiP16190.

Polymorphism and mutation databases

DMDMi2851527.

Proteomic databases

EPDiP16190.
PRIDEiP16190.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000456012; ENSP00000408986; ENSG00000231834.

Organism-specific databases

GeneCardsiHLA-A.
HGNCiHGNC:4931. HLA-A.
MalaCardsiHLA-A.
MIMi142800. gene.
neXtProtiNX_P16190.
GenAtlasiSearch...

Phylogenomic databases

HOVERGENiHBG016709.

Enzyme and pathway databases

ReactomeiR-HSA-1236974. ER-Phagosome pathway.
R-HSA-1236977. Endosomal/Vacuolar pathway.
R-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
R-HSA-877300. Interferon gamma signaling.
R-HSA-909733. Interferon alpha/beta signaling.
R-HSA-983170. Antigen Presentation: Folding, assembly and peptide loading of class I MHC.

Miscellaneous databases

ChiTaRSiHLA-A. human.
SOURCEiSearch...

Gene expression databases

CleanExiHS_HLA-A.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR027648. MHC_I_a.
IPR001039. MHC_I_a_a1/a2.
IPR010579. MHC_I_a_C.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
PF06623. MHC_I_C. 1 hit.
[Graphical view]
PRINTSiPR01638. MHCCLASSI.
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular analysis of the serologically defined HLA-Aw19 antigens. A genetically distinct family of HLA-A antigens comprising A29, A31, A32, and Aw33, but probably not A30."
    Kato K., Trapani J.A., Allopenna J., Dupont B., Yang S.Y.
    J. Immunol. 143:3371-3378(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE (ALLELE A*33:01).
  2. Yang S.Y.
    Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION TO 178-179; 210 AND 345.
  3. Szmania S., Baxter-Lowe L.A.
    Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE (ALLELE A*33:01).
  4. "Molecular analysis of a novel HLA-A33 subtype associated with HLA-B44."
    Kato N., Kikuchi A., Kano K., Egawa K., Takiguchi M.
    Tissue Antigens 41:211-213(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE A*33:02).
  5. "Molecular characterization of a novel HLA-A33 allele (A*3303)."
    Balas A., Garcia-Sanchez F., Vicario J.L.
    Tissue Antigens 45:73-76(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE A*33:03).
  6. "Identification of a novel HLA-A33 subtype (A*3303) and correction of the A*3301 sequence."
    Blasczyk R., Wehling J., Hahn U., Schwella N., Huhn D., Salama A.
    Tissue Antigens 45:348-352(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-99 AND 122-205 (ALLELES A*33:01 AND A*33:03).
  7. Gao X., Jakobsen I., Serjeantson S.W.
    Submitted (JAN-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE OF 26-206 (ALLELES A*33:01 AND A*33:03).
  8. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-356, VARIANT [LARGE SCALE ANALYSIS] VAL-358, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Platelet.
  9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-343; TYR-344; SER-345; SER-349; SER-350; SER-352; SER-356 AND SER-359, VARIANT [LARGE SCALE ANALYSIS] VAL-358, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  11. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT [LARGE SCALE ANALYSIS] VAL-358, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  12. Cited for: VARIANT [LARGE SCALE ANALYSIS] VAL-358, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry namei1A33_HUMAN
AccessioniPrimary (citable) accession number: P16190
Secondary accession number(s): O02939, O02954
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: July 15, 1998
Last modified: June 8, 2016
This is version 135 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.