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Protein

HLA class I histocompatibility antigen, A-31 alpha chain

Gene

HLA-A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the presentation of foreign antigens to the immune system.

GO - Molecular functioni

  • beta-2-microglobulin binding Source: UniProtKB
  • peptide antigen binding Source: UniProtKB
  • TAP binding Source: UniProtKB

GO - Biological processi

Keywordsi

Biological processHost-virus interaction, Immunity

Enzyme and pathway databases

ReactomeiR-HSA-1236974. ER-Phagosome pathway.
R-HSA-1236977. Endosomal/Vacuolar pathway.
R-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
R-HSA-877300. Interferon gamma signaling.
R-HSA-909733. Interferon alpha/beta signaling.
R-HSA-983170. Antigen Presentation: Folding, assembly and peptide loading of class I MHC.

Names & Taxonomyi

Protein namesi
Recommended name:
HLA class I histocompatibility antigen, A-31 alpha chain
Alternative name(s):
MHC class I antigen A*31
Gene namesi
Name:HLA-A
Synonyms:HLAA
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:4931. HLA-A.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini25 – 308ExtracellularSequence analysisAdd BLAST284
Transmembranei309 – 332HelicalSequence analysisAdd BLAST24
Topological domaini333 – 365CytoplasmicSequence analysisAdd BLAST33

Keywords - Cellular componenti

Membrane, MHC I

Pathology & Biotechi

Organism-specific databases

DisGeNETi3105.
MalaCardsiHLA-A.
MIMi608579. phenotype.

Polymorphism and mutation databases

DMDMi231367.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Add BLAST24
ChainiPRO_000001882325 – 365HLA class I histocompatibility antigen, A-31 alpha chainAdd BLAST341

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi110N-linked (GlcNAc...) asparagineBy similarity1
Disulfide bondi125 ↔ 188PROSITE-ProRule annotation
Disulfide bondi227 ↔ 283PROSITE-ProRule annotation
Modified residuei343PhosphoserineCombined sources1
Modified residuei344PhosphotyrosineCombined sources1
Modified residuei345PhosphoserineCombined sources1
Modified residuei349PhosphoserineCombined sources1
Modified residuei350PhosphoserineBy similarity1
Modified residuei352PhosphoserineCombined sources1
Modified residuei356PhosphoserineCombined sources1
Modified residuei359PhosphoserineCombined sources1

Post-translational modificationi

Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system (By similarity).By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP16189.
MaxQBiP16189.
PeptideAtlasiP16189.
PRIDEiP16189.

PTM databases

iPTMnetiP16189.
SwissPalmiP16189.

Expressioni

Gene expression databases

CleanExiHS_HLA-A.

Interactioni

Subunit structurei

Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8 MIR1 protein (By similarity).By similarity

GO - Molecular functioni

  • beta-2-microglobulin binding Source: UniProtKB
  • TAP binding Source: UniProtKB

Protein-protein interaction databases

IntActiP16189. 1 interactor.

Structurei

3D structure databases

ProteinModelPortaliP16189.
SMRiP16189.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini209 – 295Ig-like C1-typeAdd BLAST87

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni25 – 114Alpha-1Add BLAST90
Regioni115 – 206Alpha-2Add BLAST92
Regioni207 – 298Alpha-3Add BLAST92
Regioni299 – 308Connecting peptide10

Sequence similaritiesi

Belongs to the MHC class I family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG016709.
PhylomeDBiP16189.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProiView protein in InterPro
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR001039. MHC_I_a_a1/a2.
IPR010579. MHC_I_a_C.
PfamiView protein in Pfam
PF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
PF06623. MHC_I_C. 1 hit.
PRINTSiPR01638. MHCCLASSI.
SMARTiView protein in SMART
SM00407. IGc1. 1 hit.
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF54452. SSF54452. 1 hit.
PROSITEiView protein in PROSITE
PS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P16189-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVMAPRTLL LLLLGALALT QTWAGSHSMR YFTTSVSRPG RGEPRFIAVG
60 70 80 90 100
YVDDTQFVRF DSDAASQRME PRAPWIEQER PEYWDQETRN VKAHSQIDRV
110 120 130 140 150
DLGTLRGYYN QSEAGSHTIQ MMYGCDVGSD GRFLRGYQQD AYDGKDYIAL
160 170 180 190 200
NEDLRSWTAA DMAAQITQRK WEAARVAEQL RAYLEGTCVE WLRRYLENGK
210 220 230 240 250
ETLQRTDPPK THMTHHAVSD HEATLRCWAL SFYPAEITLT WQRDGEDQTQ
260 270 280 290 300
DTELVETRPA GDGTFQKWAS VVVPSGQEQR YTCHVQHEGL PKPLTLRWEP
310 320 330 340 350
SSQPTIPIVG IIAGLVLFGA VFAGAVVAAV RWRRKSSDRK GGSYSQAASS
360
DSAQGSDMSL TACKV
Length:365
Mass (Da):41,004
Last modified:April 1, 1993 - v2
Checksum:i4E760C821A3C553B
GO

Polymorphismi

The following alleles of A-31 are known: A*31:01, A*31:02, A*31:03, A*31:04, A*31:05 (A3101v1) and A*31:06. The sequence shown is that of A*31:01. Allele A*31:01 is associated with carbamazepine-induced hypersensitivity reactions among subjects of Northern European ancestry [MIMi:608579].

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01634890N → K in allele A*31:02. 1
Natural variantiVAR_016349114A → D in allele A*31:03. 1
Natural variantiVAR_010373121M → I in allele A*31:03 and allele A*31:04. 1
Natural variantiVAR_010374138Q → R in allele A*31:03, allele A*31:04 and allele A*31:06. 1
Natural variantiVAR_056280151N → K. Corresponds to variant dbSNP:rs1059509Ensembl.1
Natural variantiVAR_056281166I → T. Corresponds to variant dbSNP:rs1059516Ensembl.1
Natural variantiVAR_016350190 – 191EW → DG in allele A*31:05. 2
Natural variantiVAR_056282205R → H. Corresponds to variant dbSNP:rs17185861Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M30578 Genomic DNA. Translation: AAA59613.1.
M84375 mRNA. Translation: AAA59599.1.
L78918 Genomic DNA. Translation: AAB05976.1.
AF148863 Genomic DNA. Translation: AAD39981.1.
AH006155 Genomic DNA. Translation: AAC18859.1.
AH007022 Genomic DNA. Translation: AAC79721.1.
AJ239045 Genomic DNA. Translation: CAB43109.1.
AJ239046 Genomic DNA. Translation: CAB43110.1.
AB032597 Genomic DNA. Translation: BAA84645.1.
AH007200 Genomic DNA. Translation: AAD02207.1.
AJ506789, AJ506790 Genomic DNA. Translation: CAD44950.1.
PIRiI72170.
UniGeneiHs.181244.
Hs.713441.

Genome annotation databases

EnsembliENST00000456012; ENSP00000408986; ENSG00000231834.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry namei1A31_HUMAN
AccessioniPrimary (citable) accession number: P16189
Secondary accession number(s): O62924
, O98009, O98137, Q8MHM1, Q9TPQ3, Q9TQ24, Q9UQU6, Q9UQU7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1993
Last modified: August 30, 2017
This is version 147 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families