P16188 (1A30_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
HLA class I histocompatibility antigen, A-30 alpha chain

Alternative name(s):
MHC class I antigen A*30

Gene names

Name:	HLA-A
Synonyms:	HLAA

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	365 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Involved in the presentation of foreign antigens to the immune system.
Subunit structure	Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8 MIR1 protein By similarity.
Subcellular location	Membrane; Single-pass type I membrane protein.
Post-translational modification	Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system By similarity.
Polymorphism	The following alleles of A-30 are known: A*30:01 (A30.3), A*30:02, A*30:03, A*30:04 (A30W7), A*30:06, A*30:07 and A*30:08. The sequence shown is that of A*30:01.
Sequence similarities	Belongs to the MHC class I family. Contains 1 Ig-like C1-type (immunoglobulin-like) domain.

Ontologies

Keywords
Biological process	Host-virus interaction Immunity
Cellular component	MHC I Membrane
Coding sequence diversity	Polymorphism
Domain	Signal Transmembrane Transmembrane helix
PTM	Disulfide bond Glycoprotein Ubl conjugation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	antigen processing and presentation of peptide antigen via MHC class I Inferred from electronic annotation. Source: UniProtKB-KW immune response Non-traceable author statement Ref.1. Source: UniProtKB interspecies interaction between organisms Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	MHC class I protein complex Inferred from electronic annotation. Source: UniProtKB-KW integral to plasma membrane Non-traceable author statement Ref.1. Source: UniProtKB
Molecular function	MHC class I receptor activity Non-traceable author statement Ref.1. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 24	24
	Chain	25 – 365	341	HLA class I histocompatibility antigen, A-30 alpha chain		PRO_0000018822
Regions
	Topological domain	25 – 308	284	Extracellular Potential
	Transmembrane	309 – 332	24	Helical; Potential
	Topological domain	333 – 365	33	Cytoplasmic Potential
	Domain	209 – 295	87	Ig-like C1-type
	Region	25 – 114	90	Alpha-1
	Region	115 – 206	92	Alpha-2
	Region	207 – 298	92	Alpha-3
	Region	299 – 308	10	Connecting peptide
Amino acid modifications
	Glycosylation	110	1	N-linked (GlcNAc...) By similarity
	Disulfide bond	125 ↔ 188		By similarity
	Disulfide bond	227 ↔ 283		By similarity
Natural variations
	Natural variant	21	1	H → Q in allele A*30:02, allele A*30:04 and allele A*30:08.		VAR_004366
	Natural variant	33	1	S → Y in allele A*30:08.		VAR_010284
	Natural variant	55	1	T → A in allele A*30:06.		VAR_016653
	Natural variant	80	1	R → G in allele A*30:03.		VAR_004367
	Natural variant	86	1	Q → E in allele A*30:07.		VAR_016738
	Natural variant	89 – 90	2	RN → GK in allele A*30:07.		VAR_016739
	Natural variant	89	1	R → G. Corresponds to variant rs1059459 [ dbSNP | Ensembl ].		VAR_056271
	Natural variant	94	1	Q → H in allele A*30:02, allele A*30:03, allele A*30:04, allele A*30:06 and allele A*30:07. Corresponds to variant rs1059463 [ dbSNP | Ensembl ].		VAR_004368
	Natural variant	100 – 101	2	VD → EN in allele A*30:02, allele A*30:03, allele A*30:04, allele A*30:06 and allele A*30:07.		VAR_004369
	Natural variant	101	1	D → N. Corresponds to variant rs1136688 [ dbSNP | Ensembl ].		VAR_056272
	Natural variant	121	1	I → M. Corresponds to variant rs1136695 [ dbSNP | Ensembl ].		VAR_056273
	Natural variant	129	1	S → P. Corresponds to variant rs1136700 [ dbSNP | Ensembl ].		VAR_056274
	Natural variant	131	1	G → W. Corresponds to variant rs1136702 [ dbSNP | Ensembl ].		VAR_056275
	Natural variant	133	1	F → L. Corresponds to variant rs1059488 [ dbSNP | Ensembl ].		VAR_056276
	Natural variant	151	1	N → K. Corresponds to variant rs1059509 [ dbSNP | Ensembl ].		VAR_056277
	Natural variant	166	1	I → T. Corresponds to variant rs1059516 [ dbSNP | Ensembl ].		VAR_056278
	Natural variant	175 – 176	2	RW → HV in allele A*30:04 and allele A*30:06.		VAR_004370
	Natural variant	176	1	W → R in allele A*30:02, allele A*30:03 and allele A*30:07.		VAR_004371
	Natural variant	180	1	L → W in allele A*30:04 and allele A*30:06.		VAR_004372
	Natural variant	205	1	R → H. Corresponds to variant rs17185861 [ dbSNP | Ensembl ].		VAR_056279
Experimental info
	Sequence conflict	33	1	S → F in AAA59612. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P16188 [UniParc]. Last modified February 1, 1996. Version 2. Checksum: 521166D95FB1DC28	FASTA	365	40,905
	10 20 30 40 50 60 MAVMAPRTLL LLLSGALALT HTWAGSHSMR YFSTSVSRPG SGEPRFIAVG YVDDTQFVRF 70 80 90 100 110 120 DSDAASQRME PRAPWIEQER PEYWDQETRN VKAQSQTDRV DLGTLRGYYN QSEAGSHTIQ 130 140 150 160 170 180 IMYGCDVGSD GRFLRGYEQH AYDGKDYIAL NEDLRSWTAA DMAAQITQRK WEAARWAEQL 190 200 210 220 230 240 RAYLEGTCVE WLRRYLENGK ETLQRTDPPK THMTHHPISD HEATLRCWAL GFYPAEITLT 250 260 270 280 290 300 WQRDGEDQTQ DTELVETRPA GDGTFQKWAA VVVPSGEEQR YTCHVQHEGL PKPLTLRWEL 310 320 330 340 350 360 SSQPTIPIVG IIAGLVLLGA VITGAVVAAV MWRRKSSDRK GGSYTQAASS DSAQGSDVSL TACKV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular analysis of the serologically defined HLA-Aw19 antigens. A genetically distinct family of HLA-A antigens comprising A29, A31, A32, and Aw33, but probably not A30." Kato K., Trapani J.A., Allopenna J., Dupont B., Yang S.Y. J. Immunol. 143:3371-3378(1989) [PubMed: 2478623] [Abstract] Cited for: NUCLEOTIDE SEQUENCE (ALLELE A*30:01).
[2]	"Correct sequence of the A*3001 allele obtained by PCR-SSP typing and automated nucleotide sequencing." Olerup O., Daniels T.J., Baxter-Lowe L. Tissue Antigens 44:265-267(1994) [PubMed: 7871528] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE A*30:01).
[3]	"Distinctive HLA-A,B antigens of black populations formed by interallelic conversion." Madrigal J.A., Belich M.P., Hildebrand W.H., Benjamin R.J., Little A.-M., Zemmour J., Ennis P.D., Ward F.E., Petzl-Erler M.L., Martell R.W., du Toit E.D., Parham P. J. Immunol. 149:3411-3415(1992) [PubMed: 1431115] [Abstract] Cited for: NUCLEOTIDE SEQUENCE (ALLELE A*30:02).
[4]	"Selection of an unrelated donor for marrow transplantation facilitated by the molecular characterization of a novel HLA-A allele." Choo S.Y., Starling G.C., Anasetti C., Hansen J.A. Hum. Immunol. 36:20-26(1993) [PubMed: 8458735] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 25-279 (ALLELE A*30:03).
[5]	"Defining the allelic variants of HLA-A30 in the Sardinian population using amplification refractory mutation system -- polymerase chain reaction." Krausa P., Carcassi C., Orru S., Bodmer J.G., Browning M.J., Contu L. Hum. Immunol. 44:35-42(1995) [PubMed: 8522453] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE A*30:04).
[6]	"HLA-A*3004: a new A30 allele identified in an Australian Caucasoid population." Lienert K., Russ G., Bennett G., Gao X., McCluskey J. Tissue Antigens 46:394-397(1995) [PubMed: 8838350] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] OF 26-206 (ALLELE A*30:04).
[7]	"A novel HLA-A30 allele (A*3004) identified by single-strand conformation polymorphism analysis and confirmed by solid-phase sequencing." Blasczyk R., Wehling J., Paessler M., Hahn U., Huhn D., Salama A. Tissue Antigens 46:322-326(1995) [PubMed: 8560452] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 28-205 (ALLELE A*30:04).
[8]	"Diversity is demonstrated in class I HLA-A and HLA-B alleles in Cameroon, Africa: description of HLA-A*03012, *2612, *3006 and HLA-B*1403, *4016, *4703." Ellis J.M., Mack S.J., Leke R.F.G., Quakyi I., Johnson A.H., Hurley C.K. Tissue Antigens 56:291-302(2000) [PubMed: 11098929] [Abstract] Cited for: NUCLEOTIDE SEQUENCE OF 26-206 (ALLELE A*30:06).
[9]	"Seventeen more novel HLA-A locus alleles." Ellis J., Steiner N.K., Kosman C., Henson V., Mitton W., Koester R., Ng J., Hartzman R.J., Hurley C.K. Tissue Antigens 55:369-373(2000) [PubMed: 10852390] [Abstract] Cited for: NUCLEOTIDE SEQUENCE OF 26-206 (ALLELE A*30:07).
[10]	"Further diversity at HLA-A and -B loci identified in Afro-Caribbean potential bone marrow donors." Cox S.T., Mcwhinnie A.J., Koester R.P., Heine U., Holman R., Madrigal A.J., Little A.-M. Tissue Antigens 57:70-72(2001) [PubMed: 11169261] [Abstract] Cited for: NUCLEOTIDE SEQUENCE (ALLELE A*30:08).
[11]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed: 21269460] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M30576 Genomic DNA. Translation: AAA59612.1. U07234 mRNA. Translation: AAA70162.1. X61702 mRNA. Translation: CAA43871.1. M93657 Genomic DNA. Translation: AAA58650.1. Z34921 Genomic DNA. Translation: CAA84401.1. U19734, U18988 Genomic DNA. Translation: AAB53658.1. U24261 mRNA. Translation: AAB50434.1. X83770 Genomic DNA. Translation: CAA58723.1. X83771 Genomic DNA. Translation: CAA58724.1. AF028714, AF028713 Genomic DNA. Translation: AAC14191.1. AF065643, AF065642 Genomic DNA. Translation: AAC18600.1. AJ249308 , AJ249309, AJ249310, AJ249311, AJ249312, AJ249313, AJ249314, AJ249315 Genomic DNA. Translation: CAB57306.1.
IPI	IPI00472855.
PIR	I38519. I54307. I56039.
3D structure databases
ProteinModelPortal	P16188.
SMR	P16188. Positions 25-298.
ModBase	Search...
Protein-protein interaction databases
STRING	P16188.
Polymorphism databases
DMDM	1345596.
Proteomic databases
PRIDE	P16188.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000376809; ENSP00000366005; ENSG00000206503. ENST00000396634; ENSP00000379873; ENSG00000206503.
Organism-specific databases
GeneCards	GC06P029921.
HGNC	HGNC:4931. HLA-A.
MIM	142800. gene.
neXtProt	NX_P16188.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	HBG016709.
Gene expression databases
CleanEx	HS_HLA-A.
Genevestigator	P16188.
GermOnline	ENSG00000204632. Homo sapiens.
Family and domain databases
InterPro	IPR007110. Ig-like. IPR013783. Ig-like_fold. IPR003006. Ig/MHC_CS. IPR003597. Ig_C1-set. IPR011161. MHC_I-like_Ag-recog. IPR011162. MHC_I/II-like_Ag-recog. IPR001039. MHC_I_a_a1/a2. IPR010579. MHC_I_a_C. [Graphical view]
Gene3D	G3DSA:2.60.40.10. Ig-like_fold. 1 hit. G3DSA:3.30.500.10. MHC_I-like_Ag-recog. 1 hit.
Pfam	PF07654. C1-set. 1 hit. PF00129. MHC_I. 1 hit. PF06623. MHC_I_C. 1 hit. [Graphical view]
PRINTS	PR01638. MHCCLASSI.
SMART	SM00407. IGc1. 1 hit. [Graphical view]
SUPFAM	SSF54452. MHC_I/II-like_Ag-recog. 1 hit.
PROSITE	PS50835. IG_LIKE. 1 hit. PS00290. IG_MHC. 1 hit. [Graphical view]
ProtoNet	Search...
Other
SOURCE	Search...

Entry information

Entry name

1A30_HUMAN

Accession

Primary (citable) accession number: P16188
Secondary accession number(s): O19598 , O62921, P30452, Q9UIP7

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 1, 1990
Last sequence update:	February 1, 1996
Last modified:	December 14, 2011
This is version 102 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.