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P16177 (NK3R_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 94. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Neuromedin-K receptor
Short name=NKR
Alternative name(s):
NK-3 receptor
Short name=NK-3R
Neurokinin B receptor
Tachykinin receptor 3
Gene names
Name:Tacr3
Synonyms:Tac3r
OrganismRattus norvegicus (Rat)
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length452 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

This is a receptor for the tachykinin neuropeptide neuromedin-K (neurokinin B). It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: neuromedin-K > substance K > substance P.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Post-translational modification

The anchoring of this receptor to the plasma membrane is probably mediated by the palmitoylation of a cysteine residue.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 452452Neuromedin-K receptor
PRO_0000069902

Regions

Topological domain1 – 7171Extracellular Potential
Transmembrane72 – 9423Helical; Name=1; Potential
Topological domain95 – 10410Cytoplasmic Potential
Transmembrane105 – 12622Helical; Name=2; Potential
Topological domain127 – 14620Extracellular Potential
Transmembrane147 – 16822Helical; Name=3; Potential
Topological domain169 – 18820Cytoplasmic Potential
Transmembrane189 – 20921Helical; Name=4; Potential
Topological domain210 – 23223Extracellular Potential
Transmembrane233 – 25725Helical; Name=5; Potential
Topological domain258 – 28629Cytoplasmic Potential
Transmembrane287 – 30822Helical; Name=6; Potential
Topological domain309 – 32113Extracellular Potential
Transmembrane322 – 34625Helical; Name=7; Potential
Topological domain347 – 452106Cytoplasmic Potential

Amino acid modifications

Lipidation3611S-palmitoyl cysteine Potential
Glycosylation91N-linked (GlcNAc...) Potential
Glycosylation231N-linked (GlcNAc...) Potential
Glycosylation401N-linked (GlcNAc...) Potential
Glycosylation601N-linked (GlcNAc...) Potential
Disulfide bond145 ↔ 220 By similarity

Sequences

Sequence LengthMass (Da)Tools
P16177 [UniParc].

Last modified April 1, 1990. Version 1.
Checksum: 51D8EFC94F34CCAE

FASTA45251,107
        10         20         30         40         50         60 
MASVPRGENW TDGTVEVGTH TGNLSSALGV TEWLALQAGN FSSALGLPAT TQAPSQVRAN 

        70         80         90        100        110        120 
LTNQFVQPSW RIALWSLAYG LVVAVAVFGN LIVIWIILAH KRMRTVTNYF LVNLAFSDAS 

       130        140        150        160        170        180 
VAAFNTLINF IYGLHSEWYF GANYCRFQNF FPITAVFASI YSMTAIAVDR YMAIIDPLKP 

       190        200        210        220        230        240 
RLSATATKIV IGSIWILAFL LAFPQCLYSK IKVMPGRTLC YVQWPEGPKQ HFTYHIIVII 

       250        260        270        280        290        300 
LVYCFPLLIM GVTYTIVGIT LWGGEIPGDT CDKYHEQLKA KRKVVKMMII VVVTFAICWL 

       310        320        330        340        350        360 
PYHVYFILTA IYQQLNRWKY IQQVYLASFW LAMSSTMYNP IIYCCLNKRF RAGFKRAFRW 

       370        380        390        400        410        420 
CPFIQVSSYD ELELKTTRFH PTRQSSLYTV SRMESVTVLF DPNDGDPTKS SRKKRAVPRD 

       430        440        450 
PSANGCSHRG SKSASTTSSF ISSPYTSVDE YS

« Hide

References

[1]"Cloning and expression of a rat neuromedin K receptor cDNA."
Shigemoto R., Yokota Y., Tsuchida K., Nakanishi S.
J. Biol. Chem. 265:623-628(1990) [PubMed: 2153106] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		J05189 mRNA. Translation: AAA41688.1.
IPIIPI00210290.
PIRA34916.
RefSeqNP_058749.1. NM_017053.1.
UniGeneRn.9702.

3D structure databases

ProteinModelPortalP16177.
ModBaseSearch...

Protein-protein interaction databases

STRINGP16177.

Protein family/group databases

GPCRDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000012473; ENSRNOP00000012473; ENSRNOG00000009372.
GeneID24808.
KEGGrno:24808.
UCSCNM_017053. rat.

Organism-specific databases

CTD6870.
RGD3810. Tacr3.

Phylogenomic databases

eggNOGroNOG11982.
GeneTreeENSGT00560000076767.
HOVERGENHBG103412.
InParanoidP16177.
OMAPTRQSSM.
OrthoDBEOG41NTM9.
PhylomeDBP16177.

Gene expression databases

ArrayExpressP16177.
GenevestigatorP16177.
GermOnlineENSRNOG00000009372. Rattus norvegicus.

Family and domain databases

InterProIPR000276. 7TM_GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_supfam.
IPR001681. Neurokn_rcpt.
IPR001013. NK3_rcpt.
[Graphical view]
KOK04224.
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR01026. NEUROKININ3R.
PR00244. NEUROKININR.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio604488.

Entry information

Entry nameNK3R_RAT
AccessionPrimary (citable) accession number: P16177
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: November 16, 2011
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents