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Protein

Neuromedin-K receptor

Gene

Tacr3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

This is a receptor for the tachykinin neuropeptide neuromedin-K (neurokinin B). It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: neuromedin-K > substance K > substance P.

GO - Molecular functioni

  • tachykinin receptor activity Source: RGD

GO - Biological processi

  • aging Source: RGD
  • hyperosmotic salinity response Source: RGD
  • positive regulation of blood pressure Source: RGD
  • positive regulation of heart rate Source: RGD
  • positive regulation of uterine smooth muscle contraction Source: RGD
  • regulation of dopamine metabolic process Source: RGD
  • regulation of feeding behavior Source: RGD
  • response to cocaine Source: RGD
  • response to estradiol Source: RGD
  • response to morphine Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-RNO-380095. Tachykinin receptors bind tachykinins.
R-RNO-416476. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Neuromedin-K receptor
Short name:
NKR
Alternative name(s):
NK-3 receptor
Short name:
NK-3R
Neurokinin B receptor
Tachykinin receptor 3
Gene namesi
Name:Tacr3
Synonyms:Tac3r
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi3810. Tacr3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 7171ExtracellularSequence analysisAdd
BLAST
Transmembranei72 – 9423Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini95 – 10410CytoplasmicSequence analysis
Transmembranei105 – 12622Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini127 – 14620ExtracellularSequence analysisAdd
BLAST
Transmembranei147 – 16822Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini169 – 18820CytoplasmicSequence analysisAdd
BLAST
Transmembranei189 – 20921Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini210 – 23223ExtracellularSequence analysisAdd
BLAST
Transmembranei233 – 25725Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini258 – 28629CytoplasmicSequence analysisAdd
BLAST
Transmembranei287 – 30822Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini309 – 32113ExtracellularSequence analysisAdd
BLAST
Transmembranei322 – 34625Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini347 – 452106CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • cytoplasm Source: RGD
  • dendrite membrane Source: RGD
  • integral component of membrane Source: UniProtKB-KW
  • membrane Source: RGD
  • neuronal cell body membrane Source: RGD
  • nucleus Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL3154.
GuidetoPHARMACOLOGYi362.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 452452Neuromedin-K receptorPRO_0000069902Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi9 – 91N-linked (GlcNAc...)Sequence analysis
Glycosylationi23 – 231N-linked (GlcNAc...)Sequence analysis
Glycosylationi40 – 401N-linked (GlcNAc...)Sequence analysis
Glycosylationi60 – 601N-linked (GlcNAc...)Sequence analysis
Disulfide bondi145 ↔ 220PROSITE-ProRule annotation
Lipidationi361 – 3611S-palmitoyl cysteineSequence analysis

Post-translational modificationi

The anchoring of this receptor to the plasma membrane is probably mediated by the palmitoylation of a cysteine residue.

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiP16177.

PTM databases

PhosphoSiteiP16177.

Expressioni

Gene expression databases

BgeeiENSRNOG00000009372.
GenevisibleiP16177. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000012473.

Chemistry

BindingDBiP16177.

Structurei

3D structure databases

ProteinModelPortaliP16177.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4219. Eukaryota.
ENOG410XSC5. LUCA.
GeneTreeiENSGT00760000118781.
HOGENOMiHOG000013018.
HOVERGENiHBG103412.
InParanoidiP16177.
KOiK04224.
OMAiVMTFAIC.
OrthoDBiEOG091G0WYG.
PhylomeDBiP16177.
TreeFamiTF315303.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001681. Neurokn_rcpt.
IPR001013. NK3_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01026. NEUROKININ3R.
PR00244. NEUROKININR.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P16177-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASVPRGENW TDGTVEVGTH TGNLSSALGV TEWLALQAGN FSSALGLPAT
60 70 80 90 100
TQAPSQVRAN LTNQFVQPSW RIALWSLAYG LVVAVAVFGN LIVIWIILAH
110 120 130 140 150
KRMRTVTNYF LVNLAFSDAS VAAFNTLINF IYGLHSEWYF GANYCRFQNF
160 170 180 190 200
FPITAVFASI YSMTAIAVDR YMAIIDPLKP RLSATATKIV IGSIWILAFL
210 220 230 240 250
LAFPQCLYSK IKVMPGRTLC YVQWPEGPKQ HFTYHIIVII LVYCFPLLIM
260 270 280 290 300
GVTYTIVGIT LWGGEIPGDT CDKYHEQLKA KRKVVKMMII VVVTFAICWL
310 320 330 340 350
PYHVYFILTA IYQQLNRWKY IQQVYLASFW LAMSSTMYNP IIYCCLNKRF
360 370 380 390 400
RAGFKRAFRW CPFIQVSSYD ELELKTTRFH PTRQSSLYTV SRMESVTVLF
410 420 430 440 450
DPNDGDPTKS SRKKRAVPRD PSANGCSHRG SKSASTTSSF ISSPYTSVDE

YS
Length:452
Mass (Da):51,107
Last modified:April 1, 1990 - v1
Checksum:i51D8EFC94F34CCAE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05189 mRNA. Translation: AAA41688.1.
PIRiA34916.
RefSeqiNP_058749.1. NM_017053.1.
UniGeneiRn.9702.

Genome annotation databases

EnsembliENSRNOT00000012473; ENSRNOP00000012473; ENSRNOG00000009372.
GeneIDi24808.
KEGGirno:24808.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05189 mRNA. Translation: AAA41688.1.
PIRiA34916.
RefSeqiNP_058749.1. NM_017053.1.
UniGeneiRn.9702.

3D structure databases

ProteinModelPortaliP16177.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000012473.

Chemistry

BindingDBiP16177.
ChEMBLiCHEMBL3154.
GuidetoPHARMACOLOGYi362.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiP16177.

Proteomic databases

PaxDbiP16177.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000012473; ENSRNOP00000012473; ENSRNOG00000009372.
GeneIDi24808.
KEGGirno:24808.

Organism-specific databases

CTDi6870.
RGDi3810. Tacr3.

Phylogenomic databases

eggNOGiKOG4219. Eukaryota.
ENOG410XSC5. LUCA.
GeneTreeiENSGT00760000118781.
HOGENOMiHOG000013018.
HOVERGENiHBG103412.
InParanoidiP16177.
KOiK04224.
OMAiVMTFAIC.
OrthoDBiEOG091G0WYG.
PhylomeDBiP16177.
TreeFamiTF315303.

Enzyme and pathway databases

ReactomeiR-RNO-380095. Tachykinin receptors bind tachykinins.
R-RNO-416476. G alpha (q) signalling events.

Miscellaneous databases

PROiP16177.

Gene expression databases

BgeeiENSRNOG00000009372.
GenevisibleiP16177. RN.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001681. Neurokn_rcpt.
IPR001013. NK3_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01026. NEUROKININ3R.
PR00244. NEUROKININR.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNK3R_RAT
AccessioniPrimary (citable) accession number: P16177
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: September 7, 2016
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.