Neuromedin-K receptor - Rattus norvegicus (Rat)

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Reviewed, UniProtKB/Swiss-Prot P16177 (NK3R_RAT)

Last modified June 16, 2009. Version 73. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein names

Recommended name:
    Neuromedin-K receptor
      Short name=NKR
Alternative name(s):
    Neurokinin B receptor
    NK-3 receptor
      Short name=NK-3R
    Tachykinin receptor 3

Gene names

Name:	Tacr3
Synonyms:	Tac3r

Organism

Rattus norvegicus (Rat)

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

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Protein attributes

Sequence length	452 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

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General annotation (Comments)

Function	This is a receptor for the tachykinin neuropeptide neuromedin-K (neurokinin B). It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Post-translational modification	The anchoring of this receptor to the plasma membrane is probably mediated by the palmitoylation of a cysteine residue.
Miscellaneous	The rank order of affinity of this receptor to tachykinins is: neuromedin-K > substance K > substance P.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

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Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Transmembrane
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein Lipoprotein Palmitate Phosphoprotein
Gene Ontology (GO)
Biological process	G-protein coupled receptor protein signaling pathway Inferred from electronic annotation. Source: UniProtKB-KW aging Inferred from expression pattern. Source: RGD hyperosmotic salinity response Inferred from direct assay. Source: RGD positive regulation of blood pressure Inferred from direct assay. Source: RGD positive regulation of heart rate Inferred from direct assay. Source: RGD positive regulation of uterine smooth muscle contraction Inferred from direct assay. Source: RGD regulation of dopamine metabolic process Inferred from direct assay. Source: RGD regulation of feeding behavior Inferred from direct assay. Source: RGD response to cocaine Inferred from mutant phenotype. Source: RGD response to estradiol stimulus Inferred from direct assay. Source: RGD response to morphine Inferred from expression pattern. Source: RGD
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW nucleus Inferred from direct assay. Source: RGD plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	tachykinin receptor activity Inferred from direct assay. Source: RGD
Complete GO annotation...

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 452

452

Neuromedin-K receptor

PRO_0000069902

Regions

Topological domain

1 – 71

Extracellular Potential

Transmembrane

72 – 94

1 Potential

Topological domain

95 – 104

Cytoplasmic Potential

Transmembrane

105 – 126

2 Potential

Topological domain

127 – 146

Extracellular Potential

Transmembrane

147 – 168

3 Potential

Topological domain

169 – 188

Cytoplasmic Potential

Transmembrane

189 – 209

4 Potential

Topological domain

210 – 232

Extracellular Potential

Transmembrane

233 – 257

5 Potential

Topological domain

258 – 286

Cytoplasmic Potential

Transmembrane

287 – 308

6 Potential

Topological domain

309 – 321

Extracellular Potential

Transmembrane

322 – 346

7 Potential

Topological domain

347 – 452

106

Cytoplasmic Potential

Amino acid modifications

Lipidation

361

S-palmitoyl cysteine Potential

Glycosylation

N-linked (GlcNAc...) Potential

Glycosylation

N-linked (GlcNAc...) Potential

Glycosylation

N-linked (GlcNAc...) Potential

Glycosylation

N-linked (GlcNAc...) Potential

Disulfide bond

145 ↔ 220

By similarity

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Sequences

Sequence

Length

Mass (Da)

Tools

P16177-1 [UniParc].

Last modified April 1, 1990. Version 1.
Checksum: 51D8EFC94F34CCAE
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FASTA

452

51,107

        10         20         30         40         50         60 
MASVPRGENW TDGTVEVGTH TGNLSSALGV TEWLALQAGN FSSALGLPAT TQAPSQVRAN 

        70         80         90        100        110        120 
LTNQFVQPSW RIALWSLAYG LVVAVAVFGN LIVIWIILAH KRMRTVTNYF LVNLAFSDAS 

       130        140        150        160        170        180 
VAAFNTLINF IYGLHSEWYF GANYCRFQNF FPITAVFASI YSMTAIAVDR YMAIIDPLKP 

       190        200        210        220        230        240 
RLSATATKIV IGSIWILAFL LAFPQCLYSK IKVMPGRTLC YVQWPEGPKQ HFTYHIIVII 

       250        260        270        280        290        300 
LVYCFPLLIM GVTYTIVGIT LWGGEIPGDT CDKYHEQLKA KRKVVKMMII VVVTFAICWL 

       310        320        330        340        350        360 
PYHVYFILTA IYQQLNRWKY IQQVYLASFW LAMSSTMYNP IIYCCLNKRF RAGFKRAFRW 

       370        380        390        400        410        420 
CPFIQVSSYD ELELKTTRFH PTRQSSLYTV SRMESVTVLF DPNDGDPTKS SRKKRAVPRD 

       430        440        450 
PSANGCSHRG SKSASTTSSF ISSPYTSVDE YS

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References

[1]	"Cloning and expression of a rat neuromedin K receptor cDNA." Shigemoto R., Yokota Y., Tsuchida K., Nakanishi S. J. Biol. Chem. 265:623-628(1990) [PubMed: 2153106] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain.

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Cross-references

Sequence databases
	J05189 mRNA. Translation: AAA41688.1.
IPI	IPI00210290.
PIR	A34916.
RefSeq	NP_058749.1.
UniGene	Rn.9702
3D structure databases
HSSP	HSSP built from PDB template 1F88 based on UniProtKB P02699.
ModBase	Search...
Protein family/group databases
GPCRDB	Search...
Genome annotation databases
Ensembl	ENSRNOG00000009372. Rattus norvegicus. [Contig view]
GeneID	24808.
KEGG	rno:24808.
Organism-specific databases
RGD	3810. Tacr3.
Phylogenomic databases
HOVERGEN	P16177.
OMA	P16177. RQSSMYT.
Gene expression databases
ArrayExpress	P16177.
GermOnline	ENSRNOG00000009372. Rattus norvegicus.
Family and domain databases
InterPro	IPR000276. 7TM_GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_supfam. IPR001681. Neurokn_rcpt. IPR001013. NK3_rcpt. [Graphical view]
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00237. GPCRRHODOPSN. PR01026. NEUROKININ3R. PR00244. NEUROKININR.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	604488.

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Entry information

Entry name

NK3R_RAT

Accession

Primary (citable) accession number: P16177

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 1, 1990
Last sequence update:	April 1, 1990
Last modified:	June 16, 2009
This is version 73 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

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Relevant documents

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries

SIMILARITY comments

Index of protein domains and families

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein family/group databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other Resources

Entry information

Relevant documents