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Protein

Uricase

Gene

UOX

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin.

Catalytic activityi

Urate + O2 + H2O = 5-hydroxyisourate + H2O2.

Pathwayi: urate degradation

This protein is involved in step 1 of the subpathway that synthesizes (S)-allantoin from urate.
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Uricase (UOX), Uricase (UOX)
  2. no protein annotated in this organism
  3. no protein annotated in this organism
This subpathway is part of the pathway urate degradation, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (S)-allantoin from urate, the pathway urate degradation and in Purine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei23Charge relay systemBy similarity1
Active sitei68Charge relay systemBy similarity1
Binding sitei170SubstrateBy similarity1
Binding sitei187SubstrateBy similarity1
Active sitei264Charge relay systemBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processPurine metabolism

Enzyme and pathway databases

BRENDAi1.7.3.3. 6170.
UniPathwayiUPA00394; UER00650.

Names & Taxonomyi

Protein namesi
Recommended name:
Uricase (EC:1.7.3.3)
Alternative name(s):
Urate oxidase
Gene namesi
Name:UOX
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001659882 – 304UricaseAdd BLAST303

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei10N6-acetyllysine; alternateBy similarity1
Modified residuei10N6-succinyllysine; alternateBy similarity1
Modified residuei23N6-acetyllysine; alternateBy similarity1
Modified residuei23N6-succinyllysine; alternateBy similarity1
Modified residuei27N6-acetyllysineBy similarity1
Modified residuei36N6-acetyllysineBy similarity1
Modified residuei39PhosphoserineBy similarity1
Modified residuei63PhosphoserineBy similarity1
Modified residuei118N6-acetyllysineBy similarity1
Modified residuei122N6-acetyllysineBy similarity1
Modified residuei164N6-acetyllysineBy similarity1
Modified residuei175N6-acetyllysineBy similarity1
Modified residuei185N6-acetyllysineBy similarity1
Modified residuei221N6-acetyllysine; alternateBy similarity1
Modified residuei221N6-succinyllysine; alternateBy similarity1
Modified residuei228N6-acetyllysine; alternateBy similarity1
Modified residuei228N6-succinyllysine; alternateBy similarity1
Modified residuei232PhosphoserineBy similarity1
Modified residuei278N6-acetyllysineBy similarity1
Modified residuei289PhosphotyrosineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP16164.
PeptideAtlasiP16164.
PRIDEiP16164.

Interactioni

Subunit structurei

Homotetramer.

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000024781.

Structurei

3D structure databases

ProteinModelPortaliP16164.
SMRiP16164.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni68 – 69Substrate bindingBy similarity2
Regioni235 – 236Substrate bindingBy similarity2

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi302 – 304Microbody targeting signalSequence analysis3

Sequence similaritiesi

Belongs to the uricase family.Curated

Phylogenomic databases

eggNOGiKOG1599. Eukaryota.
COG3648. LUCA.
HOVERGENiHBG018060.
InParanoidiP16164.
KOiK00365.

Family and domain databases

InterProiView protein in InterPro
IPR002042. Uricase.
IPR019842. Uricase_CS.
PfamiView protein in Pfam
PF01014. Uricase. 2 hits.
PIRSFiPIRSF000241. Urate_oxidase. 1 hit.
PRINTSiPR00093. URICASE.
TIGRFAMsiTIGR03383. urate_oxi. 1 hit.
PROSITEiView protein in PROSITE
PS00366. URICASE. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P16164-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAHYRNDYKK NDEVEFVRTG YGKDMIKVLH IQRDGKYHSI KEVATSVQLT
60 70 80 90 100
LSSKKDYLHG DNSDVIPTDT IKNTVNVLAK FKGIKSIETF AVTICEHFLS
110 120 130 140 150
SFKHVIRAQV YVEEVPWKRF EKNGVKHVHA FIYTPTGTHF CEVEQIRNGP
160 170 180 190 200
PVIHSGIKDL KVLKTTQSGF EGFIKDQFTT LPEVKDRCFA TQVYCKWRYH
210 220 230 240 250
QGRDVDFEAT WDTVRSIVLQ KFAGPYDKGE YSPSVQKTLY DIQVLTLGQV
260 270 280 290 300
PEIEDMEISL PNIHYLNIDM SKMGLINKEE VLLPLDNPYG RITGTVKRKL

TSRL
Length:304
Mass (Da):35,008
Last modified:January 23, 2007 - v3
Checksum:i62066026C59F7FA3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M27697 mRNA. Translation: AAA31141.1.
M19733 mRNA. Translation: AAA31140.1.
PIRiC36227.
RefSeqiNP_999435.1. NM_214270.1.
UniGeneiSsc.16302.

Genome annotation databases

GeneIDi397510.
KEGGissc:397510.

Similar proteinsi

Entry informationi

Entry nameiURIC_PIG
AccessioniPrimary (citable) accession number: P16164
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: January 23, 2007
Last modified: June 7, 2017
This is version 117 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families