Reviewed, UniProtKB/Swiss-Prot P16157 (ANK1_HUMAN)

Names and origin

Protein names

Recommended name:
    Ankyrin-1
Alternative name(s):
    Erythrocyte ankyrin
    Ankyrin-R

Gene names

Name:	ANK1
Synonyms:	ANK

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	1881 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Attaches integral membrane proteins to cytoskeletal elements; binds to the erythrocyte membrane protein band 4.2, to Na-K ATPase, to the lymphocyte membrane protein GP85, and to the cytoskeletal proteins fodrin, tubulin, vimentin and desmin. Erythrocyte ankyrins also link spectrin (beta chain) to the cytoplasmic domain of the erythrocytes anion exchange protein; they retain most or all of these binding functions. Ref.14 Isoform Mu17 together with obscurin in skeletal muscle may provide a molecular link between the sarcoplasmic reticulum and myofibrils.
Subunit structure	Interacts with a number of integral membrane proteins and cytoskeletal proteins. Binds SPTB/spectrin (beta chain) through a 70 AA N-terminal region of the 62 kDa domain, and the C-terminal of SLC4A1/erythrocyte membrane protein band 3 through the ankyrin repeat region. Also interacts with TTN/titin. Isoform Mu17 interacts with OBSCN isoform 3/obscurin. Ref.9 Ref.10
Subcellular location	Isoform Er1: Cytoplasm › cytoskeleton. Note: Probably the other erythrocyte (Er) isoforms, are located near the surface of erythrocytic plasma membrane. Ref.10 Ref.4 Isoform Mu17: Membrane. Cytoplasm › myofibril › sarcomere › M-band. Note: Colocalizes with OBSCN isoform 3/obscurin at the M line in differentiated skeletal muscle cells. Ref.10 Ref.4 Isoform Mu18: Sarcoplasmic reticulum Probable. Isoform Mu19: Sarcoplasmic reticulum Probable. Isoform Mu20: Sarcoplasmic reticulum Probable.
Tissue specificity	Isoform Mu17, isoform Mu18, isoform Mu19 and isoform Mu20 are expressed in skeletal muscle. Isoform Br21 is expressed in brain. Ref.4
Domain	The 55 kDa regulatory domain is involved in regulating binding of SPTB/spectrin (beta chain) and SLC4A1/erythrocyte membrane protein band 3. Ref.14 Ref.8 The ANK repeat region forms a spiral around a large central cavity and is involved in binding of ion transporters. Ref.14 Ref.8
Post-translational modification	Regulated by phosphorylation. Palmitoylated.
Involvement in disease	Defects in ANK1 are a cause of spherocytosis type 1 (SPH1) [MIM:182900]; also called hereditary spherocytosis type 1 (HS1). Spherocytosis is a hematologic disorder leading to chronic hemolytic anemia and characterized by numerous abnormally shaped erythrocytes which are generally spheroidal. Inheritance can be autosomal dominant or recessive. Ref.16 Ref.17
Sequence similarities	Contains 23 ANK repeats. Contains 1 death domain. Contains 1 ZU5 domain.
Sequence caution	The sequence AAB47805.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Cellular component	Cytoplasm Cytoskeleton Membrane Sarcoplasmic reticulum
Coding sequence diversity	Alternative promoter usage Alternative splicing Polymorphism
Disease	Disease mutation Elliptocytosis Hereditary hemolytic anemia
Domain	ANK repeat Repeat
PTM	Lipoprotein Phosphoprotein
Technical term	3D-structure Complete proteome Direct protein sequencing
Gene Ontology (GO)
Biological process	cytoskeleton organization Ref.4 Non-traceable author statement. Source: UniProtKB exocytosis Non-traceable author statement. Source: UniProtKB maintenance of epithelial cell apical/basal polarity Traceable author statement. Source: UniProtKB signal transduction Inferred from electronic annotation. Source: InterPro
Cellular component	M band Inferred from electronic annotation. Source: UniProtKB-SubCell basolateral plasma membrane Non-traceable author statement. Source: UniProtKB sarcoplasmic reticulum Inferred from electronic annotation. Source: UniProtKB-KW spectrin-associated cytoskeleton Inferred from direct assay. Source: UniProtKB
Molecular function	cytoskeletal adaptor activity Traceable author statement. Source: UniProtKB enzyme binding Traceable author statement. Source: UniProtKB spectrin binding Ref.16 Non-traceable author statement. Source: UniProtKB structural constituent of cytoskeleton Ref.16 Traceable author statement. Source: ProtInc
Complete GO annotation...

Alternative products

This entry describes 21 isoforms produced by alternative promoter usage and alternative splicing. [Align] [Select]

Isoform Er1 (identifier: P16157-1)

Also known as: 1; 2.1;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Note: Probably the other erythrocyte (Er) isoforms, are located near the surface of erythrocytic plasma membrane. Ref.10 Ref.4 Major erythrocyte-specific isoform. Produced by alternative promoter usage.

Isoform Er2 (identifier: P16157-4)

Also known as: 2; 2.2;

The sequence of this isoform differs from the canonical sequence as follows:
     1514-1675: Missing.

Note: Predominant form of minor erythrocyte-specific isoforms. Produced by alternative splicing of isoform Er1.

Isoform Er3 (identifier: P16157-5)

Also known as: 3;

The sequence of this isoform differs from the canonical sequence as follows:
     1849-1873: Missing.

Note: Produced by alternative splicing of isoform Er1.

Isoform Er4 (identifier: P16157-6)

Also known as: 4;

The sequence of this isoform differs from the canonical sequence as follows:
     1514-1675: Missing.
     1849-1873: Missing.

Note: Produced by alternative splicing of isoform Er1.

Isoform Er5 (identifier: P16157-3)

Also known as: 5;

The sequence of this isoform differs from the canonical sequence as follows:
     1850-1881: TVEGPLEDPSELEVDIDYFMKHSKDHTSTPNP → ELRGSGLQPDLIEGRKGAQIVKRASLKRGKQ

Note: Produced by alternative splicing of isoform Er1.

Isoform Er6 (identifier: P16157-7)

Also known as: 6;

The sequence of this isoform differs from the canonical sequence as follows:
     1514-1675: Missing.
     1850-1881: TVEGPLEDPSELEVDIDYFMKHSKDHTSTPNP → ELRGSGLQPDLIEGRKGAQIVKRASLKRGKQ

Note: Produced by alternative splicing of isoform Er1.

Isoform Er7 (identifier: P16157-8)

Also known as: 7;

The sequence of this isoform differs from the canonical sequence as follows:
     1827-1873: Missing.

Note: Produced by alternative splicing of isoform Er1.

Isoform Er8 (identifier: P16157-9)

Also known as: 8;

The sequence of this isoform differs from the canonical sequence as follows:
     1514-1675: Missing.
     1827-1873: Missing.

Isoform Er9 (identifier: P16157-10)

Also known as: 9;

The sequence of this isoform differs from the canonical sequence as follows:
     1799-1873: Missing.

Note: Produced by alternative splicing of isoform Er1.

Isoform Er10 (identifier: P16157-11)

Also known as: 10;

The sequence of this isoform differs from the canonical sequence as follows:
     1514-1675: Missing.
     1799-1873: Missing.

Note: Produced by alternative splicing of isoform Er1.

Isoform Er11 (identifier: P16157-12)

Also known as: 11;

The sequence of this isoform differs from the canonical sequence as follows:
     1874-1881: DHTSTPNP → VELRGSGLQPDLIEGRKGAQIVKRASLKRGKQ

Note: Produced by alternative splicing of isoform Er1.

Isoform Er12 (identifier: P16157-13)

Also known as: 12;

The sequence of this isoform differs from the canonical sequence as follows:
     1514-1675: Missing.
     1874-1881: DHTSTPNP → VELRGSGLQPDLIEGRKGAQIVKRASLKRGKQ

Note: Produced by alternative splicing of isoform Er1.

Isoform Er13 (identifier: P16157-14)

Also known as: 13;

The sequence of this isoform differs from the canonical sequence as follows:
     1874-1881: DHTSTPNP → VLRRPRPWGT...KRASLKRGKQ

Note: Produced by alternative splicing of isoform Er1.

Isoform Er14 (identifier: P16157-15)

Also known as: 14;

The sequence of this isoform differs from the canonical sequence as follows:
     1514-1675: Missing.
     1874-1881: DHTSTPNP → VLRRPRPWGT...KRASLKRGKQ

Note: Produced by alternative splicing of isoform Er1.

Isoform Er15 (identifier: P16157-16)

Also known as: 15;

The sequence of this isoform differs from the canonical sequence as follows:
     1827-1881: IIRKVVRQID...SKDHTSTPNP → VELRGSGLQPDLIEGRKGAQIVKRASLKRGKQ

Note: Produced by alternative splicing of isoform Er1.

Isoform Er16 (identifier: P16157-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1513-1874: Missing.
     1875-1875: H → D

Note: Produced by alternative splicing of isoform Er1.

Isoform Mu17 (identifier: P16157-17)

Also known as: ank1.5; muscle-specific 1;

The sequence of this isoform differs from the canonical sequence as follows:
     1-1725: Missing.
     1726-1798: TQGPHSFQGT...AKNTFTQVVQ → MWTFVTQLLV...RVVRRRVFLK
     1850-1881: TVEGPLEDPSELEVDIDYFMKHSKDHTSTPNP → ELRGSGLQPDLIEGRKGAQIVKRASLKRGKQ

Note: Colocalizes with OBSCN isoform 3/obscurin at the M line in differentiated skeletal muscle cells. Ref.10 Ref.4 Produced by alternative promoter usage.

Isoform Mu18 (identifier: P16157-18)

Also known as: ank1.6; muscle-specific 2;

The sequence of this isoform differs from the canonical sequence as follows:
     1-1725: Missing.
     1726-1798: TQGPHSFQGT...AKNTFTQVVQ → MWTFVTQLLV...RVVRRRVFLK
     1827-1881: IIRKVVRQID...SKDHTSTPNP → VELRGSGLQPDLIEGRKGAQIVKRASLKRGKQ

Note: Produced by alternative splicing of isoform Mu17.

Isoform Mu19 (identifier: P16157-19)

Also known as: muscle-specific 3;

The sequence of this isoform differs from the canonical sequence as follows:
     1-1725: Missing.
     1726-1798: TQGPHSFQGT...AKNTFTQVVQ → MWTFVTQLLV...RVVRRRVFLK
     1799-1873: Missing.

Note: Produced by alternative splicing of isoform Mu17.

Isoform Mu20 (identifier: P16157-20)

Also known as: muscle-specific 4;

The sequence of this isoform differs from the canonical sequence as follows:
     1-1725: Missing.
     1726-1798: TQGPHSFQGT...AKNTFTQVVQ → MWTFVTQLLV...LCFVLKHIHQ
     1799-1881: GNEFQNIPGE...SKDHTSTPNP → VELRGSGLQPDLIEGRKGAQIVKRASLKRGKQ

Note: Produced by alternative splicing of isoform Mu17.

Isoform Br21 (identifier: P16157-21)

The sequence of this isoform differs from the canonical sequence as follows:
     1-9: MPYSVGFRE → MAQAAKQLKKIKDIEAQALQEQKEKEESNRKRRNRSRDRKKK
     820-820: E → EGTAHITIM
     1849-1873: Missing.

Note: No experimental confirmation available. Produced by alternative splicing of isoform Er1.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Initiator methionine

1

1

Removed

Chain

2 – 1881

1880

Ankyrin-1

PRO_0000066883

Regions

Repeat

44 – 73

30

ANK 1

Repeat

77 – 106

30

ANK 2

Repeat

110 – 139

30

ANK 3

Repeat

143 – 172

30

ANK 4

Repeat

174 – 201

28

ANK 5

Repeat

205 – 234

30

ANK 6

Repeat

238 – 267

30

ANK 7

Repeat

271 – 300

30

ANK 8

Repeat

304 – 333

30

ANK 9

Repeat

337 – 366

30

ANK 10

Repeat

370 – 399

30

ANK 11

Repeat

403 – 432

30

ANK 12

Repeat

436 – 465

30

ANK 13

Repeat

469 – 498

30

ANK 14

Repeat

502 – 531

30

ANK 15

Repeat

535 – 564

30

ANK 16

Repeat

568 – 597

30

ANK 17

Repeat

601 – 630

30

ANK 18

Repeat

634 – 663

30

ANK 19

Repeat

667 – 696

30

ANK 20

Repeat

700 – 729

30

ANK 21

Repeat

733 – 762

30

ANK 22

Repeat

766 – 795

30

ANK 23

Domain

911 – 1018

108

ZU5

Domain

1403 – 1487

85

Death

Region

2 – 827

826

89 kDa domain

Region

1383 – 1881

499

55 kDa regulatory domain

Amino acid modifications

Modified residue

834

1

Phosphoserine Ref.13

Modified residue

856

1

Phosphoserine By similarity

Modified residue

1073

1

Phosphotyrosine By similarity

Modified residue

1684

1

Phosphothreonine Ref.11

Modified residue

1686

1

Phosphoserine Ref.11 Ref.12

Natural variations

Alternative sequence

1 – 1725

1725

Missing in isoform Mu17, isoform Mu18, isoform Mu19 and isoform Mu20.

VSP_018440

Alternative sequence

1 – 9

9

MPYSVGFRE → MAQAAKQLKKIKDIEAQALQ EQKEKEESNRKRRNRSRDRK KK in isoform Br21.

VSP_018439

Alternative sequence

820

1

E → EGTAHITIM in isoform Br21.

VSP_018441

Alternative sequence

1513 – 1874

362

Missing in isoform Er16.

VSP_000264

Alternative sequence

1514 – 1675

162

Missing in isoform Er2, isoform Er4, isoform Er6, isoform Er8, isoform Er10, isoform Er12 and isoform Er14.

VSP_018442

Alternative sequence

1726 – 1798

73

TQGPH…TQVVQ → MWTFVTQLLVTLVLLSFFLV SCQNVMHIVRGSLCFVLKHI HQELDKELGESEGLSDDEET ISPRVVRRRVFLK in isoform Mu17, isoform Mu18 and isoform Mu19.

VSP_018443

Alternative sequence

1726 – 1798

73

TQGPH…TQVVQ → MWTFVTQLLVTLVLLSFFLV SCQNVMHIVRGSLCFVLKHI HQ in isoform Mu20.

VSP_018444

Alternative sequence

1799 – 1881

83

GNEFQ…STPNP → VELRGSGLQPDLIEGRKGAQ IVKRASLKRGKQ in isoform Mu20.

VSP_018446

Alternative sequence

1799 – 1873

75

Missing in isoform Er9, isoform Er10 and isoform Mu19.

VSP_018445

Alternative sequence

1827 – 1881

55

IIRKV…STPNP → VELRGSGLQPDLIEGRKGAQ IVKRASLKRGKQ in isoform Er15 and isoform Mu18.

VSP_018448

Alternative sequence

1827 – 1873

47

Missing in isoform Er7 and isoform Er8.

VSP_018447

Alternative sequence

1849 – 1873

25

Missing in isoform Er3, isoform Er4 and isoform Br21.

VSP_018449

Alternative sequence

1850 – 1881

32

TVEGP…STPNP → ELRGSGLQPDLIEGRKGAQI VKRASLKRGKQ in isoform Er5, isoform Er6 and isoform Mu17.

VSP_000266

Alternative sequence

1874 – 1881

8

DHTSTPNP → VELRGSGLQPDLIEGRKGAQ IVKRASLKRGKQ in isoform Er11 and isoform Er12.

VSP_018450

Alternative sequence

1874 – 1881

8

DHTSTPNP → VLRRPRPWGTQRHHCCLALP GRLHDTSLHSPLYELSLQSL FSLVGSVSAPPCRSFRSSAC VLPVFAICPAFCLCCCLQVE LRGSGLQPDLIEGRKGAQIV KRASLKRGKQ in isoform Er13 and isoform Er14.

VSP_018451

Alternative sequence

1875

1

H → D in isoform Er16.

VSP_000265

Natural variant

21

1

R → T

VAR_000595

Natural variant

276

1

L → R in SPH1. Ref.17

VAR_054991

Natural variant

332

1

D → H in a breast cancer sample; somatic mutation. Ref.18

VAR_035605

Natural variant

463

1

V → I in SPH1. Ref.16

VAR_000596

Natural variant

619

1

R → H in Brueggen. dbSNP rs2304877.

VAR_000597

Natural variant

733

1

L → I: dbSNP rs11778936.

VAR_028769

Natural variant

750

1

V → A

VAR_000598

Natural variant

832

1

R → Q: dbSNP rs34523608.

VAR_061012

Natural variant

845

1

D → E

VAR_000599

Natural variant

991

1

V → L

VAR_026411

Natural variant

1054

1

I → T in SPH1. Ref.17

VAR_054992

Natural variant

1075

1

T → I: dbSNP rs35213384. Ref.1 Ref.2 Ref.3 Ref.5

VAR_048263

Natural variant

1126

1

A → P: dbSNP rs504465.

VAR_028770

Natural variant

1192

1

T → P: dbSNP rs486770.

VAR_028771

Natural variant

1286

1

E → D

VAR_000601

Natural variant

1325

1

M → V: dbSNP rs10093583.

VAR_028772

Natural variant

1392

1

S → T

VAR_000600

Natural variant

1546

1

V → I: dbSNP rs1060130. Ref.2

VAR_028773

Natural variant

1592

1

D → N in Duesseldorf.

VAR_000602

Experimental info

Mutagenesis

1824

1

T → P: Abolishes interaction with OBSCN (in isoform Mu17). Ref.10

Mutagenesis

1826

1

K → E: Abolishes interaction with OBSCN (in isoform Mu17). Ref.10

Mutagenesis

1829

1

R → G: Abolishes interaction with OBSCN (in isoform Mu17). Ref.10

Mutagenesis

1830

1

K → E: Abolishes interaction with OBSCN (in isoform Mu17). Ref.10

Sequence conflict

230

1

A → S in AAA51732. Ref.2

Sequence conflict

801

1

K → L in AAB47805. Ref.3

Sequence conflict

845

1

D → R AA sequence Ref.1

Sequence conflict

902

1

I → T in AAB47805. Ref.3

Secondary structure

1

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1881

Helix Strand Turn

Details...

Helix

407 – 414

8

Helix

417 – 425

9

Beta strand

433 – 435

3

Helix

440 – 447

8

Helix

450 – 459

10

Helix

473 – 480

8

Helix

483 – 492

10

Helix

506 – 513

8

Helix

516 – 524

9

Helix

539 – 545

7

Helix

549 – 557

9

Helix

572 – 578

7

Helix

582 – 588

7

Helix

589 – 591

3

Helix

605 – 611

7

Helix

615 – 623

9

Helix

638 – 644

7

Helix

648 – 655

8

Turn

656 – 658

3

Helix

671 – 678

8

Helix

681 – 690

10

Helix

704 – 710

7

Helix

715 – 722

8

Helix

737 – 743

7

Helix

747 – 755

9

Beta strand

765 – 767

3

Helix

770 – 776

7

Helix

780 – 789

10

Turn

1398 – 1402

5

Helix

1403 – 1414

12

Helix

1415 – 1417

3

Helix

1418 – 1424

7

Helix

1429 – 1438

10

Helix

1443 – 1458

16

Helix

1459 – 1461

3

Helix

1464 – 1473

10

Helix

1477 – 1483

7

Sequences

	Sequence		Length	Mass (Da)
	Isoform Er1 (1) (2.1) [UniParc]. Last modified January 23, 2007. Version 3. Checksum: 49466F6F915019EC	FASTA	1,881	206,265
	10 20 30 40 50 60 MPYSVGFREA DAATSFLRAA RSGNLDKALD HLRNGVDINT CNQNGLNGLH LASKEGHVKM 70 80 90 100 110 120 VVELLHKEII LETTTKKGNT ALHIAALAGQ DEVVRELVNY GANVNAQSQK GFTPLYMAAQ 130 140 150 160 170 180 ENHLEVVKFL LENGANQNVA TEDGFTPLAV ALQQGHENVV AHLINYGTKG KVRLPALHIA 190 200 210 220 230 240 ARNDDTRTAA VLLQNDPNPD VLSKTGFTPL HIAAHYENLN VAQLLLNRGA SVNFTPQNGI 250 260 270 280 290 300 TPLHIASRRG NVIMVRLLLD RGAQIETKTK DELTPLHCAA RNGHVRISEI LLDHGAPIQA 310 320 330 340 350 360 KTKNGLSPIH MAAQGDHLDC VRLLLQYDAE IDDITLDHLT PLHVAAHCGH HRVAKVLLDK 370 380 390 400 410 420 GAKPNSRALN GFTPLHIACK KNHVRVMELL LKTGASIDAV TESGLTPLHV ASFMGHLPIV 430 440 450 460 470 480 KNLLQRGASP NVSNVKVETP LHMAARAGHT EVAKYLLQNK AKVNAKAKDD QTPLHCAARI 490 500 510 520 530 540 GHTNMVKLLL ENNANPNLAT TAGHTPLHIA AREGHVETVL ALLEKEASQA CMTKKGFTPL 550 560 570 580 590 600 HVAAKYGKVR VAELLLERDA HPNAAGKNGL TPLHVAVHHN NLDIVKLLLP RGGSPHSPAW 610 620 630 640 650 660 NGYTPLHIAA KQNQVEVARS LLQYGGSANA ESVQGVTPLH LAAQEGHAEM VALLLSKQAN 670 680 690 700 710 720 GNLGNKSGLT PLHLVAQEGH VPVADVLIKH GVMVDATTRM GYTPLHVASH YGNIKLVKFL 730 740 750 760 770 780 LQHQADVNAK TKLGYSPLHQ AAQQGHTDIV TLLLKNGASP NEVSSDGTTP LAIAKRLGYI 790 800 810 820 830 840 SVTDVLKVVT DETSFVLVSD KHRMSFPETV DEILDVSEDE GEELISFKAE RRDSRDVDEE 850 860 870 880 890 900 KELLDFVPKL DQVVESPAIP RIPCAMPETV VIRSEEQEQA SKEYDEDSLI PSSPATETSD 910 920 930 940 950 960 NISPVASPVH TGFLVSFMVD ARGGSMRGSR HNGLRVVIPP RTCAAPTRIT CRLVKPQKLS 970 980 990 1000 1010 1020 TPPPLAEEEG LASRIIALGP TGAQFLSPVI VEIPHFASHG RGDRELVVLR SENGSVWKEH 1030 1040 1050 1060 1070 1080 RSRYGESYLD QILNGMDEEL GSLEELEKKR VCRIITTDFP LYFVIMSRLC QDYDTIGPEG 1090 1100 1110 1120 1130 1140 GSLKSKLVPL VQATFPENAV TKRVKLALQA QPVPDELVTK LLGNQATFSP IVTVEPRRRK 1150 1160 1170 1180 1190 1200 FHRPIGLRIP LPPSWTDNPR DSGEGDTTSL RLLCSVIGGT DQAQWEDITG TTKLVYANEC 1210 1220 1230 1240 1250 1260 ANFTTNVSAR FWLSDCPRTA EAVNFATLLY KELTAVPYMA KFVIFAKMND PREGRLRCYC 1270 1280 1290 1300 1310 1320 MTDDKVDKTL EQHENFVEVA RSRDIEVLEG MSLFAELSGN LVPVKKAAQQ RSFHFQSFRE 1330 1340 1350 1360 1370 1380 NRLAMPVKVR DSSREPGGSL SFLRKAMKYE DTQHILCHLN ITMPPCAKGS GAEDRRRTPT 1390 1400 1410 1420 1430 1440 PLALRYSILS ESTPGSLSGT EQAEMKMAVI SEHLGLSWAE LARELQFSVE DINRIRVENP 1450 1460 1470 1480 1490 1500 NSLLEQSVAL LNLWVIREGQ NANMENLYTA LQSIDRGEIV NMLEGSGRQS RNLKPDRRHT 1510 1520 1530 1540 1550 1560 DRDYSLSPSQ MNGYSSLQDE LLSPASLGCA LSSPLRADQY WNEVAVLDAI PLAATEHDTM 1570 1580 1590 1600 1610 1620 LEMSDMQVWS AGLTPSLVTA EDSSLECSKA EDSDATGHEW KLEGALSEEP RGPELGSLEL 1630 1640 1650 1660 1670 1680 VEDDTVDSDA TNGLIDLLEQ EEGQRSEEKL PGSKRQDDAT GAGQDSENEV SLVSGHQRGQ 1690 1700 1710 1720 1730 1740 ARITHSPTVS QVTERSQDRL QDWDADGSIV SYLQDAAQGS WQEEVTQGPH SFQGTSTMTE 1750 1760 1770 1780 1790 1800 GLEPGGSQEY EKVLVSVSEH TWTEQPEAES SQADRDRRQQ GQEEQVQEAK NTFTQVVQGN 1810 1820 1830 1840 1850 1860 EFQNIPGEQV TEEQFTDEQG NIVTKKIIRK VVRQIDLSSA DAAQEHEEVT VEGPLEDPSE 1870 1880 LEVDIDYFMK HSKDHTSTPN P
	Isoform Er2 (2) (2.2). Checksum: 407D614678AF8EE0	FASTA	1,719	188,999
	10 20 30 40 50 60 MPYSVGFREA DAATSFLRAA RSGNLDKALD HLRNGVDINT CNQNGLNGLH LASKEGHVKM 70 80 90 100 110 120 VVELLHKEII LETTTKKGNT ALHIAALAGQ DEVVRELVNY GANVNAQSQK GFTPLYMAAQ 130 140 150 160 170 180 ENHLEVVKFL LENGANQNVA TEDGFTPLAV ALQQGHENVV AHLINYGTKG KVRLPALHIA 190 200 210 220 230 240 ARNDDTRTAA VLLQNDPNPD VLSKTGFTPL HIAAHYENLN VAQLLLNRGA SVNFTPQNGI 250 260 270 280 290 300 TPLHIASRRG NVIMVRLLLD RGAQIETKTK DELTPLHCAA RNGHVRISEI LLDHGAPIQA 310 320 330 340 350 360 KTKNGLSPIH MAAQGDHLDC VRLLLQYDAE IDDITLDHLT PLHVAAHCGH HRVAKVLLDK 370 380 390 400 410 420 GAKPNSRALN GFTPLHIACK KNHVRVMELL LKTGASIDAV TESGLTPLHV ASFMGHLPIV 430 440 450 460 470 480 KNLLQRGASP NVSNVKVETP LHMAARAGHT EVAKYLLQNK AKVNAKAKDD QTPLHCAARI 490 500 510 520 530 540 GHTNMVKLLL ENNANPNLAT TAGHTPLHIA AREGHVETVL ALLEKEASQA CMTKKGFTPL 550 560 570 580 590 600 HVAAKYGKVR VAELLLERDA HPNAAGKNGL TPLHVAVHHN NLDIVKLLLP RGGSPHSPAW 610 620 630 640 650 660 NGYTPLHIAA KQNQVEVARS LLQYGGSANA ESVQGVTPLH LAAQEGHAEM VALLLSKQAN 670 680 690 700 710 720 GNLGNKSGLT PLHLVAQEGH VPVADVLIKH GVMVDATTRM GYTPLHVASH YGNIKLVKFL 730 740 750 760 770 780 LQHQADVNAK TKLGYSPLHQ AAQQGHTDIV TLLLKNGASP NEVSSDGTTP LAIAKRLGYI 790 800 810 820 830 840 SVTDVLKVVT DETSFVLVSD KHRMSFPETV DEILDVSEDE GEELISFKAE RRDSRDVDEE 850 860 870 880 890 900 KELLDFVPKL DQVVESPAIP RIPCAMPETV VIRSEEQEQA SKEYDEDSLI PSSPATETSD 910 920 930 940 950 960 NISPVASPVH TGFLVSFMVD ARGGSMRGSR HNGLRVVIPP RTCAAPTRIT CRLVKPQKLS 970 980 990 1000 1010 1020 TPPPLAEEEG LASRIIALGP TGAQFLSPVI VEIPHFASHG RGDRELVVLR SENGSVWKEH 1030 1040 1050 1060 1070 1080 RSRYGESYLD QILNGMDEEL GSLEELEKKR VCRIITTDFP LYFVIMSRLC QDYDTIGPEG 1090 1100 1110 1120 1130 1140 GSLKSKLVPL VQATFPENAV TKRVKLALQA QPVPDELVTK LLGNQATFSP IVTVEPRRRK 1150 1160 1170 1180 1190 1200 FHRPIGLRIP LPPSWTDNPR DSGEGDTTSL RLLCSVIGGT DQAQWEDITG TTKLVYANEC 1210 1220 1230 1240 1250 1260 ANFTTNVSAR FWLSDCPRTA EAVNFATLLY KELTAVPYMA KFVIFAKMND PREGRLRCYC 1270 1280 1290 1300 1310 1320 MTDDKVDKTL EQHENFVEVA RSRDIEVLEG MSLFAELSGN LVPVKKAAQQ RSFHFQSFRE 1330 1340 1350 1360 1370 1380 NRLAMPVKVR DSSREPGGSL SFLRKAMKYE DTQHILCHLN ITMPPCAKGS GAEDRRRTPT 1390 1400 1410 1420 1430 1440 PLALRYSILS ESTPGSLSGT EQAEMKMAVI SEHLGLSWAE LARELQFSVE DINRIRVENP 1450 1460 1470 1480 1490 1500 NSLLEQSVAL LNLWVIREGQ NANMENLYTA LQSIDRGEIV NMLEGSGRQS RNLKPDRRHT 1510 1520 1530 1540 1550 1560 DRDYSLSPSQ MNGHQRGQAR ITHSPTVSQV TERSQDRLQD WDADGSIVSY LQDAAQGSWQ 1570 1580 1590 1600 1610 1620 EEVTQGPHSF QGTSTMTEGL EPGGSQEYEK VLVSVSEHTW TEQPEAESSQ ADRDRRQQGQ 1630 1640 1650 1660 1670 1680 EEQVQEAKNT FTQVVQGNEF QNIPGEQVTE EQFTDEQGNI VTKKIIRKVV RQIDLSSADA 1690 1700 1710 AQEHEEVTVE GPLEDPSELE VDIDYFMKHS KDHTSTPNP
	Isoform Er3 (3). Checksum: FEC7837B2E7711B8	FASTA	1,856	203,405
	10 20 30 40 50 60 MPYSVGFREA DAATSFLRAA RSGNLDKALD HLRNGVDINT CNQNGLNGLH LASKEGHVKM 70 80 90 100 110 120 VVELLHKEII LETTTKKGNT ALHIAALAGQ DEVVRELVNY GANVNAQSQK GFTPLYMAAQ 130 140 150 160 170 180 ENHLEVVKFL LENGANQNVA TEDGFTPLAV ALQQGHENVV AHLINYGTKG KVRLPALHIA 190 200 210 220 230 240 ARNDDTRTAA VLLQNDPNPD VLSKTGFTPL HIAAHYENLN VAQLLLNRGA SVNFTPQNGI 250 260 270 280 290 300 TPLHIASRRG NVIMVRLLLD RGAQIETKTK DELTPLHCAA RNGHVRISEI LLDHGAPIQA 310 320 330 340 350 360 KTKNGLSPIH MAAQGDHLDC VRLLLQYDAE IDDITLDHLT PLHVAAHCGH HRVAKVLLDK 370 380 390 400 410 420 GAKPNSRALN GFTPLHIACK KNHVRVMELL LKTGASIDAV TESGLTPLHV ASFMGHLPIV 430 440 450 460 470 480 KNLLQRGASP NVSNVKVETP LHMAARAGHT EVAKYLLQNK AKVNAKAKDD QTPLHCAARI 490 500 510 520 530 540 GHTNMVKLLL ENNANPNLAT TAGHTPLHIA AREGHVETVL ALLEKEASQA CMTKKGFTPL 550 560 570 580 590 600 HVAAKYGKVR VAELLLERDA HPNAAGKNGL TPLHVAVHHN NLDIVKLLLP RGGSPHSPAW 610 620 630 640 650 660 NGYTPLHIAA KQNQVEVARS LLQYGGSANA ESVQGVTPLH LAAQEGHAEM VALLLSKQAN 670 680 690 700 710 720 GNLGNKSGLT PLHLVAQEGH VPVADVLIKH GVMVDATTRM GYTPLHVASH YGNIKLVKFL 730 740 750 760 770 780 LQHQADVNAK TKLGYSPLHQ AAQQGHTDIV TLLLKNGASP NEVSSDGTTP LAIAKRLGYI 790 800 810 820 830 840 SVTDVLKVVT DETSFVLVSD KHRMSFPETV DEILDVSEDE GEELISFKAE RRDSRDVDEE 850 860 870 880 890 900 KELLDFVPKL DQVVESPAIP RIPCAMPETV VIRSEEQEQA SKEYDEDSLI PSSPATETSD 910 920 930 940 950 960 NISPVASPVH TGFLVSFMVD ARGGSMRGSR HNGLRVVIPP RTCAAPTRIT CRLVKPQKLS 970 980 990 1000 1010 1020 TPPPLAEEEG LASRIIALGP TGAQFLSPVI VEIPHFASHG RGDRELVVLR SENGSVWKEH 1030 1040 1050 1060 1070 1080 RSRYGESYLD QILNGMDEEL GSLEELEKKR VCRIITTDFP LYFVIMSRLC QDYDTIGPEG 1090 1100 1110 1120 1130 1140 GSLKSKLVPL VQATFPENAV TKRVKLALQA QPVPDELVTK LLGNQATFSP IVTVEPRRRK 1150 1160 1170 1180 1190 1200 FHRPIGLRIP LPPSWTDNPR DSGEGDTTSL RLLCSVIGGT DQAQWEDITG TTKLVYANEC 1210 1220 1230 1240 1250 1260 ANFTTNVSAR FWLSDCPRTA EAVNFATLLY KELTAVPYMA KFVIFAKMND PREGRLRCYC 1270 1280 1290 1300 1310 1320 MTDDKVDKTL EQHENFVEVA RSRDIEVLEG MSLFAELSGN LVPVKKAAQQ RSFHFQSFRE 1330 1340 1350 1360 1370 1380 NRLAMPVKVR DSSREPGGSL SFLRKAMKYE DTQHILCHLN ITMPPCAKGS GAEDRRRTPT 1390 1400 1410 1420 1430 1440 PLALRYSILS ESTPGSLSGT EQAEMKMAVI SEHLGLSWAE LARELQFSVE DINRIRVENP 1450 1460 1470 1480 1490 1500 NSLLEQSVAL LNLWVIREGQ NANMENLYTA LQSIDRGEIV NMLEGSGRQS RNLKPDRRHT 1510 1520 1530 1540 1550 1560 DRDYSLSPSQ MNGYSSLQDE LLSPASLGCA LSSPLRADQY WNEVAVLDAI PLAATEHDTM 1570 1580 1590 1600 1610 1620 LEMSDMQVWS AGLTPSLVTA EDSSLECSKA EDSDATGHEW KLEGALSEEP RGPELGSLEL 1630 1640 1650 1660 1670 1680 VEDDTVDSDA TNGLIDLLEQ EEGQRSEEKL PGSKRQDDAT GAGQDSENEV SLVSGHQRGQ 1690 1700 1710 1720 1730 1740 ARITHSPTVS QVTERSQDRL QDWDADGSIV SYLQDAAQGS WQEEVTQGPH SFQGTSTMTE 1750 1760 1770 1780 1790 1800 GLEPGGSQEY EKVLVSVSEH TWTEQPEAES SQADRDRRQQ GQEEQVQEAK NTFTQVVQGN 1810 1820 1830 1840 1850 EFQNIPGEQV TEEQFTDEQG NIVTKKIIRK VVRQIDLSSA DAAQEHEEDH TSTPNP
	Isoform Er4 (4). Checksum: BB17E7510AE1067A	FASTA	1,694	186,139
	10 20 30 40 50 60 MPYSVGFREA DAATSFLRAA RSGNLDKALD HLRNGVDINT CNQNGLNGLH LASKEGHVKM 70 80 90 100 110 120 VVELLHKEII LETTTKKGNT ALHIAALAGQ DEVVRELVNY GANVNAQSQK GFTPLYMAAQ 130 140 150 160 170 180 ENHLEVVKFL LENGANQNVA TEDGFTPLAV ALQQGHENVV AHLINYGTKG KVRLPALHIA 190 200 210 220 230 240 ARNDDTRTAA VLLQNDPNPD VLSKTGFTPL HIAAHYENLN VAQLLLNRGA SVNFTPQNGI 250 260 270 280 290 300 TPLHIASRRG NVIMVRLLLD RGAQIETKTK DELTPLHCAA RNGHVRISEI LLDHGAPIQA 310 320 330 340 350 360 KTKNGLSPIH MAAQGDHLDC VRLLLQYDAE IDDITLDHLT PLHVAAHCGH HRVAKVLLDK 370 380 390 400 410 420 GAKPNSRALN GFTPLHIACK KNHVRVMELL LKTGASIDAV TESGLTPLHV ASFMGHLPIV 430 440 450 460 470 480 KNLLQRGASP NVSNVKVETP LHMAARAGHT EVAKYLLQNK AKVNAKAKDD QTPLHCAARI 490 500 510 520 530 540 GHTNMVKLLL ENNANPNLAT TAGHTPLHIA AREGHVETVL ALLEKEASQA CMTKKGFTPL 550 560 570 580 590 600 HVAAKYGKVR VAELLLERDA HPNAAGKNGL TPLHVAVHHN NLDIVKLLLP RGGSPHSPAW 610 620 630 640 650 660 NGYTPLHIAA KQNQVEVARS LLQYGGSANA ESVQGVTPLH LAAQEGHAEM VALLLSKQAN 670 680 690 700 710 720 GNLGNKSGLT PLHLVAQEGH VPVADVLIKH GVMVDATTRM GYTPLHVASH YGNIKLVKFL 730 740 750 760 770 780 LQHQADVNAK TKLGYSPLHQ AAQQGHTDIV TLLLKNGASP NEVSSDGTTP LAIAKRLGYI 790 800 810 820 830 840 SVTDVLKVVT DETSFVLVSD KHRMSFPETV DEILDVSEDE GEELISFKAE RRDSRDVDEE 850 860 870 880 890 900 KELLDFVPKL DQVVESPAIP RIPCAMPETV VIRSEEQEQA SKEYDEDSLI PSSPATETSD 910 920 930 940 950 960 NISPVASPVH TGFLVSFMVD ARGGSMRGSR HNGLRVVIPP RTCAAPTRIT CRLVKPQKLS 970 980 990 1000 1010 1020 TPPPLAEEEG LASRIIALGP TGAQFLSPVI VEIPHFASHG RGDRELVVLR SENGSVWKEH 1030 1040 1050 1060 1070 1080 RSRYGESYLD QILNGMDEEL GSLEELEKKR VCRIITTDFP LYFVIMSRLC QDYDTIGPEG 1090 1100 1110 1120 1130 1140 GSLKSKLVPL VQATFPENAV TKRVKLALQA QPVPDELVTK LLGNQATFSP IVTVEPRRRK 1150 1160 1170 1180 1190 1200 FHRPIGLRIP LPPSWTDNPR DSGEGDTTSL RLLCSVIGGT DQAQWEDITG TTKLVYANEC 1210 1220 1230 1240 1250 1260 ANFTTNVSAR FWLSDCPRTA EAVNFATLLY KELTAVPYMA KFVIFAKMND PREGRLRCYC 1270 1280 1290 1300 1310 1320 MTDDKVDKTL EQHENFVEVA RSRDIEVLEG MSLFAELSGN LVPVKKAAQQ RSFHFQSFRE 1330 1340 1350 1360 1370 1380 NRLAMPVKVR DSSREPGGSL SFLRKAMKYE DTQHILCHLN ITMPPCAKGS GAEDRRRTPT 1390 1400 1410 1420 1430 1440 PLALRYSILS ESTPGSLSGT EQAEMKMAVI SEHLGLSWAE LARELQFSVE DINRIRVENP 1450 1460 1470 1480 1490 1500 NSLLEQSVAL LNLWVIREGQ NANMENLYTA LQSIDRGEIV NMLEGSGRQS RNLKPDRRHT 1510 1520 1530 1540 1550 1560 DRDYSLSPSQ MNGHQRGQAR ITHSPTVSQV TERSQDRLQD WDADGSIVSY LQDAAQGSWQ 1570 1580 1590 1600 1610 1620 EEVTQGPHSF QGTSTMTEGL EPGGSQEYEK VLVSVSEHTW TEQPEAESSQ ADRDRRQQGQ 1630 1640 1650 1660 1670 1680 EEQVQEAKNT FTQVVQGNEF QNIPGEQVTE EQFTDEQGNI VTKKIIRKVV RQIDLSSADA 1690 AQEHEEDHTS TPNP
	Isoform Er5 (5). Checksum: 3153959168D8D91D	FASTA	1,880	206,026
	10 20 30 40 50 60 MPYSVGFREA DAATSFLRAA RSGNLDKALD HLRNGVDINT CNQNGLNGLH LASKEGHVKM 70 80 90 100 110 120 VVELLHKEII LETTTKKGNT ALHIAALAGQ DEVVRELVNY GANVNAQSQK GFTPLYMAAQ 130 140 150 160 170 180 ENHLEVVKFL LENGANQNVA TEDGFTPLAV ALQQGHENVV AHLINYGTKG KVRLPALHIA 190 200 210 220 230 240 ARNDDTRTAA VLLQNDPNPD VLSKTGFTPL HIAAHYENLN VAQLLLNRGA SVNFTPQNGI 250 260 270 280 290 300 TPLHIASRRG NVIMVRLLLD RGAQIETKTK DELTPLHCAA RNGHVRISEI LLDHGAPIQA 310 320 330 340 350 360 KTKNGLSPIH MAAQGDHLDC VRLLLQYDAE IDDITLDHLT PLHVAAHCGH HRVAKVLLDK 370 380 390 400 410 420 GAKPNSRALN GFTPLHIACK KNHVRVMELL LKTGASIDAV TESGLTPLHV ASFMGHLPIV 430 440 450 460 470 480 KNLLQRGASP NVSNVKVETP LHMAARAGHT EVAKYLLQNK AKVNAKAKDD QTPLHCAARI 490 500 510 520 530 540 GHTNMVKLLL ENNANPNLAT TAGHTPLHIA AREGHVETVL ALLEKEASQA CMTKKGFTPL 550 560 570 580 590 600 HVAAKYGKVR VAELLLERDA HPNAAGKNGL TPLHVAVHHN NLDIVKLLLP RGGSPHSPAW 610 620 630 640 650 660 NGYTPLHIAA KQNQVEVARS LLQYGGSANA ESVQGVTPLH LAAQEGHAEM VALLLSKQAN 670 680 690 700 710 720 GNLGNKSGLT PLHLVAQEGH VPVADVLIKH GVMVDATTRM GYTPLHVASH YGNIKLVKFL 730 740 750 760 770 780 LQHQADVNAK TKLGYSPLHQ AAQQGHTDIV TLLLKNGASP NEVSSDGTTP LAIAKRLGYI 790 800 810 820 830 840 SVTDVLKVVT DETSFVLVSD KHRMSFPETV DEILDVSEDE GEELISFKAE RRDSRDVDEE 850 860 870 880 890 900 KELLDFVPKL DQVVESPAIP RIPCAMPETV VIRSEEQEQA SKEYDEDSLI PSSPATETSD 910 920 930 940 950 960 NISPVASPVH TGFLVSFMVD ARGGSMRGSR HNGLRVVIPP RTCAAPTRIT CRLVKPQKLS 970 980 990 1000 1010 1020 TPPPLAEEEG LASRIIALGP TGAQFLSPVI VEIPHFASHG RGDRELVVLR SENGSVWKEH 1030 1040 1050 1060 1070 1080 RSRYGESYLD QILNGMDEEL GSLEELEKKR VCRIITTDFP LYFVIMSRLC QDYDTIGPEG 1090 1100 1110 1120 1130 1140 GSLKSKLVPL VQATFPENAV TKRVKLALQA QPVPDELVTK LLGNQATFSP IVTVEPRRRK 1150 1160 1170 1180 1190 1200 FHRPIGLRIP LPPSWTDNPR DSGEGDTTSL RLLCSVIGGT DQAQWEDITG TTKLVYANEC 1210 1220 1230 1240 1250 1260 ANFTTNVSAR FWLSDCPRTA EAVNFATLLY KELTAVPYMA KFVIFAKMND PREGRLRCYC 1270 1280 1290 1300 1310 1320 MTDDKVDKTL EQHENFVEVA RSRDIEVLEG MSLFAELSGN LVPVKKAAQQ RSFHFQSFRE 1330 1340 1350 1360 1370 1380 NRLAMPVKVR DSSREPGGSL SFLRKAMKYE DTQHILCHLN ITMPPCAKGS GAEDRRRTPT 1390 1400 1410 1420 1430 1440 PLALRYSILS ESTPGSLSGT EQAEMKMAVI SEHLGLSWAE LARELQFSVE DINRIRVENP 1450 1460 1470 1480 1490 1500 NSLLEQSVAL LNLWVIREGQ NANMENLYTA LQSIDRGEIV NMLEGSGRQS RNLKPDRRHT 1510 1520 1530 1540 1550 1560 DRDYSLSPSQ MNGYSSLQDE LLSPASLGCA LSSPLRADQY WNEVAVLDAI PLAATEHDTM 1570 1580 1590 1600 1610 1620 LEMSDMQVWS AGLTPSLVTA EDSSLECSKA EDSDATGHEW KLEGALSEEP RGPELGSLEL 1630 1640 1650 1660 1670 1680 VEDDTVDSDA TNGLIDLLEQ EEGQRSEEKL PGSKRQDDAT GAGQDSENEV SLVSGHQRGQ 1690 1700 1710 1720 1730 1740 ARITHSPTVS QVTERSQDRL QDWDADGSIV SYLQDAAQGS WQEEVTQGPH SFQGTSTMTE 1750 1760 1770 1780 1790 1800 GLEPGGSQEY EKVLVSVSEH TWTEQPEAES SQADRDRRQQ GQEEQVQEAK NTFTQVVQGN 1810 1820 1830 1840 1850 1860 EFQNIPGEQV TEEQFTDEQG NIVTKKIIRK VVRQIDLSSA DAAQEHEEVE LRGSGLQPDL 1870 1880 IEGRKGAQIV KRASLKRGKQ
	Isoform Er6 (6). Checksum: 9A5DBC78974FD512	FASTA	1,718	188,760
	10 20 30 40 50 60 MPYSVGFREA DAATSFLRAA RSGNLDKALD HLRNGVDINT CNQNGLNGLH LASKEGHVKM 70 80 90 100 110 120 VVELLHKEII LETTTKKGNT ALHIAALAGQ DEVVRELVNY GANVNAQSQK GFTPLYMAAQ 130 140 150 160 170 180 ENHLEVVKFL LENGANQNVA TEDGFTPLAV ALQQGHENVV AHLINYGTKG KVRLPALHIA 190 200 210 220 230 240 ARNDDTRTAA VLLQNDPNPD VLSKTGFTPL HIAAHYENLN VAQLLLNRGA SVNFTPQNGI 250 260 270 280 290 300 TPLHIASRRG NVIMVRLLLD RGAQIETKTK DELTPLHCAA RNGHVRISEI LLDHGAPIQA 310 320 330 340 350 360 KTKNGLSPIH MAAQGDHLDC VRLLLQYDAE IDDITLDHLT PLHVAAHCGH HRVAKVLLDK 370 380 390 400 410 420 GAKPNSRALN GFTPLHIACK KNHVRVMELL LKTGASIDAV TESGLTPLHV ASFMGHLPIV 430 440 450 460 470 480 KNLLQRGASP NVSNVKVETP LHMAARAGHT EVAKYLLQNK AKVNAKAKDD QTPLHCAARI 490 500 510 520 530 540 GHTNMVKLLL ENNANPNLAT TAGHTPLHIA AREGHVETVL ALLEKEASQA CMTKKGFTPL 550 560 570 580 590 600 HVAAKYGKVR VAELLLERDA HPNAAGKNGL TPLHVAVHHN NLDIVKLLLP RGGSPHSPAW 610 620 630 640 650 660 NGYTPLHIAA KQNQVEVARS LLQYGGSANA ESVQGVTPLH LAAQEGHAEM VALLLSKQAN 670 680 690 700 710 720 GNLGNKSGLT PLHLVAQEGH VPVADVLIKH GVMVDATTRM GYTPLHVASH YGNIKLVKFL 730 740 750 760 770 780 LQHQADVNAK TKLGYSPLHQ AAQQGHTDIV TLLLKNGASP NEVSSDGTTP LAIAKRLGYI 790 800 810 820 830 840 SVTDVLKVVT DETSFVLVSD KHRMSFPETV DEILDVSEDE GEELISFKAE RRDSRDVDEE 850 860 870 880 890 900 KELLDFVPKL DQVVESPAIP RIPCAMPETV VIRSEEQEQA SKEYDEDSLI PSSPATETSD 910 920 930 940 950 960 NISPVASPVH TGFLVSFMVD ARGGSMRGSR HNGLRVVIPP RTCAAPTRIT CRLVKPQKLS 970 980 990 1000 1010 1020 TPPPLAEEEG LASRIIALGP TGAQFLSPVI VEIPHFASHG RGDRELVVLR SENGSVWKEH 1030 1040 1050 1060 1070 1080 RSRYGESYLD QILNGMDEEL GSLEELEKKR VCRIITTDFP LYFVIMSRLC QDYDTIGPEG 1090 1100 1110 1120 1130 1140 GSLKSKLVPL VQATFPENAV TKRVKLALQA QPVPDELVTK LLGNQATFSP IVTVEPRRRK 1150 1160 1170 1180 1190 1200 FHRPIGLRIP LPPSWTDNPR DSGEGDTTSL RLLCSVIGGT DQAQWEDITG TTKLVYANEC 1210 1220 1230 1240 1250 1260 ANFTTNVSAR FWLSDCPRTA EAVNFATLLY KELTAVPYMA KFVIFAKMND PREGRLRCYC 1270 1280 1290 1300 1310 1320 MTDDKVDKTL EQHENFVEVA RSRDIEVLEG MSLFAELSGN LVPVKKAAQQ RSFHFQSFRE 1330 1340 1350 1360 1370 1380 NRLAMPVKVR DSSREPGGSL SFLRKAMKYE DTQHILCHLN ITMPPCAKGS GAEDRRRTPT 1390 1400 1410 1420 1430 1440 PLALRYSILS ESTPGSLSGT EQAEMKMAVI SEHLGLSWAE LARELQFSVE DINRIRVENP 1450 1460 1470 1480 1490 1500 NSLLEQSVAL LNLWVIREGQ NANMENLYTA LQSIDRGEIV NMLEGSGRQS RNLKPDRRHT 1510 1520 1530 1540 1550 1560 DRDYSLSPSQ MNGHQRGQAR ITHSPTVSQV TERSQDRLQD WDADGSIVSY LQDAAQGSWQ 1570 1580 1590 1600 1610 1620 EEVTQGPHSF QGTSTMTEGL EPGGSQEYEK VLVSVSEHTW TEQPEAESSQ ADRDRRQQGQ 1630 1640 1650 1660 1670 1680 EEQVQEAKNT FTQVVQGNEF QNIPGEQVTE EQFTDEQGNI VTKKIIRKVV RQIDLSSADA 1690 1700 1710 AQEHEEVELR GSGLQPDLIE GRKGAQIVKR ASLKRGKQ
	Isoform Er7 (7). Checksum: B3735FA102F08B3D	FASTA	1,834	200,915
	10 20 30 40 50 60 MPYSVGFREA DAATSFLRAA RSGNLDKALD HLRNGVDINT CNQNGLNGLH LASKEGHVKM 70 80 90 100 110 120 VVELLHKEII LETTTKKGNT ALHIAALAGQ DEVVRELVNY GANVNAQSQK GFTPLYMAAQ 130 140 150 160 170 180 ENHLEVVKFL LENGANQNVA TEDGFTPLAV ALQQGHENVV AHLINYGTKG KVRLPALHIA 190 200 210 220 230 240 ARNDDTRTAA VLLQNDPNPD VLSKTGFTPL HIAAHYENLN VAQLLLNRGA SVNFTPQNGI 250 260 270 280 290 300 TPLHIASRRG NVIMVRLLLD RGAQIETKTK DELTPLHCAA RNGHVRISEI LLDHGAPIQA 310 320 330 340 350 360 KTKNGLSPIH MAAQGDHLDC VRLLLQYDAE IDDITLDHLT PLHVAAHCGH HRVAKVLLDK 370 380 390 400 410 420 GAKPNSRALN GFTPLHIACK KNHVRVMELL LKTGASIDAV TESGLTPLHV ASFMGHLPIV 430 440 450 460 470 480 KNLLQRGASP NVSNVKVETP LHMAARAGHT EVAKYLLQNK AKVNAKAKDD QTPLHCAARI 490 500 510 520 530 540 GHTNMVKLLL ENNANPNLAT TAGHTPLHIA AREGHVETVL ALLEKEASQA CMTKKGFTPL 550 560 570 580 590 600 HVAAKYGKVR VAELLLERDA HPNAAGKNGL TPLHVAVHHN NLDIVKLLLP RGGSPHSPAW 610 620 630 640 650 660 NGYTPLHIAA KQNQVEVARS LLQYGGSANA ESVQGVTPLH LAAQEGHAEM VALLLSKQAN 670 680 690 700 710 720 GNLGNKSGLT PLHLVAQEGH VPVADVLIKH GVMVDATTRM GYTPLHVASH YGNIKLVKFL 730 740 750 760 770 780 LQHQADVNAK TKLGYSPLHQ AAQQGHTDIV TLLLKNGASP NEVSSDGTTP LAIAKRLGYI 790 800 810 820 830 840 SVTDVLKVVT DETSFVLVSD KHRMSFPETV DEILDVSEDE GEELISFKAE RRDSRDVDEE 850 860 870 880 890 900 KELLDFVPKL DQVVESPAIP RIPCAMPETV VIRSEEQEQA SKEYDEDSLI PSSPATETSD 910 920 930 940 950 960 NISPVASPVH TGFLVSFMVD ARGGSMRGSR HNGLRVVIPP RTCAAPTRIT CRLVKPQKLS 970 980 990 1000 1010 1020 TPPPLAEEEG LASRIIALGP TGAQFLSPVI VEIPHFASHG RGDRELVVLR SENGSVWKEH 1030 1040 1050 1060 1070 1080 RSRYGESYLD QILNGMDEEL GSLEELEKKR VCRIITTDFP LYFVIMSRLC QDYDTIGPEG 1090 1100 1110 1120 1130 1140 GSLKSKLVPL VQATFPENAV TKRVKLALQA QPVPDELVTK LLGNQATFSP IVTVEPRRRK 1150 1160 1170 1180 1190 1200 FHRPIGLRIP LPPSWTDNPR DSGEGDTTSL RLLCSVIGGT DQAQWEDITG TTKLVYANEC 1210 1220 1230 1240 1250 1260 ANFTTNVSAR FWLSDCPRTA EAVNFATLLY KELTAVPYMA KFVIFAKMND PREGRLRCYC 1270 1280 1290 1300 1310 1320 MTDDKVDKTL EQHENFVEVA RSRDIEVLEG MSLFAELSGN LVPVKKAAQQ RSFHFQSFRE 1330 1340 1350 1360 1370 1380 NRLAMPVKVR DSSREPGGSL SFLRKAMKYE DTQHILCHLN ITMPPCAKGS GAEDRRRTPT 1390 1400 1410 1420 1430 1440 PLALRYSILS ESTPGSLSGT EQAEMKMAVI SEHLGLSWAE LARELQFSVE DINRIRVENP 1450 1460 1470 1480 1490 1500 NSLLEQSVAL LNLWVIREGQ NANMENLYTA LQSIDRGEIV NMLEGSGRQS RNLKPDRRHT 1510 1520 1530 1540 1550 1560 DRDYSLSPSQ MNGYSSLQDE LLSPASLGCA LSSPLRADQY WNEVAVLDAI PLAATEHDTM 1570 1580 1590 1600 1610 1620 LEMSDMQVWS AGLTPSLVTA EDSSLECSKA EDSDATGHEW KLEGALSEEP RGPELGSLEL 1630 1640 1650 1660 1670 1680 VEDDTVDSDA TNGLIDLLEQ EEGQRSEEKL PGSKRQDDAT GAGQDSENEV SLVSGHQRGQ 1690 1700 1710 1720 1730 1740 ARITHSPTVS QVTERSQDRL QDWDADGSIV SYLQDAAQGS WQEEVTQGPH SFQGTSTMTE 1750 1760 1770 1780 1790 1800 GLEPGGSQEY EKVLVSVSEH TWTEQPEAES SQADRDRRQQ GQEEQVQEAK NTFTQVVQGN 1810 1820 1830 EFQNIPGEQV TEEQFTDEQG NIVTKKDHTS TPNP
	Isoform Er8 (8). Checksum: 195930085EF487B7	FASTA	1,672	183,649
	10 20 30 40 50 60 MPYSVGFREA DAATSFLRAA RSGNLDKALD HLRNGVDINT CNQNGLNGLH LASKEGHVKM 70 80 90 100 110 120 VVELLHKEII LETTTKKGNT ALHIAALAGQ DEVVRELVNY GANVNAQSQK GFTPLYMAAQ 130 140 150 160 170 180 ENHLEVVKFL LENGANQNVA TEDGFTPLAV ALQQGHENVV AHLINYGTKG KVRLPALHIA 190 200 210 220 230 240 ARNDDTRTAA VLLQNDPNPD VLSKTGFTPL HIAAHYENLN VAQLLLNRGA SVNFTPQNGI 250 260 270 280 290 300 TPLHIASRRG NVIMVRLLLD RGAQIETKTK DELTPLHCAA RNGHVRISEI LLDHGAPIQA 310 320 330 340 350 360 KTKNGLSPIH MAAQGDHLDC VRLLLQYDAE IDDITLDHLT PLHVAAHCGH HRVAKVLLDK 370 380 390 400 410 420 GAKPNSRALN GFTPLHIACK KNHVRVMELL LKTGASIDAV TESGLTPLHV ASFMGHLPIV 430 440 450 460 470 480 KNLLQRGASP NVSNVKVETP LHMAARAGHT EVAKYLLQNK AKVNAKAKDD QTPLHCAARI 490 500 510 520 530 540 GHTNMVKLLL ENNANPNLAT TAGHTPLHIA AREGHVETVL ALLEKEASQA CMTKKGFTPL 550 560 570 580 590 600 HVAAKYGKVR VAELLLERDA HPNAAGKNGL TPLHVAVHHN NLDIVKLLLP RGGSPHSPAW 610 620 630 640 650 660 NGYTPLHIAA KQNQVEVARS LLQYGGSANA ESVQGVTPLH LAAQEGHAEM VALLLSKQAN 670 680 690 700 710 720 GNLGNKSGLT PLHLVAQEGH VPVADVLIKH GVMVDATTRM GYTPLHVASH YGNIKLVKFL 730 740 750 760 770 780 LQHQADVNAK TKLGYSPLHQ AAQQGHTDIV TLLLKNGASP NEVSSDGTTP LAIAKRLGYI 790 800 810 820 830 840 SVTDVLKVVT DETSFVLVSD KHRMSFPETV DEILDVSEDE GEELISFKAE RRDSRDVDEE 850 860 870 880 890 900 KELLDFVPKL DQVVESPAIP RIPCAMPETV VIRSEEQEQA SKEYDEDSLI PSSPATETSD 910 920 930 940 950 960 NISPVASPVH TGFLVSFMVD ARGGSMRGSR HNGLRVVIPP RTCAAPTRIT CRLVKPQKLS 970 980 990 1000 1010 1020 TPPPLAEEEG LASRIIALGP TGAQFLSPVI VEIPHFASHG RGDRELVVLR SENGSVWKEH 1030 1040 1050 1060 1070 1080 RSRYGESYLD QILNGMDEEL GSLEELEKKR VCRIITTDFP LYFVIMSRLC QDYDTIGPEG 1090 1100 1110 1120 1130 1140 GSLKSKLVPL VQATFPENAV TKRVKLALQA QPVPDELVTK LLGNQATFSP IVTVEPRRRK 1150 1160 1170 1180 1190 1200 FHRPIGLRIP LPPSWTDNPR DSGEGDTTSL RLLCSVIGGT DQAQWEDITG TTKLVYANEC 1210 1220 1230 1240 1250 1260 ANFTTNVSAR FWLSDCPRTA EAVNFATLLY KELTAVPYMA KFVIFAKMND PREGRLRCYC 1270 1280 1290 1300 1310 1320 MTDDKVDKTL EQHENFVEVA RSRDIEVLEG MSLFAELSGN LVPVKKAAQQ RSFHFQSFRE 1330 1340 1350 1360 1370 1380 NRLAMPVKVR DSSREPGGSL SFLRKAMKYE DTQHILCHLN ITMPPCAKGS GAEDRRRTPT 1390 1400 1410 1420 1430 1440 PLALRYSILS ESTPGSLSGT EQAEMKMAVI SEHLGLSWAE LARELQFSVE DINRIRVENP 1450 1460 1470 1480 1490 1500 NSLLEQSVAL LNLWVIREGQ NANMENLYTA LQSIDRGEIV NMLEGSGRQS RNLKPDRRHT 1510 1520 1530 1540 1550 1560 DRDYSLSPSQ MNGHQRGQAR ITHSPTVSQV TERSQDRLQD WDADGSIVSY LQDAAQGSWQ 1570 1580 1590 1600 1610 1620 EEVTQGPHSF QGTSTMTEGL EPGGSQEYEK VLVSVSEHTW TEQPEAESSQ ADRDRRQQGQ 1630 1640 1650 1660 1670 EEQVQEAKNT FTQVVQGNEF QNIPGEQVTE EQFTDEQGNI VTKKDHTSTP NP
	Isoform Er9 (9). Checksum: A50828175CF6AD01	FASTA	1,806	197,752
	10 20 30 40 50 60 MPYSVGFREA DAATSFLRAA RSGNLDKALD HLRNGVDINT CNQNGLNGLH LASKEGHVKM 70 80 90 100 110 120 VVELLHKEII LETTTKKGNT ALHIAALAGQ DEVVRELVNY GANVNAQSQK GFTPLYMAAQ 130 140 150 160 170 180 ENHLEVVKFL LENGANQNVA TEDGFTPLAV ALQQGHENVV AHLINYGTKG KVRLPALHIA 190 200 210 220 230 240 ARNDDTRTAA VLLQNDPNPD VLSKTGFTPL HIAAHYENLN VAQLLLNRGA SVNFTPQNGI 250 260 270 280 290 300 TPLHIASRRG NVIMVRLLLD RGAQIETKTK DELTPLHCAA RNGHVRISEI LLDHGAPIQA 310 320 330 340 350 360 KTKNGLSPIH MAAQGDHLDC VRLLLQYDAE IDDITLDHLT PLHVAAHCGH HRVAKVLLDK 370 380 390 400 410 420 GAKPNSRALN GFTPLHIACK KNHVRVMELL LKTGASIDAV TESGLTPLHV ASFMGHLPIV 430 440 450 460 470 480 KNLLQRGASP NVSNVKVETP LHMAARAGHT EVAKYLLQNK AKVNAKAKDD QTPLHCAARI 490 500 510 520 530 540 GHTNMVKLLL ENNANPNLAT TAGHTPLHIA AREGHVETVL ALLEKEASQA CMTKKGFTPL 550 560 570 580 590 600 HVAAKYGKVR VAELLLERDA HPNAAGKNGL TPLHVAVHHN NLDIVKLLLP RGGSPHSPAW 610 620 630 640 650 660 NGYTPLHIAA KQNQVEVARS LLQYGGSANA ESVQGVTPLH LAAQEGHAEM VALLLSKQAN 670 680 690 700 710 720 GNLGNKSGLT PLHLVAQEGH VPVADVLIKH GVMVDATTRM GYTPLHVASH YGNIKLVKFL 730 740 750 760 770 780 LQHQADVNAK TKLGYSPLHQ AAQQGHTDIV TLLLKNGASP NEVSSDGTTP LAIAKRLGYI 790 800 810 820 830 840 SVTDVLKVVT DETSFVLVSD KHRMSFPETV DEILDVSEDE GEELISFKAE RRDSRDVDEE 850 860 870 880 890 900 KELLDFVPKL DQVVESPAIP RIPCAMPETV VIRSEEQEQA SKEYDEDSLI PSSPATETSD 910 920 930 940 950 960 NISPVASPVH TGFLVSFMVD ARGGSMRGSR HNGLRVVIPP RTCAAPTRIT CRLVKPQKLS 970 980 990 1000 1010 1020 TPPPLAEEEG LASRIIALGP TGAQFLSPVI VEIPHFASHG RGDRELVVLR SENGSVWKEH 1030 1040 1050 1060 1070 1080 RSRYGESYLD QILNGMDEEL GSLEELEKKR VCRIITTDFP LYFVIMSRLC QDYDTIGPEG 1090 1100 1110 1120 1130 1140 GSLKSKLVPL VQATFPENAV TKRVKLALQA QPVPDELVTK LLGNQATFSP IVTVEPRRRK 1150 1160 1170 1180 1190 1200 FHRPIGLRIP LPPSWTDNPR DSGEGDTTSL RLLCSVIGGT DQAQWEDITG TTKLVYANEC 1210 1220 1230 1240 1250 1260 ANFTTNVSAR FWLSDCPRTA EAVNFATLLY KELTAVPYMA KFVIFAKMND PREGRLRCYC 1270 1280 1290 1300 1310 1320 MTDDKVDKTL EQHENFVEVA RSRDIEVLEG MSLFAELSGN LVPVKKAAQQ RSFHFQSFRE 1330 1340 1350 1360 1370 1380 NRLAMPVKVR DSSREPGGSL SFLRKAMKYE DTQHILCHLN ITMPPCAKGS GAEDRRRTPT 1390 1400 1410 1420 1430 1440 PLALRYSILS ESTPGSLSGT EQAEMKMAVI SEHLGLSWAE LARELQFSVE DINRIRVENP 1450 1460 1470 1480 1490 1500 NSLLEQSVAL LNLWVIREGQ NANMENLYTA LQSIDRGEIV NMLEGSGRQS RNLKPDRRHT 1510 1520 1530 1540 1550 1560 DRDYSLSPSQ MNGYSSLQDE LLSPASLGCA LSSPLRADQY WNEVAVLDAI PLAATEHDTM 1570 1580 1590 1600 1610 1620 LEMSDMQVWS AGLTPSLVTA EDSSLECSKA EDSDATGHEW KLEGALSEEP RGPELGSLEL 1630 1640 1650 1660 1670 1680 VEDDTVDSDA TNGLIDLLEQ EEGQRSEEKL PGSKRQDDAT GAGQDSENEV SLVSGHQRGQ 1690 1700 1710 1720 1730 1740 ARITHSPTVS QVTERSQDRL QDWDADGSIV SYLQDAAQGS WQEEVTQGPH SFQGTSTMTE 1750 1760 1770 1780 1790 1800 GLEPGGSQEY EKVLVSVSEH TWTEQPEAES SQADRDRRQQ GQEEQVQEAK NTFTQVVQDH TSTPNP
	Isoform Er10 (10). Checksum: 21DC6E7730722E51	FASTA	1,644	180,487
	10 20 30 40 50 60 MPYSVGFREA DAATSFLRAA RSGNLDKALD HLRNGVDINT CNQNGLNGLH LASKEGHVKM 70 80 90 100 110 120 VVELLHKEII LETTTKKGNT ALHIAALAGQ DEVVRELVNY GANVNAQSQK GFTPLYMAAQ 130 140 150 160 170 180 ENHLEVVKFL LENGANQNVA TEDGFTPLAV ALQQGHENVV AHLINYGTKG KVRLPALHIA 190 200 210 220 230 240 ARNDDTRTAA VLLQNDPNPD VLSKTGFTPL HIAAHYENLN VAQLLLNRGA SVNFTPQNGI 250 260 270 280 290 300 TPLHIASRRG NVIMVRLLLD RGAQIETKTK DELTPLHCAA RNGHVRISEI LLDHGAPIQA 310 320 330 340 350 360 KTKNGLSPIH MAAQGDHLDC VRLLLQYDAE IDDITLDHLT PLHVAAHCGH HRVAKVLLDK 370 380 390 400 410 420 GAKPNSRALN GFTPLHIACK KNHVRVMELL LKTGASIDAV TESGLTPLHV ASFMGHLPIV 430 440 450 460 470 480 KNLLQRGASP NVSNVKVETP LHMAARAGHT EVAKYLLQNK AKVNAKAKDD QTPLHCAARI 490 500 510 520 530 540 GHTNMVKLLL ENNANPNLAT TAGHTPLHIA AREGHVETVL ALLEKEASQA CMTKKGFTPL 550 560 570 580 590 600 HVAAKYGKVR VAELLLERDA HPNAAGKNGL TPLHVAVHHN NLDIVKLLLP RGGSPHSPAW 610 620 630 640 650 660 NGYTPLHIAA KQNQVEVARS LLQYGGSANA ESVQGVTPLH LAAQEGHAEM VALLLSKQAN 670 680 690 700 710 720 GNLGNKSGLT PLHLVAQEGH VPVADVLIKH GVMVDATTRM GYTPLHVASH YGNIKLVKFL 730 740 750 760 770 780 LQHQADVNAK TKLGYSPLHQ AAQQGHTDIV TLLLKNGASP NEVSSDGTTP LAIAKRLGYI 790 800 810 820 830 840 SVTDVLKVVT DETSFVLVSD KHRMSFPETV DEILDVSEDE GEELISFKAE RRDSRDVDEE 850 860 870 880 890 900 KELLDFVPKL DQVVESPAIP RIPCAMPETV VIRSEEQEQA SKEYDEDSLI PSSPATETSD 910 920 930 940 950 960 NISPVASPVH TGFLVSFMVD ARGGSMRGSR HNGLRVVIPP RTCAAPTRIT CRLVKPQKLS 970 980 990 1000 1010 1020 TPPPLAEEEG LASRIIALGP TGAQFLSPVI VEIPHFASHG RGDRELVVLR SENGSVWKEH 1030 1040 1050 1060 1070 1080 RSRYGESYLD QILNGMDEEL GSLEELEKKR VCRIITTDFP LYFVIMSRLC QDYDTIGPEG 1090 1100 1110 1120 1130 1140 GSLKSKLVPL VQATFPENAV TKRVKLALQA QPVPDELVTK LLGNQATFSP IVTVEPRRRK 1150 1160 1170 1180 1190 1200 FHRPIGLRIP LPPSWTDNPR DSGEGDTTSL RLLCSVIGGT DQAQWEDITG TTKLVYANEC 1210 1220 1230 1240 1250 1260 ANFTTNVSAR FWLSDCPRTA EAVNFATLLY KELTAVPYMA KFVIFAKMND PREGRLRCYC 1270 1280 1290 1300 1310 1320 MTDDKVDKTL EQHENFVEVA RSRDIEVLEG MSLFAELSGN LVPVKKAAQQ RSFHFQSFRE 1330 1340 1350 1360 1370 1380 NRLAMPVKVR DSSREPGGSL SFLRKAMKYE DTQHILCHLN ITMPPCAKGS GAEDRRRTPT 1390 1400 1410 1420 1430 1440 PLALRYSILS ESTPGSLSGT EQAEMKMAVI SEHLGLSWAE LARELQFSVE DINRIRVENP 1450 1460 1470 1480 1490 1500 NSLLEQSVAL LNLWVIREGQ NANMENLYTA LQSIDRGEIV NMLEGSGRQS RNLKPDRRHT 1510 1520 1530 1540 1550 1560 DRDYSLSPSQ MNGHQRGQAR ITHSPTVSQV TERSQDRLQD WDADGSIVSY LQDAAQGSWQ 1570 1580 1590 1600 1610 1620 EEVTQGPHSF QGTSTMTEGL EPGGSQEYEK VLVSVSEHTW TEQPEAESSQ ADRDRRQQGQ 1630 1640 EEQVQEAKNT FTQVVQDHTS TPNP
	Isoform Er11 (11). Checksum: 22CA0F47329C69FA	FASTA	1,905	208,886
	10 20 30 40 50 60 MPYSVGFREA DAATSFLRAA RSGNLDKALD HLRNGVDINT CNQNGLNGLH LASKEGHVKM 70 80 90 100 110 120 VVELLHKEII LETTTKKGNT ALHIAALAGQ DEVVRELVNY GANVNAQSQK GFTPLYMAAQ 130 140 150 160 170 180 ENHLEVVKFL LENGANQNVA TEDGFTPLAV ALQQGHENVV AHLINYGTKG KVRLPALHIA 190 200 210 220 230 240 ARNDDTRTAA VLLQNDPNPD VLSKTGFTPL HIAAHYENLN VAQLLLNRGA SVNFTPQNGI 250 260 270 280 290 300 TPLHIASRRG NVIMVRLLLD RGAQIETKTK DELTPLHCAA RNGHVRISEI LLDHGAPIQA 310 320 330 340 350 360 KTKNGLSPIH MAAQGDHLDC VRLLLQYDAE IDDITLDHLT PLHVAAHCGH HRVAKVLLDK 370 380 390 400 410 420 GAKPNSRALN GFTPLHIACK KNHVRVMELL LKTGASIDAV TESGLTPLHV ASFMGHLPIV 430 440 450 460 470 480 KNLLQRGASP NVSNVKVETP LHMAARAGHT EVAKYLLQNK AKVNAKAKDD QTPLHCAARI 490 500 510 520 530 540 GHTNMVKLLL ENNANPNLAT TAGHTPLHIA AREGHVETVL ALLEKEASQA CMTKKGFTPL 550 560 570 580 590 600 HVAAKYGKVR VAELLLERDA HPNAAGKNGL TPLHVAVHHN NLDIVKLLLP RGGSPHSPAW 610 620 630 640 650 660 NGYTPLHIAA KQNQVEVARS LLQYGGSANA ESVQGVTPLH LAAQEGHAEM VALLLSKQAN 670 680 690 700 710 720 GNLGNKSGLT PLHLVAQEGH VPVADVLIKH GVMVDATTRM GYTPLHVASH YGNIKLVKFL 730 740 750 760 770 780 LQHQADVNAK TKLGYSPLHQ AAQQGHTDIV TLLLKNGASP NEVSSDGTTP LAIAKRLGYI 790 800 810 820 830 840 SVTDVLKVVT DETSFVLVSD KHRMSFPETV DEILDVSEDE GEELISFKAE RRDSRDVDEE 850 860 870 880 890 900 KELLDFVPKL DQVVESPAIP RIPCAMPETV VIRSEEQEQA SKEYDEDSLI PSSPATETSD 910 920 930 940 950 960 NISPVASPVH TGFLVSFMVD ARGGSMRGSR HNGLRVVIPP RTCAAPTRIT CRLVKPQKLS 970 980 990 1000 1010 1020 TPPPLAEEEG LASRIIALGP TGAQFLSPVI VEIPHFASHG RGDRELVVLR SENGSVWKEH 1030 1040 1050 1060 1070 1080 RSRYGESYLD QILNGMDEEL GSLEELEKKR VCRIITTDFP LYFVIMSRLC QDYDTIGPEG 1090 1100 1110 1120 1130 1140 GSLKSKLVPL VQATFPENAV TKRVKLALQA QPVPDELVTK LLGNQATFSP IVTVEPRRRK 1150 1160 1170 1180 1190 1200 FHRPIGLRIP LPPSWTDNPR DSGEGDTTSL RLLCSVIGGT DQAQWEDITG TTKLVYANEC 1210 1220 1230 1240 1250 1260 ANFTTNVSAR FWLSDCPRTA EAVNFATLLY KELTAVPYMA KFVIFAKMND PREGRLRCYC 1270 1280 1290 1300 1310 1320 MTDDKVDKTL EQHENFVEVA RSRDIEVLEG MSLFAELSGN LVPVKKAAQQ RSFHFQSFRE 1330 1340 1350 1360 1370 1380 NRLAMPVKVR DSSREPGGSL SFLRKAMKYE DTQHILCHLN ITMPPCAKGS GAEDRRRTPT 1390 1400 1410 1420 1430 1440 PLALRYSILS ESTPGSLSGT EQAEMKMAVI SEHLGLSWAE LARELQFSVE DINRIRVENP 1450 1460 1470 1480 1490 1500 NSLLEQSVAL LNLWVIREGQ NANMENLYTA LQSIDRGEIV NMLEGSGRQS RNLKPDRRHT 1510 1520 1530 1540 1550 1560 DRDYSLSPSQ MNGYSSLQDE LLSPASLGCA LSSPLRADQY WNEVAVLDAI PLAATEHDTM 1570 1580 1590 1600 1610 1620 LEMSDMQVWS AGLTPSLVTA EDSSLECSKA EDSDATGHEW KLEGALSEEP RGPELGSLEL 1630 1640 1650 1660 1670 1680 VEDDTVDSDA TNGLIDLLEQ EEGQRSEEKL PGSKRQDDAT GAGQDSENEV SLVSGHQRGQ 1690 1700 1710 1720 1730 1740 ARITHSPTVS QVTERSQDRL QDWDADGSIV SYLQDAAQGS WQEEVTQGPH SFQGTSTMTE 1750 1760 1770 1780 1790 1800 GLEPGGSQEY EKVLVSVSEH TWTEQPEAES SQADRDRRQQ GQEEQVQEAK NTFTQVVQGN 1810 1820 1830 1840 1850 1860 EFQNIPGEQV TEEQFTDEQG NIVTKKIIRK VVRQIDLSSA DAAQEHEEVT VEGPLEDPSE 1870 1880 1890 1900 LEVDIDYFMK HSKVELRGSG LQPDLIEGRK GAQIVKRASL KRGKQ
	Isoform Er12 (12). Checksum: AA2C9A6353D00A2C	FASTA	1,743	191,620
	10 20 30 40 50 60 MPYSVGFREA DAATSFLRAA RSGNLDKALD HLRNGVDINT CNQNGLNGLH LASKEGHVKM 70 80 90 100 110 120 VVELLHKEII LETTTKKGNT ALHIAALAGQ DEVVRELVNY GANVNAQSQK GFTPLYMAAQ 130 140 150 160 170 180 ENHLEVVKFL LENGANQNVA TEDGFTPLAV ALQQGHENVV AHLINYGTKG KVRLPALHIA 190 200 210 220 230 240 ARNDDTRTAA VLLQNDPNPD VLSKTGFTPL HIAAHYENLN VAQLLLNRGA SVNFTPQNGI 250 260 270 280 290 300 TPLHIASRRG NVIMVRLLLD RGAQIETKTK DELTPLHCAA RNGHVRISEI LLDHGAPIQA 310 320 330 340 350 360 KTKNGLSPIH MAAQGDHLDC VRLLLQYDAE IDDITLDHLT PLHVAAHCGH HRVAKVLLDK 370 380 390 400 410 420 GAKPNSRALN GFTPLHIACK KNHVRVMELL LKTGASIDAV TESGLTPLHV ASFMGHLPIV 430 440 450 460 470 480 KNLLQRGASP NVSNVKVETP LHMAARAGHT EVAKYLLQNK AKVNAKAKDD QTPLHCAARI 490 500 510 520 530 540 GHTNMVKLLL ENNANPNLAT TAGHTPLHIA AREGHVETVL ALLEKEASQA CMTKKGFTPL 550 560 570 580 590 600 HVAAKYGKVR VAELLLERDA HPNAAGKNGL TPLHVAVHHN NLDIVKLLLP RGGSPHSPAW 610 620 630 640 650 660 NGYTPLHIAA KQNQVEVARS LLQYGGSANA ESVQGVTPLH LAAQEGHAEM VALLLSKQAN 670 680 690 700 710 720 GNLGNKSGLT PLHLVAQEGH VPVADVLIKH GVMVDATTRM GYTPLHVASH YGNIKLVKFL 730 740 750 760 770 780 LQHQADVNAK TKLGYSPLHQ AAQQGHTDIV TLLLKNGASP NEVSSDGTTP LAIAKRLGYI 790 800 810 820 830 840 SVTDVLKVVT DETSFVLVSD KHRMSFPETV DEILDVSEDE GEELISFKAE RRDSRDVDEE 850 860 870 880 890 900 KELLDFVPKL DQVVESPAIP RIPCAMPETV VIRSEEQEQA SKEYDEDSLI PSSPATETSD 910 920 930 940 950 960 NISPVASPVH TGFLVSFMVD ARGGSMRGSR HNGLRVVIPP RTCAAPTRIT CRLVKPQKLS 970 980 990 1000 1010 1020 TPPPLAEEEG LASRIIALGP TGAQFLSPVI VEIPHFASHG RGDRELVVLR SENGSVWKEH 1030 1040 1050 1060 1070 1080 RSRYGESYLD QILNGMDEEL GSLEELEKKR VCRIITTDFP LYFVIMSRLC QDYDTIGPEG 1090 1100 1110 1120 1130 1140 GSLKSKLVPL VQATFPENAV TKRVKLALQA QPVPDELVTK LLGNQATFSP IVTVEPRRRK 1150 1160 1170 1180 1190 1200 FHRPIGLRIP LPPSWTDNPR DSGEGDTTSL RLLCSVIGGT DQAQWEDITG TTKLVYANEC 1210 1220 1230 1240 1250 1260 ANFTTNVSAR FWLSDCPRTA EAVNFATLLY KELTAVPYMA KFVIFAKMND PREGRLRCYC 1270 1280 1290 1300 1310 1320 MTDDKVDKTL EQHENFVEVA RSRDIEVLEG MSLFAELSGN LVPVKKAAQQ RSFHFQSFRE 1330 1340 1350 1360 1370 1380 NRLAMPVKVR DSSREPGGSL SFLRKAMKYE DTQHILCHLN ITMPPCAKGS GAEDRRRTPT 1390 1400 1410 1420 1430 1440 PLALRYSILS ESTPGSLSGT EQAEMKMAVI SEHLGLSWAE LARELQFSVE DINRIRVENP 1450 1460 1470 1480 1490 1500 NSLLEQSVAL LNLWVIREGQ NANMENLYTA LQSIDRGEIV NMLEGSGRQS RNLKPDRRHT 1510 1520 1530 1540 1550 1560 DRDYSLSPSQ MNGHQRGQAR ITHSPTVSQV TERSQDRLQD WDADGSIVSY LQDAAQGSWQ 1570 1580 1590 1600 1610 1620 EEVTQGPHSF QGTSTMTEGL EPGGSQEYEK VLVSVSEHTW TEQPEAESSQ ADRDRRQQGQ 1630 1640 1650 1660 1670 1680 EEQVQEAKNT FTQVVQGNEF QNIPGEQVTE EQFTDEQGNI VTKKIIRKVV RQIDLSSADA 1690 1700 1710 1720 1730 1740 AQEHEEVTVE GPLEDPSELE VDIDYFMKHS KVELRGSGLQ PDLIEGRKGA QIVKRASLKR GKQ
	Isoform Er13 (13). Checksum: 94434C72B761D98D	FASTA	1,983	217,479
	10 20 30 40 50 60 MPYSVGFREA DAATSFLRAA RSGNLDKALD HLRNGVDINT CNQNGLNGLH LASKEGHVKM 70 80 90 100 110 120 VVELLHKEII LETTTKKGNT ALHIAALAGQ DEVVRELVNY GANVNAQSQK GFTPLYMAAQ 130 140 150 160 170 180 ENHLEVVKFL LENGANQNVA TEDGFTPLAV ALQQGHENVV AHLINYGTKG KVRLPALHIA 190 200 210 220 230 240 ARNDDTRTAA VLLQNDPNPD VLSKTGFTPL HIAAHYENLN VAQLLLNRGA SVNFTPQNGI 250 260 270 280 290 300 TPLHIASRRG NVIMVRLLLD RGAQIETKTK DELTPLHCAA RNGHVRISEI LLDHGAPIQA 310 320 330 340 350 360 KTKNGLSPIH MAAQGDHLDC VRLLLQYDAE IDDITLDHLT PLHVAAHCGH HRVAKVLLDK 370 380 390 400 410 420 GAKPNSRALN GFTPLHIACK KNHVRVMELL LKTGASIDAV TESGLTPLHV ASFMGHLPIV 430 440 450 460 470 480 KNLLQRGASP NVSNVKVETP LHMAARAGHT EVAKYLLQNK AKVNAKAKDD QTPLHCAARI 490 500 510 520 530 540 GHTNMVKLLL ENNANPNLAT TAGHTPLHIA AREGHVETVL ALLEKEASQA CMTKKGFTPL 550 560 570 580 590 600 HVAAKYGKVR VAELLLERDA HPNAAGKNGL TPLHVAVHHN NLDIVKLLLP RGGSPHSPAW 610 620 630 640 650 660 NGYTPLHIAA KQNQVEVARS LLQYGGSANA ESVQGVTPLH LAAQEGHAEM VALLLSKQAN 670 680 690 700 710 720 GNLGNKSGLT PLHLVAQEGH VPVADVLIKH GVMVDATTRM GYTPLHVASH YGNIKLVKFL 730 740 750 760 770 780 LQHQADVNAK TKLGYSPLHQ AAQQGHTDIV TLLLKNGASP NEVSSDGTTP LAIAKRLGYI 790 800 810 820 830 840 SVTDVLKVVT DETSFVLVSD KHRMSFPETV DEILDVSEDE GEELISFKAE RRDSRDVDEE 850 860 870 880 890 900 KELLDFVPKL DQVVESPAIP RIPCAMPETV VIRSEEQEQA SKEYDEDSLI PSSPATETSD 910 920 930 940 950 960 NISPVASPVH TGFLVSFMVD ARGGSMRGSR HNGLRVVIPP RTCAAPTRIT CRLVKPQKLS 970 980 990 1000 1010 1020 TPPPLAEEEG LASRIIALGP TGAQFLSPVI VEIPHFASHG RGDRELVVLR SENGSVWKEH 1030 1040 1050 1060 1070 1080 RSRYGESYLD QILNGMDEEL GSLEELEKKR VCRIITTDFP LYFVIMSRLC QDYDTIGPEG 1090 1100 1110 1120 1130 1140 GSLKSKLVPL VQATFPENAV TKRVKLALQA QPVPDELVTK LLGNQATFSP IVTVEPRRRK 1150 1160 1170 1180 1190 1200 FHRPIGLRIP LPPSWTDNPR DSGEGDTTSL RLLCSVIGGT DQAQWEDITG TTKLVYANEC 1210 1220 1230 1240 1250 1260 ANFTTNVSAR FWLSDCPRTA EAVNFATLLY KELTAVPYMA KFVIFAKMND PREGRLRCYC 1270 1280 1290 1300 1310 1320 MTDDKVDKTL EQHENFVEVA RSRDIEVLEG MSLFAELSGN LVPVKKAAQQ RSFHFQSFRE 1330 1340 1350 1360 1370 1380 NRLAMPVKVR DSSREPGGSL SFLRKAMKYE DTQHILCHLN ITMPPCAKGS GAEDRRRTPT 1390 1400 1410 1420 1430 1440 PLALRYSILS ESTPGSLSGT EQAEMKMAVI SEHLGLSWAE LARELQFSVE DINRIRVENP 1450 1460 1470 1480 1490 1500 NSLLEQSVAL LNLWVIREGQ NANMENLYTA LQSIDRGEIV NMLEGSGRQS RNLKPDRRHT 1510 1520 1530 1540 1550 1560 DRDYSLSPSQ MNGYSSLQDE LLSPASLGCA LSSPLRADQY WNEVAVLDAI PLAATEHDTM 1570 1580 1590 1600 1610 1620 LEMSDMQVWS AGLTPSLVTA EDSSLECSKA EDSDATGHEW KLEGALSEEP RGPELGSLEL 1630 1640 1650 1660 1670 1680 VEDDTVDSDA TNGLIDLLEQ EEGQRSEEKL PGSKRQDDAT GAGQDSENEV SLVSGHQRGQ 1690 1700 1710 1720 1730 1740 ARITHSPTVS QVTERSQDRL QDWDADGSIV SYLQDAAQGS WQEEVTQGPH SFQGTSTMTE 1750 1760 1770 1780 1790 1800 GLEPGGSQEY EKVLVSVSEH TWTEQPEAES SQADRDRRQQ GQEEQVQEAK NTFTQVVQGN 1810 1820 1830 1840 1850 1860 EFQNIPGEQV TEEQFTDEQG NIVTKKIIRK VVRQIDLSSA DAAQEHEEVT VEGPLEDPSE 1870 1880 1890 1900 1910 1920 LEVDIDYFMK HSKVLRRPRP WGTQRHHCCL ALPGRLHDTS LHSPLYELSL QSLFSLVGSV 1930 1940 1950 1960 1970 1980 SAPPCRSFRS SACVLPVFAI CPAFCLCCCL QVELRGSGLQ PDLIEGRKGA QIVKRASLKR GKQ
	Isoform Er14 (14). Checksum: 748E485DAAC8FAAC	FASTA	1,821	200,214
	10 20 30 40 50 60 MPYSVGFREA DAATSFLRAA RSGNLDKALD HLRNGVDINT CNQNGLNGLH LASKEGHVKM 70 80 90 100 110 120 VVELLHKEII LETTTKKGNT ALHIAALAGQ DEVVRELVNY GANVNAQSQK GFTPLYMAAQ 130 140 150 160 170 180 ENHLEVVKFL LENGANQNVA TEDGFTPLAV ALQQGHENVV AHLINYGTKG KVRLPALHIA 190 200 210 220 230 240 ARNDDTRTAA VLLQNDPNPD VLSKTGFTPL HIAAHYENLN VAQLLLNRGA SVNFTPQNGI 250 260 270 280 290 300 TPLHIASRRG NVIMVRLLLD RGAQIETKTK DELTPLHCAA RNGHVRISEI LLDHGAPIQA 310 320 330 340 350 360 KTKNGLSPIH MAAQGDHLDC VRLLLQYDAE IDDITLDHLT PLHVAAHCGH HRVAKVLLDK 370 380 390 400 410 420 GAKPNSRALN GFTPLHIACK KNHVRVMELL LKTGASIDAV TESGLTPLHV ASFMGHLPIV 430 440 450 460 470 480 KNLLQRGASP NVSNVKVETP LHMAARAGHT EVAKYLLQNK AKVNAKAKDD QTPLHCAARI 490 500 510 520 530 540 GHTNMVKLLL ENNANPNLAT TAGHTPLHIA AREGHVETVL ALLEKEASQA CMTKKGFTPL 550 560 570 580 590 600 HVAAKYGKVR VAELLLERDA HPNAAGKNGL TPLHVAVHHN NLDIVKLLLP RGGSPHSPAW 610 620 630 640 650 660 NGYTPLHIAA KQNQVEVARS LLQYGGSANA ESVQGVTPLH LAAQEGHAEM VALLLSKQAN 670 680 690 700 710 720 GNLGNKSGLT PLHLVAQEGH VPVADVLIKH GVMVDATTRM GYTPLHVASH YGNIKLVKFL 730 740 750 760 770 780 LQHQADVNAK TKLGYSPLHQ AAQQGHTDIV TLLLKNGASP NEVSSDGTTP LAIAKRLGYI 790 800 810 820 830 840 SVTDVLKVVT DETSFVLVSD KHRMSFPETV DEILDVSEDE GEELISFKAE RRDSRDVDEE 850 860 870 880 890 900 KELLDFVPKL DQVVESPAIP RIPCAMPETV VIRSEEQEQA SKEYDEDSLI PSSPATETSD 910 920 930 940 950 960 NISPVASPVH TGFLVSFMVD ARGGSMRGSR HNGLRVVIPP RTCAAPTRIT CRLVKPQKLS 970 980 990 1000 1010 1020 TPPPLAEEEG LASRIIALGP TGAQFLSPVI VEIPHFASHG RGDRELVVLR SENGSVWKEH 1030 1040 1050 1060 1070 1080 RSRYGESYLD QILNGMDEEL GSLEELEKKR VCRIITTDFP LYFVIMSRLC QDYDTIGPEG 1090 1100 1110 1120 1130 1140 GSLKSKLVPL VQATFPENAV TKRVKLALQA QPVPDELVTK LLGNQATFSP IVTVEPRRRK 1150 1160 1170 1180 1190 1200 FHRPIGLRIP LPPSWTDNPR DSGEGDTTSL RLLCSVIGGT DQAQWEDITG TTKLVYANEC 1210 1220 1230 1240 1250 1260 ANFTTNVSAR FWLSDCPRTA EAVNFATLLY KELTAVPYMA KFVIFAKMND PREGRLRCYC 1270 1280 1290 1300 1310 1320 MTDDKVDKTL EQHENFVEVA RSRDIEVLEG MSLFAELSGN LVPVKKAAQQ RSFHFQSFRE 1330 1340 1350 1360 1370 1380 NRLAMPVKVR DSSREPGGSL SFLRKAMKYE DTQHILCHLN ITMPPCAKGS GAEDRRRTPT 1390 1400 1410 1420 1430 1440 PLALRYSILS ESTPGSLSGT EQAEMKMAVI SEHLGLSWAE LARELQFSVE DINRIRVENP 1450 1460 1470 1480 1490 1500 NSLLEQSVAL LNLWVIREGQ NANMENLYTA LQSIDRGEIV NMLEGSGRQS RNLKPDRRHT 1510 1520 1530 1540 1550 1560 DRDYSLSPSQ MNGHQRGQAR ITHSPTVSQV TERSQDRLQD WDADGSIVSY LQDAAQGSWQ 1570 1580 1590 1600 1610 1620 EEVTQGPHSF QGTSTMTEGL EPGGSQEYEK VLVSVSEHTW TEQPEAESSQ ADRDRRQQGQ 1630 1640 1650 1660 1670 1680 EEQVQEAKNT FTQVVQGNEF QNIPGEQVTE EQFTDEQGNI VTKKIIRKVV RQIDLSSADA 1690 1700 1710 1720 1730 1740 AQEHEEVTVE GPLEDPSELE VDIDYFMKHS KVLRRPRPWG TQRHHCCLAL PGRLHDTSLH 1750 1760 1770 1780 1790 1800 SPLYELSLQS LFSLVGSVSA PPCRSFRSSA CVLPVFAICP AFCLCCCLQV ELRGSGLQPD 1810 1820 LIEGRKGAQI VKRASLKRGK Q
	Isoform Er15 (15). Checksum: 1DFB26BFA488DCC4	FASTA	1,858	203,536
	10 20 30 40 50 60 MPYSVGFREA DAATSFLRAA RSGNLDKALD HLRNGVDINT CNQNGLNGLH LASKEGHVKM 70 80 90 100 110 120 VVELLHKEII LETTTKKGNT ALHIAALAGQ DEVVRELVNY GANVNAQSQK GFTPLYMAAQ 130 140 150 160 170 180 ENHLEVVKFL LENGANQNVA TEDGFTPLAV ALQQGHENVV AHLINYGTKG KVRLPALHIA 190 200 210 220 230 240 ARNDDTRTAA VLLQNDPNPD VLSKTGFTPL HIAAHYENLN VAQLLLNRGA SVNFTPQNGI 250 260 270 280 290 300 TPLHIASRRG NVIMVRLLLD RGAQIETKTK DELTPLHCAA RNGHVRISEI LLDHGAPIQA 310 320 330 340 350 360 KTKNGLSPIH MAAQGDHLDC VRLLLQYDAE IDDITLDHLT PLHVAAHCGH HRVAKVLLDK 370 380 390 400 410 420 GAKPNSRALN GFTPLHIACK KNHVRVMELL LKTGASIDAV TESGLTPLHV ASFMGHLPIV 430 440 450 460 470 480 KNLLQRGASP NVSNVKVETP LHMAARAGHT EVAKYLLQNK AKVNAKAKDD QTPLHCAARI 490 500 510 520 530 540 GHTNMVKLLL ENNANPNLAT TAGHTPLHIA AREGHVETVL ALLEKEASQA CMTKKGFTPL 550 560 570 580 590 600 HVAAKYGKVR VAELLLERDA HPNAAGKNGL TPLHVAVHHN NLDIVKLLLP RGGSPHSPAW 610 620 630 640 650 660 NGYTPLHIAA KQNQVEVARS LLQYGGSANA ESVQGVTPLH LAAQEGHAEM VALLLSKQAN 670 680 690 700 710 720 GNLGNKSGLT PLHLVAQEGH VPVADVLIKH GVMVDATTRM GYTPLHVASH YGNIKLVKFL 730 740 750 760 770 780 LQHQADVNAK TKLGYSPLHQ AAQQGHTDIV TLLLKNGASP NEVSSDGTTP LAIAKRLGYI 790 800 810 820 830 840 SVTDVLKVVT DETSFVLVSD KHRMSFPETV DEILDVSEDE GEELISFKAE RRDSRDVDEE 850 860 870 880 890 900 KELLDFVPKL DQVVESPAIP RIPCAMPETV VIRSEEQEQA SKEYDEDSLI PSSPATETSD 910 920 930 940 950 960 NISPVASPVH TGFLVSFMVD ARGGSMRGSR HNGLRVVIPP RTCAAPTRIT CRLVKPQKLS 970 980 990 1000 1010 1020 TPPPLAEEEG LASRIIALGP TGAQFLSPVI VEIPHFASHG RGDRELVVLR SENGSVWKEH 1030 1040 1050 1060 1070 1080 RSRYGESYLD QILNGMDEEL GSLEELEKKR VCRIITTDFP LYFVIMSRLC QDYDTIGPEG 1090 1100 1110 1120 1130 1140 GSLKSKLVPL VQATFPENAV TKRVKLALQA QPVPDELVTK LLGNQATFSP IVTVEPRRRK 1150 1160 1170 1180 1190 1200 FHRPIGLRIP LPPSWTDNPR DSGEGDTTSL RLLCSVIGGT DQAQWEDITG TTKLVYANEC 1210 1220 1230 1240 1250 1260 ANFTTNVSAR FWLSDCPRTA EAVNFATLLY KELTAVPYMA KFVIFAKMND PREGRLRCYC 1270 1280 1290 1300 1310 1320 MTDDKVDKTL EQHENFVEVA RSRDIEVLEG MSLFAELSGN LVPVKKAAQQ RSFHFQSFRE 1330 1340 1350 1360 1370 1380 NRLAMPVKVR DSSREPGGSL SFLRKAMKYE DTQHILCHLN ITMPPCAKGS GAEDRRRTPT 1390 1400 1410 1420 1430 1440 PLALRYSILS ESTPGSLSGT EQAEMKMAVI SEHLGLSWAE LARELQFSVE DINRIRVENP 1450 1460 1470 1480 1490 1500 NSLLEQSVAL LNLWVIREGQ NANMENLYTA LQSIDRGEIV NMLEGSGRQS RNLKPDRRHT 1510 1520 1530 1540 1550 1560 DRDYSLSPSQ MNGYSSLQDE LLSPASLGCA LSSPLRADQY WNEVAVLDAI PLAATEHDTM 1570 1580 1590 1600 1610 1620 LEMSDMQVWS AGLTPSLVTA EDSSLECSKA EDSDATGHEW KLEGALSEEP RGPELGSLEL 1630 1640 1650 1660 1670 1680 VEDDTVDSDA TNGLIDLLEQ EEGQRSEEKL PGSKRQDDAT GAGQDSENEV SLVSGHQRGQ 1690 1700 1710 1720 1730 1740 ARITHSPTVS QVTERSQDRL QDWDADGSIV SYLQDAAQGS WQEEVTQGPH SFQGTSTMTE 1750 1760 1770 1780 1790 1800 GLEPGGSQEY EKVLVSVSEH TWTEQPEAES SQADRDRRQQ GQEEQVQEAK NTFTQVVQGN 1810 1820 1830 1840 1850 EFQNIPGEQV TEEQFTDEQG NIVTKKVELR GSGLQPDLIE GRKGAQIVKR ASLKRGKQ
	Isoform Er16. Checksum: 1D71CA896F1FDD7F	FASTA	1,519	166,480
	10 20 30 40 50 60 MPYSVGFREA DAATSFLRAA RSGNLDKALD HLRNGVDINT CNQNGLNGLH LASKEGHVKM 70 80 90 100 110 120 VVELLHKEII LETTTKKGNT ALHIAALAGQ DEVVRELVNY GANVNAQSQK GFTPLYMAAQ 130 140 150 160 170 180 ENHLEVVKFL LENGANQNVA TEDGFTPLAV ALQQGHENVV AHLINYGTKG KVRLPALHIA 190 200 210 220 230 240 ARNDDTRTAA VLLQNDPNPD VLSKTGFTPL HIAAHYENLN VAQLLLNRGA SVNFTPQNGI 250 260 270 280 290 300 TPLHIASRRG NVIMVRLLLD RGAQIETKTK DELTPLHCAA RNGHVRISEI LLDHGAPIQA 310 320 330 340 350 360 KTKNGLSPIH MAAQGDHLDC VRLLLQYDAE IDDITLDHLT PLHVAAHCGH HRVAKVLLDK 370 380 390 400 410 420 GAKPNSRALN GFTPLHIACK KNHVRVMELL LKTGASIDAV TESGLTPLHV ASFMGHLPIV 430 440 450 460 470 480 KNLLQRGASP NVSNVKVETP LHMAARAGHT EVAKYLLQNK AKVNAKAKDD QTPLHCAARI 490 500 510 520 530 540 GHTNMVKLLL ENNANPNLAT TAGHTPLHIA AREGHVETVL ALLEKEASQA CMTKKGFTPL 550 560 570 580 590 600 HVAAKYGKVR VAELLLERDA HPNAAGKNGL TPLHVAVHHN NLDIVKLLLP RGGSPHSPAW 610 620 630 640 650 660 NGYTPLHIAA KQNQVEVARS LLQYGGSANA ESVQGVTPLH LAAQEGHAEM VALLLSKQAN 670 680 690 700 710 720 GNLGNKSGLT PLHLVAQEGH VPVADVLIKH GVMVDATTRM GYTPLHVASH YGNIKLVKFL 730 740 750 760 770 780 LQHQADVNAK TKLGYSPLHQ AAQQGHTDIV TLLLKNGASP NEVSSDGTTP LAIAKRLGYI 790 800 810 820 830 840 SVTDVLKVVT DETSFVLVSD KHRMSFPETV DEILDVSEDE GEELISFKAE RRDSRDVDEE 850 860 870 880 890 900 KELLDFVPKL DQVVESPAIP RIPCAMPETV VIRSEEQEQA SKEYDEDSLI PSSPATETSD 910 920 930 940 950 960 NISPVASPVH TGFLVSFMVD ARGGSMRGSR HNGLRVVIPP RTCAAPTRIT CRLVKPQKLS 970 980 990 1000 1010 1020 TPPPLAEEEG LASRIIALGP TGAQFLSPVI VEIPHFASHG RGDRELVVLR SENGSVWKEH 1030 1040 1050 1060 1070 1080 RSRYGESYLD QILNGMDEEL GSLEELEKKR VCRIITTDFP LYFVIMSRLC QDYDTIGPEG 1090 1100 1110 1120 1130 1140 GSLKSKLVPL VQATFPENAV TKRVKLALQA QPVPDELVTK LLGNQATFSP IVTVEPRRRK 1150 1160 1170 1180 1190 1200 FHRPIGLRIP LPPSWTDNPR DSGEGDTTSL RLLCSVIGGT DQAQWEDITG TTKLVYANEC 1210 1220 1230 1240 1250 1260 ANFTTNVSAR FWLSDCPRTA EAVNFATLLY KELTAVPYMA KFVIFAKMND PREGRLRCYC 1270 1280 1290 1300 1310 1320 MTDDKVDKTL EQHENFVEVA RSRDIEVLEG MSLFAELSGN LVPVKKAAQQ RSFHFQSFRE 1330 1340 1350 1360 1370 1380 NRLAMPVKVR DSSREPGGSL SFLRKAMKYE DTQHILCHLN ITMPPCAKGS GAEDRRRTPT 1390 1400 1410 1420 1430 1440 PLALRYSILS ESTPGSLSGT EQAEMKMAVI SEHLGLSWAE LARELQFSVE DINRIRVENP 1450 1460 1470 1480 1490 1500 NSLLEQSVAL LNLWVIREGQ NANMENLYTA LQSIDRGEIV NMLEGSGRQS RNLKPDRRHT 1510 DRDYSLSPSQ MNDTSTPNP
	Isoform Mu17 (ank1.5) (muscle-specific 1). Checksum: 3F0340F88C404BBB	FASTA	155	17,611
	10 20 30 40 50 60 MWTFVTQLLV TLVLLSFFLV SCQNVMHIVR GSLCFVLKHI HQELDKELGE SEGLSDDEET 70 80 90 100 110 120 ISPRVVRRRV FLKGNEFQNI PGEQVTEEQF TDEQGNIVTK KIIRKVVRQI DLSSADAAQE 130 140 150 HEEVELRGSG LQPDLIEGRK GAQIVKRASL KRGKQ
	Isoform Mu18 (ank1.6) (muscle-specific 2). Checksum: 7D82C9FB586B61C2	FASTA	133	15,121
	10 20 30 40 50 60 MWTFVTQLLV TLVLLSFFLV SCQNVMHIVR GSLCFVLKHI HQELDKELGE SEGLSDDEET 70 80 90 100 110 120 ISPRVVRRRV FLKGNEFQNI PGEQVTEEQF TDEQGNIVTK KVELRGSGLQ PDLIEGRKGA 130 QIVKRASLKR GKQ
	Isoform Mu19 (muscle-specific 3). Checksum: 6A4EA22EC8E3B04B	FASTA	81	9,338
	10 20 30 40 50 60 MWTFVTQLLV TLVLLSFFLV SCQNVMHIVR GSLCFVLKHI HQELDKELGE SEGLSDDEET 70 80 ISPRVVRRRV FLKDHTSTPN P
	Isoform Mu20 (muscle-specific 4). Checksum: FA79EF4284FBDDEB	FASTA	74	8,374
	10 20 30 40 50 60 MWTFVTQLLV TLVLLSFFLV SCQNVMHIVR GSLCFVLKHI HQVELRGSGL QPDLIEGRKG 70 AQIVKRASLK RGKQ
	Isoform Br21. Checksum: 82682973D1A52BA2	FASTA	1,897	208,239
	10 20 30 40 50 60 MAQAAKQLKK IKDIEAQALQ EQKEKEESNR KRRNRSRDRK KKADAATSFL RAARSGNLDK 70 80 90 100 110 120 ALDHLRNGVD INTCNQNGLN GLHLASKEGH VKMVVELLHK EIILETTTKK GNTALHIAAL 130 140 150 160 170 180 AGQDEVVREL VNYGANVNAQ SQKGFTPLYM AAQENHLEVV KFLLENGANQ NVATEDGFTP 190 200 210 220 230 240 LAVALQQGHE NVVAHLINYG TKGKVRLPAL HIAARNDDTR TAAVLLQNDP NPDVLSKTGF 250 260 270 280 290 300 TPLHIAAHYE NLNVAQLLLN RGASVNFTPQ NGITPLHIAS RRGNVIMVRL LLDRGAQIET 310 320 330 340 350 360 KTKDELTPLH CAARNGHVRI SEILLDHGAP IQAKTKNGLS PIHMAAQGDH LDCVRLLLQY 370 380 390 400 410 420 DAEIDDITLD HLTPLHVAAH CGHHRVAKVL LDKGAKPNSR ALNGFTPLHI ACKKNHVRVM 430 440 450 460 470 480 ELLLKTGASI DAVTESGLTP LHVASFMGHL PIVKNLLQRG ASPNVSNVKV ETPLHMAARA 490 500 510 520 530 540 GHTEVAKYLL QNKAKVNAKA KDDQTPLHCA ARIGHTNMVK LLLENNANPN LATTAGHTPL 550 560 570 580 590 600 HIAAREGHVE TVLALLEKEA SQACMTKKGF TPLHVAAKYG KVRVAELLLE RDAHPNAAGK 610 620 630 640 650 660 NGLTPLHVAV HHNNLDIVKL LLPRGGSPHS PAWNGYTPLH IAAKQNQVEV ARSLLQYGGS 670 680 690 700 710 720 ANAESVQGVT PLHLAAQEGH AEMVALLLSK QANGNLGNKS GLTPLHLVAQ EGHVPVADVL 730 740 750 760 770 780 IKHGVMVDAT TRMGYTPLHV ASHYGNIKLV KFLLQHQADV NAKTKLGYSP LHQAAQQGHT 790 800 810 820 830 840 DIVTLLLKNG ASPNEVSSDG TTPLAIAKRL GYISVTDVLK VVTDETSFVL VSDKHRMSFP 850 860 870 880 890 900 ETVDEILDVS EDEGTAHITI MGEELISFKA ERRDSRDVDE EKELLDFVPK LDQVVESPAI 910 920 930 940 950 960 PRIPCAMPET VVIRSEEQEQ ASKEYDEDSL IPSSPATETS DNISPVASPV HTGFLVSFMV 970 980 990 1000 1010 1020 DARGGSMRGS RHNGLRVVIP PRTCAAPTRI TCRLVKPQKL STPPPLAEEE GLASRIIALG 1030 1040 1050 1060 1070 1080 PTGAQFLSPV IVEIPHFASH GRGDRELVVL RSENGSVWKE HRSRYGESYL DQILNGMDEE 1090 1100 1110 1120 1130 1140 LGSLEELEKK RVCRIITTDF PLYFVIMSRL CQDYDTIGPE GGSLKSKLVP LVQATFPENA 1150 1160 1170 1180 1190 1200 VTKRVKLALQ AQPVPDELVT KLLGNQATFS PIVTVEPRRR KFHRPIGLRI PLPPSWTDNP 1210 1220 1230 1240 1250 1260 RDSGEGDTTS LRLLCSVIGG TDQAQWEDIT GTTKLVYANE CANFTTNVSA RFWLSDCPRT 1270 1280 1290 1300 1310 1320 AEAVNFATLL YKELTAVPYM AKFVIFAKMN DPREGRLRCY CMTDDKVDKT LEQHENFVEV 1330 1340 1350 1360 1370 1380 ARSRDIEVLE GMSLFAELSG NLVPVKKAAQ QRSFHFQSFR ENRLAMPVKV RDSSREPGGS 1390 1400 1410 1420 1430 1440 LSFLRKAMKY EDTQHILCHL NITMPPCAKG SGAEDRRRTP TPLALRYSIL SESTPGSLSG 1450 1460 1470 1480 1490 1500 TEQAEMKMAV ISEHLGLSWA ELARELQFSV EDINRIRVEN PNSLLEQSVA LLNLWVIREG 1510 1520 1530 1540 1550 1560 QNANMENLYT ALQSIDRGEI VNMLEGSGRQ SRNLKPDRRH TDRDYSLSPS QMNGYSSLQD 1570 1580 1590 1600 1610 1620 ELLSPASLGC ALSSPLRADQ YWNEVAVLDA IPLAATEHDT MLEMSDMQVW SAGLTPSLVT 1630 1640 1650 1660 1670 1680 AEDSSLECSK AEDSDATGHE WKLEGALSEE PRGPELGSLE LVEDDTVDSD ATNGLIDLLE 1690 1700 1710 1720 1730 1740 QEEGQRSEEK LPGSKRQDDA TGAGQDSENE VSLVSGHQRG QARITHSPTV SQVTERSQDR 1750 1760 1770 1780 1790 1800 LQDWDADGSI VSYLQDAAQG SWQEEVTQGP HSFQGTSTMT EGLEPGGSQE YEKVLVSVSE 1810 1820 1830 1840 1850 1860 HTWTEQPEAE SSQADRDRRQ QGQEEQVQEA KNTFTQVVQG NEFQNIPGEQ VTEEQFTDEQ 1870 1880 1890 GNIVTKKIIR KVVRQIDLSS ADAAQEHEED HTSTPNP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Analysis of cDNA for human erythrocyte ankyrin indicates a repeated structure with homology to tissue-differentiation and cell-cycle control proteins." Lux S.E., John K.M., Bennett V. Nature 344:36-42(1990) [PubMed: 2137557] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS ER1 AND ER2), PROTEIN SEQUENCE OF 3-30; 733-753; 828-871; 959-1003; 1106-1128; 1149-1168; 1282-1288; 1345-1367; 1383-1427; 1601-1626; 1686-1700 AND 1763-1772, VARIANTS ALA-750 AND ILE-1075. Tissue: Hematopoietic.
[2]	"cDNA sequence for human erythrocyte ankyrin." Lambert S., Yu H., Prchal J.T., Lawler J., Ruff P., Speicher D., Cheung M.C., Kan Y.W., Palek J. Proc. Natl. Acad. Sci. U.S.A. 87:1730-1734(1990) [PubMed: 1689849] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS ER1; ER5 AND ER16), VARIANTS ILE-1075 AND ILE-1546.
[3]	"Structure and organization of the human ankyrin-1 gene. Basis for complexity of pre-mRNA processing." Gallagher P.G., Tse W.T., Scarpa A.L., Lux S.E., Forget B.G. J. Biol. Chem. 272:19220-19228(1997) [PubMed: 9235914] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING, VARIANTS LEU-991 AND ILE-1075.
[4]	"An alternate promoter directs expression of a truncated, muscle-specific isoform of the human ankyrin 1 gene." Gallagher P.G., Forget B.G. J. Biol. Chem. 273:1339-1348(1998) [PubMed: 9430667] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS MU17; MU18; MU19 AND MU20), TISSUE SPECIFICITY, SUBCELLULAR LOCATION. Tissue: Skeletal muscle.
[5]	Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F. Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM BR21), VARIANT ILE-1075. Tissue: Brain.
[6]	"DNA sequence and analysis of human chromosome 8." Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T. , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S. Nature 439:331-335(2006) [PubMed: 16421571] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM MU17). Tissue: Skeletal muscle.
[8]	"Mapping the binding sites of human erythrocyte ankyrin for the anion exchanger and spectrin." Davis L.H., Bennett V. J. Biol. Chem. 265:10589-10596(1990) [PubMed: 2141335] [Abstract] Cited for: PROTEIN SEQUENCE OF 5-12; 403-422; 797-814; 862-877 AND 899-912, DOMAINS SPTB AND SLC4A1 BINDING, VARIANT ASP-1286.
[9]	"The hydrophilic domain of small ankyrin-1 interacts with the two N-terminal immunoglobulin domains of titin." Kontrogianni-Konstantopoulos A., Bloch R.J. J. Biol. Chem. 278:3985-3991(2003) [PubMed: 12444090] [Abstract] Cited for: INTERACTION WITH TTN.
[10]	"Binding of an ankyrin-1 isoform to obscurin suggests a molecular link between the sarcoplasmic reticulum and myofibrils in striated muscles." Bagnato P., Barone V., Giacomello E., Rossi D., Sorrentino V. J. Cell Biol. 160:245-253(2003) [PubMed: 12527750] [Abstract] Cited for: SUBCELLULAR LOCATION, INTERACTION WITH OBSCN, MUTAGENESIS OF THR-1824; LYS-1826; ARG-1829 AND LYS-1830.
[11]	"Phosphoproteome of resting human platelets." Zahedi R.P., Lewandrowski U., Wiesner J., Wortelkamp S., Moebius J., Schuetz C., Walter U., Gambaryan S., Sickmann A. J. Proteome Res. 7:526-534(2008) [PubMed: 18088087] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1684 AND SER-1686, MASS SPECTROMETRY. Tissue: Platelet.
[12]	"Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment." Carrascal M., Ovelleiro D., Casas V., Gay M., Abian J. J. Proteome Res. 7:5167-5176(2008) [PubMed: 19367720] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1686, MASS SPECTROMETRY. Tissue: T-cell.
[13]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-834, MASS SPECTROMETRY.
[14]	"Crystal structure of a 12 ANK repeat stack from human ankyrinR." Michaely P., Tomchick D.R., Machius M., Anderson R.G. EMBO J. 21:6387-6396(2002) [PubMed: 12456646] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) OF 402-827, FUNCTION OF ANK REPEAT DOMAIN.
[15]	"Solution structure of the DEATH domain of ankyrin-1." RIKEN structural genomics initiative (RSGI) Submitted (APR-2008) to the PDB data bank Cited for: STRUCTURE BY NMR OF 1392-1497.
[16]	"Ankyrin-1 mutations are a major cause of dominant and recessive hereditary spherocytosis." Eber S.W., Gonzalez J.M., Lux M.L., Scarpa A.L., Tse W.T., Dornwell M., Herbers J., Kugler W., Oezcan R., Pekrun A., Gallagher P.G., Schroeter W., Forget B.G., Lux S.E. Nat. Genet. 13:214-218(1996) [PubMed: 8640229] [Abstract] Cited for: VARIANT SPH1 ILE-463.
[17]	"Low frequency of ankyrin mutations in hereditary spherocytosis: identification of three novel mutations." Leite R.C.A., Basseres D.S., Ferreira J.S., Alberto F.L., Costa F.F., Saad S.T.O. Hum. Mutat. 16:529-529(2000) [PubMed: 11102985] [Abstract] Cited for: VARIANTS SPH1 ARG-276 AND THR-1054.
[18]	"The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E. Science 314:268-274(2006) [PubMed: 16959974] [Abstract] Cited for: VARIANT [LARGE SCALE ANALYSIS] HIS-332.
+	Additional computationally mapped references.

Web resources

Wikipedia

Ankyrin entry

Cross-references

Sequence databases

EMBLGenBankDDBJ

X16609 mRNA. Translation: CAA34610.1.
X16609 mRNA. Translation: CAA34611.1.
M28880 mRNA. Translation: AAA51732.1.
U50133 , U50092, U50093, U50094, U50095, U50096, U50097, U50098, U50099, U50100, U50101, U50102, U50103, U50104, U50105, U50106, U50107, U50108, U50109, U50110, U50111, U50112, U50113, U50114, U50115, U50116, U50117, U50118, U50119, U50120, U50121, U50122, U50123, U50124, U50125, U50126, U50127, U50128, U50129, U50130, U50131, U50132 Genomic DNA. Translation: AAB47805.1. Sequence problems.
AF005213 mRNA. Translation: AAC01950.1.
AB209418 mRNA. Translation: BAD92655.1.
AC113133 Genomic DNA. No translation available.
BC030957 mRNA. Translation: AAH30957.1.

IPI

IPI00007623.
IPI00007625.
IPI00216697.
IPI00297532.
IPI00374973.
IPI00646300.
IPI00654646.
IPI00743884.
IPI00744408.
IPI00744846.
IPI00744895.
IPI00744986.
IPI00745348.
IPI00747536.
IPI00747552.
IPI00748074.
IPI00748154.
IPI00748330.
IPI00748439.
IPI00748895.
IPI00749301.

PIR

A35049.
SJHUK. S08275.

RefSeq

NP_000028.3.
NP_001135918.1.
NP_065208.2.
NP_065209.2.
NP_065210.2.

UniGene

Hs.654438
Hs.667377

3D structure databases

PDBPDBe

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1N11	X-ray	2.70	A	402-827	[»]
2YQF	NMR	-	A	1394-1497	[»]
2YVI	X-ray	1.92	A	1394-1497	[»]
3F59	X-ray	2.00	A/B/C/D	911-1068	[»]

ModBase

Search...

Protein-protein interaction databases

STRING

P16157.

PTM databases

PhosphoSite

P16157.

Proteomic databases

PRIDE

P16157.

Genome annotation databases

Ensembl

ENST00000347528; ENSP00000339620; ENSG00000029534; Homo sapiens. [Genome view]

GeneID

286.

KEGG

hsa:286.

UCSC

uc003xoi.1. human.
uc003xoj.1. human.
uc003xok.1. human.
uc003xol.1. human.
uc003xom.1. human.

Organism-specific databases

CTD

286.

GeneCards

GC08M041629.

H-InvDB

HIX0025552.

HGNC

HGNC:492. ANK1.

HPA

CAB016057.
HPA004842.

MIM

182900. phenotype.
612641. gene.

Orphanet

822. Spherocytosis hereditary.

PharmGKB

PA24798.

GenAtlas

Search...

Phylogenomic databases

HOVERGEN

P16157.

OrthoDB

EOG9VHNS3.

Gene expression databases

ArrayExpress

P16157.

Bgee

P16157.

CleanEx

HS_ANK1.

Genevestigator

P16157.

GermOnline

ENSG00000029534. Homo sapiens.

Family and domain databases

InterPro

IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR000488. Death.
IPR011029. DEATH-like.
IPR000906. ZU5.
[Graphical view]

Gene3D

G3DSA:1.25.40.20. ANK. 4 hits.
G3DSA:1.10.533.10. DEATH_like. 1 hit.

Pfam

PF00023. Ank. 23 hits.
PF00531. Death. 1 hit.
PF00791. ZU5. 1 hit.
[Graphical view]

SMART

SM00248. ANK. 23 hits.
SM00005. DEATH. 1 hit.
SM00218. ZU5. 1 hit.
[Graphical view]

PROSITE

PS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 20 hits.
PS50017. DEATH_DOMAIN. 1 hit.
PS51145. ZU5. 1 hit.
[Graphical view]

ProtoNet

Search...

Other Resources

NextBio

1155.

PMAP-CutDB

P16157.

SOURCE

Search...

Entry information

Entry name

ANK1_HUMAN

Accession

Primary (citable) accession number: P16157
Secondary accession number(s): A6NJ23 , O43400, Q13768, Q59FP2, Q8N604, Q99407

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 1, 1990
Last sequence update:	January 23, 2007
Last modified:	December 15, 2009
This is version 122 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.