P16157 (ANK1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ankyrin-1
Short name=ANK-1

Alternative name(s):
Ankyrin-R
Erythrocyte ankyrin

Gene names

Name:	ANK1
Synonyms:	ANK

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1881 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Attaches integral membrane proteins to cytoskeletal elements; binds to the erythrocyte membrane protein band 4.2, to Na-K ATPase, to the lymphocyte membrane protein GP85, and to the cytoskeletal proteins fodrin, tubulin, vimentin and desmin. Erythrocyte ankyrins also link spectrin (beta chain) to the cytoplasmic domain of the erythrocytes anion exchange protein; they retain most or all of these binding functions. Ref.17 Isoform Mu17 together with obscurin in skeletal muscle may provide a molecular link between the sarcoplasmic reticulum and myofibrils. Ref.17
Subunit structure	Interacts with a number of integral membrane proteins and cytoskeletal proteins. Interacts (via N-terminus) with SPTB/spectrin (beta chain). Interacts (via N-terminus ANK repeats) with SLC4A1/erythrocyte membrane protein band 3 (via cytoplasmic N-terminus). Also interacts with TTN/titin. Isoform Mu17 interacts with OBSCN isoform 3/obscurin. Interacts with HIF1AN. Ref.10 Ref.11 Ref.12 Ref.13
Subcellular location	Isoform Er1: Cytoplasm › cytoskeleton. Note: Probably the other erythrocyte (Er) isoforms, are located near the surface of erythrocytic plasma membrane. Ref.4 Ref.13 Isoform Mu17: Membrane. Cytoplasm › myofibril › sarcomere › M line. Note: Colocalizes with OBSCN isoform 3/obscurin at the M line in differentiated skeletal muscle cells. Ref.4 Ref.13 Isoform Mu18: Sarcoplasmic reticulum Probable Ref.4 Ref.13. Isoform Mu19: Sarcoplasmic reticulum Probable Ref.4 Ref.13. Isoform Mu20: Sarcoplasmic reticulum Probable Ref.4 Ref.13.
Tissue specificity	Isoform Mu17, isoform Mu18, isoform Mu19 and isoform Mu20 are expressed in skeletal muscle. Isoform Br21 is expressed in brain. Ref.4
Domain	The 55 kDa regulatory domain is involved in regulating binding of SPTB/spectrin (beta chain) and SLC4A1/erythrocyte membrane protein band 3. Ref.9 Ref.17 Ref.19 The ANK repeat region forms a spiral around a large central cavity and is involved in binding of ion transporters. Ref.9 Ref.17 Ref.19 The tandem configuration of the two ZU5 and the UPA domains forms a structural supramodule termed ZZU. ZU5-1 mediates interaction with beta-spectrin, and the ZU5-1/UPA interface is required for ankyrin's function other than binding to spectrin By similarity. Ref.9 Ref.17 Ref.19
Post-translational modification	Regulated by phosphorylation. Palmitoylated. Hydroxylated by HIF1AN at several asparagine and 1 aspartate residue within ANK repeat region. Hydroxylation seems to increase the conformational stability of this region and may also modulate protein-protein interactions mediated by the ANK repeat region.
Involvement in disease	Spherocytosis 1 (SPH1) [MIM:182900]: Spherocytosis is a hematologic disorder leading to chronic hemolytic anemia and characterized by numerous abnormally shaped erythrocytes which are generally spheroidal. SPH1 is characterized by severe hemolytic anemia. Inheritance is autosomal recessive. Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.20 Ref.21
Sequence similarities	Contains 23 ANK repeats. Contains 1 death domain. Contains 2 ZU5 domains.
Sequence caution	The sequence AAB47805.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Cellular component	Cytoplasm Cytoskeleton Membrane Sarcoplasmic reticulum
Coding sequence diversity	Alternative promoter usage Alternative splicing Polymorphism
Disease	Disease mutation Elliptocytosis Hereditary hemolytic anemia
Domain	ANK repeat Repeat
PTM	Hydroxylation Lipoprotein Phosphoprotein
Technical term	3D-structure Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	ER to Golgi vesicle-mediated transport Inferred from direct assay PubMed 18768923. Source: BHF-UCL axon guidance Traceable author statement. Source: Reactome cytoskeleton organization Non-traceable author statement Ref.4. Source: UniProtKB erythrocyte development Inferred from electronic annotation. Source: Compara exocytosis Non-traceable author statement PubMed 1833445. Source: UniProtKB maintenance of epithelial cell apical/basal polarity Traceable author statement PubMed 11427698. Source: UniProtKB monovalent inorganic cation transport Inferred from electronic annotation. Source: Compara porphyrin-containing compound biosynthetic process Inferred from electronic annotation. Source: Compara protein targeting to plasma membrane Inferred from mutant phenotype PubMed 18768923. Source: BHF-UCL signal transduction Inferred from electronic annotation. Source: InterPro
Cellular_component	M band Inferred from electronic annotation. Source: UniProtKB-SubCell basolateral plasma membrane Non-traceable author statement PubMed 12409278. Source: UniProtKB cortical cytoskeleton Inferred from electronic annotation. Source: Compara cytosol Traceable author statement. Source: Reactome sarcoplasmic reticulum Inferred from electronic annotation. Source: UniProtKB-SubCell spectrin-associated cytoskeleton Inferred from direct assay PubMed 379653. Source: BHF-UCL
Molecular_function	cytoskeletal adaptor activity Traceable author statement PubMed 11427698. Source: UniProtKB enzyme binding Traceable author statement PubMed 11427698. Source: UniProtKB spectrin binding Non-traceable author statement Ref.20. Source: UniProtKB structural constituent of cytoskeleton Traceable author statement Ref.20. Source: ProtInc
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
OBSCN	Q5VST9-3	8	EBI-941819,EBI-941921

Alternative products

This entry describes 22 isoforms produced by alternative promoter usage and alternative splicing. [Align] [Select]

Isoform Er1 (identifier: P16157-1)

Also known as: 1; 2.1;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Note: Major erythrocyte-specific isoform. Produced by alternative promoter usage.

Isoform Er2 (identifier: P16157-4)

Also known as: 2; 2.2;

The sequence of this isoform differs from the canonical sequence as follows:
     1514-1675: Missing.

Note: Predominant form of minor erythrocyte-specific isoforms. Produced by alternative splicing of isoform Er1.

Isoform Er3 (identifier: P16157-5)

Also known as: 3;

The sequence of this isoform differs from the canonical sequence as follows:
     1849-1873: Missing.

Note: Produced by alternative splicing of isoform Er1.

Isoform Er4 (identifier: P16157-6)

Also known as: 4;

The sequence of this isoform differs from the canonical sequence as follows:
     1514-1675: Missing.
     1849-1873: Missing.

Note: Produced by alternative splicing of isoform Er1.

Isoform Er5 (identifier: P16157-3)

Also known as: 5;

The sequence of this isoform differs from the canonical sequence as follows:
     1850-1881: TVEGPLEDPSELEVDIDYFMKHSKDHTSTPNP → ELRGSGLQPDLIEGRKGAQIVKRASLKRGKQ

Note: Produced by alternative splicing of isoform Er1.

Isoform Er6 (identifier: P16157-7)

Also known as: 6;

The sequence of this isoform differs from the canonical sequence as follows:
     1514-1675: Missing.
     1850-1881: TVEGPLEDPSELEVDIDYFMKHSKDHTSTPNP → ELRGSGLQPDLIEGRKGAQIVKRASLKRGKQ

Note: Produced by alternative splicing of isoform Er1.

Isoform Er7 (identifier: P16157-8)

Also known as: 7;

The sequence of this isoform differs from the canonical sequence as follows:
     1827-1873: Missing.

Note: Produced by alternative splicing of isoform Er1.

Isoform Er8 (identifier: P16157-9)

Also known as: 8;

The sequence of this isoform differs from the canonical sequence as follows:
     1514-1675: Missing.
     1827-1873: Missing.

Isoform Er9 (identifier: P16157-10)

Also known as: 9;

The sequence of this isoform differs from the canonical sequence as follows:
     1799-1873: Missing.

Note: Produced by alternative splicing of isoform Er1.

Isoform Er10 (identifier: P16157-11)

Also known as: 10;

The sequence of this isoform differs from the canonical sequence as follows:
     1514-1675: Missing.
     1799-1873: Missing.

Note: Produced by alternative splicing of isoform Er1.

Isoform Er11 (identifier: P16157-12)

Also known as: 11;

The sequence of this isoform differs from the canonical sequence as follows:
     1874-1881: DHTSTPNP → VELRGSGLQPDLIEGRKGAQIVKRASLKRGKQ

Note: Produced by alternative splicing of isoform Er1.

Isoform Er12 (identifier: P16157-13)

Also known as: 12;

The sequence of this isoform differs from the canonical sequence as follows:
     1514-1675: Missing.
     1874-1881: DHTSTPNP → VELRGSGLQPDLIEGRKGAQIVKRASLKRGKQ

Note: Produced by alternative splicing of isoform Er1.

Isoform Er13 (identifier: P16157-14)

Also known as: 13;

The sequence of this isoform differs from the canonical sequence as follows:
     1874-1881: DHTSTPNP → VLRRPRPWGT...KRASLKRGKQ

Note: Produced by alternative splicing of isoform Er1.

Isoform Er14 (identifier: P16157-15)

Also known as: 14;

The sequence of this isoform differs from the canonical sequence as follows:
     1514-1675: Missing.
     1874-1881: DHTSTPNP → VLRRPRPWGT...KRASLKRGKQ

Note: Produced by alternative splicing of isoform Er1.

Isoform Er15 (identifier: P16157-16)

Also known as: 15;

The sequence of this isoform differs from the canonical sequence as follows:
     1827-1881: IIRKVVRQID...SKDHTSTPNP → VELRGSGLQPDLIEGRKGAQIVKRASLKRGKQ

Note: Produced by alternative splicing of isoform Er1.

Isoform Er16 (identifier: P16157-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1513-1874: Missing.
     1875-1875: H → D

Note: Produced by alternative splicing of isoform Er1.

Isoform Mu17 (identifier: P16157-17)

Also known as: ank1.5; muscle-specific 1;

The sequence of this isoform differs from the canonical sequence as follows:
     1-1725: Missing.
     1726-1798: TQGPHSFQGT...AKNTFTQVVQ → MWTFVTQLLV...RVVRRRVFLK
     1850-1881: TVEGPLEDPSELEVDIDYFMKHSKDHTSTPNP → ELRGSGLQPDLIEGRKGAQIVKRASLKRGKQ

Note: Produced by alternative promoter usage.

Isoform Mu18 (identifier: P16157-18)

Also known as: ank1.6; muscle-specific 2;

The sequence of this isoform differs from the canonical sequence as follows:
     1-1725: Missing.
     1726-1798: TQGPHSFQGT...AKNTFTQVVQ → MWTFVTQLLV...RVVRRRVFLK
     1827-1881: IIRKVVRQID...SKDHTSTPNP → VELRGSGLQPDLIEGRKGAQIVKRASLKRGKQ

Note: Produced by alternative splicing of isoform Mu17.

Isoform Mu19 (identifier: P16157-19)

Also known as: muscle-specific 3;

The sequence of this isoform differs from the canonical sequence as follows:
     1-1725: Missing.
     1726-1798: TQGPHSFQGT...AKNTFTQVVQ → MWTFVTQLLV...RVVRRRVFLK
     1799-1873: Missing.

Note: Produced by alternative splicing of isoform Mu17.

Isoform Mu20 (identifier: P16157-20)

Also known as: muscle-specific 4;

The sequence of this isoform differs from the canonical sequence as follows:
     1-1725: Missing.
     1726-1798: TQGPHSFQGT...AKNTFTQVVQ → MWTFVTQLLV...LCFVLKHIHQ
     1799-1881: GNEFQNIPGE...SKDHTSTPNP → VELRGSGLQPDLIEGRKGAQIVKRASLKRGKQ

Note: Produced by alternative splicing of isoform Mu17.

Isoform Br21 (identifier: P16157-21)

The sequence of this isoform differs from the canonical sequence as follows:
     1-9: MPYSVGFRE → MAQAAKQLKKIKDIEAQALQEQKEKEESNRKRRNRSRDRKKK
     820-820: E → EGTAHITIM
     1849-1873: Missing.

Note: No experimental confirmation available. Produced by alternative splicing of isoform Er1.

Isoform 22 (identifier: P16157-22)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1725: Missing.
     1726-1798: TQGPHSFQGT...AKNTFTQVVQ → MWTFVTQLLV...RVVRRRVFLK
     1826-1872: Missing.

Note: Produced by alternative splicing.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 1881

1881

Ankyrin-1

PRO_0000066883

Regions

Repeat

44 – 73

30

ANK 1

Repeat

77 – 106

30

ANK 2

Repeat

110 – 139

30

ANK 3

Repeat

143 – 172

30

ANK 4

Repeat

174 – 201

28

ANK 5

Repeat

205 – 234

30

ANK 6

Repeat

238 – 267

30

ANK 7

Repeat

271 – 300

30

ANK 8

Repeat

304 – 333

30

ANK 9

Repeat

337 – 366

30

ANK 10

Repeat

370 – 399

30

ANK 11

Repeat

403 – 432

30

ANK 12

Repeat

436 – 465

30

ANK 13

Repeat

469 – 498

30

ANK 14

Repeat

502 – 531

30

ANK 15

Repeat

535 – 564

30

ANK 16

Repeat

568 – 597

30

ANK 17

Repeat

601 – 630

30

ANK 18

Repeat

634 – 663

30

ANK 19

Repeat

667 – 696

30

ANK 20

Repeat

700 – 729

30

ANK 21

Repeat

733 – 762

30

ANK 22

Repeat

766 – 795

30

ANK 23

Domain

911 – 1066

156

ZU5 1

Domain

1067 – 1233

167

ZU5 2

Domain

1403 – 1487

85

Death

Region

1 – 827

827

89 kDa domain

Region

1234 – 1362

129

UPA domain By similarity

Region

1383 – 1881

499

55 kDa regulatory domain

Amino acid modifications

Modified residue

105

1

(3S)-3-hydroxyasparagine; by HIF1AN; partial Ref.10

Modified residue

233

1

(3S)-3-hydroxyasparagine; by HIF1AN; partial Ref.10

Modified residue

431

1

(3S)-3-hydroxyasparagine; by HIF1AN; partial Ref.10

Modified residue

464

1

(3S)-3-hydroxyasparagine; by HIF1AN; partial Ref.10

Modified residue

629

1

(3S)-3-hydroxyasparagine; by HIF1AN; partial Ref.10

Modified residue

662

1

(3S)-3-hydroxyasparagine; by HIF1AN; partial Ref.10

Modified residue

695

1

(3S)-3-hydroxyaspartate; by HIF1AN; partial

Modified residue

728

1

(3S)-3-hydroxyasparagine; by HIF1AN; partial Ref.10

Modified residue

761

1

(3S)-3-hydroxyasparagine; by HIF1AN; partial Ref.10

Modified residue

856

1

Phosphoserine By similarity

Modified residue

1073

1

Phosphotyrosine By similarity

Natural variations

Alternative sequence

1 – 1725

1725

Missing in isoform Mu17, isoform Mu18, isoform Mu19, isoform Mu20 and isoform 22.

VSP_018440

Alternative sequence

1 – 9

9

MPYSVGFRE → MAQAAKQLKKIKDIEAQALQ EQKEKEESNRKRRNRSRDRK KK in isoform Br21.

VSP_018439

Alternative sequence

820

1

E → EGTAHITIM in isoform Br21.

VSP_018441

Alternative sequence

1513 – 1874

362

Missing in isoform Er16.

VSP_000264

Alternative sequence

1514 – 1675

162

Missing in isoform Er2, isoform Er4, isoform Er6, isoform Er8, isoform Er10, isoform Er12 and isoform Er14.

VSP_018442

Alternative sequence

1726 – 1798

73

TQGPH…TQVVQ → MWTFVTQLLVTLVLLSFFLV SCQNVMHIVRGSLCFVLKHI HQELDKELGESEGLSDDEET ISTRVVRRRVFLK in isoform Mu17, isoform Mu18, isoform Mu19 and isoform 22.

VSP_018443

Alternative sequence

1726 – 1798

73

TQGPH…TQVVQ → MWTFVTQLLVTLVLLSFFLV SCQNVMHIVRGSLCFVLKHI HQ in isoform Mu20.

VSP_018444

Alternative sequence

1799 – 1881

83

GNEFQ…STPNP → VELRGSGLQPDLIEGRKGAQ IVKRASLKRGKQ in isoform Mu20.

VSP_018446

Alternative sequence

1799 – 1873

75

Missing in isoform Er9, isoform Er10 and isoform Mu19.

VSP_018445

Alternative sequence

1826 – 1872

47

Missing in isoform 22.

VSP_045439

Alternative sequence

1827 – 1881

55

IIRKV…STPNP → VELRGSGLQPDLIEGRKGAQ IVKRASLKRGKQ in isoform Er15 and isoform Mu18.

VSP_018448

Alternative sequence

1827 – 1873

47

Missing in isoform Er7 and isoform Er8.

VSP_018447

Alternative sequence

1849 – 1873

25

Missing in isoform Er3, isoform Er4 and isoform Br21.

VSP_018449

Alternative sequence

1850 – 1881

32

TVEGP…STPNP → ELRGSGLQPDLIEGRKGAQI VKRASLKRGKQ in isoform Er5, isoform Er6 and isoform Mu17.

VSP_000266

Alternative sequence

1874 – 1881

8

DHTSTPNP → VELRGSGLQPDLIEGRKGAQ IVKRASLKRGKQ in isoform Er11 and isoform Er12.

VSP_018450

Alternative sequence

1874 – 1881

8

DHTSTPNP → VLRRPRPWGTQRHHCCLALP GRLHDTSLHSPLYELSLQSL FSLVGSVSAPPCRSFRSSAC VLPVFAICPAFCLCCCLQVE LRGSGLQPDLIEGRKGAQIV KRASLKRGKQ in isoform Er13 and isoform Er14.

VSP_018451

Alternative sequence

1875

1

H → D in isoform Er16.

VSP_000265

Natural variant

21

1

R → T.

VAR_000595

Natural variant

276

1

L → R in SPH1. Ref.21

VAR_054991

Natural variant

332

1

D → H in a breast cancer sample; somatic mutation. Ref.22

VAR_035605

Natural variant

463

1

V → I in SPH1. Ref.20

VAR_000596

Natural variant

619

1

R → H in Brueggen.
Corresponds to variant rs2304877 [ dbSNP | Ensembl ].

VAR_000597

Natural variant

733

1

L → I.
Corresponds to variant rs11778936 [ dbSNP | Ensembl ].

VAR_028769

Natural variant

750

1

V → A. Ref.1

VAR_000598

Natural variant

832

1

R → Q.
Corresponds to variant rs34523608 [ dbSNP | Ensembl ].

VAR_061012

Natural variant

845

1

D → E.

VAR_000599

Natural variant

991

1

V → L. Ref.3

VAR_026411

Natural variant

1054

1

I → T in SPH1. Ref.21

VAR_054992

Natural variant

1075

1

T → I. Ref.1 Ref.2 Ref.3 Ref.5
Corresponds to variant rs35213384 [ dbSNP | Ensembl ].

VAR_048263

Natural variant

1126

1

A → P.
Corresponds to variant rs504465 [ dbSNP | Ensembl ].

VAR_028770

Natural variant

1192

1

T → P.
Corresponds to variant rs486770 [ dbSNP | Ensembl ].

VAR_028771

Natural variant

1286

1

E → D. Ref.9

VAR_000601

Natural variant

1325

1

M → V.
Corresponds to variant rs10093583 [ dbSNP | Ensembl ].

VAR_028772

Natural variant

1392

1

S → T.

VAR_000600

Natural variant

1546

1

V → I. Ref.2
Corresponds to variant rs1060130 [ dbSNP | Ensembl ].

VAR_028773

Natural variant

1592

1

D → N in Duesseldorf.

VAR_000602

Experimental info

Mutagenesis

1824

1

T → P: Abolishes interaction with OBSCN (in isoform Mu17). Ref.13

Mutagenesis

1826

1

K → E: Abolishes interaction with OBSCN (in isoform Mu17). Ref.13

Mutagenesis

1829

1

R → G: Abolishes interaction with OBSCN (in isoform Mu17). Ref.13

Mutagenesis

1830

1

K → E: Abolishes interaction with OBSCN (in isoform Mu17). Ref.13

Sequence conflict

230

1

A → S in AAA51732. Ref.2

Sequence conflict

801

1

K → L in AAB47805. Ref.3

Sequence conflict

845

1

D → R AA sequence Ref.1

Sequence conflict

902

1

I → T in AAB47805. Ref.3

Isoform Mu17:

Sequence conflict

63

1

T → P in AAC01950. Ref.4

Secondary structure

1

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1881

Helix Strand Turn

Details...

Helix

407 – 414

8

Helix

417 – 425

9

Beta strand

433 – 435

3

Helix

440 – 447

8

Helix

450 – 459

10

Helix

473 – 480

8

Helix

483 – 492

10

Helix

506 – 513

8

Helix

516 – 524

9

Helix

539 – 545

7

Helix

549 – 557

9

Helix

572 – 578

7

Helix

582 – 588

7

Helix

589 – 591

3

Helix

605 – 611

7

Helix

615 – 623

9

Helix

638 – 644

7

Helix

648 – 655

8

Turn

656 – 658

3

Helix

671 – 678

8

Helix

681 – 690

10

Helix

704 – 710

7

Helix

715 – 722

8

Helix

737 – 743

7

Helix

747 – 755

9

Beta strand

765 – 767

3

Helix

770 – 776

7

Helix

780 – 789

10

Beta strand

914 – 919

6

Beta strand

924 – 927

4

Turn

930 – 932

3

Beta strand

935 – 938

4

Beta strand

942 – 945

4

Beta strand

947 – 954

8

Helix

956 – 958

3

Beta strand

959 – 961

3

Beta strand

970 – 973

4

Beta strand

975 – 980

6

Beta strand

984 – 994

11

Beta strand

1000 – 1003

4

Beta strand

1006 – 1015

10

Beta strand

1018 – 1020

3

Helix

1026 – 1028

3

Helix

1029 – 1033

5

Helix

1043 – 1049

7

Beta strand

1051 – 1058

8

Beta strand

1061 – 1067

7

Beta strand

1074 – 1076

3

Beta strand

1081 – 1084

4

Beta strand

1092 – 1095

4

Beta strand

1099 – 1102

4

Beta strand

1104 – 1111

8

Helix

1115 – 1122

8

Beta strand

1131 – 1138

8

Beta strand

1140 – 1150

11

Helix

1153 – 1157

5

Beta strand

1165 – 1167

3

Beta strand

1169 – 1175

7

Beta strand

1195 – 1197

3

Beta strand

1200 – 1207

8

Beta strand

1210 – 1215

6

Helix

1219 – 1221

3

Helix

1222 – 1232

11

Turn

1398 – 1402

5

Helix

1403 – 1414

12

Helix

1415 – 1417

3

Helix

1418 – 1424

7

Helix

1429 – 1438

10

Helix

1443 – 1458

16

Helix

1459 – 1461

3

Helix

1464 – 1473

10

Helix

1477 – 1483

7

Sequences

	Sequence		Length	Mass (Da)
	Isoform Er1 (1) (2.1) [UniParc]. Last modified January 23, 2007. Version 3. Checksum: 49466F6F915019EC	FASTA	1,881	206,265
	10 20 30 40 50 60 MPYSVGFREA DAATSFLRAA RSGNLDKALD HLRNGVDINT CNQNGLNGLH LASKEGHVKM 70 80 90 100 110 120 VVELLHKEII LETTTKKGNT ALHIAALAGQ DEVVRELVNY GANVNAQSQK GFTPLYMAAQ 130 140 150 160 170 180 ENHLEVVKFL LENGANQNVA TEDGFTPLAV ALQQGHENVV AHLINYGTKG KVRLPALHIA 190 200 210 220 230 240 ARNDDTRTAA VLLQNDPNPD VLSKTGFTPL HIAAHYENLN VAQLLLNRGA SVNFTPQNGI 250 260 270 280 290 300 TPLHIASRRG NVIMVRLLLD RGAQIETKTK DELTPLHCAA RNGHVRISEI LLDHGAPIQA 310 320 330 340 350 360 KTKNGLSPIH MAAQGDHLDC VRLLLQYDAE IDDITLDHLT PLHVAAHCGH HRVAKVLLDK 370 380 390 400 410 420 GAKPNSRALN GFTPLHIACK KNHVRVMELL LKTGASIDAV TESGLTPLHV ASFMGHLPIV 430 440 450 460 470 480 KNLLQRGASP NVSNVKVETP LHMAARAGHT EVAKYLLQNK AKVNAKAKDD QTPLHCAARI 490 500 510 520 530 540 GHTNMVKLLL ENNANPNLAT TAGHTPLHIA AREGHVETVL ALLEKEASQA CMTKKGFTPL 550 560 570 580 590 600 HVAAKYGKVR VAELLLERDA HPNAAGKNGL TPLHVAVHHN NLDIVKLLLP RGGSPHSPAW 610 620 630 640 650 660 NGYTPLHIAA KQNQVEVARS LLQYGGSANA ESVQGVTPLH LAAQEGHAEM VALLLSKQAN 670 680 690 700 710 720 GNLGNKSGLT PLHLVAQEGH VPVADVLIKH GVMVDATTRM GYTPLHVASH YGNIKLVKFL 730 740 750 760 770 780 LQHQADVNAK TKLGYSPLHQ AAQQGHTDIV TLLLKNGASP NEVSSDGTTP LAIAKRLGYI 790 800 810 820 830 840 SVTDVLKVVT DETSFVLVSD KHRMSFPETV DEILDVSEDE GEELISFKAE RRDSRDVDEE 850 860 870 880 890 900 KELLDFVPKL DQVVESPAIP RIPCAMPETV VIRSEEQEQA SKEYDEDSLI PSSPATETSD 910 920 930 940 950 960 NISPVASPVH TGFLVSFMVD ARGGSMRGSR HNGLRVVIPP RTCAAPTRIT CRLVKPQKLS 970 980 990 1000 1010 1020 TPPPLAEEEG LASRIIALGP TGAQFLSPVI VEIPHFASHG RGDRELVVLR SENGSVWKEH 1030 1040 1050 1060 1070 1080 RSRYGESYLD QILNGMDEEL GSLEELEKKR VCRIITTDFP LYFVIMSRLC QDYDTIGPEG 1090 1100 1110 1120 1130 1140 GSLKSKLVPL VQATFPENAV TKRVKLALQA QPVPDELVTK LLGNQATFSP IVTVEPRRRK 1150 1160 1170 1180 1190 1200 FHRPIGLRIP LPPSWTDNPR DSGEGDTTSL RLLCSVIGGT DQAQWEDITG TTKLVYANEC 1210 1220 1230 1240 1250 1260 ANFTTNVSAR FWLSDCPRTA EAVNFATLLY KELTAVPYMA KFVIFAKMND PREGRLRCYC 1270 1280 1290 1300 1310 1320 MTDDKVDKTL EQHENFVEVA RSRDIEVLEG MSLFAELSGN LVPVKKAAQQ RSFHFQSFRE 1330 1340 1350 1360 1370 1380 NRLAMPVKVR DSSREPGGSL SFLRKAMKYE DTQHILCHLN ITMPPCAKGS GAEDRRRTPT 1390 1400 1410 1420 1430 1440 PLALRYSILS ESTPGSLSGT EQAEMKMAVI SEHLGLSWAE LARELQFSVE DINRIRVENP 1450 1460 1470 1480 1490 1500 NSLLEQSVAL LNLWVIREGQ NANMENLYTA LQSIDRGEIV NMLEGSGRQS RNLKPDRRHT 1510 1520 1530 1540 1550 1560 DRDYSLSPSQ MNGYSSLQDE LLSPASLGCA LSSPLRADQY WNEVAVLDAI PLAATEHDTM 1570 1580 1590 1600 1610 1620 LEMSDMQVWS AGLTPSLVTA EDSSLECSKA EDSDATGHEW KLEGALSEEP RGPELGSLEL 1630 1640 1650 1660 1670 1680 VEDDTVDSDA TNGLIDLLEQ EEGQRSEEKL PGSKRQDDAT GAGQDSENEV SLVSGHQRGQ 1690 1700 1710 1720 1730 1740 ARITHSPTVS QVTERSQDRL QDWDADGSIV SYLQDAAQGS WQEEVTQGPH SFQGTSTMTE 1750 1760 1770 1780 1790 1800 GLEPGGSQEY EKVLVSVSEH TWTEQPEAES SQADRDRRQQ GQEEQVQEAK NTFTQVVQGN 1810 1820 1830 1840 1850 1860 EFQNIPGEQV TEEQFTDEQG NIVTKKIIRK VVRQIDLSSA DAAQEHEEVT VEGPLEDPSE 1870 1880 LEVDIDYFMK HSKDHTSTPN P
	Isoform Er2 (2) (2.2) [UniParc]. Checksum: 407D614678AF8EE0	FASTA	1,719	188,999
	10 20 30 40 50 60 MPYSVGFREA DAATSFLRAA RSGNLDKALD HLRNGVDINT CNQNGLNGLH LASKEGHVKM 70 80 90 100 110 120 VVELLHKEII LETTTKKGNT ALHIAALAGQ DEVVRELVNY GANVNAQSQK GFTPLYMAAQ 130 140 150 160 170 180 ENHLEVVKFL LENGANQNVA TEDGFTPLAV ALQQGHENVV AHLINYGTKG KVRLPALHIA 190 200 210 220 230 240 ARNDDTRTAA VLLQNDPNPD VLSKTGFTPL HIAAHYENLN VAQLLLNRGA SVNFTPQNGI 250 260 270 280 290 300 TPLHIASRRG NVIMVRLLLD RGAQIETKTK DELTPLHCAA RNGHVRISEI LLDHGAPIQA 310 320 330 340 350 360 KTKNGLSPIH MAAQGDHLDC VRLLLQYDAE IDDITLDHLT PLHVAAHCGH HRVAKVLLDK 370 380 390 400 410 420 GAKPNSRALN GFTPLHIACK KNHVRVMELL LKTGASIDAV TESGLTPLHV ASFMGHLPIV 430 440 450 460 470 480 KNLLQRGASP NVSNVKVETP LHMAARAGHT EVAKYLLQNK AKVNAKAKDD QTPLHCAARI 490 500 510 520 530 540 GHTNMVKLLL ENNANPNLAT TAGHTPLHIA AREGHVETVL ALLEKEASQA CMTKKGFTPL 550 560 570 580 590 600 HVAAKYGKVR VAELLLERDA HPNAAGKNGL TPLHVAVHHN NLDIVKLLLP RGGSPHSPAW 610 620 630 640 650 660 NGYTPLHIAA KQNQVEVARS LLQYGGSANA ESVQGVTPLH LAAQEGHAEM VALLLSKQAN 670 680 690 700 710 720 GNLGNKSGLT PLHLVAQEGH VPVADVLIKH GVMVDATTRM GYTPLHVASH YGNIKLVKFL 730 740 750 760 770 780 LQHQADVNAK TKLGYSPLHQ AAQQGHTDIV TLLLKNGASP NEVSSDGTTP LAIAKRLGYI 790 800 810 820 830 840 SVTDVLKVVT DETSFVLVSD KHRMSFPETV DEILDVSEDE GEELISFKAE RRDSRDVDEE 850 860 870 880 890 900 KELLDFVPKL DQVVESPAIP RIPCAMPETV VIRSEEQEQA SKEYDEDSLI PSSPATETSD 910 920 930 940 950 960 NISPVASPVH TGFLVSFMVD ARGGSMRGSR HNGLRVVIPP RTCAAPTRIT CRLVKPQKLS 970 980 990 1000 1010 1020 TPPPLAEEEG LASRIIALGP TGAQFLSPVI VEIPHFASHG RGDRELVVLR SENGSVWKEH 1030 1040 1050 1060 1070 1080 RSRYGESYLD QILNGMDEEL GSLEELEKKR VCRIITTDFP LYFVIMSRLC QDYDTIGPEG 1090 1100 1110 1120 1130 1140 GSLKSKLVPL VQATFPENAV TKRVKLALQA QPVPDELVTK LLGNQATFSP IVTVEPRRRK 1150 1160 1170 1180 1190 1200 FHRPIGLRIP LPPSWTDNPR DSGEGDTTSL RLLCSVIGGT DQAQWEDITG TTKLVYANEC 1210 1220 1230 1240 1250 1260 ANFTTNVSAR FWLSDCPRTA EAVNFATLLY KELTAVPYMA KFVIFAKMND PREGRLRCYC 1270 1280 1290 1300 1310 1320 MTDDKVDKTL EQHENFVEVA RSRDIEVLEG MSLFAELSGN LVPVKKAAQQ RSFHFQSFRE 1330 1340 1350 1360 1370 1380 NRLAMPVKVR DSSREPGGSL SFLRKAMKYE DTQHILCHLN ITMPPCAKGS GAEDRRRTPT 1390 1400 1410 1420 1430 1440 PLALRYSILS ESTPGSLSGT EQAEMKMAVI SEHLGLSWAE LARELQFSVE DINRIRVENP 1450 1460 1470 1480 1490 1500 NSLLEQSVAL LNLWVIREGQ NANMENLYTA LQSIDRGEIV NMLEGSGRQS RNLKPDRRHT 1510 1520 1530 1540 1550 1560 DRDYSLSPSQ MNGHQRGQAR ITHSPTVSQV TERSQDRLQD WDADGSIVSY LQDAAQGSWQ 1570 1580 1590 1600 1610 1620 EEVTQGPHSF QGTSTMTEGL EPGGSQEYEK VLVSVSEHTW TEQPEAESSQ ADRDRRQQGQ 1630 1640 1650 1660 1670 1680 EEQVQEAKNT FTQVVQGNEF QNIPGEQVTE EQFTDEQGNI VTKKIIRKVV RQIDLSSADA 1690 1700 1710 AQEHEEVTVE GPLEDPSELE VDIDYFMKHS KDHTSTPNP
	Isoform Er3 (3) [UniParc]. Checksum: FEC7837B2E7711B8	FASTA	1,856	203,405
	10 20 30 40 50 60 MPYSVGFREA DAATSFLRAA RSGNLDKALD HLRNGVDINT CNQNGLNGLH LASKEGHVKM 70 80 90 100 110 120 VVELLHKEII LETTTKKGNT ALHIAALAGQ DEVVRELVNY GANVNAQSQK GFTPLYMAAQ 130 140 150 160 170 180 ENHLEVVKFL LENGANQNVA TEDGFTPLAV ALQQGHENVV AHLINYGTKG KVRLPALHIA 190 200 210 220 230 240 ARNDDTRTAA VLLQNDPNPD VLSKTGFTPL HIAAHYENLN VAQLLLNRGA SVNFTPQNGI 250 260 270 280 290 300 TPLHIASRRG NVIMVRLLLD RGAQIETKTK DELTPLHCAA RNGHVRISEI LLDHGAPIQA 310 320 330 340 350 360 KTKNGLSPIH MAAQGDHLDC VRLLLQYDAE IDDITLDHLT PLHVAAHCGH HRVAKVLLDK 370 380 390 400 410 420 GAKPNSRALN GFTPLHIACK KNHVRVMELL LKTGASIDAV TESGLTPLHV ASFMGHLPIV 430 440 450 460 470 480 KNLLQRGASP NVSNVKVETP LHMAARAGHT EVAKYLLQNK AKVNAKAKDD QTPLHCAARI 490 500 510 520 530 540 GHTNMVKLLL ENNANPNLAT TAGHTPLHIA AREGHVETVL ALLEKEASQA CMTKKGFTPL 550 560 570 580 590 600 HVAAKYGKVR VAELLLERDA HPNAAGKNGL TPLHVAVHHN NLDIVKLLLP RGGSPHSPAW 610 620 630 640 650 660 NGYTPLHIAA KQNQVEVARS LLQYGGSANA ESVQGVTPLH LAAQEGHAEM VALLLSKQAN 670 680 690 700 710 720 GNLGNKSGLT PLHLVAQEGH VPVADVLIKH GVMVDATTRM GYTPLHVASH YGNIKLVKFL 730 740 750 760 770 780 LQHQADVNAK TKLGYSPLHQ AAQQGHTDIV TLLLKNGASP NEVSSDGTTP LAIAKRLGYI 790 800 810 820 830 840 SVTDVLKVVT DETSFVLVSD KHRMSFPETV DEILDVSEDE GEELISFKAE RRDSRDVDEE 850 860 870 880 890 900 KELLDFVPKL DQVVESPAIP RIPCAMPETV VIRSEEQEQA SKEYDEDSLI PSSPATETSD 910 920 930 940 950 960 NISPVASPVH TGFLVSFMVD ARGGSMRGSR HNGLRVVIPP RTCAAPTRIT CRLVKPQKLS 970 980 990 1000 1010 1020 TPPPLAEEEG LASRIIALGP TGAQFLSPVI VEIPHFASHG RGDRELVVLR SENGSVWKEH 1030 1040 1050 1060 1070 1080 RSRYGESYLD QILNGMDEEL GSLEELEKKR VCRIITTDFP LYFVIMSRLC QDYDTIGPEG 1090 1100 1110 1120 1130 1140 GSLKSKLVPL VQATFPENAV TKRVKLALQA QPVPDELVTK LLGNQATFSP IVTVEPRRRK 1150 1160 1170 1180 1190 1200 FHRPIGLRIP LPPSWTDNPR DSGEGDTTSL RLLCSVIGGT DQAQWEDITG TTKLVYANEC 1210 1220 1230 1240 1250 1260 ANFTTNVSAR FWLSDCPRTA EAVNFATLLY KELTAVPYMA KFVIFAKMND PREGRLRCYC 1270 1280 1290 1300 1310 1320 MTDDKVDKTL EQHENFVEVA RSRDIEVLEG MSLFAELSGN LVPVKKAAQQ RSFHFQSFRE 1330 1340 1350 1360 1370 1380 NRLAMPVKVR DSSREPGGSL SFLRKAMKYE DTQHILCHLN ITMPPCAKGS GAEDRRRTPT 1390 1400 1410 1420 1430 1440 PLALRYSILS ESTPGSLSGT EQAEMKMAVI SEHLGLSWAE LARELQFSVE DINRIRVENP 1450 1460 1470 1480 1490 1500 NSLLEQSVAL LNLWVIREGQ NANMENLYTA LQSIDRGEIV NMLEGSGRQS RNLKPDRRHT 1510 1520 1530 1540 1550 1560 DRDYSLSPSQ MNGYSSLQDE LLSPASLGCA LSSPLRADQY WNEVAVLDAI PLAATEHDTM 1570 1580 1590 1600 1610 1620 LEMSDMQVWS AGLTPSLVTA EDSSLECSKA EDSDATGHEW KLEGALSEEP RGPELGSLEL 1630 1640 1650 1660 1670 1680 VEDDTVDSDA TNGLIDLLEQ EEGQRSEEKL PGSKRQDDAT GAGQDSENEV SLVSGHQRGQ 1690 1700 1710 1720 1730 1740 ARITHSPTVS QVTERSQDRL QDWDADGSIV SYLQDAAQGS WQEEVTQGPH SFQGTSTMTE 1750 1760 1770 1780 1790 1800 GLEPGGSQEY EKVLVSVSEH TWTEQPEAES SQADRDRRQQ GQEEQVQEAK NTFTQVVQGN 1810 1820 1830 1840 1850 EFQNIPGEQV TEEQFTDEQG NIVTKKIIRK VVRQIDLSSA DAAQEHEEDH TSTPNP
	Isoform Er4 (4) [UniParc]. Checksum: BB17E7510AE1067A	FASTA	1,694	186,139
	10 20 30 40 50 60 MPYSVGFREA DAATSFLRAA RSGNLDKALD HLRNGVDINT CNQNGLNGLH LASKEGHVKM 70 80 90 100 110 120 VVELLHKEII LETTTKKGNT ALHIAALAGQ DEVVRELVNY GANVNAQSQK GFTPLYMAAQ 130 140 150 160 170 180 ENHLEVVKFL LENGANQNVA TEDGFTPLAV ALQQGHENVV AHLINYGTKG KVRLPALHIA 190 200 210 220 230 240 ARNDDTRTAA VLLQNDPNPD VLSKTGFTPL HIAAHYENLN VAQLLLNRGA SVNFTPQNGI 250 260 270 280 290 300 TPLHIASRRG NVIMVRLLLD RGAQIETKTK DELTPLHCAA RNGHVRISEI LLDHGAPIQA 310 320 330 340 350 360 KTKNGLSPIH MAAQGDHLDC VRLLLQYDAE IDDITLDHLT PLHVAAHCGH HRVAKVLLDK 370 380 390 400 410 420 GAKPNSRALN GFTPLHIACK KNHVRVMELL LKTGASIDAV TESGLTPLHV ASFMGHLPIV 430 440 450 460 470 480 KNLLQRGASP NVSNVKVETP LHMAARAGHT EVAKYLLQNK AKVNAKAKDD QTPLHCAARI 490 500 510 520 530 540 GHTNMVKLLL ENNANPNLAT TAGHTPLHIA AREGHVETVL ALLEKEASQA CMTKKGFTPL 550 560 570 580 590 600 HVAAKYGKVR VAELLLERDA HPNAAGKNGL TPLHVAVHHN NLDIVKLLLP RGGSPHSPAW 610 620 630 640 650 660 NGYTPLHIAA KQNQVEVARS LLQYGGSANA ESVQGVTPLH LAAQEGHAEM VALLLSKQAN 670 680 690 700 710 720 GNLGNKSGLT PLHLVAQEGH VPVADVLIKH GVMVDATTRM GYTPLHVASH YGNIKLVKFL 730 740 750 760 770 780 LQHQADVNAK TKLGYSPLHQ AAQQGHTDIV TLLLKNGASP NEVSSDGTTP LAIAKRLGYI 790 800 810 820 830 840 SVTDVLKVVT DETSFVLVSD KHRMSFPETV DEILDVSEDE GEELISFKAE RRDSRDVDEE 850 860 870 880 890 900 KELLDFVPKL DQVVESPAIP RIPCAMPETV VIRSEEQEQA SKEYDEDSLI PSSPATETSD 910 920 930 940 950 960 NISPVASPVH TGFLVSFMVD ARGGSMRGSR HNGLRVVIPP RTCAAPTRIT CRLVKPQKLS 970 980 990 1000 1010 1020 TPPPLAEEEG LASRIIALGP TGAQFLSPVI VEIPHFASHG RGDRELVVLR SENGSVWKEH 1030 1040 1050 1060 1070 1080 RSRYGESYLD QILNGMDEEL GSLEELEKKR VCRIITTDFP LYFVIMSRLC QDYDTIGPEG 1090 1100 1110 1120 1130 1140 GSLKSKLVPL VQATFPENAV TKRVKLALQA QPVPDELVTK LLGNQATFSP IVTVEPRRRK 1150 1160 1170 1180 1190 1200 FHRPIGLRIP LPPSWTDNPR DSGEGDTTSL RLLCSVIGGT DQAQWEDITG TTKLVYANEC 1210 1220 1230 1240 1250 1260 ANFTTNVSAR FWLSDCPRTA EAVNFATLLY KELTAVPYMA KFVIFAKMND PREGRLRCYC 1270 1280 1290 1300 1310 1320 MTDDKVDKTL EQHENFVEVA RSRDIEVLEG MSLFAELSGN LVPVKKAAQQ RSFHFQSFRE 1330 1340 1350 1360 1370 1380 NRLAMPVKVR DSSREPGGSL SFLRKAMKYE DTQHILCHLN ITMPPCAKGS GAEDRRRTPT 1390 1400 1410 1420 1430 1440 PLALRYSILS ESTPGSLSGT EQAEMKMAVI SEHLGLSWAE LARELQFSVE DINRIRVENP 1450 1460 1470 1480 1490 1500 NSLLEQSVAL LNLWVIREGQ NANMENLYTA LQSIDRGEIV NMLEGSGRQS RNLKPDRRHT 1510 1520 1530 1540 1550 1560 DRDYSLSPSQ MNGHQRGQAR ITHSPTVSQV TERSQDRLQD WDADGSIVSY LQDAAQGSWQ 1570 1580 1590 1600 1610 1620 EEVTQGPHSF QGTSTMTEGL EPGGSQEYEK VLVSVSEHTW TEQPEAESSQ ADRDRRQQGQ 1630 1640 1650 1660 1670 1680 EEQVQEAKNT FTQVVQGNEF QNIPGEQVTE EQFTDEQGNI VTKKIIRKVV RQIDLSSADA 1690 AQEHEEDHTS TPNP
	Isoform Er5 (5) [UniParc]. Checksum: 3153959168D8D91D	FASTA	1,880	206,026
	10 20 30 40 50 60 MPYSVGFREA DAATSFLRAA RSGNLDKALD HLRNGVDINT CNQNGLNGLH LASKEGHVKM 70 80 90 100 110 120 VVELLHKEII LETTTKKGNT ALHIAALAGQ DEVVRELVNY GANVNAQSQK GFTPLYMAAQ 130 140 150 160 170 180 ENHLEVVKFL LENGANQNVA TEDGFTPLAV ALQQGHENVV AHLINYGTKG KVRLPALHIA 190 200 210 220 230 240 ARNDDTRTAA VLLQNDPNPD VLSKTGFTPL HIAAHYENLN VAQLLLNRGA SVNFTPQNGI 250 260 270 280 290 300 TPLHIASRRG NVIMVRLLLD RGAQIETKTK DELTPLHCAA RNGHVRISEI LLDHGAPIQA 310 320 330 340 350 360 KTKNGLSPIH MAAQGDHLDC VRLLLQYDAE IDDITLDHLT PLHVAAHCGH HRVAKVLLDK 370 380 390 400 410 420 GAKPNSRALN GFTPLHIACK KNHVRVMELL LKTGASIDAV TESGLTPLHV ASFMGHLPIV 430 440 450 460 470 480 KNLLQRGASP NVSNVKVETP LHMAARAGHT EVAKYLLQNK AKVNAKAKDD QTPLHCAARI 490 500 510 520 530 540 GHTNMVKLLL ENNANPNLAT TAGHTPLHIA AREGHVETVL ALLEKEASQA CMTKKGFTPL 550 560 570 580 590 600 HVAAKYGKVR VAELLLERDA HPNAAGKNGL TPLHVAVHHN NLDIVKLLLP RGGSPHSPAW 610 620 630 640 650 660 NGYTPLHIAA KQNQVEVARS LLQYGGSANA ESVQGVTPLH LAAQEGHAEM VALLLSKQAN 670 680 690 700 710 720 GNLGNKSGLT PLHLVAQEGH VPVADVLIKH GVMVDATTRM GYTPLHVASH YGNIKLVKFL 730 740 750 760 770 780 LQHQADVNAK TKLGYSPLHQ AAQQGHTDIV TLLLKNGASP NEVSSDGTTP LAIAKRLGYI 790 800 810 820 830 840 SVTDVLKVVT DETSFVLVSD KHRMSFPETV DEILDVSEDE GEELISFKAE RRDSRDVDEE 850 860 870 880 890 900 KELLDFVPKL DQVVESPAIP RIPCAMPETV VIRSEEQEQA SKEYDEDSLI PSSPATETSD 910 920 930 940 950 960 NISPVASPVH TGFLVSFMVD ARGGSMRGSR HNGLRVVIPP RTCAAPTRIT CRLVKPQKLS 970 980 990 1000 1010 1020 TPPPLAEEEG LASRIIALGP TGAQFLSPVI VEIPHFASHG RGDRELVVLR SENGSVWKEH 1030 1040 1050 1060 1070 1080 RSRYGESYLD QILNGMDEEL GSLEELEKKR VCRIITTDFP LYFVIMSRLC QDYDTIGPEG 1090 1100 1110 1120 1130 1140 GSLKSKLVPL VQATFPENAV TKRVKLALQA QPVPDELVTK LLGNQATFSP IVTVEPRRRK 1150 1160 1170 1180 1190 1200 FHRPIGLRIP LPPSWTDNPR DSGEGDTTSL RLLCSVIGGT DQAQWEDITG TTKLVYANEC 1210 1220 1230 1240 1250 1260 ANFTTNVSAR FWLSDCPRTA EAVNFATLLY KELTAVPYMA KFVIFAKMND PREGRLRCYC 1270 1280 1290 1300 1310 1320 MTDDKVDKTL EQHENFVEVA RSRDIEVLEG MSLFAELSGN LVPVKKAAQQ RSFHFQSFRE 1330 1340 1350 1360 1370 1380 NRLAMPVKVR DSSREPGGSL SFLRKAMKYE DTQHILCHLN ITMPPCAKGS GAEDRRRTPT 1390 1400 1410 1420 1430 1440 PLALRYSILS ESTPGSLSGT EQAEMKMAVI SEHLGLSWAE LARELQFSVE DINRIRVENP 1450 1460 1470 1480 1490 1500 NSLLEQSVAL LNLWVIREGQ NANMENLYTA LQSIDRGEIV NMLEGSGRQS RNLKPDRRHT 1510 1520 1530 1540 1550 1560 DRDYSLSPSQ MNGYSSLQDE LLSPASLGCA LSSPLRADQY WNEVAVLDAI PLAATEHDTM 1570 1580 1590 1600 1610 1620 LEMSDMQVWS AGLTPSLVTA EDSSLECSKA EDSDATGHEW KLEGALSEEP RGPELGSLEL 1630 1640 1650 1660 1670 1680 VEDDTVDSDA TNGLIDLLEQ EEGQRSEEKL PGSKRQDDAT GAGQDSENEV SLVSGHQRGQ 1690 1700 1710 1720 1730 1740 ARITHSPTVS QVTERSQDRL QDWDADGSIV SYLQDAAQGS WQEEVTQGPH SFQGTSTMTE 1750 1760 1770 1780 1790 1800 GLEPGGSQEY EKVLVSVSEH TWTEQPEAES SQADRDRRQQ GQEEQVQEAK NTFTQVVQGN 1810 1820 1830 1840 1850 1860 EFQNIPGEQV TEEQFTDEQG NIVTKKIIRK VVRQIDLSSA DAAQEHEEVE LRGSGLQPDL 1870 1880 IEGRKGAQIV KRASLKRGKQ
	Isoform Er6 (6) [UniParc]. Checksum: 9A5DBC78974FD512	FASTA	1,718	188,760
	10 20 30 40 50 60 MPYSVGFREA DAATSFLRAA RSGNLDKALD HLRNGVDINT CNQNGLNGLH LASKEGHVKM 70 80 90 100 110 120 VVELLHKEII LETTTKKGNT ALHIAALAGQ DEVVRELVNY GANVNAQSQK GFTPLYMAAQ 130 140 150 160 170 180 ENHLEVVKFL LENGANQNVA TEDGFTPLAV ALQQGHENVV AHLINYGTKG KVRLPALHIA 190 200 210 220 230 240 ARNDDTRTAA VLLQNDPNPD VLSKTGFTPL HIAAHYENLN VAQLLLNRGA SVNFTPQNGI 250 260 270 280 290 300 TPLHIASRRG NVIMVRLLLD RGAQIETKTK DELTPLHCAA RNGHVRISEI LLDHGAPIQA 310 320 330 340 350 360 KTKNGLSPIH MAAQGDHLDC VRLLLQYDAE IDDITLDHLT PLHVAAHCGH HRVAKVLLDK 370 380 390 400 410 420 GAKPNSRALN GFTPLHIACK KNHVRVMELL LKTGASIDAV TESGLTPLHV ASFMGHLPIV 430 440 450 460 470 480 KNLLQRGASP NVSNVKVETP LHMAARAGHT EVAKYLLQNK AKVNAKAKDD QTPLHCAARI 490 500 510 520 530 540 GHTNMVKLLL ENNANPNLAT TAGHTPLHIA AREGHVETVL ALLEKEASQA CMTKKGFTPL 550 560 570 580 590 600 HVAAKYGKVR VAELLLERDA HPNAAGKNGL TPLHVAVHHN NLDIVKLLLP RGGSPHSPAW 610 620 630 640 650 660 NGYTPLHIAA KQNQVEVARS LLQYGGSANA ESVQGVTPLH LAAQEGHAEM VALLLSKQAN 670 680 690 700 710 720 GNLGNKSGLT PLHLVAQEGH VPVADVLIKH GVMVDATTRM GYTPLHVASH YGNIKLVKFL 730 740 750 760 770 780 LQHQADVNAK TKLGYSPLHQ AAQQGHTDIV TLLLKNGASP NEVSSDGTTP LAIAKRLGYI 790 800 810 820 830 840 SVTDVLKVVT DETSFVLVSD KHRMSFPETV DEILDVSEDE GEELISFKAE RRDSRDVDEE 850 860 870 880 890 900 KELLDFVPKL DQVVESPAIP RIPCAMPETV VIRSEEQEQA SKEYDEDSLI PSSPATETSD 910 920 930 940 950 960 NISPVASPVH TGFLVSFMVD ARGGSMRGSR HNGLRVVIPP RTCAAPTRIT CRLVKPQKLS 970 980 990 1000 1010 1020 TPPPLAEEEG LASRIIALGP TGAQFLSPVI VEIPHFASHG RGDRELVVLR SENGSVWKEH 1030 1040 1050 1060 1070 1080 RSRYGESYLD QILNGMDEEL GSLEELEKKR VCRIITTDFP LYFVIMSRLC QDYDTIGPEG 1090 1100 1110 1120 1130 1140 GSLKSKLVPL VQATFPENAV TKRVKLALQA QPVPDELVTK LLGNQATFSP IVTVEPRRRK 1150 1160 1170 1180 1190 1200 FHRPIGLRIP LPPSWTDNPR DSGEGDTTSL RLLCSVIGGT DQAQWEDITG TTKLVYANEC 1210 1220 1230 1240 1250 1260 ANFTTNVSAR FWLSDCPRTA EAVNFATLLY KELTAVPYMA KFVIFAKMND PREGRLRCYC 1270 1280 1290 1300 1310 1320 MTDDKVDKTL EQHENFVEVA RSRDIEVLEG MSLFAELSGN LVPVKKAAQQ RSFHFQSFRE 1330 1340 1350 1360 1370 1380 NRLAMPVKVR DSSREPGGSL SFLRKAMKYE DTQHILCHLN ITMPPCAKGS GAEDRRRTPT 1390 1400 1410 1420 1430 1440 PLALRYSILS ESTPGSLSGT EQAEMKMAVI SEHLGLSWAE LARELQFSVE DINRIRVENP 1450 1460 1470 1480 1490 1500 NSLLEQSVAL LNLWVIREGQ NANMENLYTA LQSIDRGEIV NMLEGSGRQS RNLKPDRRHT 1510 1520 1530 1540 1550 1560 DRDYSLSPSQ MNGHQRGQAR ITHSPTVSQV TERSQDRLQD WDADGSIVSY LQDAAQGSWQ 1570 1580 1590 1600 1610 1620 EEVTQGPHSF QGTSTMTEGL EPGGSQEYEK VLVSVSEHTW TEQPEAESSQ ADRDRRQQGQ 1630 1640 1650 1660 1670 1680 EEQVQEAKNT FTQVVQGNEF QNIPGEQVTE EQFTDEQGNI VTKKIIRKVV RQIDLSSADA 1690 1700 1710 AQEHEEVELR GSGLQPDLIE GRKGAQIVKR ASLKRGKQ
	Isoform Er7 (7) [UniParc]. Checksum: B3735FA102F08B3D	FASTA	1,834	200,915
	10 20 30 40 50 60 MPYSVGFREA DAATSFLRAA RSGNLDKALD HLRNGVDINT CNQNGLNGLH LASKEGHVKM 70 80 90 100 110 120 VVELLHKEII LETTTKKGNT ALHIAALAGQ DEVVRELVNY GANVNAQSQK GFTPLYMAAQ 130 140 150 160 170 180 ENHLEVVKFL LENGANQNVA TEDGFTPLAV ALQQGHENVV AHLINYGTKG KVRLPALHIA 190 200 210 220 230 240 ARNDDTRTAA VLLQNDPNPD VLSKTGFTPL HIAAHYENLN VAQLLLNRGA SVNFTPQNGI 250 260 270 280 290 300 TPLHIASRRG NVIMVRLLLD RGAQIETKTK DELTPLHCAA RNGHVRISEI LLDHGAPIQA 310 320 330 340 350 360 KTKNGLSPIH MAAQGDHLDC VRLLLQYDAE IDDITLDHLT PLHVAAHCGH HRVAKVLLDK 370 380 390 400 410 420 GAKPNSRALN GFTPLHIACK KNHVRVMELL LKTGASIDAV TESGLTPLHV ASFMGHLPIV 430 440 450 460 470 480 KNLLQRGASP NVSNVKVETP LHMAARAGHT EVAKYLLQNK AKVNAKAKDD QTPLHCAARI 490 500 510 520 530 540 GHTNMVKLLL ENNANPNLAT TAGHTPLHIA AREGHVETVL ALLEKEASQA CMTKKGFTPL 550 560 570 580 590 600 HVAAKYGKVR VAELLLERDA HPNAAGKNGL TPLHVAVHHN NLDIVKLLLP RGGSPHSPAW 610 620 630 640 650 660 NGYTPLHIAA KQNQVEVARS LLQYGGSANA ESVQGVTPLH LAAQEGHAEM VALLLSKQAN 670 680 690 700 710 720 GNLGNKSGLT PLHLVAQEGH VPVADVLIKH GVMVDATTRM GYTPLHVASH YGNIKLVKFL 730 740 750 760 770 780 LQHQADVNAK TKLGYSPLHQ AAQQGHTDIV TLLLKNGASP NEVSSDGTTP LAIAKRLGYI 790 800 810 820 830 840 SVTDVLKVVT DETSFVLVSD KHRMSFPETV DEILDVSEDE GEELISFKAE RRDSRDVDEE 850 860 870 880 890 900 KELLDFVPKL DQVVESPAIP RIPCAMPETV VIRSEEQEQA SKEYDEDSLI PSSPATETSD 910 920 930 940 950 960 NISPVASPVH TGFLVSFMVD ARGGSMRGSR HNGLRVVIPP RTCAAPTRIT CRLVKPQKLS 970 980 990 1000 1010 1020 TPPPLAEEEG LASRIIALGP TGAQFLSPVI VEIPHFASHG RGDRELVVLR SENGSVWKEH 1030 1040 1050 1060 1070 1080 RSRYGESYLD QILNGMDEEL GSLEELEKKR VCRIITTDFP LYFVIMSRLC QDYDTIGPEG 1090 1100 1110 1120 1130 1140 GSLKSKLVPL VQATFPENAV TKRVKLALQA QPVPDELVTK LLGNQATFSP IVTVEPRRRK 1150 1160 1170 1180 1190 1200 FHRPIGLRIP LPPSWTDNPR DSGEGDTTSL RLLCSVIGGT DQAQWEDITG TTKLVYANEC 1210 1220 1230 1240 1250 1260 ANFTTNVSAR FWLSDCPRTA EAVNFATLLY KELTAVPYMA KFVIFAKMND PREGRLRCYC 1270 1280 1290 1300 1310 1320 MTDDKVDKTL EQHENFVEVA RSRDIEVLEG MSLFAELSGN LVPVKKAAQQ RSFHFQSFRE 1330 1340 1350 1360 1370 1380 NRLAMPVKVR DSSREPGGSL SFLRKAMKYE DTQHILCHLN ITMPPCAKGS GAEDRRRTPT 1390 1400 1410 1420 1430 1440 PLALRYSILS ESTPGSLSGT EQAEMKMAVI SEHLGLSWAE LARELQFSVE DINRIRVENP 1450 1460 1470 1480 1490 1500 NSLLEQSVAL LNLWVIREGQ NANMENLYTA LQSIDRGEIV NMLEGSGRQS RNLKPDRRHT 1510 1520 1530 1540 1550 1560 DRDYSLSPSQ MNGYSSLQDE LLSPASLGCA LSSPLRADQY WNEVAVLDAI PLAATEHDTM 1570 1580 1590 1600 1610 1620 LEMSDMQVWS AGLTPSLVTA EDSSLECSKA EDSDATGHEW KLEGALSEEP RGPELGSLEL 1630 1640 1650 1660 1670 1680 VEDDTVDSDA TNGLIDLLEQ EEGQRSEEKL PGSKRQDDAT GAGQDSENEV SLVSGHQRGQ 1690 1700 1710 1720 1730 1740 ARITHSPTVS QVTERSQDRL QDWDADGSIV SYLQDAAQGS WQEEVTQGPH SFQGTSTMTE 1750 1760 1770 1780 1790 1800 GLEPGGSQEY EKVLVSVSEH TWTEQPEAES SQADRDRRQQ GQEEQVQEAK NTFTQVVQGN 1810 1820 1830 EFQNIPGEQV TEEQFTDEQG NIVTKKDHTS TPNP
	Isoform Er8 (8) [UniParc]. Checksum: 195930085EF487B7	FASTA	1,672	183,649
	10 20 30 40 50 60 MPYSVGFREA DAATSFLRAA RSGNLDKALD HLRNGVDINT CNQNGLNGLH LASKEGHVKM 70 80 90 100 110 120 VVELLHKEII LETTTKKGNT ALHIAALAGQ DEVVRELVNY GANVNAQSQK GFTPLYMAAQ 130 140 150 160 170 180 ENHLEVVKFL LENGANQNVA TEDGFTPLAV ALQQGHENVV AHLINYGTKG KVRLPALHIA 190 200 210 220 230 240 ARNDDTRTAA VLLQNDPNPD VLSKTGFTPL HIAAHYENLN VAQLLLNRGA SVNFTPQNGI 250 260 270 280 290 300 TPLHIASRRG NVIMVRLLLD RGAQIETKTK DELTPLHCAA RNGHVRISEI LLDHGAPIQA 310 320 330 340 350 360 KTKNGLSPIH MAAQGDHLDC VRLLLQYDAE IDDITLDHLT PLHVAAHCGH HRVAKVLLDK 370 380 390 400 410 420 GAKPNSRALN GFTPLHIACK KNHVRVMELL LKTGASIDAV TESGLTPLHV ASFMGHLPIV 430 440 450 460 470 480 KNLLQRGASP NVSNVKVETP LHMAARAGHT EVAKYLLQNK AKVNAKAKDD QTPLHCAARI 490 500 510 520 530 540 GHTNMVKLLL ENNANPNLAT TAGHTPLHIA AREGHVETVL ALLEKEASQA CMTKKGFTPL 550 560 570 580 590 600 HVAAKYGKVR VAELLLERDA HPNAAGKNGL TPLHVAVHHN NLDIVKLLLP RGGSPHSPAW 610 620 630 640 650 660 NGYTPLHIAA KQNQVEVARS LLQYGGSANA ESVQGVTPLH LAAQEGHAEM VALLLSKQAN 670 680 690 700 710 720 GNLGNKSGLT PLHLVAQEGH VPVADVLIKH GVMVDATTRM GYTPLHVASH YGNIKLVKFL 730 740 750 760 770 780 LQHQADVNAK TKLGYSPLHQ AAQQGHTDIV TLLLKNGASP NEVSSDGTTP LAIAKRLGYI 790 800 810 820 830 840 SVTDVLKVVT DETSFVLVSD KHRMSFPETV DEILDVSEDE GEELISFKAE RRDSRDVDEE 850 860 870 880 890 900 KELLDFVPKL DQVVESPAIP RIPCAMPETV VIRSEEQEQA SKEYDEDSLI PSSPATETSD 910 920 930 940 950 960 NISPVASPVH TGFLVSFMVD ARGGSMRGSR HNGLRVVIPP RTCAAPTRIT CRLVKPQKLS 970 980 990 1000 1010 1020 TPPPLAEEEG LASRIIALGP TGAQFLSPVI VEIPHFASHG RGDRELVVLR SENGSVWKEH 1030 1040 1050 1060 1070 1080 RSRYGESYLD QILNGMDEEL GSLEELEKKR VCRIITTDFP LYFVIMSRLC QDYDTIGPEG 1090 1100 1110 1120 1130 1140 GSLKSKLVPL VQATFPENAV TKRVKLALQA QPVPDELVTK LLGNQATFSP IVTVEPRRRK 1150 1160 1170 1180 1190 1200 FHRPIGLRIP LPPSWTDNPR DSGEGDTTSL RLLCSVIGGT DQAQWEDITG TTKLVYANEC 1210 1220 1230 1240 1250 1260 ANFTTNVSAR FWLSDCPRTA EAVNFATLLY KELTAVPYMA KFVIFAKMND PREGRLRCYC 1270 1280 1290 1300 1310 1320 MTDDKVDKTL EQHENFVEVA RSRDIEVLEG MSLFAELSGN LVPVKKAAQQ RSFHFQSFRE 1330 1340 1350 1360 1370 1380 NRLAMPVKVR DSSREPGGSL SFLRKAMKYE DTQHILCHLN ITMPPCAKGS GAEDRRRTPT 1390 1400 1410 1420 1430 1440 PLALRYSILS ESTPGSLSGT EQAEMKMAVI SEHLGLSWAE LARELQFSVE DINRIRVENP 1450 1460 1470 1480 1490 1500 NSLLEQSVAL LNLWVIREGQ NANMENLYTA LQSIDRGEIV NMLEGSGRQS RNLKPDRRHT 1510 1520 1530 1540 1550 1560 DRDYSLSPSQ MNGHQRGQAR ITHSPTVSQV TERSQDRLQD WDADGSIVSY LQDAAQGSWQ 1570 1580 1590 1600 1610 1620 EEVTQGPHSF QGTSTMTEGL EPGGSQEYEK VLVSVSEHTW TEQPEAESSQ ADRDRRQQGQ 1630 1640 1650 1660 1670 EEQVQEAKNT FTQVVQGNEF QNIPGEQVTE EQFTDEQGNI VTKKDHTSTP NP
	Isoform Er9 (9) [UniParc]. Checksum: A50828175CF6AD01	FASTA	1,806	197,752
	10 20 30 40 50 60 MPYSVGFREA DAATSFLRAA RSGNLDKALD HLRNGVDINT CNQNGLNGLH LASKEGHVKM 70 80 90 100 110 120 VVELLHKEII LETTTKKGNT ALHIAALAGQ DEVVRELVNY GANVNAQSQK GFTPLYMAAQ 130 140 150 160 170 180 ENHLEVVKFL LENGANQNVA TEDGFTPLAV ALQQGHENVV AHLINYGTKG KVRLPALHIA 190 200 210 220 230 240 ARNDDTRTAA VLLQNDPNPD VLSKTGFTPL HIAAHYENLN VAQLLLNRGA SVNFTPQNGI 250 260 270 280 290 300 TPLHIASRRG NVIMVRLLLD RGAQIETKTK DELTPLHCAA RNGHVRISEI LLDHGAPIQA 310 320 330 340 350 360 KTKNGLSPIH MAAQGDHLDC VRLLLQYDAE IDDITLDHLT PLHVAAHCGH HRVAKVLLDK 370 380 390 400 410 420 GAKPNSRALN GFTPLHIACK KNHVRVMELL LKTGASIDAV TESGLTPLHV ASFMGHLPIV 430 440 450 460 470 480 KNLLQRGASP NVSNVKVETP LHMAARAGHT EVAKYLLQNK AKVNAKAKDD QTPLHCAARI 490 500 510 520 530 540 GHTNMVKLLL ENNANPNLAT TAGHTPLHIA AREGHVETVL ALLEKEASQA CMTKKGFTPL 550 560 570 580 590 600 HVAAKYGKVR VAELLLERDA HPNAAGKNGL TPLHVAVHHN NLDIVKLLLP RGGSPHSPAW 610 620 630 640 650 660 NGYTPLHIAA KQNQVEVARS LLQYGGSANA ESVQGVTPLH LAAQEGHAEM VALLLSKQAN 670 680 690 700 710 720 GNLGNKSGLT PLHLVAQEGH VPVADVLIKH GVMVDATTRM GYTPLHVASH YGNIKLVKFL 730 740 750 760 770 780 LQHQADVNAK TKLGYSPLHQ AAQQGHTDIV TLLLKNGASP NEVSSDGTTP LAIAKRLGYI 790 800 810 820 830 840 SVTDVLKVVT DETSFVLVSD KHRMSFPETV DEILDVSEDE GEELISFKAE RRDSRDVDEE 850 860 870 880 890 900 KELLDFVPKL DQVVESPAIP RIPCAMPETV VIRSEEQEQA SKEYDEDSLI PSSPATETSD 910 920 930 940 950 960 NISPVASPVH TGFLVSFMVD ARGGSMRGSR HNGLRVVIPP RTCAAPTRIT CRLVKPQKLS 970 980 990 1000 1010 1020 TPPPLAEEEG LASRIIALGP TGAQFLSPVI VEIPHFASHG RGDRELVVLR SENGSVWKEH 1030 1040 1050 1060 1070 1080 RSRYGESYLD QILNGMDEEL GSLEELEKKR VCRIITTDFP LYFVIMSRLC QDYDTIGPEG 1090 1100 1110 1120 1130 1140 GSLKSKLVPL VQATFPENAV TKRVKLALQA QPVPDELVTK LLGNQATFSP IVTVEPRRRK 1150 1160 1170 1180 1190 1200 FHRPIGLRIP LPPSWTDNPR DSGEGDTTSL RLLCSVIGGT DQAQWEDITG TTKLVYANEC 1210 1220 1230 1240 1250 1260 ANFTTNVSAR FWLSDCPRTA EAVNFATLLY KELTAVPYMA KFVIFAKMND PREGRLRCYC 1270 1280 1290 1300 1310 1320 MTDDKVDKTL EQHENFVEVA RSRDIEVLEG MSLFAELSGN LVPVKKAAQQ RSFHFQSFRE 1330 1340 1350 1360 1370 1380 NRLAMPVKVR DSSREPGGSL SFLRKAMKYE DTQHILCHLN ITMPPCAKGS GAEDRRRTPT 1390 1400 1410 1420 1430 1440 PLALRYSILS ESTPGSLSGT EQAEMKMAVI SEHLGLSWAE LARELQFSVE DINRIRVENP 1450 1460 1470 1480 1490 1500 NSLLEQSVAL LNLWVIREGQ NANMENLYTA LQSIDRGEIV NMLEGSGRQS RNLKPDRRHT 1510 1520 1530 1540 1550 1560 DRDYSLSPSQ MNGYSSLQDE LLSPASLGCA LSSPLRADQY WNEVAVLDAI PLAATEHDTM 1570 1580 1590 1600 1610 1620 LEMSDMQVWS AGLTPSLVTA EDSSLECSKA EDSDATGHEW KLEGALSEEP RGPELGSLEL 1630 1640 1650 1660 1670 1680 VEDDTVDSDA TNGLIDLLEQ EEGQRSEEKL PGSKRQDDAT GAGQDSENEV SLVSGHQRGQ 1690 1700 1710 1720 1730 1740 ARITHSPTVS QVTERSQDRL QDWDADGSIV SYLQDAAQGS WQEEVTQGPH SFQGTSTMTE 1750 1760 1770 1780 1790 1800 GLEPGGSQEY EKVLVSVSEH TWTEQPEAES SQADRDRRQQ GQEEQVQEAK NTFTQVVQDH TSTPNP
	Isoform Er10 (10) [UniParc]. Checksum: 21DC6E7730722E51	FASTA	1,644	180,487
	10 20 30 40 50 60 MPYSVGFREA DAATSFLRAA RSGNLDKALD HLRNGVDINT CNQNGLNGLH LASKEGHVKM 70 80 90 100 110 120 VVELLHKEII LETTTKKGNT ALHIAALAGQ DEVVRELVNY GANVNAQSQK GFTPLYMAAQ 130 140 150 160 170 180 ENHLEVVKFL LENGANQNVA TEDGFTPLAV ALQQGHENVV AHLINYGTKG KVRLPALHIA 190 200 210 220 230 240 ARNDDTRTAA VLLQNDPNPD VLSKTGFTPL HIAAHYENLN VAQLLLNRGA SVNFTPQNGI 250 260 270 280 290 300 TPLHIASRRG NVIMVRLLLD RGAQIETKTK DELTPLHCAA RNGHVRISEI LLDHGAPIQA 310 320 330 340 350 360 KTKNGLSPIH MAAQGDHLDC VRLLLQYDAE IDDITLDHLT PLHVAAHCGH HRVAKVLLDK 370 380 390 400 410 420 GAKPNSRALN GFTPLHIACK KNHVRVMELL LKTGASIDAV TESGLTPLHV ASFMGHLPIV 430 440 450 460 470 480 KNLLQRGASP NVSNVKVETP LHMAARAGHT EVAKYLLQNK AKVNAKAKDD QTPLHCAARI 490 500 510 520 530 540 GHTNMVKLLL ENNANPNLAT TAGHTPLHIA AREGHVETVL ALLEKEASQA CMTKKGFTPL 550 560 570 580 590 600 HVAAKYGKVR VAELLLERDA HPNAAGKNGL TPLHVAVHHN NLDIVKLLLP RGGSPHSPAW 610 620 630 640 650 660 NGYTPLHIAA KQNQVEVARS LLQYGGSANA ESVQGVTPLH LAAQEGHAEM VALLLSKQAN 670 680 690 700 710 720 GNLGNKSGLT PLHLVAQEGH VPVADVLIKH GVMVDATTRM GYTPLHVASH YGNIKLVKFL 730 740 750 760 770 780 LQHQADVNAK TKLGYSPLHQ AAQQGHTDIV TLLLKNGASP NEVSSDGTTP LAIAKRLGYI 790 800 810 820 830 840 SVTDVLKVVT DETSFVLVSD KHRMSFPETV DEILDVSEDE GEELISFKAE RRDSRDVDEE 850 860 870 880 890 900 KELLDFVPKL DQVVESPAIP RIPCAMPETV VIRSEEQEQA SKEYDEDSLI PSSPATETSD 910 920 930 940 950 960 NISPVASPVH TGFLVSFMVD ARGGSMRGSR HNGLRVVIPP RTCAAPTRIT CRLVKPQKLS 970 980 990 1000 1010 1020 TPPPLAEEEG LASRIIALGP TGAQFLSPVI VEIPHFASHG RGDRELVVLR SENGSVWKEH 1030 1040 1050 1060 1070 1080 RSRYGESYLD QILNGMDEEL GSLEELEKKR VCRIITTDFP LYFVIMSRLC QDYDTIGPEG 1090 1100 1110 1120 1130 1140 GSLKSKLVPL VQATFPENAV TKRVKLALQA QPVPDELVTK LLGNQATFSP IVTVEPRRRK 1150 1160 1170 1180 1190 1200 FHRPIGLRIP LPPSWTDNPR DSGEGDTTSL RLLCSVIGGT DQAQWEDITG TTKLVYANEC 1210 1220 1230 1240 1250 1260 ANFTTNVSAR FWLSDCPRTA EAVNFATLLY KELTAVPYMA KFVIFAKMND PREGRLRCYC 1270 1280 1290 1300 1310 1320 MTDDKVDKTL EQHENFVEVA RSRDIEVLEG MSLFAELSGN LVPVKKAAQQ RSFHFQSFRE 1330 1340 1350 1360 1370 1380 NRLAMPVKVR DSSREPGGSL SFLRKAMKYE DTQHILCHLN ITMPPCAKGS GAEDRRRTPT 1390 1400 1410 1420 1430 1440 PLALRYSILS ESTPGSLSGT EQAEMKMAVI SEHLGLSWAE LARELQFSVE DINRIRVENP 1450 1460 1470 1480 1490 1500 NSLLEQSVAL LNLWVIREGQ NANMENLYTA LQSIDRGEIV NMLEGSGRQS RNLKPDRRHT 1510 1520 1530 1540 1550 1560 DRDYSLSPSQ MNGHQRGQAR ITHSPTVSQV TERSQDRLQD WDADGSIVSY LQDAAQGSWQ 1570 1580 1590 1600 1610 1620 EEVTQGPHSF QGTSTMTEGL EPGGSQEYEK VLVSVSEHTW TEQPEAESSQ ADRDRRQQGQ 1630 1640 EEQVQEAKNT FTQVVQDHTS TPNP
	Isoform Er11 (11) [UniParc]. Checksum: 22CA0F47329C69FA	FASTA	1,905	208,886
	10 20 30 40 50 60 MPYSVGFREA DAATSFLRAA RSGNLDKALD HLRNGVDINT CNQNGLNGLH LASKEGHVKM 70 80 90 100 110 120 VVELLHKEII LETTTKKGNT ALHIAALAGQ DEVVRELVNY GANVNAQSQK GFTPLYMAAQ 130 140 150 160 170 180 ENHLEVVKFL LENGANQNVA TEDGFTPLAV ALQQGHENVV AHLINYGTKG KVRLPALHIA 190 200 210 220 230 240 ARNDDTRTAA VLLQNDPNPD VLSKTGFTPL HIAAHYENLN VAQLLLNRGA SVNFTPQNGI 250 260 270 280 290 300 TPLHIASRRG NVIMVRLLLD RGAQIETKTK DELTPLHCAA RNGHVRISEI LLDHGAPIQA 310 320 330 340 350 360 KTKNGLSPIH MAAQGDHLDC VRLLLQYDAE IDDITLDHLT PLHVAAHCGH HRVAKVLLDK 370 380 390 400 410 420 GAKPNSRALN GFTPLHIACK KNHVRVMELL LKTGASIDAV TESGLTPLHV ASFMGHLPIV 430 440 450 460 470 480 KNLLQRGASP NVSNVKVETP LHMAARAGHT EVAKYLLQNK AKVNAKAKDD QTPLHCAARI 490 500 510 520 530 540 GHTNMVKLLL ENNANPNLAT TAGHTPLHIA AREGHVETVL ALLEKEASQA CMTKKGFTPL 550 560 570 580 590 600 HVAAKYGKVR VAELLLERDA HPNAAGKNGL TPLHVAVHHN NLDIVKLLLP RGGSPHSPAW 610 620 630 640 650 660 NGYTPLHIAA KQNQVEVARS LLQYGGSANA ESVQGVTPLH LAAQEGHAEM VALLLSKQAN 670 680 690 700 710 720 GNLGNKSGLT PLHLVAQEGH VPVADVLIKH GVMVDATTRM GYTPLHVASH YGNIKLVKFL 730 740 750 760 770 780 LQHQADVNAK TKLGYSPLHQ AAQQGHTDIV TLLLKNGASP NEVSSDGTTP LAIAKRLGYI 790 800 810 820 830 840 SVTDVLKVVT DETSFVLVSD KHRMSFPETV DEILDVSEDE GEELISFKAE RRDSRDVDEE 850 860 870 880 890 900 KELLDFVPKL DQVVESPAIP RIPCAMPETV VIRSEEQEQA SKEYDEDSLI PSSPATETSD 910 920 930 940 950 960 NISPVASPVH TGFLVSFMVD ARGGSMRGSR HNGLRVVIPP RTCAAPTRIT CRLVKPQKLS 970 980 990 1000 1010 1020 TPPPLAEEEG LASRIIALGP TGAQFLSPVI VEIPHFASHG RGDRELVVLR SENGSVWKEH 1030 1040 1050 1060 1070 1080 RSRYGESYLD QILNGMDEEL GSLEELEKKR VCRIITTDFP LYFVIMSRLC QDYDTIGPEG 1090 1100 1110 1120 1130 1140 GSLKSKLVPL VQATFPENAV TKRVKLALQA QPVPDELVTK LLGNQATFSP IVTVEPRRRK 1150 1160 1170 1180 1190 1200 FHRPIGLRIP LPPSWTDNPR DSGEGDTTSL RLLCSVIGGT DQAQWEDITG TTKLVYANEC 1210 1220 1230 1240 1250 1260 ANFTTNVSAR FWLSDCPRTA EAVNFATLLY KELTAVPYMA KFVIFAKMND PREGRLRCYC 1270 1280 1290 1300 1310 1320 MTDDKVDKTL EQHENFVEVA RSRDIEVLEG MSLFAELSGN LVPVKKAAQQ RSFHFQSFRE 1330 1340 1350 1360 1370 1380 NRLAMPVKVR DSSREPGGSL SFLRKAMKYE DTQHILCHLN ITMPPCAKGS GAEDRRRTPT 1390 1400 1410 1420 1430 1440 PLALRYSILS ESTPGSLSGT EQAEMKMAVI SEHLGLSWAE LARELQFSVE DINRIRVENP 1450 1460 1470 1480 1490 1500 NSLLEQSVAL LNLWVIREGQ NANMENLYTA LQSIDRGEIV NMLEGSGRQS RNLKPDRRHT 1510 1520 1530 1540 1550 1560 DRDYSLSPSQ MNGYSSLQDE LLSPASLGCA LSSPLRADQY WNEVAVLDAI PLAATEHDTM 1570 1580 1590 1600 1610 1620 LEMSDMQVWS AGLTPSLVTA EDSSLECSKA EDSDATGHEW KLEGALSEEP RGPELGSLEL 1630 1640 1650 1660 1670 1680 VEDDTVDSDA TNGLIDLLEQ EEGQRSEEKL PGSKRQDDAT GAGQDSENEV SLVSGHQRGQ 1690 1700 1710 1720 1730 1740 ARITHSPTVS QVTERSQDRL QDWDADGSIV SYLQDAAQGS WQEEVTQGPH SFQGTSTMTE 1750 1760 1770 1780 1790 1800 GLEPGGSQEY EKVLVSVSEH TWTEQPEAES SQADRDRRQQ GQEEQVQEAK NTFTQVVQGN 1810 1820 1830 1840 1850 1860 EFQNIPGEQV TEEQFTDEQG NIVTKKIIRK VVRQIDLSSA DAAQEHEEVT VEGPLEDPSE 1870 1880 1890 1900 LEVDIDYFMK HSKVELRGSG LQPDLIEGRK GAQIVKRASL KRGKQ
	Isoform Er12 (12) [UniParc]. Checksum: AA2C9A6353D00A2C	FASTA	1,743	191,620
	10 20 30 40 50 60 MPYSVGFREA DAATSFLRAA RSGNLDKALD HLRNGVDINT CNQNGLNGLH LASKEGHVKM 70 80 90 100 110 120 VVELLHKEII LETTTKKGNT ALHIAALAGQ DEVVRELVNY GANVNAQSQK GFTPLYMAAQ 130 140 150 160 170 180 ENHLEVVKFL LENGANQNVA TEDGFTPLAV ALQQGHENVV AHLINYGTKG KVRLPALHIA 190 200 210 220 230 240 ARNDDTRTAA VLLQNDPNPD VLSKTGFTPL HIAAHYENLN VAQLLLNRGA SVNFTPQNGI 250 260 270 280 290 300 TPLHIASRRG NVIMVRLLLD RGAQIETKTK DELTPLHCAA RNGHVRISEI LLDHGAPIQA 310 320 330 340 350 360 KTKNGLSPIH MAAQGDHLDC VRLLLQYDAE IDDITLDHLT PLHVAAHCGH HRVAKVLLDK 370 380 390 400 410 420 GAKPNSRALN GFTPLHIACK KNHVRVMELL LKTGASIDAV TESGLTPLHV ASFMGHLPIV 430 440 450 460 470 480 KNLLQRGASP NVSNVKVETP LHMAARAGHT EVAKYLLQNK AKVNAKAKDD QTPLHCAARI 490 500 510 520 530 540 GHTNMVKLLL ENNANPNLAT TAGHTPLHIA AREGHVETVL ALLEKEASQA CMTKKGFTPL 550 560 570 580 590 600 HVAAKYGKVR VAELLLERDA HPNAAGKNGL TPLHVAVHHN NLDIVKLLLP RGGSPHSPAW 610 620 630 640 650 660 NGYTPLHIAA KQNQVEVARS LLQYGGSANA ESVQGVTPLH LAAQEGHAEM VALLLSKQAN 670 680 690 700 710 720 GNLGNKSGLT PLHLVAQEGH VPVADVLIKH GVMVDATTRM GYTPLHVASH YGNIKLVKFL 730 740 750 760 770 780 LQHQADVNAK TKLGYSPLHQ AAQQGHTDIV TLLLKNGASP NEVSSDGTTP LAIAKRLGYI 790 800 810 820 830 840 SVTDVLKVVT DETSFVLVSD KHRMSFPETV DEILDVSEDE GEELISFKAE RRDSRDVDEE 850 860 870 880 890 900 KELLDFVPKL DQVVESPAIP RIPCAMPETV VIRSEEQEQA SKEYDEDSLI PSSPATETSD 910 920 930 940 950 960 NISPVASPVH TGFLVSFMVD ARGGSMRGSR HNGLRVVIPP RTCAAPTRIT CRLVKPQKLS 970 980 990 1000 1010 1020 TPPPLAEEEG LASRIIALGP TGAQFLSPVI VEIPHFASHG RGDRELVVLR SENGSVWKEH 1030 1040 1050 1060 1070 1080 RSRYGESYLD QILNGMDEEL GSLEELEKKR VCRIITTDFP LYFVIMSRLC QDYDTIGPEG 1090 1100 1110 1120 1130 1140 GSLKSKLVPL VQATFPENAV TKRVKLALQA QPVPDELVTK LLGNQATFSP IVTVEPRRRK 1150 1160 1170 1180 1190 1200 FHRPIGLRIP LPPSWTDNPR DSGEGDTTSL RLLCSVIGGT DQAQWEDITG TTKLVYANEC 1210 1220 1230 1240 1250 1260 ANFTTNVSAR FWLSDCPRTA EAVNFATLLY KELTAVPYMA KFVIFAKMND PREGRLRCYC 1270 1280 1290 1300 1310 1320 MTDDKVDKTL EQHENFVEVA RSRDIEVLEG MSLFAELSGN LVPVKKAAQQ RSFHFQSFRE 1330 1340 1350 1360 1370 1380 NRLAMPVKVR DSSREPGGSL SFLRKAMKYE DTQHILCHLN ITMPPCAKGS GAEDRRRTPT 1390 1400 1410 1420 1430 1440 PLALRYSILS ESTPGSLSGT EQAEMKMAVI SEHLGLSWAE LARELQFSVE DINRIRVENP 1450 1460 1470 1480 1490 1500 NSLLEQSVAL LNLWVIREGQ NANMENLYTA LQSIDRGEIV NMLEGSGRQS RNLKPDRRHT 1510 1520 1530 1540 1550 1560 DRDYSLSPSQ MNGHQRGQAR ITHSPTVSQV TERSQDRLQD WDADGSIVSY LQDAAQGSWQ 1570 1580 1590 1600 1610 1620 EEVTQGPHSF QGTSTMTEGL EPGGSQEYEK VLVSVSEHTW TEQPEAESSQ ADRDRRQQGQ 1630 1640 1650 1660 1670 1680 EEQVQEAKNT FTQVVQGNEF QNIPGEQVTE EQFTDEQGNI VTKKIIRKVV RQIDLSSADA 1690 1700 1710 1720 1730 1740 AQEHEEVTVE GPLEDPSELE VDIDYFMKHS KVELRGSGLQ PDLIEGRKGA QIVKRASLKR GKQ
	Isoform Er13 (13) [UniParc]. Checksum: 94434C72B761D98D	FASTA	1,983	217,479
	10 20 30 40 50 60 MPYSVGFREA DAATSFLRAA RSGNLDKALD HLRNGVDINT CNQNGLNGLH LASKEGHVKM 70 80 90 100 110 120 VVELLHKEII LETTTKKGNT ALHIAALAGQ DEVVRELVNY GANVNAQSQK GFTPLYMAAQ 130 140 150 160 170 180 ENHLEVVKFL LENGANQNVA TEDGFTPLAV ALQQGHENVV AHLINYGTKG KVRLPALHIA 190 200 210 220 230 240 ARNDDTRTAA VLLQNDPNPD VLSKTGFTPL HIAAHYENLN VAQLLLNRGA SVNFTPQNGI 250 260 270 280 290 300 TPLHIASRRG NVIMVRLLLD RGAQIETKTK DELTPLHCAA RNGHVRISEI LLDHGAPIQA 310 320 330 340 350 360 KTKNGLSPIH MAAQGDHLDC VRLLLQYDAE IDDITLDHLT PLHVAAHCGH HRVAKVLLDK 370 380 390 400 410 420 GAKPNSRALN GFTPLHIACK KNHVRVMELL LKTGASIDAV TESGLTPLHV ASFMGHLPIV 430 440 450 460 470 480 KNLLQRGASP NVSNVKVETP LHMAARAGHT EVAKYLLQNK AKVNAKAKDD QTPLHCAARI 490 500 510 520 530 540 GHTNMVKLLL ENNANPNLAT TAGHTPLHIA AREGHVETVL ALLEKEASQA CMTKKGFTPL 550 560 570 580 590 600 HVAAKYGKVR VAELLLERDA HPNAAGKNGL TPLHVAVHHN NLDIVKLLLP RGGSPHSPAW 610 620 630 640 650 660 NGYTPLHIAA KQNQVEVARS LLQYGGSANA ESVQGVTPLH LAAQEGHAEM VALLLSKQAN 670 680 690 700 710 720 GNLGNKSGLT PLHLVAQEGH VPVADVLIKH GVMVDATTRM GYTPLHVASH YGNIKLVKFL 730 740 750 760 770 780 LQHQADVNAK TKLGYSPLHQ AAQQGHTDIV TLLLKNGASP NEVSSDGTTP LAIAKRLGYI 790 800 810 820 830 840 SVTDVLKVVT DETSFVLVSD KHRMSFPETV DEILDVSEDE GEELISFKAE RRDSRDVDEE 850 860 870 880 890 900 KELLDFVPKL DQVVESPAIP RIPCAMPETV VIRSEEQEQA SKEYDEDSLI PSSPATETSD 910 920 930 940 950 960 NISPVASPVH TGFLVSFMVD ARGGSMRGSR HNGLRVVIPP RTCAAPTRIT CRLVKPQKLS 970 980 990 1000 1010 1020 TPPPLAEEEG LASRIIALGP TGAQFLSPVI VEIPHFASHG RGDRELVVLR SENGSVWKEH 1030 1040 1050 1060 1070 1080 RSRYGESYLD QILNGMDEEL GSLEELEKKR VCRIITTDFP LYFVIMSRLC QDYDTIGPEG 1090 1100 1110 1120 1130 1140 GSLKSKLVPL VQATFPENAV TKRVKLALQA QPVPDELVTK LLGNQATFSP IVTVEPRRRK 1150 1160 1170 1180 1190 1200 FHRPIGLRIP LPPSWTDNPR DSGEGDTTSL RLLCSVIGGT DQAQWEDITG TTKLVYANEC 1210 1220 1230 1240 1250 1260 ANFTTNVSAR FWLSDCPRTA EAVNFATLLY KELTAVPYMA KFVIFAKMND PREGRLRCYC 1270 1280 1290 1300 1310 1320 MTDDKVDKTL EQHENFVEVA RSRDIEVLEG MSLFAELSGN LVPVKKAAQQ RSFHFQSFRE 1330 1340 1350 1360 1370 1380 NRLAMPVKVR DSSREPGGSL SFLRKAMKYE DTQHILCHLN ITMPPCAKGS GAEDRRRTPT 1390 1400 1410 1420 1430 1440 PLALRYSILS ESTPGSLSGT EQAEMKMAVI SEHLGLSWAE LARELQFSVE DINRIRVENP 1450 1460 1470 1480 1490 1500 NSLLEQSVAL LNLWVIREGQ NANMENLYTA LQSIDRGEIV NMLEGSGRQS RNLKPDRRHT 1510 1520 1530 1540 1550 1560 DRDYSLSPSQ MNGYSSLQDE LLSPASLGCA LSSPLRADQY WNEVAVLDAI PLAATEHDTM 1570 1580 1590 1600 1610 1620 LEMSDMQVWS AGLTPSLVTA EDSSLECSKA EDSDATGHEW KLEGALSEEP RGPELGSLEL 1630 1640 1650 1660 1670 1680 VEDDTVDSDA TNGLIDLLEQ EEGQRSEEKL PGSKRQDDAT GAGQDSENEV SLVSGHQRGQ 1690 1700 1710 1720 1730 1740 ARITHSPTVS QVTERSQDRL QDWDADGSIV SYLQDAAQGS WQEEVTQGPH SFQGTSTMTE 1750 1760 1770 1780 1790 1800 GLEPGGSQEY EKVLVSVSEH TWTEQPEAES SQADRDRRQQ GQEEQVQEAK NTFTQVVQGN 1810 1820 1830 1840 1850 1860 EFQNIPGEQV TEEQFTDEQG NIVTKKIIRK VVRQIDLSSA DAAQEHEEVT VEGPLEDPSE 1870 1880 1890 1900 1910 1920 LEVDIDYFMK HSKVLRRPRP WGTQRHHCCL ALPGRLHDTS LHSPLYELSL QSLFSLVGSV 1930 1940 1950 1960 1970 1980 SAPPCRSFRS SACVLPVFAI CPAFCLCCCL QVELRGSGLQ PDLIEGRKGA QIVKRASLKR GKQ
	Isoform Er14 (14) [UniParc]. Checksum: 748E485DAAC8FAAC	FASTA	1,821	200,214
	10 20 30 40 50 60 MPYSVGFREA DAATSFLRAA RSGNLDKALD HLRNGVDINT CNQNGLNGLH LASKEGHVKM 70 80 90 100 110 120 VVELLHKEII LETTTKKGNT ALHIAALAGQ DEVVRELVNY GANVNAQSQK GFTPLYMAAQ 130 140 150 160 170 180 ENHLEVVKFL LENGANQNVA TEDGFTPLAV ALQQGHENVV AHLINYGTKG KVRLPALHIA 190 200 210 220 230 240 ARNDDTRTAA VLLQNDPNPD VLSKTGFTPL HIAAHYENLN VAQLLLNRGA SVNFTPQNGI 250 260 270 280 290 300 TPLHIASRRG NVIMVRLLLD RGAQIETKTK DELTPLHCAA RNGHVRISEI LLDHGAPIQA 310 320 330 340 350 360 KTKNGLSPIH MAAQGDHLDC VRLLLQYDAE IDDITLDHLT PLHVAAHCGH HRVAKVLLDK 370 380 390 400 410 420 GAKPNSRALN GFTPLHIACK KNHVRVMELL LKTGASIDAV TESGLTPLHV ASFMGHLPIV 430 440 450 460 470 480 KNLLQRGASP NVSNVKVETP LHMAARAGHT EVAKYLLQNK AKVNAKAKDD QTPLHCAARI 490 500 510 520 530 540 GHTNMVKLLL ENNANPNLAT TAGHTPLHIA AREGHVETVL ALLEKEASQA CMTKKGFTPL 550 560 570 580 590 600 HVAAKYGKVR VAELLLERDA HPNAAGKNGL TPLHVAVHHN NLDIVKLLLP RGGSPHSPAW 610 620 630 640 650 660 NGYTPLHIAA KQNQVEVARS LLQYGGSANA ESVQGVTPLH LAAQEGHAEM VALLLSKQAN 670 680 690 700 710 720 GNLGNKSGLT PLHLVAQEGH VPVADVLIKH GVMVDATTRM GYTPLHVASH YGNIKLVKFL 730 740 750 760 770 780 LQHQADVNAK TKLGYSPLHQ AAQQGHTDIV TLLLKNGASP NEVSSDGTTP LAIAKRLGYI 790 800 810 820 830 840 SVTDVLKVVT DETSFVLVSD KHRMSFPETV DEILDVSEDE GEELISFKAE RRDSRDVDEE 850 860 870 880 890 900 KELLDFVPKL DQVVESPAIP RIPCAMPETV VIRSEEQEQA SKEYDEDSLI PSSPATETSD 910 920 930 940 950 960 NISPVASPVH TGFLVSFMVD ARGGSMRGSR HNGLRVVIPP RTCAAPTRIT CRLVKPQKLS 970 980 990 1000 1010 1020 TPPPLAEEEG LASRIIALGP TGAQFLSPVI VEIPHFASHG RGDRELVVLR SENGSVWKEH 1030 1040 1050 1060 1070 1080 RSRYGESYLD QILNGMDEEL GSLEELEKKR VCRIITTDFP LYFVIMSRLC QDYDTIGPEG 1090 1100 1110 1120 1130 1140 GSLKSKLVPL VQATFPENAV TKRVKLALQA QPVPDELVTK LLGNQATFSP IVTVEPRRRK 1150 1160 1170 1180 1190 1200 FHRPIGLRIP LPPSWTDNPR DSGEGDTTSL RLLCSVIGGT DQAQWEDITG TTKLVYANEC 1210 1220 1230 1240 1250 1260 ANFTTNVSAR FWLSDCPRTA EAVNFATLLY KELTAVPYMA KFVIFAKMND PREGRLRCYC 1270 1280 1290 1300 1310 1320 MTDDKVDKTL EQHENFVEVA RSRDIEVLEG MSLFAELSGN LVPVKKAAQQ RSFHFQSFRE 1330 1340 1350 1360 1370 1380 NRLAMPVKVR DSSREPGGSL SFLRKAMKYE DTQHILCHLN ITMPPCAKGS GAEDRRRTPT 1390 1400 1410 1420 1430 1440 PLALRYSILS ESTPGSLSGT EQAEMKMAVI SEHLGLSWAE LARELQFSVE DINRIRVENP 1450 1460 1470 1480 1490 1500 NSLLEQSVAL LNLWVIREGQ NANMENLYTA LQSIDRGEIV NMLEGSGRQS RNLKPDRRHT 1510 1520 1530 1540 1550 1560 DRDYSLSPSQ MNGHQRGQAR ITHSPTVSQV TERSQDRLQD WDADGSIVSY LQDAAQGSWQ 1570 1580 1590 1600 1610 1620 EEVTQGPHSF QGTSTMTEGL EPGGSQEYEK VLVSVSEHTW TEQPEAESSQ ADRDRRQQGQ 1630 1640 1650 1660 1670 1680 EEQVQEAKNT FTQVVQGNEF QNIPGEQVTE EQFTDEQGNI VTKKIIRKVV RQIDLSSADA 1690 1700 1710 1720 1730 1740 AQEHEEVTVE GPLEDPSELE VDIDYFMKHS KVLRRPRPWG TQRHHCCLAL PGRLHDTSLH 1750 1760 1770 1780 1790 1800 SPLYELSLQS LFSLVGSVSA PPCRSFRSSA CVLPVFAICP AFCLCCCLQV ELRGSGLQPD 1810 1820 LIEGRKGAQI VKRASLKRGK Q
	Isoform Er15 (15) [UniParc]. Checksum: 1DFB26BFA488DCC4	FASTA	1,858	203,536
	10 20 30 40 50 60 MPYSVGFREA DAATSFLRAA RSGNLDKALD HLRNGVDINT CNQNGLNGLH LASKEGHVKM 70 80 90 100 110 120 VVELLHKEII LETTTKKGNT ALHIAALAGQ DEVVRELVNY GANVNAQSQK GFTPLYMAAQ 130 140 150 160 170 180 ENHLEVVKFL LENGANQNVA TEDGFTPLAV ALQQGHENVV AHLINYGTKG KVRLPALHIA 190 200 210 220 230 240 ARNDDTRTAA VLLQNDPNPD VLSKTGFTPL HIAAHYENLN VAQLLLNRGA SVNFTPQNGI 250 260 270 280 290 300 TPLHIASRRG NVIMVRLLLD RGAQIETKTK DELTPLHCAA RNGHVRISEI LLDHGAPIQA 310 320 330 340 350 360 KTKNGLSPIH MAAQGDHLDC VRLLLQYDAE IDDITLDHLT PLHVAAHCGH HRVAKVLLDK 370 380 390 400 410 420 GAKPNSRALN GFTPLHIACK KNHVRVMELL LKTGASIDAV TESGLTPLHV ASFMGHLPIV 430 440 450 460 470 480 KNLLQRGASP NVSNVKVETP LHMAARAGHT EVAKYLLQNK AKVNAKAKDD QTPLHCAARI 490 500 510 520 530 540 GHTNMVKLLL ENNANPNLAT TAGHTPLHIA AREGHVETVL ALLEKEASQA CMTKKGFTPL 550 560 570 580 590 600 HVAAKYGKVR VAELLLERDA HPNAAGKNGL TPLHVAVHHN NLDIVKLLLP RGGSPHSPAW 610 620 630 640 650 660 NGYTPLHIAA KQNQVEVARS LLQYGGSANA ESVQGVTPLH LAAQEGHAEM VALLLSKQAN 670 680 690 700 710 720 GNLGNKSGLT PLHLVAQEGH VPVADVLIKH GVMVDATTRM GYTPLHVASH YGNIKLVKFL 730 740 750 760 770 780 LQHQADVNAK TKLGYSPLHQ AAQQGHTDIV TLLLKNGASP NEVSSDGTTP LAIAKRLGYI 790 800 810 820 830 840 SVTDVLKVVT DETSFVLVSD KHRMSFPETV DEILDVSEDE GEELISFKAE RRDSRDVDEE 850 860 870 880 890 900 KELLDFVPKL DQVVESPAIP RIPCAMPETV VIRSEEQEQA SKEYDEDSLI PSSPATETSD 910 920 930 940 950 960 NISPVASPVH TGFLVSFMVD ARGGSMRGSR HNGLRVVIPP RTCAAPTRIT CRLVKPQKLS 970 980 990 1000 1010 1020 TPPPLAEEEG LASRIIALGP TGAQFLSPVI VEIPHFASHG RGDRELVVLR SENGSVWKEH 1030 1040 1050 1060 1070 1080 RSRYGESYLD QILNGMDEEL GSLEELEKKR VCRIITTDFP LYFVIMSRLC QDYDTIGPEG 1090 1100 1110 1120 1130 1140 GSLKSKLVPL VQATFPENAV TKRVKLALQA QPVPDELVTK LLGNQATFSP IVTVEPRRRK 1150 1160 1170 1180 1190 1200 FHRPIGLRIP LPPSWTDNPR DSGEGDTTSL RLLCSVIGGT DQAQWEDITG TTKLVYANEC 1210 1220 1230 1240 1250 1260 ANFTTNVSAR FWLSDCPRTA EAVNFATLLY KELTAVPYMA KFVIFAKMND PREGRLRCYC 1270 1280 1290 1300 1310 1320 MTDDKVDKTL EQHENFVEVA RSRDIEVLEG MSLFAELSGN LVPVKKAAQQ RSFHFQSFRE 1330 1340 1350 1360 1370 1380 NRLAMPVKVR DSSREPGGSL SFLRKAMKYE DTQHILCHLN ITMPPCAKGS GAEDRRRTPT 1390 1400 1410 1420 1430 1440 PLALRYSILS ESTPGSLSGT EQAEMKMAVI SEHLGLSWAE LARELQFSVE DINRIRVENP 1450 1460 1470 1480 1490 1500 NSLLEQSVAL LNLWVIREGQ NANMENLYTA LQSIDRGEIV NMLEGSGRQS RNLKPDRRHT 1510 1520 1530 1540 1550 1560 DRDYSLSPSQ MNGYSSLQDE LLSPASLGCA LSSPLRADQY WNEVAVLDAI PLAATEHDTM 1570 1580 1590 1600 1610 1620 LEMSDMQVWS AGLTPSLVTA EDSSLECSKA EDSDATGHEW KLEGALSEEP RGPELGSLEL 1630 1640 1650 1660 1670 1680 VEDDTVDSDA TNGLIDLLEQ EEGQRSEEKL PGSKRQDDAT GAGQDSENEV SLVSGHQRGQ 1690 1700 1710 1720 1730 1740 ARITHSPTVS QVTERSQDRL QDWDADGSIV SYLQDAAQGS WQEEVTQGPH SFQGTSTMTE 1750 1760 1770 1780 1790 1800 GLEPGGSQEY EKVLVSVSEH TWTEQPEAES SQADRDRRQQ GQEEQVQEAK NTFTQVVQGN 1810 1820 1830 1840 1850 EFQNIPGEQV TEEQFTDEQG NIVTKKVELR GSGLQPDLIE GRKGAQIVKR ASLKRGKQ
	Isoform Er16 [UniParc]. Checksum: 1D71CA896F1FDD7F	FASTA	1,519	166,480
	10 20 30 40 50 60 MPYSVGFREA DAATSFLRAA RSGNLDKALD HLRNGVDINT CNQNGLNGLH LASKEGHVKM 70 80 90 100 110 120 VVELLHKEII LETTTKKGNT ALHIAALAGQ DEVVRELVNY GANVNAQSQK GFTPLYMAAQ 130 140 150 160 170 180 ENHLEVVKFL LENGANQNVA TEDGFTPLAV ALQQGHENVV AHLINYGTKG KVRLPALHIA 190 200 210 220 230 240 ARNDDTRTAA VLLQNDPNPD VLSKTGFTPL HIAAHYENLN VAQLLLNRGA SVNFTPQNGI 250 260 270 280 290 300 TPLHIASRRG NVIMVRLLLD RGAQIETKTK DELTPLHCAA RNGHVRISEI LLDHGAPIQA 310 320 330 340 350 360 KTKNGLSPIH MAAQGDHLDC VRLLLQYDAE IDDITLDHLT PLHVAAHCGH HRVAKVLLDK 370 380 390 400 410 420 GAKPNSRALN GFTPLHIACK KNHVRVMELL LKTGASIDAV TESGLTPLHV ASFMGHLPIV 430 440 450 460 470 480 KNLLQRGASP NVSNVKVETP LHMAARAGHT EVAKYLLQNK AKVNAKAKDD QTPLHCAARI 490 500 510 520 530 540 GHTNMVKLLL ENNANPNLAT TAGHTPLHIA AREGHVETVL ALLEKEASQA CMTKKGFTPL 550 560 570 580 590 600 HVAAKYGKVR VAELLLERDA HPNAAGKNGL TPLHVAVHHN NLDIVKLLLP RGGSPHSPAW 610 620 630 640 650 660 NGYTPLHIAA KQNQVEVARS LLQYGGSANA ESVQGVTPLH LAAQEGHAEM VALLLSKQAN 670 680 690 700 710 720 GNLGNKSGLT PLHLVAQEGH VPVADVLIKH GVMVDATTRM GYTPLHVASH YGNIKLVKFL 730 740 750 760 770 780 LQHQADVNAK TKLGYSPLHQ AAQQGHTDIV TLLLKNGASP NEVSSDGTTP LAIAKRLGYI 790 800 810 820 830 840 SVTDVLKVVT DETSFVLVSD KHRMSFPETV DEILDVSEDE GEELISFKAE RRDSRDVDEE 850 860 870 880 890 900 KELLDFVPKL DQVVESPAIP RIPCAMPETV VIRSEEQEQA SKEYDEDSLI PSSPATETSD 910 920 930 940 950 960 NISPVASPVH TGFLVSFMVD ARGGSMRGSR HNGLRVVIPP RTCAAPTRIT CRLVKPQKLS 970 980 990 1000 1010 1020 TPPPLAEEEG LASRIIALGP TGAQFLSPVI VEIPHFASHG RGDRELVVLR SENGSVWKEH 1030 1040 1050 1060 1070 1080 RSRYGESYLD QILNGMDEEL GSLEELEKKR VCRIITTDFP LYFVIMSRLC QDYDTIGPEG 1090 1100 1110 1120 1130 1140 GSLKSKLVPL VQATFPENAV TKRVKLALQA QPVPDELVTK LLGNQATFSP IVTVEPRRRK 1150 1160 1170 1180 1190 1200 FHRPIGLRIP LPPSWTDNPR DSGEGDTTSL RLLCSVIGGT DQAQWEDITG TTKLVYANEC 1210 1220 1230 1240 1250 1260 ANFTTNVSAR FWLSDCPRTA EAVNFATLLY KELTAVPYMA KFVIFAKMND PREGRLRCYC 1270 1280 1290 1300 1310 1320 MTDDKVDKTL EQHENFVEVA RSRDIEVLEG MSLFAELSGN LVPVKKAAQQ RSFHFQSFRE 1330 1340 1350 1360 1370 1380 NRLAMPVKVR DSSREPGGSL SFLRKAMKYE DTQHILCHLN ITMPPCAKGS GAEDRRRTPT 1390 1400 1410 1420 1430 1440 PLALRYSILS ESTPGSLSGT EQAEMKMAVI SEHLGLSWAE LARELQFSVE DINRIRVENP 1450 1460 1470 1480 1490 1500 NSLLEQSVAL LNLWVIREGQ NANMENLYTA LQSIDRGEIV NMLEGSGRQS RNLKPDRRHT 1510 DRDYSLSPSQ MNDTSTPNP
	Isoform Mu17 (ank1.5) (muscle-specific 1) [UniParc]. Checksum: 55C5EA3888044FFB	FASTA	155	17,615
	10 20 30 40 50 60 MWTFVTQLLV TLVLLSFFLV SCQNVMHIVR GSLCFVLKHI HQELDKELGE SEGLSDDEET 70 80 90 100 110 120 ISTRVVRRRV FLKGNEFQNI PGEQVTEEQF TDEQGNIVTK KIIRKVVRQI DLSSADAAQE 130 140 150 HEEVELRGSG LQPDLIEGRK GAQIVKRASL KRGKQ
	Isoform Mu18 (ank1.6) (muscle-specific 2) [UniParc]. Checksum: C987D8EF586B6704	FASTA	133	15,125
	10 20 30 40 50 60 MWTFVTQLLV TLVLLSFFLV SCQNVMHIVR GSLCFVLKHI HQELDKELGE SEGLSDDEET 70 80 90 100 110 120 ISTRVVRRRV FLKGNEFQNI PGEQVTEEQF TDEQGNIVTK KVELRGSGLQ PDLIEGRKGA 130 QIVKRASLKR GKQ
	Isoform Mu19 (muscle-specific 3) [UniParc]. Checksum: 6A4EA54308E3B04B	FASTA	81	9,342
	10 20 30 40 50 60 MWTFVTQLLV TLVLLSFFLV SCQNVMHIVR GSLCFVLKHI HQELDKELGE SEGLSDDEET 70 80 ISTRVVRRRV FLKDHTSTPN P
	Isoform Mu20 (muscle-specific 4) [UniParc]. Checksum: FA79EF4284FBDDEB	FASTA	74	8,374
	10 20 30 40 50 60 MWTFVTQLLV TLVLLSFFLV SCQNVMHIVR GSLCFVLKHI HQVELRGSGL QPDLIEGRKG 70 AQIVKRASLK RGKQ
	Isoform Br21 [UniParc]. Checksum: 82682973D1A52BA2	FASTA	1,897	208,239
	10 20 30 40 50 60 MAQAAKQLKK IKDIEAQALQ EQKEKEESNR KRRNRSRDRK KKADAATSFL RAARSGNLDK 70 80 90 100 110 120 ALDHLRNGVD INTCNQNGLN GLHLASKEGH VKMVVELLHK EIILETTTKK GNTALHIAAL 130 140 150 160 170 180 AGQDEVVREL VNYGANVNAQ SQKGFTPLYM AAQENHLEVV KFLLENGANQ NVATEDGFTP 190 200 210 220 230 240 LAVALQQGHE NVVAHLINYG TKGKVRLPAL HIAARNDDTR TAAVLLQNDP NPDVLSKTGF 250 260 270 280 290 300 TPLHIAAHYE NLNVAQLLLN RGASVNFTPQ NGITPLHIAS RRGNVIMVRL LLDRGAQIET 310 320 330 340 350 360 KTKDELTPLH CAARNGHVRI SEILLDHGAP IQAKTKNGLS PIHMAAQGDH LDCVRLLLQY 370 380 390 400 410 420 DAEIDDITLD HLTPLHVAAH CGHHRVAKVL LDKGAKPNSR ALNGFTPLHI ACKKNHVRVM 430 440 450 460 470 480 ELLLKTGASI DAVTESGLTP LHVASFMGHL PIVKNLLQRG ASPNVSNVKV ETPLHMAARA 490 500 510 520 530 540 GHTEVAKYLL QNKAKVNAKA KDDQTPLHCA ARIGHTNMVK LLLENNANPN LATTAGHTPL 550 560 570 580 590 600 HIAAREGHVE TVLALLEKEA SQACMTKKGF TPLHVAAKYG KVRVAELLLE RDAHPNAAGK 610 620 630 640 650 660 NGLTPLHVAV HHNNLDIVKL LLPRGGSPHS PAWNGYTPLH IAAKQNQVEV ARSLLQYGGS 670 680 690 700 710 720 ANAESVQGVT PLHLAAQEGH AEMVALLLSK QANGNLGNKS GLTPLHLVAQ EGHVPVADVL 730 740 750 760 770 780 IKHGVMVDAT TRMGYTPLHV ASHYGNIKLV KFLLQHQADV NAKTKLGYSP LHQAAQQGHT 790 800 810 820 830 840 DIVTLLLKNG ASPNEVSSDG TTPLAIAKRL GYISVTDVLK VVTDETSFVL VSDKHRMSFP 850 860 870 880 890 900 ETVDEILDVS EDEGTAHITI MGEELISFKA ERRDSRDVDE EKELLDFVPK LDQVVESPAI 910 920 930 940 950 960 PRIPCAMPET VVIRSEEQEQ ASKEYDEDSL IPSSPATETS DNISPVASPV HTGFLVSFMV 970 980 990 1000 1010 1020 DARGGSMRGS RHNGLRVVIP PRTCAAPTRI TCRLVKPQKL STPPPLAEEE GLASRIIALG 1030 1040 1050 1060 1070 1080 PTGAQFLSPV IVEIPHFASH GRGDRELVVL RSENGSVWKE HRSRYGESYL DQILNGMDEE 1090 1100 1110 1120 1130 1140 LGSLEELEKK RVCRIITTDF PLYFVIMSRL CQDYDTIGPE GGSLKSKLVP LVQATFPENA 1150 1160 1170 1180 1190 1200 VTKRVKLALQ AQPVPDELVT KLLGNQATFS PIVTVEPRRR KFHRPIGLRI PLPPSWTDNP 1210 1220 1230 1240 1250 1260 RDSGEGDTTS LRLLCSVIGG TDQAQWEDIT GTTKLVYANE CANFTTNVSA RFWLSDCPRT 1270 1280 1290 1300 1310 1320 AEAVNFATLL YKELTAVPYM AKFVIFAKMN DPREGRLRCY CMTDDKVDKT LEQHENFVEV 1330 1340 1350 1360 1370 1380 ARSRDIEVLE GMSLFAELSG NLVPVKKAAQ QRSFHFQSFR ENRLAMPVKV RDSSREPGGS 1390 1400 1410 1420 1430 1440 LSFLRKAMKY EDTQHILCHL NITMPPCAKG SGAEDRRRTP TPLALRYSIL SESTPGSLSG 1450 1460 1470 1480 1490 1500 TEQAEMKMAV ISEHLGLSWA ELARELQFSV EDINRIRVEN PNSLLEQSVA LLNLWVIREG 1510 1520 1530 1540 1550 1560 QNANMENLYT ALQSIDRGEI VNMLEGSGRQ SRNLKPDRRH TDRDYSLSPS QMNGYSSLQD 1570 1580 1590 1600 1610 1620 ELLSPASLGC ALSSPLRADQ YWNEVAVLDA IPLAATEHDT MLEMSDMQVW SAGLTPSLVT 1630 1640 1650 1660 1670 1680 AEDSSLECSK AEDSDATGHE WKLEGALSEE PRGPELGSLE LVEDDTVDSD ATNGLIDLLE 1690 1700 1710 1720 1730 1740 QEEGQRSEEK LPGSKRQDDA TGAGQDSENE VSLVSGHQRG QARITHSPTV SQVTERSQDR 1750 1760 1770 1780 1790 1800 LQDWDADGSI VSYLQDAAQG SWQEEVTQGP HSFQGTSTMT EGLEPGGSQE YEKVLVSVSE 1810 1820 1830 1840 1850 1860 HTWTEQPEAE SSQADRDRRQ QGQEEQVQEA KNTFTQVVQG NEFQNIPGEQ VTEEQFTDEQ 1870 1880 1890 GNIVTKKIIR KVVRQIDLSS ADAAQEHEED HTSTPNP
	Isoform 22 [UniParc]. Checksum: CA36067BFBD7B9A4	FASTA	109	12,504
	10 20 30 40 50 60 MWTFVTQLLV TLVLLSFFLV SCQNVMHIVR GSLCFVLKHI HQELDKELGE SEGLSDDEET 70 80 90 100 ISTRVVRRRV FLKGNEFQNI PGEQVTEEQF TDEQGNIVTK KDHTSTPNP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Analysis of cDNA for human erythrocyte ankyrin indicates a repeated structure with homology to tissue-differentiation and cell-cycle control proteins." Lux S.E., John K.M., Bennett V. Nature 344:36-42(1990) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS ER1 AND ER2), PROTEIN SEQUENCE OF 3-30; 733-753; 828-871; 959-1003; 1106-1128; 1149-1168; 1282-1288; 1345-1367; 1383-1427; 1601-1626; 1686-1700 AND 1763-1772, VARIANTS ALA-750 AND ILE-1075. Tissue: Hematopoietic.
[2]	"cDNA sequence for human erythrocyte ankyrin." Lambert S., Yu H., Prchal J.T., Lawler J., Ruff P., Speicher D., Cheung M.C., Kan Y.W., Palek J. Proc. Natl. Acad. Sci. U.S.A. 87:1730-1734(1990) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS ER1; ER5 AND ER16), VARIANTS ILE-1075 AND ILE-1546.
[3]	"Structure and organization of the human ankyrin-1 gene. Basis for complexity of pre-mRNA processing." Gallagher P.G., Tse W.T., Scarpa A.L., Lux S.E., Forget B.G. J. Biol. Chem. 272:19220-19228(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING, VARIANTS LEU-991 AND ILE-1075.
[4]	"An alternate promoter directs expression of a truncated, muscle-specific isoform of the human ankyrin 1 gene." Gallagher P.G., Forget B.G. J. Biol. Chem. 273:1339-1348(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS MU17; MU18; MU19 AND MU20), TISSUE SPECIFICITY, SUBCELLULAR LOCATION. Tissue: Skeletal muscle.
[5]	Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F. Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM BR21), VARIANT ILE-1075. Tissue: Brain.
[6]	"DNA sequence and analysis of human chromosome 8." Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T. , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S. Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS MU17 AND 22). Tissue: Skeletal muscle.
[9]	"Mapping the binding sites of human erythrocyte ankyrin for the anion exchanger and spectrin." Davis L.H., Bennett V. J. Biol. Chem. 265:10589-10596(1990) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 5-12; 403-422; 797-814; 862-877 AND 899-912, DOMAINS SPTB AND SLC4A1 BINDING, VARIANT ASP-1286.
[10]	"Asparagine and aspartate hydroxylation of the cytoskeletal ankyrin family is catalyzed by factor-inhibiting hypoxia-inducible factor." Yang M., Ge W., Chowdhury R., Claridge T.D., Kramer H.B., Schmierer B., McDonough M.A., Gong L., Kessler B.M., Ratcliffe P.J., Coleman M.L., Schofield C.J. J. Biol. Chem. 286:7648-7660(2011) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 99-110; 129-169 AND 233-248, INTERACTION WITH HIF1AN, HYDROXYLATION AT ASN-105; ASN-233; ASN-431; ASN-464; ASN-629; ASN-662; ASP-695; ASN-728 AND ASN-761.
[11]	"The ANK repeats of erythrocyte ankyrin form two distinct but cooperative binding sites for the erythrocyte anion exchanger." Michaely P., Bennett V. J. Biol. Chem. 270:22050-22057(1995) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH SLC4A1.
[12]	"The hydrophilic domain of small ankyrin-1 interacts with the two N-terminal immunoglobulin domains of titin." Kontrogianni-Konstantopoulos A., Bloch R.J. J. Biol. Chem. 278:3985-3991(2003) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH TTN.
[13]	"Binding of an ankyrin-1 isoform to obscurin suggests a molecular link between the sarcoplasmic reticulum and myofibrils in striated muscles." Bagnato P., Barone V., Giacomello E., Rossi D., Sorrentino V. J. Cell Biol. 160:245-253(2003) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION, INTERACTION WITH OBSCN, MUTAGENESIS OF THR-1824; LYS-1826; ARG-1829 AND LYS-1830.
[14]	"Phosphoproteome of resting human platelets." Zahedi R.P., Lewandrowski U., Wiesner J., Wortelkamp S., Moebius J., Schuetz C., Walter U., Gambaryan S., Sickmann A. J. Proteome Res. 7:526-534(2008) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Platelet.
[15]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[16]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[17]	"Crystal structure of a 12 ANK repeat stack from human ankyrinR." Michaely P., Tomchick D.R., Machius M., Anderson R.G. EMBO J. 21:6387-6396(2002) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) OF 402-827, FUNCTION OF ANK REPEAT DOMAIN.
[18]	"Solution structure of the DEATH domain of ankyrin-1." RIKEN structural genomics initiative (RSGI) Submitted (APR-2008) to the PDB data bank Cited for: STRUCTURE BY NMR OF 1392-1497.
[19]	"Structurally similar but functionally diverse ZU5 domains in human erythrocyte ankyrin." Yasunaga M., Ipsaro J.J., Mondragon A. J. Mol. Biol. 417:336-350(2012) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 911-1233, ZU5 DOMAINS.
[20]	"Ankyrin-1 mutations are a major cause of dominant and recessive hereditary spherocytosis." Eber S.W., Gonzalez J.M., Lux M.L., Scarpa A.L., Tse W.T., Dornwell M., Herbers J., Kugler W., Oezcan R., Pekrun A., Gallagher P.G., Schroeter W., Forget B.G., Lux S.E. Nat. Genet. 13:214-218(1996) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT SPH1 ILE-463.
[21]	"Low frequency of ankyrin mutations in hereditary spherocytosis: identification of three novel mutations." Leite R.C.A., Basseres D.S., Ferreira J.S., Alberto F.L., Costa F.F., Saad S.T.O. Hum. Mutat. 16:529-529(2000) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS SPH1 ARG-276 AND THR-1054.
[22]	"The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E. Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT [LARGE SCALE ANALYSIS] HIS-332.
+	Additional computationally mapped references.

Web resources

Wikipedia

Ankyrin entry

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

X16609 mRNA. Translation: CAA34610.1.
X16609 mRNA. Translation: CAA34611.1.
M28880 mRNA. Translation: AAA51732.1.
U50133 , U50092, U50093, U50094, U50095, U50096, U50097, U50098, U50099, U50100, U50101, U50102, U50103, U50104, U50105, U50106, U50107, U50108, U50109, U50110, U50111, U50112, U50113, U50114, U50115, U50116, U50117, U50118, U50119, U50120, U50121, U50122, U50123, U50124, U50125, U50126, U50127, U50128, U50129, U50130, U50131, U50132 Genomic DNA. Translation: AAB47805.1. Sequence problems.
AF005213 mRNA. Translation: AAC01950.1.
AB209418 mRNA. Translation: BAD92655.1.
AK223578 mRNA. Translation: BAD97298.1.
AC027702 Genomic DNA. No translation available.
AC113133 Genomic DNA. No translation available.
CH471080 Genomic DNA. Translation: EAW63243.1.
CH471080 Genomic DNA. Translation: EAW63244.1.
BC030957 mRNA. Translation: AAH30957.1.
BC117121 mRNA. Translation: AAI17122.1.

IPI

IPI00007623.
IPI00007625.
IPI00216697.
IPI00297532.
IPI00374973.
IPI00646300.
IPI00654646.
IPI00743884.
IPI00744408.
IPI00744846.
IPI00744895.
IPI00744986.
IPI00745348.
IPI00747536.
IPI00747552.
IPI00748074.
IPI00748154.
IPI00748330.
IPI00748439.
IPI00748895.
IPI00749301.

PIR

A35049.
SJHUK. S08275.

RefSeq

NP_000028.3. NM_000037.3.
NP_001135918.1. NM_001142446.1.
NP_065208.2. NM_020475.2.
NP_065209.2. NM_020476.2.
NP_065210.2. NM_020477.2.
NP_065211.2. NM_020478.4.
NP_065213.2. NM_020480.4.

UniGene

Hs.654438.
Hs.667377.
Hs.708861.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1N11	X-ray	2.70	A	402-827	[»]
2YQF	NMR	-	A	1394-1497	[»]
2YVI	X-ray	1.92	A	1394-1497	[»]
3F59	X-ray	2.00	A/B/C/D	911-1068	[»]
3KBT	X-ray	2.75	C/D	911-1068	[»]
3KBU	X-ray	2.75	C/D	911-1068	[»]
3UD1	X-ray	2.00	A/B/C	911-1233	[»]
3UD2	X-ray	2.21	A/B/C	911-1233	[»]

ProteinModelPortal

P16157.

ModBase

Search...

Protein-protein interaction databases

IntAct

P16157. 1 interaction.

MINT

MINT-254860.

STRING

9606.ENSP00000265709.

PTM databases

PhosphoSite

P16157.

Polymorphism databases

DMDM

116241246.

Proteomic databases

PaxDb

P16157.

PRIDE

P16157.

Protocols and materials databases

DNASU

286.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000265709; ENSP00000265709; ENSG00000029534.
ENST00000289734; ENSP00000289734; ENSG00000029534.
ENST00000314214; ENSP00000319123; ENSG00000029534.
ENST00000347528; ENSP00000339620; ENSG00000029534.
ENST00000348036; ENSP00000297744; ENSG00000029534.
ENST00000352337; ENSP00000309131; ENSG00000029534.
ENST00000379758; ENSP00000369082; ENSG00000029534.
ENST00000396942; ENSP00000380147; ENSG00000029534.
ENST00000396945; ENSP00000380149; ENSG00000029534.
ENST00000457297; ENSP00000403589; ENSG00000029534.

GeneID

286.

KEGG

hsa:286.

UCSC

uc003xoi.3. human.
uc003xoj.3. human.
uc003xok.3. human.
uc003xol.3. human.
uc003xom.3. human.

Organism-specific databases

CTD

286.

GeneCards

GC08M041510.

HGNC

HGNC:492. ANK1.

HPA

CAB016057.
HPA004842.

MIM

182900. phenotype.
612641. gene.

neXtProt

NX_P16157.

Orphanet

251066. 8p11.2 deletion syndrome.
822. Hereditary spherocytosis.

PharmGKB

PA24798.

GenAtlas

Search...

Phylogenomic databases

eggNOG

COG0666.

HOVERGEN

HBG004234.

KO

K10380.

OMA

CRIITTD.

OrthoDB

EOG418BMG.

PhylomeDB

P16157.

Enzyme and pathway databases

Reactome

REACT_111045. Developmental Biology.

Gene expression databases

ArrayExpress

P16157.

Bgee

P16157.

CleanEx

HS_ANK1.

Genevestigator

P16157.

GermOnline

ENSG00000029534. Homo sapiens.

Family and domain databases

Gene3D

1.10.533.10. 1 hit.
1.25.40.20. 3 hits.

InterPro

IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR011029. DEATH-like_dom.
IPR000488. Death_domain.
IPR000906. ZU5.
[Graphical view]

Pfam

PF00023. Ank. 20 hits.
PF00531. Death. 1 hit.
PF00791. ZU5. 1 hit.
[Graphical view]

PRINTS

PR01415. ANKYRIN.

SMART

SM00248. ANK. 23 hits.
SM00005. DEATH. 1 hit.
SM00218. ZU5. 1 hit.
[Graphical view]

SUPFAM

SSF48403. ANK. 2 hits.
SSF47986. DEATH_like. 1 hit.

PROSITE

PS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 20 hits.
PS50017. DEATH_DOMAIN. 1 hit.
PS51145. ZU5. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

EvolutionaryTrace

P16157.

GenomeRNAi

286.

NextBio

1155.

PMAP-CutDB

P16157.

SOURCE

Search...

Entry information

Entry name

ANK1_HUMAN

Accession

Primary (citable) accession number: P16157
Secondary accession number(s): A0PJN8 , A6NJ23, O43400, Q13768, Q53ER1, Q59FP2, Q8N604, Q99407

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 1, 1990
Last sequence update:	January 23, 2007
Last modified:	May 1, 2013
This is version 156 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.