##gff-version 3
P16118	UniProtKB	Initiator methionine	1	1	.	.	.	Note=Removed;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P07953	
P16118	UniProtKB	Chain	2	471	.	.	.	ID=PRO_0000179960;Note=6-phosphofructo-2-kinase/fructose-2%2C6-bisphosphatase 1	
P16118	UniProtKB	Region	2	250	.	.	.	Note=6-phosphofructo-2-kinase	
P16118	UniProtKB	Region	251	471	.	.	.	Note=Fructose-2%2C6-bisphosphatase	
P16118	UniProtKB	Active site	131	131	.	.	.	Ontology_term=ECO:0000255;evidence=ECO:0000255	
P16118	UniProtKB	Active site	161	161	.	.	.	Ontology_term=ECO:0000255;evidence=ECO:0000255	
P16118	UniProtKB	Active site	259	259	.	.	.	Note=Tele-phosphohistidine intermediate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P07953	
P16118	UniProtKB	Active site	328	328	.	.	.	Note=Proton donor/acceptor;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P07953	
P16118	UniProtKB	Binding site	49	57	.	.	.	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12379646;Dbxref=PMID:12379646	
P16118	UniProtKB	Binding site	82	82	.	.	.	Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q16875	
P16118	UniProtKB	Binding site	105	105	.	.	.	Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q16875	
P16118	UniProtKB	Binding site	133	133	.	.	.	Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q16875	
P16118	UniProtKB	Binding site	139	139	.	.	.	Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q16875	
P16118	UniProtKB	Binding site	170	175	.	.	.	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12379646;Dbxref=PMID:12379646	
P16118	UniProtKB	Binding site	175	175	.	.	.	Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q16875	
P16118	UniProtKB	Binding site	196	196	.	.	.	Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q16875	
P16118	UniProtKB	Binding site	200	200	.	.	.	Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q16875	
P16118	UniProtKB	Binding site	258	258	.	.	.	Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q16875	
P16118	UniProtKB	Binding site	265	265	.	.	.	Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q16875	
P16118	UniProtKB	Binding site	271	271	.	.	.	Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P07953	
P16118	UniProtKB	Binding site	308	308	.	.	.	Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q16875	
P16118	UniProtKB	Binding site	339	339	.	.	.	Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P07953	
P16118	UniProtKB	Binding site	350	353	.	.	.	Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P07953	
P16118	UniProtKB	Binding site	353	353	.	.	.	Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P07953	
P16118	UniProtKB	Binding site	357	357	.	.	.	Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P07953	
P16118	UniProtKB	Binding site	368	368	.	.	.	Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P07953	
P16118	UniProtKB	Binding site	394	398	.	.	.	Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P07953	
P16118	UniProtKB	Binding site	394	394	.	.	.	Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P07953	
P16118	UniProtKB	Binding site	398	398	.	.	.	Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P07953	
P16118	UniProtKB	Binding site	430	430	.	.	.	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12379646;Dbxref=PMID:12379646	
P16118	UniProtKB	Site	393	393	.	.	.	Note=Transition state stabilizer;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P00950	
P16118	UniProtKB	Modified residue	2	2	.	.	.	Note=N-acetylserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P07953	
P16118	UniProtKB	Modified residue	33	33	.	.	.	Note=Phosphoserine%3B by PKA;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P07953	
P16118	UniProtKB	Modified residue	141	141	.	.	.	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P07953	
P16118	UniProtKB	Alternative sequence	1	73	.	.	.	ID=VSP_054795;Note=In isoform 2. MSPEMGELTQTRLQKIWIPHSSGSSRLQRRRGSSIPQFTNSPTMVIMVGLPARGKTYISTKLTRYLNWIGTPT->MEEKTSRI;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039	
P16118	UniProtKB	Sequence conflict	305	305	.	.	.	Note=H->R;Ontology_term=ECO:0000305;evidence=ECO:0000305	
P16118	UniProtKB	Sequence conflict	359	359	.	.	.	Note=R->H;Ontology_term=ECO:0000305;evidence=ECO:0000305	
P16118	UniProtKB	Sequence conflict	397	398	.	.	.	Note=MR->HA;Ontology_term=ECO:0000305;evidence=ECO:0000305	
P16118	UniProtKB	Beta strand	43	48	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1K6M	
P16118	UniProtKB	Helix	55	68	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1K6M	
P16118	UniProtKB	Beta strand	73	77	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1K6M	
P16118	UniProtKB	Helix	78	83	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1K6M	
P16118	UniProtKB	Helix	91	94	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1K6M	
P16118	UniProtKB	Helix	99	121	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1K6M	
P16118	UniProtKB	Beta strand	126	132	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1K6M	
P16118	UniProtKB	Helix	137	150	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1K6M	
P16118	UniProtKB	Beta strand	153	160	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1K6M	
P16118	UniProtKB	Helix	164	175	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1K6M	
P16118	UniProtKB	Helix	187	201	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1K6M	
P16118	UniProtKB	Turn	209	214	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1K6M	
P16118	UniProtKB	Beta strand	217	221	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1K6M	
P16118	UniProtKB	Turn	222	225	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1K6M	
P16118	UniProtKB	Beta strand	226	230	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1K6M	
P16118	UniProtKB	Helix	235	244	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1K6M	
P16118	UniProtKB	Beta strand	254	258	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1K6M	
P16118	UniProtKB	Helix	263	266	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1K6M	
P16118	UniProtKB	Helix	278	293	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1K6M	
P16118	UniProtKB	Beta strand	300	303	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1K6M	
P16118	UniProtKB	Helix	307	314	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1K6M	
P16118	UniProtKB	Helix	324	326	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1K6M	
P16118	UniProtKB	Helix	332	334	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1K6M	
P16118	UniProtKB	Helix	339	345	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1K6M	
P16118	UniProtKB	Helix	347	355	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1K6M	
P16118	UniProtKB	Turn	357	359	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1K6M	
P16118	UniProtKB	Helix	368	384	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1K6M	
P16118	UniProtKB	Beta strand	386	392	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1K6M	
P16118	UniProtKB	Helix	394	405	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1K6M	
P16118	UniProtKB	Turn	409	411	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1K6M	
P16118	UniProtKB	Helix	412	414	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1K6M	
P16118	UniProtKB	Beta strand	421	427	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1K6M	
P16118	UniProtKB	Beta strand	429	438	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1K6M	
P16118	UniProtKB	Helix	460	464	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1K6M