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Protein

P-selectin

Gene

SELP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Ca2+-dependent receptor for myeloid cells that binds to carbohydrates on neutrophils and monocytes. Mediates the interaction of activated endothelial cells or platelets with leukocytes. The ligand recognized is sialyl-Lewis X. Mediates rapid rolling of leukocyte rolling over vascular surfaces during the initial steps in inflammation through interaction with PSGL1.1 Publication

GO - Molecular functioni

  • calcium-dependent protein binding Source: Ensembl
  • fucose binding Source: BHF-UCL
  • glycoprotein binding Source: Ensembl
  • glycosphingolipid binding Source: BHF-UCL
  • heparin binding Source: BHF-UCL
  • lipopolysaccharide binding Source: BHF-UCL
  • oligosaccharide binding Source: BHF-UCL
  • sialic acid binding Source: BHF-UCL

GO - Biological processi

  • calcium-mediated signaling using intracellular calcium source Source: UniProtKB
  • cell adhesion Source: ProtInc
  • defense response to Gram-negative bacterium Source: BHF-UCL
  • heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules Source: Ensembl
  • inflammatory response Source: Ensembl
  • leukocyte cell-cell adhesion Source: BHF-UCL
  • leukocyte migration Source: Reactome
  • leukocyte tethering or rolling Source: Ensembl
  • platelet degranulation Source: Reactome
  • positive regulation of leukocyte migration Source: Ensembl
  • positive regulation of phosphatidylinositol 3-kinase signaling Source: UniProtKB
  • positive regulation of platelet activation Source: BHF-UCL
  • regulation of integrin activation Source: UniProtKB
  • response to lipopolysaccharide Source: BHF-UCL

Keywordsi

Biological processCell adhesion
LigandLectin

Enzyme and pathway databases

ReactomeiR-HSA-114608. Platelet degranulation.
R-HSA-202733. Cell surface interactions at the vascular wall.
SIGNORiP16109.

Names & Taxonomyi

Protein namesi
Recommended name:
P-selectin
Alternative name(s):
CD62 antigen-like family member P
Granule membrane protein 140
Short name:
GMP-140
Leukocyte-endothelial cell adhesion molecule 3
Short name:
LECAM3
Platelet activation dependent granule-external membrane protein
Short name:
PADGEM
CD_antigen: CD62P
Gene namesi
Name:SELP
Synonyms:GMRP, GRMP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:10721. SELP.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini42 – 771ExtracellularSequence analysisAdd BLAST730
Transmembranei772 – 795HelicalSequence analysisAdd BLAST24
Topological domaini796 – 830CytoplasmicSequence analysisAdd BLAST35

GO - Cellular componenti

  • external side of plasma membrane Source: BHF-UCL
  • extracellular space Source: BHF-UCL
  • integral component of plasma membrane Source: ProtInc
  • plasma membrane Source: Reactome
  • platelet alpha granule membrane Source: MGI
  • platelet dense granule membrane Source: Reactome

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Involvement in diseasei

Ischemic stroke (ISCHSTR)1 Publication
Disease susceptibility is associated with variations affecting the gene represented in this entry.
Disease descriptionA stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors.
See also OMIM:601367

Organism-specific databases

DisGeNETi6403.
MalaCardsiSELP.
MIMi173610. gene+phenotype.
601367. phenotype.
PharmGKBiPA35643.

Chemistry databases

ChEMBLiCHEMBL5378.
DrugBankiDB06779. Dalteparin.
DB01109. Heparin.
DB03721. N-acetyl-alpha-neuraminic acid.
DB08813. Nadroparin.

Polymorphism and mutation databases

BioMutaiSELP.
DMDMi215274139.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 41Add BLAST41
ChainiPRO_000001749842 – 830P-selectinAdd BLAST789

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi54N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi60 ↔ 158By similarity
Glycosylationi98N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi131 ↔ 150By similarity
Disulfide bondi163 ↔ 174
Disulfide bondi168 ↔ 183
Glycosylationi180N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi185 ↔ 1941 Publication
Disulfide bondi200 ↔ 244By similarity
Glycosylationi212N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi219N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi230 ↔ 257By similarity
Disulfide bondi262 ↔ 306By similarity
Disulfide bondi292 ↔ 319By similarity
Disulfide bondi324 ↔ 368By similarity
Disulfide bondi354 ↔ 381By similarity
Disulfide bondi386 ↔ 430By similarity
Glycosylationi411N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi416 ↔ 443By similarity
Disulfide bondi448 ↔ 492By similarity
Glycosylationi460N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi478 ↔ 505By similarity
Disulfide bondi510 ↔ 554By similarity
Glycosylationi518N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi540 ↔ 567By similarity
Disulfide bondi572 ↔ 616By similarity
Disulfide bondi602 ↔ 629By similarity
Disulfide bondi642 ↔ 686By similarity
Glycosylationi665N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi672 ↔ 699By similarity
Disulfide bondi704 ↔ 748By similarity
Glycosylationi716N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi723N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi734 ↔ 761By similarity
Glycosylationi741N-linked (GlcNAc...) asparagineSequence analysis1
Lipidationi807S-palmitoyl cysteine; alternate1 Publication1
Lipidationi807S-stearoyl cysteine; alternate1 Publication1

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiP16109.
PeptideAtlasiP16109.
PRIDEiP16109.

PTM databases

iPTMnetiP16109.
PhosphoSitePlusiP16109.
SwissPalmiP16109.

Expressioni

Tissue specificityi

Stored in the alpha-granules of platelets and Weibel-Palade bodies of endothelial cells. Upon cell activation by agonists, P-selectin is transported rapidly to the cell surface.

Gene expression databases

BgeeiENSG00000174175.
CleanExiHS_SELP.
ExpressionAtlasiP16109. baseline and differential.
GenevisibleiP16109. HS.

Organism-specific databases

HPAiCAB002145.
HPA002655.
HPA005990.

Interactioni

Subunit structurei

Interacts with SNX17. Interacts with PSGL1/SEPL and PODXL2 and mediates neutrophil adhesion and leukocyte rolling. This interaction requires the sialyl-Lewis X epitope of PSGL1 and PODXL2, and specific tyrosine sulfation on PSGL1.7 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
SELPLGQ142423EBI-1030170,EBI-1030190

GO - Molecular functioni

Protein-protein interaction databases

BioGridi112303. 9 interactors.
DIPiDIP-37667N.
ELMiP16109.
IntActiP16109. 2 interactors.
STRINGi9606.ENSP00000263686.

Chemistry databases

BindingDBiP16109.

Structurei

Secondary structure

1830
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi43 – 46Combined sources4
Helixi53 – 63Combined sources11
Beta strandi64 – 67Combined sources4
Helixi73 – 82Combined sources10
Beta strandi90 – 97Combined sources8
Beta strandi100 – 103Combined sources4
Turni104 – 106Combined sources3
Turni112 – 114Combined sources3
Beta strandi131 – 134Combined sources4
Beta strandi139 – 141Combined sources3
Beta strandi145 – 148Combined sources4
Beta strandi154 – 160Combined sources7
Helixi167 – 170Combined sources4
Beta strandi171 – 176Combined sources6
Beta strandi178 – 185Combined sources8
Beta strandi189 – 191Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1FSBNMR-A160-199[»]
1G1QX-ray2.40A/B/C/D42-198[»]
1G1RX-ray3.40A/B/C/D42-198[»]
1G1SX-ray1.90A/B42-198[»]
1HESX-ray3.00P813-830[»]
1KJDmodel-A42-161[»]
ProteinModelPortaliP16109.
SMRiP16109.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP16109.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini58 – 158C-type lectinPROSITE-ProRule annotationAdd BLAST101
Domaini159 – 195EGF-likePROSITE-ProRule annotationAdd BLAST37
Domaini198 – 259Sushi 1PROSITE-ProRule annotationAdd BLAST62
Domaini260 – 321Sushi 2PROSITE-ProRule annotationAdd BLAST62
Domaini322 – 383Sushi 3PROSITE-ProRule annotationAdd BLAST62
Domaini384 – 445Sushi 4PROSITE-ProRule annotationAdd BLAST62
Domaini446 – 507Sushi 5PROSITE-ProRule annotationAdd BLAST62
Domaini508 – 569Sushi 6PROSITE-ProRule annotationAdd BLAST62
Domaini570 – 631Sushi 7PROSITE-ProRule annotationAdd BLAST62
Domaini640 – 701Sushi 8PROSITE-ProRule annotationAdd BLAST62
Domaini702 – 763Sushi 9PROSITE-ProRule annotationAdd BLAST62

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni821 – 830Interaction with SNX1710

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi818 – 821Endocytosis signalCurated4

Sequence similaritiesi

Belongs to the selectin/LECAM family.Curated

Keywords - Domaini

EGF-like domain, Repeat, Signal, Sushi, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IS44. Eukaryota.
ENOG410Y5JF. LUCA.
HOGENOMiHOG000236254.
HOVERGENiHBG052375.
InParanoidiP16109.
KOiK06496.
OrthoDBiEOG091G00VV.
PhylomeDBiP16109.
TreeFamiTF326910.

Family and domain databases

CDDicd00033. CCP. 9 hits.
cd03592. CLECT_selectins_like. 1 hit.
Gene3Di3.10.100.10. 1 hit.
InterProiView protein in InterPro
IPR001304. C-type_lectin-like.
IPR016186. C-type_lectin-like/link.
IPR018378. C-type_lectin_CS.
IPR016187. CTDL_fold.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR033991. Selectin_CTLD.
IPR002396. Selectin_superfamily.
IPR000436. Sushi_SCR_CCP_dom.
PfamiView protein in Pfam
PF00059. Lectin_C. 1 hit.
PF00084. Sushi. 9 hits.
PRINTSiPR00343. SELECTIN.
SMARTiView protein in SMART
SM00032. CCP. 9 hits.
SM00034. CLECT. 1 hit.
SUPFAMiSSF56436. SSF56436. 1 hit.
SSF57535. SSF57535. 9 hits.
PROSITEiView protein in PROSITE
PS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 1 hit.
PS50923. SUSHI. 9 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P16109-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANCQIAILY QRFQRVVFGI SQLLCFSALI SELTNQKEVA AWTYHYSTKA
60 70 80 90 100
YSWNISRKYC QNRYTDLVAI QNKNEIDYLN KVLPYYSSYY WIGIRKNNKT
110 120 130 140 150
WTWVGTKKAL TNEAENWADN EPNNKRNNED CVEIYIKSPS APGKWNDEHC
160 170 180 190 200
LKKKHALCYT ASCQDMSCSK QGECLETIGN YTCSCYPGFY GPECEYVREC
210 220 230 240 250
GELELPQHVL MNCSHPLGNF SFNSQCSFHC TDGYQVNGPS KLECLASGIW
260 270 280 290 300
TNKPPQCLAA QCPPLKIPER GNMTCLHSAK AFQHQSSCSF SCEEGFALVG
310 320 330 340 350
PEVVQCTASG VWTAPAPVCK AVQCQHLEAP SEGTMDCVHP LTAFAYGSSC
360 370 380 390 400
KFECQPGYRV RGLDMLRCID SGHWSAPLPT CEAISCEPLE SPVHGSMDCS
410 420 430 440 450
PSLRAFQYDT NCSFRCAEGF MLRGADIVRC DNLGQWTAPA PVCQALQCQD
460 470 480 490 500
LPVPNEARVN CSHPFGAFRY QSVCSFTCNE GLLLVGASVL QCLATGNWNS
510 520 530 540 550
VPPECQAIPC TPLLSPQNGT MTCVQPLGSS SYKSTCQFIC DEGYSLSGPE
560 570 580 590 600
RLDCTRSGRW TDSPPMCEAI KCPELFAPEQ GSLDCSDTRG EFNVGSTCHF
610 620 630 640 650
SCDNGFKLEG PNNVECTTSG RWSATPPTCK GIASLPTPGL QCPALTTPGQ
660 670 680 690 700
GTMYCRHHPG TFGFNTTCYF GCNAGFTLIG DSTLSCRPSG QWTAVTPACR
710 720 730 740 750
AVKCSELHVN KPIAMNCSNL WGNFSYGSIC SFHCLEGQLL NGSAQTACQE
760 770 780 790 800
NGHWSTTVPT CQAGPLTIQE ALTYFGGAVA STIGLIMGGT LLALLRKRFR
810 820 830
QKDDGKCPLN PHSHLGTYGV FTNAAFDPSP
Length:830
Mass (Da):90,834
Last modified:November 25, 2008 - v3
Checksum:iF53BC476AB6F70AC
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_019381179G → R1 PublicationCorresponds to variant dbSNP:rs3917718Ensembl.1
Natural variantiVAR_013910209V → M2 PublicationsCorresponds to variant dbSNP:rs6125Ensembl.1
Natural variantiVAR_019382230C → F1 PublicationCorresponds to variant dbSNP:rs3917869Ensembl.1
Natural variantiVAR_019383274T → I2 PublicationsCorresponds to variant dbSNP:rs3917724Ensembl.1
Natural variantiVAR_013911301P → L1 PublicationCorresponds to variant dbSNP:rs6124Ensembl.1
Natural variantiVAR_004192331S → N3 PublicationsCorresponds to variant dbSNP:rs6131Ensembl.1
Natural variantiVAR_013912365M → V1 PublicationCorresponds to variant dbSNP:rs6134Ensembl.1
Natural variantiVAR_019384385S → L1 PublicationCorresponds to variant dbSNP:rs3917742Ensembl.1
Natural variantiVAR_013913500S → F1 PublicationCorresponds to variant dbSNP:rs6130Ensembl.1
Natural variantiVAR_019385542E → K1 PublicationCorresponds to variant dbSNP:rs3917769Ensembl.1
Natural variantiVAR_004193603D → N4 PublicationsCorresponds to variant dbSNP:rs6127Ensembl.1
Natural variantiVAR_019386619S → A1 PublicationCorresponds to variant dbSNP:rs2228672Ensembl.1
Natural variantiVAR_019387631G → V1 PublicationCorresponds to variant dbSNP:rs3917812Ensembl.1
Natural variantiVAR_004194640L → V Associated with susceptibility to ischemic stroke. 5 PublicationsCorresponds to variant dbSNP:rs6133Ensembl.1
Natural variantiVAR_019388661T → N1 PublicationCorresponds to variant dbSNP:rs3917814Ensembl.1
Natural variantiVAR_019389673N → S1 PublicationCorresponds to variant dbSNP:rs3917815Ensembl.1
Natural variantiVAR_004195756T → P Reduced frequency in patients with myocardial infarction. 3 PublicationsCorresponds to variant dbSNP:rs6136Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M60234
, M60217, M60218, M60219, M60222, M60223, M60224, M60225, M60226, M60227, M60228, M60229, M60231, M60232, M60233 Genomic DNA. Translation: AAA35910.1.
M25322 mRNA. Translation: AAA35911.1.
AF542391 Genomic DNA. Translation: AAN06828.1.
AL022146, Z99572 Genomic DNA. Translation: CAI22753.1.
Z99572, AL022146 Genomic DNA. Translation: CAI23058.1.
CH471067 Genomic DNA. Translation: EAW90851.1.
CCDSiCCDS1282.1.
PIRiA30359.
RefSeqiNP_002996.2. NM_003005.3.
XP_005245492.1. XM_005245435.1.
XP_005245493.1. XM_005245436.3.
UniGeneiHs.73800.

Genome annotation databases

EnsembliENST00000263686; ENSP00000263686; ENSG00000174175.
GeneIDi6403.
KEGGihsa:6403.
UCSCiuc001ggi.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiLYAM3_HUMAN
AccessioniPrimary (citable) accession number: P16109
Secondary accession number(s): Q5R344, Q8IVD1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: November 25, 2008
Last modified: August 30, 2017
This is version 208 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families