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P16107

- CHSY_PETCR

UniProt

P16107 - CHSY_PETCR

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Protein

Chalcone synthase

Gene

CHS

Organism
Petroselinum crispum (Parsley) (Petroselinum hortense)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

The primary product of this enzyme is 4,2',4',6'-tetrahydroxychalcone (also termed naringenin-chalcone or chalcone) which can under specific conditions spontaneously isomerize into naringenin.

Catalytic activityi

3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + naringenin chalcone + 3 CO2.PROSITE-ProRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei169 – 1691PROSITE-ProRule annotation

GO - Molecular functioni

  1. naringenin-chalcone synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. flavonoid biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Flavonoid biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00154.

Names & Taxonomyi

Protein namesi
Recommended name:
Chalcone synthase (EC:2.3.1.74)
Alternative name(s):
Naringenin-chalcone synthase
Gene namesi
Name:CHS
OrganismiPetroselinum crispum (Parsley) (Petroselinum hortense)
Taxonomic identifieri4043 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridscampanulidsApialesApiaceaeApioideaeapioid supercladeApieaePetroselinum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 398398Chalcone synthasePRO_0000216028Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP16107.
SMRiP16107. Positions 9-392.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the chalcone/stilbene synthases family.Curated

Family and domain databases

Gene3Di3.40.47.10. 2 hits.
InterProiIPR012328. Chalcone/stilbene_synth_C.
IPR018088. Chalcone/stilbene_synthase_AS.
IPR001099. Chalcone/stilbene_synthase_N.
IPR011141. Polyketide_synthase_type-III.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
PfamiPF02797. Chal_sti_synt_C. 1 hit.
PF00195. Chal_sti_synt_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000451. PKS_III. 1 hit.
SUPFAMiSSF53901. SSF53901. 2 hits.
PROSITEiPS00441. CHALCONE_SYNTH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P16107-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MANHHNAEIE EIRNRQRAQG PANILAIGTA TPSNCVYQAD YPDYYFRITN
60 70 80 90 100
SEHMTDLKLK FKRMCEKSMI RKRYMHITEE YLKENPNVCA YEAPSLDARQ
110 120 130 140 150
DLVVVEVPRL GKEAASKAIK EWGQPKSKIT HLIFCTTSGV DMPGADYQLT
160 170 180 190 200
KLLGLRPSVK RFMMYQQGCF AGGTVLRLAK DLAENNAGAR VLVVCSEITA
210 220 230 240 250
VTFRGPSDSH LDSLVGQALF GDGAAAVILG SDPDLSVERP LFQLISAAQT
260 270 280 290 300
ILPDSDGAID GHLREVGLTF HLLKDVPGLI SKNIEKSLKE AFGPIGISDW
310 320 330 340 350
NSLFWIAHPG GPAILDQVEL KLGLKEEKMR ATRQVLSDYG NMSSACVLFI
360 370 380 390
LDEMRKKSIE EGKATTGEGL DWGVLFGFGP GLTVETVVLH SVPATFTH
Length:398
Mass (Da):43,735
Last modified:April 1, 1990 - v1
Checksum:iE8B19149AD3DAB1E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V01538 Genomic DNA. Translation: CAA24779.1.
PIRiS42523.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V01538 Genomic DNA. Translation: CAA24779.1 .
PIRi S42523.

3D structure databases

ProteinModelPortali P16107.
SMRi P16107. Positions 9-392.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00154 .

Family and domain databases

Gene3Di 3.40.47.10. 2 hits.
InterProi IPR012328. Chalcone/stilbene_synth_C.
IPR018088. Chalcone/stilbene_synthase_AS.
IPR001099. Chalcone/stilbene_synthase_N.
IPR011141. Polyketide_synthase_type-III.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view ]
Pfami PF02797. Chal_sti_synt_C. 1 hit.
PF00195. Chal_sti_synt_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000451. PKS_III. 1 hit.
SUPFAMi SSF53901. SSF53901. 2 hits.
PROSITEi PS00441. CHALCONE_SYNTH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Coding and 3' non-coding nucleotide sequence of chalcone synthase mRNA and assignment of amino acid sequence of the enzyme."
    Reimold U., Kroeger M., Kreuzaler F., Hahlbrock K.
    EMBO J. 2:1801-1805(1983) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiCHSY_PETCR
AccessioniPrimary (citable) accession number: P16107
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: October 1, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3