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P16107

- CHSY_PETCR

UniProt

P16107 - CHSY_PETCR

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Protein

Chalcone synthase

Gene
CHS
Organism
Petroselinum crispum (Parsley) (Petroselinum hortense)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The primary product of this enzyme is 4,2',4',6'-tetrahydroxychalcone (also termed naringenin-chalcone or chalcone) which can under specific conditions spontaneously isomerize into naringenin.

Catalytic activityi

3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + naringenin chalcone + 3 CO2.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei169 – 1691 By similarity

GO - Molecular functioni

  1. naringenin-chalcone synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. flavonoid biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Flavonoid biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00154.

Names & Taxonomyi

Protein namesi
Recommended name:
Chalcone synthase (EC:2.3.1.74)
Alternative name(s):
Naringenin-chalcone synthase
Gene namesi
Name:CHS
OrganismiPetroselinum crispum (Parsley) (Petroselinum hortense)
Taxonomic identifieri4043 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridscampanulidsApialesApiaceaeApioideaeapioid supercladeApieaePetroselinum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 398398Chalcone synthasePRO_0000216028Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP16107.
SMRiP16107. Positions 9-392.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di3.40.47.10. 2 hits.
InterProiIPR012328. Chalcone/stilbene_synth_C.
IPR018088. Chalcone/stilbene_synthase_AS.
IPR001099. Chalcone/stilbene_synthase_N.
IPR011141. Polyketide_synthase_type-III.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
PfamiPF02797. Chal_sti_synt_C. 1 hit.
PF00195. Chal_sti_synt_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000451. PKS_III. 1 hit.
SUPFAMiSSF53901. SSF53901. 2 hits.
PROSITEiPS00441. CHALCONE_SYNTH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P16107-1 [UniParc]FASTAAdd to Basket

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MANHHNAEIE EIRNRQRAQG PANILAIGTA TPSNCVYQAD YPDYYFRITN    50
SEHMTDLKLK FKRMCEKSMI RKRYMHITEE YLKENPNVCA YEAPSLDARQ 100
DLVVVEVPRL GKEAASKAIK EWGQPKSKIT HLIFCTTSGV DMPGADYQLT 150
KLLGLRPSVK RFMMYQQGCF AGGTVLRLAK DLAENNAGAR VLVVCSEITA 200
VTFRGPSDSH LDSLVGQALF GDGAAAVILG SDPDLSVERP LFQLISAAQT 250
ILPDSDGAID GHLREVGLTF HLLKDVPGLI SKNIEKSLKE AFGPIGISDW 300
NSLFWIAHPG GPAILDQVEL KLGLKEEKMR ATRQVLSDYG NMSSACVLFI 350
LDEMRKKSIE EGKATTGEGL DWGVLFGFGP GLTVETVVLH SVPATFTH 398
Length:398
Mass (Da):43,735
Last modified:April 1, 1990 - v1
Checksum:iE8B19149AD3DAB1E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
V01538 Genomic DNA. Translation: CAA24779.1.
PIRiS42523.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
V01538 Genomic DNA. Translation: CAA24779.1 .
PIRi S42523.

3D structure databases

ProteinModelPortali P16107.
SMRi P16107. Positions 9-392.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00154 .

Family and domain databases

Gene3Di 3.40.47.10. 2 hits.
InterProi IPR012328. Chalcone/stilbene_synth_C.
IPR018088. Chalcone/stilbene_synthase_AS.
IPR001099. Chalcone/stilbene_synthase_N.
IPR011141. Polyketide_synthase_type-III.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view ]
Pfami PF02797. Chal_sti_synt_C. 1 hit.
PF00195. Chal_sti_synt_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000451. PKS_III. 1 hit.
SUPFAMi SSF53901. SSF53901. 2 hits.
PROSITEi PS00441. CHALCONE_SYNTH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Coding and 3' non-coding nucleotide sequence of chalcone synthase mRNA and assignment of amino acid sequence of the enzyme."
    Reimold U., Kroeger M., Kreuzaler F., Hahlbrock K.
    EMBO J. 2:1801-1805(1983) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiCHSY_PETCR
AccessioniPrimary (citable) accession number: P16107
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: February 19, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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