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Protein

Ribosome-inactivating protein momordin I

Gene
N/A
Organism
Momordica charantia (Bitter gourd) (Balsam pear)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Endohydrolysis of the N-glycosidic bond at one specific adenosine on the 28S rRNA.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei1831

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein synthesis inhibitor, Toxin

Keywords - Biological processi

Plant defense

Names & Taxonomyi

Protein namesi
Recommended name:
Ribosome-inactivating protein momordin I (EC:3.2.2.22)
Alternative name(s):
Alpha-momorcharin
Short name:
Alpha-MMC
rRNA N-glycosidase
OrganismiMomordica charantia (Bitter gourd) (Balsam pear)
Taxonomic identifieri3673 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsCucurbitalesCucurbitaceaeMomordiceaeMomordica

Pathology & Biotechi

Protein family/group databases

Allergomei2800. Mom c RIP.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 232 PublicationsAdd BLAST23
ChainiPRO_000003077024 – 269Ribosome-inactivating protein momordin IAdd BLAST246
PropeptideiPRO_0000030771270 – 286Removed in mature formAdd BLAST17

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
GlycosylationiCAR_000082250N-linked (GlcNAc...)1

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiP16094.

PTM databases

UniCarbKBiP16094.

Structurei

Secondary structure

1286
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi25 – 29Combined sources5
Helixi34 – 46Combined sources13
Beta strandi50 – 54Combined sources5
Beta strandi57 – 60Combined sources4
Helixi66 – 69Combined sources4
Beta strandi70 – 76Combined sources7
Beta strandi82 – 88Combined sources7
Turni89 – 91Combined sources3
Beta strandi94 – 99Combined sources6
Beta strandi102 – 105Combined sources4
Helixi109 – 114Combined sources6
Turni115 – 117Combined sources3
Beta strandi123 – 127Combined sources5
Helixi134 – 141Combined sources8
Helixi145 – 147Combined sources3
Helixi152 – 162Combined sources11
Helixi167 – 180Combined sources14
Helixi182 – 186Combined sources5
Helixi188 – 196Combined sources9
Beta strandi198 – 200Combined sources3
Helixi206 – 213Combined sources8
Helixi215 – 225Combined sources11
Turni226 – 230Combined sources5
Beta strandi231 – 239Combined sources9
Beta strandi242 – 244Combined sources3
Beta strandi245 – 250Combined sources6
Helixi254 – 257Combined sources4
Helixi266 – 268Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1AHAX-ray2.20A24-269[»]
1AHBX-ray2.20A24-269[»]
1AHCX-ray2.00A24-269[»]
1F8QX-ray2.20A24-286[»]
1MOMX-ray2.16A24-269[»]
1MRGX-ray1.80A24-286[»]
1MRHX-ray2.00A24-286[»]
1MRIX-ray2.20A24-286[»]
4YP2X-ray1.35B24-269[»]
5CF9X-ray1.52B24-269[»]
ProteinModelPortaliP16094.
SMRiP16094.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP16094.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Family and domain databases

Gene3Di3.40.420.10. 1 hit.
4.10.470.10. 1 hit.
InterProiIPR001574. Ribosome_inactivat_prot.
IPR017988. Ribosome_inactivat_prot_CS.
IPR016138. Ribosome_inactivat_prot_sub1.
IPR016139. Ribosome_inactivat_prot_sub2.
IPR017989. Ribosome_inactivat_prot_subgr.
[Graphical view]
PfamiPF00161. RIP. 1 hit.
[Graphical view]
PRINTSiPR00396. SHIGARICIN.
SUPFAMiSSF56371. SSF56371. 1 hit.
PROSITEiPS00275. SHIGA_RICIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P16094-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRFSVLSFL ILAIFLGGSI VKGDVSFRLS GADPRSYGMF IKDLRNALPF
60 70 80 90 100
REKVYNIPLL LPSVSGAGRY LLMHLFNYDG KTITVAVDVT NVYIMGYLAD
110 120 130 140 150
TTSYFFNEPA AELASQYVFR DARRKITLPY SGNYERLQIA AGKPREKIPI
160 170 180 190 200
GLPALDSAIS TLLHYDSTAA AGALLVLIQT TAEAARFKYI EQQIQERAYR
210 220 230 240 250
DEVPSLATIS LENSWSGLSK QIQLAQGNNG IFRTPIVLVD NKGNRVQITN
260 270 280
VTSKVVTSNI QLLLNTRNIA EGDNGDVSTT HGFSSY
Length:286
Mass (Da):31,532
Last modified:December 1, 1992 - v2
Checksum:iE1B013ABEBC216CF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X57682 mRNA. Translation: CAA40869.1.
PIRiS14273. RLPUGG.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X57682 mRNA. Translation: CAA40869.1.
PIRiS14273. RLPUGG.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1AHAX-ray2.20A24-269[»]
1AHBX-ray2.20A24-269[»]
1AHCX-ray2.00A24-269[»]
1F8QX-ray2.20A24-286[»]
1MOMX-ray2.16A24-269[»]
1MRGX-ray1.80A24-286[»]
1MRHX-ray2.00A24-286[»]
1MRIX-ray2.20A24-286[»]
4YP2X-ray1.35B24-269[»]
5CF9X-ray1.52B24-269[»]
ProteinModelPortaliP16094.
SMRiP16094.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

Allergomei2800. Mom c RIP.

PTM databases

UniCarbKBiP16094.

Proteomic databases

PRIDEiP16094.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiP16094.

Family and domain databases

Gene3Di3.40.420.10. 1 hit.
4.10.470.10. 1 hit.
InterProiIPR001574. Ribosome_inactivat_prot.
IPR017988. Ribosome_inactivat_prot_CS.
IPR016138. Ribosome_inactivat_prot_sub1.
IPR016139. Ribosome_inactivat_prot_sub2.
IPR017989. Ribosome_inactivat_prot_subgr.
[Graphical view]
PfamiPF00161. RIP. 1 hit.
[Graphical view]
PRINTSiPR00396. SHIGARICIN.
SUPFAMiSSF56371. SSF56371. 1 hit.
PROSITEiPS00275. SHIGA_RICIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRIP1_MOMCH
AccessioniPrimary (citable) accession number: P16094
Secondary accession number(s): P24697
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: December 1, 1992
Last modified: November 2, 2016
This is version 99 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.