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P16087

- GAG_FIVPE

UniProt

P16087 - GAG_FIVPE

Protein

Gag polyprotein

Gene

gag

Organism
Feline immunodeficiency virus (isolate Petaluma) (FIV)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 86 (01 Oct 2014)
      Sequence version 1 (01 Apr 1990)
      Previous versions | rss
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    Functioni

    Matrix protein p15 forms the outer shell of the core of the virus, lining the inner surface of the viral membrane.By similarity
    Capsid protein p24 forms the conical core of the virus that encapsulates the genomic RNA-nucleocapsid complex.By similarity
    Nucleocapsid protein p13 encapsulates and protects viral dimeric unspliced (genomic) RNA. Binds these RNAs through its zinc fingers By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri375 – 39218CCHC-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri394 – 41118CCHC-type 2PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. nucleic acid binding Source: InterPro
    2. structural constituent of virion Source: UniProtKB-KW
    3. zinc ion binding Source: InterPro

    GO - Biological processi

    1. viral budding via host ESCRT complex Source: UniProtKB-KW
    2. viral release from host cell Source: UniProtKB-KW

    Keywords - Biological processi

    Host-virus interaction, Viral budding, Viral budding via the host ESCRT complexes, Virion maturation, Virus exit from host cell

    Keywords - Ligandi

    Metal-binding, Viral nucleoprotein, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Gag polyprotein
    Cleaved into the following 4 chains:
    Matrix protein p15
    Short name:
    MA
    Capsid protein p24
    Short name:
    CA
    Gene namesi
    Name:gag
    OrganismiFeline immunodeficiency virus (isolate Petaluma) (FIV)
    Taxonomic identifieri11674 [NCBI]
    Taxonomic lineageiVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeLentivirusFeline lentivirus group
    Virus hostiFelidae (cat family) [TaxID: 9681]

    Subcellular locationi

    GO - Cellular componenti

    1. viral nucleocapsid Source: UniProtKB-KW

    Keywords - Cellular componenti

    Capsid protein, Viral matrix protein, Virion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 135135Matrix protein p15PRO_0000038784Add
    BLAST
    Chaini136 – 357222Capsid protein p24PRO_0000038785Add
    BLAST
    Peptidei358 – 3669p1Sequence AnalysisPRO_0000272316
    Chaini367 – 45084Nucleocapsid protein p13PRO_0000038786Add
    BLAST

    Structurei

    Secondary structure

    1
    450
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi7 – 1610
    Beta strandi19 – 268
    Helixi32 – 4514
    Helixi57 – 7418
    Helixi78 – 9316
    Helixi103 – 11210
    Turni113 – 1164
    Helixi121 – 1244

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4IC9X-ray2.00A1-135[»]
    4ICAX-ray2.70A/B1-120[»]
    ProteinModelPortaliP16087.
    SMRiP16087. Positions 376-409.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi438 – 4414PTAP/PSAP motif

    Domaini

    Late-budding domains (L domains) are short sequence motifs essential for viral particle budding. They recruit proteins of the host ESCRT machinery (Endosomal Sorting Complex Required for Transport) or ESCRT-associated proteins. Nucleocapsid protein p13 contains one L domain: a PTAP/PSAP motif, which interacts with the UEV domain of TSG101 By similarity.By similarity

    Sequence similaritiesi

    Contains 2 CCHC-type zinc fingers.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri375 – 39218CCHC-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri394 – 41118CCHC-type 2PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Family and domain databases

    Gene3Di1.10.1200.30. 1 hit.
    1.10.375.10. 1 hit.
    4.10.60.10. 1 hit.
    InterProiIPR000721. Gag_p24.
    IPR008916. Retrov_capsid_C.
    IPR008919. Retrov_capsid_N.
    IPR001878. Znf_CCHC.
    [Graphical view]
    PfamiPF00607. Gag_p24. 1 hit.
    PF00098. zf-CCHC. 2 hits.
    [Graphical view]
    SMARTiSM00343. ZnF_C2HC. 2 hits.
    [Graphical view]
    SUPFAMiSSF47353. SSF47353. 1 hit.
    SSF47943. SSF47943. 1 hit.
    SSF57756. SSF57756. 1 hit.
    PROSITEiPS50158. ZF_CCHC. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P16087-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGNGQGRDWK MAIKRCSNVA VGVGGKSKKF GEGNFRWAIR MANVSTGREP    50
    GDIPETLDQL RLVICDLQER REKFGSSKEI DMAIVTLKVF AVAGLLNMTV 100
    STAAAAENMY SQMGLDTRPS MKEAGGKEEG PPQAYPIQTV NGVPQYVALD 150
    PKMVSIFMEK AREGLGGEEV QLWFTAFSAN LTPTDMATLI MAAPGCAADK 200
    EILDESLKQL TAEYDRTHPP DAPRPLPYFT AAEIMGIGLT QEQQAEARFA 250
    PARMQCRAWY LEALGKLAAI KAKSPRAVQL RQGAKEDYSS FIDRLFAQID 300
    QEQNTAEVKL YLKQSLSIAN ANADCKKAMS HLKPESTLEE KLRACQEIGS 350
    PGYKMQLLAE ALTKVQVVQS KGSGPVCFNC KKPGHLARQC REVKKCNKCG 400
    KPGHLAAKCW QGNRKNSGNW KAGRAAAPVN QMQQAVMPSA PPMEEKLLDL 450
    Length:450
    Mass (Da):49,244
    Last modified:April 1, 1990 - v1
    Checksum:iE10A98DEB9494B94
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti405 – 4051L → V in AAB59936. (PubMed:2762293)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M25381 Genomic RNA. Translation: AAB59936.1.
    PIRiA33543. FOLJFP.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M25381 Genomic RNA. Translation: AAB59936.1 .
    PIRi A33543. FOLJFP.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4IC9 X-ray 2.00 A 1-135 [» ]
    4ICA X-ray 2.70 A/B 1-120 [» ]
    ProteinModelPortali P16087.
    SMRi P16087. Positions 376-409.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 1.10.1200.30. 1 hit.
    1.10.375.10. 1 hit.
    4.10.60.10. 1 hit.
    InterProi IPR000721. Gag_p24.
    IPR008916. Retrov_capsid_C.
    IPR008919. Retrov_capsid_N.
    IPR001878. Znf_CCHC.
    [Graphical view ]
    Pfami PF00607. Gag_p24. 1 hit.
    PF00098. zf-CCHC. 2 hits.
    [Graphical view ]
    SMARTi SM00343. ZnF_C2HC. 2 hits.
    [Graphical view ]
    SUPFAMi SSF47353. SSF47353. 1 hit.
    SSF47943. SSF47943. 1 hit.
    SSF57756. SSF57756. 1 hit.
    PROSITEi PS50158. ZF_CCHC. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
      Strain: Clone 34TF10.
    2. "Nucleotide sequence analysis of feline immunodeficiency virus: genome organization and relationship to other lentiviruses."
      Olmsted R.A., Hirsch V.M., Purcell R.H., Johnson P.R.
      Proc. Natl. Acad. Sci. U.S.A. 86:8088-8092(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
      Strain: Clone FIV-14.

    Entry informationi

    Entry nameiGAG_FIVPE
    AccessioniPrimary (citable) accession number: P16087
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1990
    Last sequence update: April 1, 1990
    Last modified: October 1, 2014
    This is version 86 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3