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P16087 (GAG_FIVPE) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 85. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Gag polyprotein

Cleaved into the following 4 chains:

  1. Matrix protein p15
    Short name=MA
  2. Capsid protein p24
    Short name=CA
  3. p1
  4. Nucleocapsid protein p13
    Short name=NC
Gene names
Name:gag
OrganismFeline immunodeficiency virus (isolate Petaluma) (FIV)
Taxonomic identifier11674 [NCBI]
Taxonomic lineageVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeLentivirusFeline lentivirus group
Virus hostFelidae (cat family) [TaxID: 9681]

Protein attributes

Sequence length450 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Matrix protein p15 forms the outer shell of the core of the virus, lining the inner surface of the viral membrane By similarity.

Capsid protein p24 forms the conical core of the virus that encapsulates the genomic RNA-nucleocapsid complex By similarity.

Nucleocapsid protein p13 encapsulates and protects viral dimeric unspliced (genomic) RNA. Binds these RNAs through its zinc fingers By similarity.

Subcellular location

Matrix protein p15: Virion Potential.

Capsid protein p24: Virion Potential.

Nucleocapsid protein p13: Virion Potential.

Domain

Late-budding domains (L domains) are short sequence motifs essential for viral particle budding. They recruit proteins of the host ESCRT machinery (Endosomal Sorting Complex Required for Transport) or ESCRT-associated proteins. Nucleocapsid protein p13 contains one L domain: a PTAP/PSAP motif, which interacts with the UEV domain of TSG101 By similarity.

Sequence similarities

Belongs to the feline lentivirus group gag polyprotein family.

Contains 2 CCHC-type zinc fingers.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 135135Matrix protein p15
PRO_0000038784
Chain136 – 357222Capsid protein p24
PRO_0000038785
Peptide358 – 3669p1 Potential
PRO_0000272316
Chain367 – 45084Nucleocapsid protein p13
PRO_0000038786

Regions

Zinc finger375 – 39218CCHC-type 1
Zinc finger394 – 41118CCHC-type 2
Motif438 – 4414PTAP/PSAP motif

Experimental info

Sequence conflict4051L → V in AAB59936. Ref.1

Secondary structure

................ 450
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P16087 [UniParc].

Last modified April 1, 1990. Version 1.
Checksum: E10A98DEB9494B94

FASTA45049,244
        10         20         30         40         50         60 
MGNGQGRDWK MAIKRCSNVA VGVGGKSKKF GEGNFRWAIR MANVSTGREP GDIPETLDQL 

        70         80         90        100        110        120 
RLVICDLQER REKFGSSKEI DMAIVTLKVF AVAGLLNMTV STAAAAENMY SQMGLDTRPS 

       130        140        150        160        170        180 
MKEAGGKEEG PPQAYPIQTV NGVPQYVALD PKMVSIFMEK AREGLGGEEV QLWFTAFSAN 

       190        200        210        220        230        240 
LTPTDMATLI MAAPGCAADK EILDESLKQL TAEYDRTHPP DAPRPLPYFT AAEIMGIGLT 

       250        260        270        280        290        300 
QEQQAEARFA PARMQCRAWY LEALGKLAAI KAKSPRAVQL RQGAKEDYSS FIDRLFAQID 

       310        320        330        340        350        360 
QEQNTAEVKL YLKQSLSIAN ANADCKKAMS HLKPESTLEE KLRACQEIGS PGYKMQLLAE 

       370        380        390        400        410        420 
ALTKVQVVQS KGSGPVCFNC KKPGHLARQC REVKKCNKCG KPGHLAAKCW QGNRKNSGNW 

       430        440        450 
KAGRAAAPVN QMQQAVMPSA PPMEEKLLDL 

« Hide

References

[1]"Nucleotide sequence and genomic organization of feline immunodeficiency virus."
Talbott R.L., Sparger E.E., Lovelace K.M., Fitch W.M., Pedersen N.C., Luciw P.A., Elder J.H.
Proc. Natl. Acad. Sci. U.S.A. 86:5743-5747(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
Strain: Clone 34TF10.
[2]"Nucleotide sequence analysis of feline immunodeficiency virus: genome organization and relationship to other lentiviruses."
Olmsted R.A., Hirsch V.M., Purcell R.H., Johnson P.R.
Proc. Natl. Acad. Sci. U.S.A. 86:8088-8092(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
Strain: Clone FIV-14.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M25381 Genomic RNA. Translation: AAB59936.1.
PIRFOLJFP. A33543.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
4IC9X-ray2.00A1-135[»]
4ICAX-ray2.70A/B1-120[»]
ProteinModelPortalP16087.
SMRP16087. Positions 376-409.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D1.10.1200.30. 1 hit.
1.10.375.10. 1 hit.
4.10.60.10. 1 hit.
InterProIPR000721. Gag_p24.
IPR008916. Retrov_capsid_C.
IPR008919. Retrov_capsid_N.
IPR001878. Znf_CCHC.
[Graphical view]
PfamPF00607. Gag_p24. 1 hit.
PF00098. zf-CCHC. 2 hits.
[Graphical view]
SMARTSM00343. ZnF_C2HC. 2 hits.
[Graphical view]
SUPFAMSSF47353. SSF47353. 1 hit.
SSF47943. SSF47943. 1 hit.
SSF57756. SSF57756. 1 hit.
PROSITEPS50158. ZF_CCHC. 2 hits.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGAG_FIVPE
AccessionPrimary (citable) accession number: P16087
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: February 19, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references