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P16087

- GAG_FIVPE

UniProt

P16087 - GAG_FIVPE

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Protein
Gag polyprotein
Gene
gag
Organism
Feline immunodeficiency virus (isolate Petaluma) (FIV)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Matrix protein p15 forms the outer shell of the core of the virus, lining the inner surface of the viral membrane By similarity.
Capsid protein p24 forms the conical core of the virus that encapsulates the genomic RNA-nucleocapsid complex By similarity.
Nucleocapsid protein p13 encapsulates and protects viral dimeric unspliced (genomic) RNA. Binds these RNAs through its zinc fingers By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri375 – 39218CCHC-type 1
Add
BLAST
Zinc fingeri394 – 41118CCHC-type 2
Add
BLAST

GO - Molecular functioni

  1. nucleic acid binding Source: InterPro
  2. structural constituent of virion Source: UniProtKB-KW
  3. zinc ion binding Source: InterPro

GO - Biological processi

  1. viral budding via host ESCRT complex Source: UniProtKB-KW
  2. viral release from host cell Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Host-virus interaction, Viral budding, Viral budding via the host ESCRT complexes, Virion maturation, Virus exit from host cell

Keywords - Ligandi

Metal-binding, Viral nucleoprotein, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Gag polyprotein
Cleaved into the following 4 chains:
Matrix protein p15
Short name:
MA
Capsid protein p24
Short name:
CA
Gene namesi
Name:gag
OrganismiFeline immunodeficiency virus (isolate Petaluma) (FIV)
Taxonomic identifieri11674 [NCBI]
Taxonomic lineageiVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeLentivirusFeline lentivirus group
Virus hostiFelidae (cat family) [TaxID: 9681]

Subcellular locationi

Chain Matrix protein p15 : Virion Reviewed prediction
Chain Capsid protein p24 : Virion Reviewed prediction

GO - Cellular componenti

  1. viral nucleocapsid Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Capsid protein, Viral matrix protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 135135Matrix protein p15
PRO_0000038784Add
BLAST
Chaini136 – 357222Capsid protein p24
PRO_0000038785Add
BLAST
Peptidei358 – 3669p1 Reviewed prediction
PRO_0000272316
Chaini367 – 45084Nucleocapsid protein p13
PRO_0000038786Add
BLAST

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi7 – 1610
Beta strandi19 – 268
Helixi32 – 4514
Helixi57 – 7418
Helixi78 – 9316
Helixi103 – 11210
Turni113 – 1164
Helixi121 – 1244

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4IC9X-ray2.00A1-135[»]
4ICAX-ray2.70A/B1-120[»]
ProteinModelPortaliP16087.
SMRiP16087. Positions 376-409.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi438 – 4414PTAP/PSAP motif

Domaini

Late-budding domains (L domains) are short sequence motifs essential for viral particle budding. They recruit proteins of the host ESCRT machinery (Endosomal Sorting Complex Required for Transport) or ESCRT-associated proteins. Nucleocapsid protein p13 contains one L domain: a PTAP/PSAP motif, which interacts with the UEV domain of TSG101 By similarity.

Sequence similaritiesi

Keywords - Domaini

Repeat, Zinc-finger

Family and domain databases

Gene3Di1.10.1200.30. 1 hit.
1.10.375.10. 1 hit.
4.10.60.10. 1 hit.
InterProiIPR000721. Gag_p24.
IPR008916. Retrov_capsid_C.
IPR008919. Retrov_capsid_N.
IPR001878. Znf_CCHC.
[Graphical view]
PfamiPF00607. Gag_p24. 1 hit.
PF00098. zf-CCHC. 2 hits.
[Graphical view]
SMARTiSM00343. ZnF_C2HC. 2 hits.
[Graphical view]
SUPFAMiSSF47353. SSF47353. 1 hit.
SSF47943. SSF47943. 1 hit.
SSF57756. SSF57756. 1 hit.
PROSITEiPS50158. ZF_CCHC. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P16087-1 [UniParc]FASTAAdd to Basket

« Hide

MGNGQGRDWK MAIKRCSNVA VGVGGKSKKF GEGNFRWAIR MANVSTGREP    50
GDIPETLDQL RLVICDLQER REKFGSSKEI DMAIVTLKVF AVAGLLNMTV 100
STAAAAENMY SQMGLDTRPS MKEAGGKEEG PPQAYPIQTV NGVPQYVALD 150
PKMVSIFMEK AREGLGGEEV QLWFTAFSAN LTPTDMATLI MAAPGCAADK 200
EILDESLKQL TAEYDRTHPP DAPRPLPYFT AAEIMGIGLT QEQQAEARFA 250
PARMQCRAWY LEALGKLAAI KAKSPRAVQL RQGAKEDYSS FIDRLFAQID 300
QEQNTAEVKL YLKQSLSIAN ANADCKKAMS HLKPESTLEE KLRACQEIGS 350
PGYKMQLLAE ALTKVQVVQS KGSGPVCFNC KKPGHLARQC REVKKCNKCG 400
KPGHLAAKCW QGNRKNSGNW KAGRAAAPVN QMQQAVMPSA PPMEEKLLDL 450
Length:450
Mass (Da):49,244
Last modified:April 1, 1990 - v1
Checksum:iE10A98DEB9494B94
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti405 – 4051L → V in AAB59936. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M25381 Genomic RNA. Translation: AAB59936.1.
PIRiA33543. FOLJFP.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M25381 Genomic RNA. Translation: AAB59936.1 .
PIRi A33543. FOLJFP.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4IC9 X-ray 2.00 A 1-135 [» ]
4ICA X-ray 2.70 A/B 1-120 [» ]
ProteinModelPortali P16087.
SMRi P16087. Positions 376-409.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 1.10.1200.30. 1 hit.
1.10.375.10. 1 hit.
4.10.60.10. 1 hit.
InterProi IPR000721. Gag_p24.
IPR008916. Retrov_capsid_C.
IPR008919. Retrov_capsid_N.
IPR001878. Znf_CCHC.
[Graphical view ]
Pfami PF00607. Gag_p24. 1 hit.
PF00098. zf-CCHC. 2 hits.
[Graphical view ]
SMARTi SM00343. ZnF_C2HC. 2 hits.
[Graphical view ]
SUPFAMi SSF47353. SSF47353. 1 hit.
SSF47943. SSF47943. 1 hit.
SSF57756. SSF57756. 1 hit.
PROSITEi PS50158. ZF_CCHC. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
    Strain: Clone 34TF10.
  2. "Nucleotide sequence analysis of feline immunodeficiency virus: genome organization and relationship to other lentiviruses."
    Olmsted R.A., Hirsch V.M., Purcell R.H., Johnson P.R.
    Proc. Natl. Acad. Sci. U.S.A. 86:8088-8092(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
    Strain: Clone FIV-14.

Entry informationi

Entry nameiGAG_FIVPE
AccessioniPrimary (citable) accession number: P16087
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: February 19, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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