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P16071

- HN_PI1HW

UniProt

P16071 - HN_PI1HW

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Protein
Hemagglutinin-neuraminidase
Gene
HN
Organism
Human parainfluenza 1 virus (strain Washington/1957) (HPIV-1)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Attaches the virus to sialic acid-containing cell receptors and thereby initiating infection. Binding of HN protein to the receptor induces a conformational change that allows the F protein to trigger virion/cell membranes fusion By similarity.
Neuraminidase activity ensures the efficient spread of the virus by dissociating the mature virions from the neuraminic acid containing glycoproteins By similarity.

Catalytic activityi

Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.

GO - Molecular functioni

  1. exo-alpha-(2->3)-sialidase activity Source: UniProtKB-EC
  2. exo-alpha-(2->6)-sialidase activity Source: UniProtKB-EC
  3. exo-alpha-(2->8)-sialidase activity Source: UniProtKB-EC

GO - Biological processi

  1. viral entry into host cell Source: UniProtKB-KW
  2. virion attachment to host cell Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hemagglutinin, Hydrolase

Keywords - Biological processi

Host-virus interaction, Viral attachment to host cell, Virus entry into host cell

Protein family/group databases

CAZyiGH83. Glycoside Hydrolase Family 83.

Names & Taxonomyi

Protein namesi
Recommended name:
Hemagglutinin-neuraminidase (EC:3.2.1.18)
Gene namesi
Name:HN
OrganismiHuman parainfluenza 1 virus (strain Washington/1957) (HPIV-1)
Taxonomic identifieri11211 [NCBI]
Taxonomic lineageiVirusesssRNA negative-strand virusesMononegaviralesParamyxoviridaeParamyxovirinaeRespirovirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3434Intravirion Reviewed prediction
Add
BLAST
Transmembranei35 – 5521Helical; Reviewed prediction
Add
BLAST
Topological domaini56 – 575520Virion surface Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. host cell plasma membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
  3. viral envelope Source: UniProtKB-KW
  4. virion membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Host cell membrane, Host membrane, Membrane, Viral envelope protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 575575Hemagglutinin-neuraminidase
PRO_0000142621Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi77 – 771N-linked (GlcNAc...); by host Reviewed prediction
Glycosylationi499 – 4991N-linked (GlcNAc...); by host Reviewed prediction
Glycosylationi511 – 5111N-linked (GlcNAc...); by host Reviewed prediction

Keywords - PTMi

Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliP16071.
SMRiP16071. Positions 144-572.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di2.120.10.10. 1 hit.
InterProiIPR000665. Hemagglutn-neuramid.
IPR016285. Hemagglutn-neuramid_paramyxo.
IPR011040. Sialidases.
[Graphical view]
PfamiPF00423. HN. 1 hit.
[Graphical view]
PIRSFiPIRSF001072. Hemagglut-neuramid_paramyxoV. 1 hit.
SUPFAMiSSF50939. SSF50939. 1 hit.

Sequencei

Sequence statusi: Complete.

P16071-1 [UniParc]FASTAAdd to Basket

« Hide

MAEKGKTNSS YWSTTRNDNS TVNTYIDTPA GKTHIWLLIA TTMHTILSFI    50
IMILCIDLII KQDTCMKTNI MTVSSMNESA KTIKETITEL IRQEVISRTI 100
NIQSSVQSGI PILLNKQSRD LTQLIEKSCN RQELAQICEN TIAIHHADGI 150
SPLDPHDFWR CPVGEPLLSN NPNISLLPGP SLLSGSTTIS GCVRLPSLSI 200
GDAIYAYSSN LITQGCADIG KSYQVLQLGY ISLNSDMYPD LKPVISHTYD 250
INDNRKSCSV IAAGTRGYQL CSLPTVNETT DYSSEGIEDL VFDILDLKGK 300
TKSHRYKNED ITFDHPFSAM YPSVGSGIKI ENTLIFLGYG GLTTPLQGDT 350
KCVTNRCANV NQSVCNDALK ITWLKKRQVV NVLIRINNYL SDRPKIVVET 400
IPITQNYLGA EGRLLKLGKK IYIYTRSSGW HSHLQIGSLD INNPMTIKWA 450
PHEVLSRPGN QDCNWYNRCP RECISGVYTD AYPLSPDAVN VATTTLYANT 500
SRVNPTIMYS NTSEIINMLR LKNVQLEAAY TTTSCITHFG KGYCFHIVEI 550
NQTSLNTLQP MLFKTSIPKI CKITS 575
Length:575
Mass (Da):63,981
Last modified:February 1, 1996 - v2
Checksum:i63E55E481A0DB322
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M31228 Genomic RNA. Translation: AAA46798.1.
PIRiA34682. HNNZ39.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M31228 Genomic RNA. Translation: AAA46798.1 .
PIRi A34682. HNNZ39.

3D structure databases

ProteinModelPortali P16071.
SMRi P16071. Positions 144-572.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

CAZyi GH83. Glycoside Hydrolase Family 83.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 2.120.10.10. 1 hit.
InterProi IPR000665. Hemagglutn-neuramid.
IPR016285. Hemagglutn-neuramid_paramyxo.
IPR011040. Sialidases.
[Graphical view ]
Pfami PF00423. HN. 1 hit.
[Graphical view ]
PIRSFi PIRSF001072. Hemagglut-neuramid_paramyxoV. 1 hit.
SUPFAMi SSF50939. SSF50939. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The hemagglutinin-neuraminidase glycoproteins of human parainfluenza virus type 1 and Sendai virus have high structure-function similarity with limited antigenic cross-reactivity."
    Gorman W.L., Gill D.S., Scroggs R.A., Portner A.
    Virology 175:211-221(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Entry informationi

Entry nameiHN_PI1HW
AccessioniPrimary (citable) accession number: P16071
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: February 1, 1996
Last modified: April 16, 2014
This is version 91 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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