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P16071

- HN_PI1HW

UniProt

P16071 - HN_PI1HW

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Protein

Hemagglutinin-neuraminidase

Gene

HN

Organism
Human parainfluenza 1 virus (strain Washington/1957) (HPIV-1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Attaches the virus to sialic acid-containing cell receptors and thereby initiating infection. Binding of HN protein to the receptor induces a conformational change that allows the F protein to trigger virion/cell membranes fusion (By similarity).By similarity
Neuraminidase activity ensures the efficient spread of the virus by dissociating the mature virions from the neuraminic acid containing glycoproteins.By similarity

Catalytic activityi

Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.

GO - Molecular functioni

  1. exo-alpha-(2->3)-sialidase activity Source: UniProtKB-EC
  2. exo-alpha-(2->6)-sialidase activity Source: UniProtKB-EC
  3. exo-alpha-(2->8)-sialidase activity Source: UniProtKB-EC

GO - Biological processi

  1. viral entry into host cell Source: UniProtKB-KW
  2. virion attachment to host cell Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hemagglutinin, Hydrolase

Keywords - Biological processi

Host-virus interaction, Viral attachment to host cell, Virus entry into host cell

Protein family/group databases

CAZyiGH83. Glycoside Hydrolase Family 83.

Names & Taxonomyi

Protein namesi
Recommended name:
Hemagglutinin-neuraminidase (EC:3.2.1.18)
Gene namesi
Name:HN
OrganismiHuman parainfluenza 1 virus (strain Washington/1957) (HPIV-1)
Taxonomic identifieri11211 [NCBI]
Taxonomic lineageiVirusesssRNA negative-strand virusesMononegaviralesParamyxoviridaeParamyxovirinaeRespirovirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]

Subcellular locationi

GO - Cellular componenti

  1. host cell plasma membrane Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
  3. viral envelope Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Host cell membrane, Host membrane, Membrane, Viral envelope protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 575575Hemagglutinin-neuraminidasePRO_0000142621Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi77 – 771N-linked (GlcNAc...); by hostSequence Analysis
Glycosylationi499 – 4991N-linked (GlcNAc...); by hostSequence Analysis
Glycosylationi511 – 5111N-linked (GlcNAc...); by hostSequence Analysis

Keywords - PTMi

Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliP16071.
SMRiP16071. Positions 144-572.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3434IntravirionSequence AnalysisAdd
BLAST
Topological domaini56 – 575520Virion surfaceSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei35 – 5521HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di2.120.10.10. 1 hit.
InterProiIPR000665. Hemagglutn-neuramid.
IPR016285. Hemagglutn-neuramid_paramyxo.
IPR011040. Sialidases.
[Graphical view]
PfamiPF00423. HN. 1 hit.
[Graphical view]
PIRSFiPIRSF001072. Hemagglut-neuramid_paramyxoV. 1 hit.
SUPFAMiSSF50939. SSF50939. 1 hit.

Sequencei

Sequence statusi: Complete.

P16071-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAEKGKTNSS YWSTTRNDNS TVNTYIDTPA GKTHIWLLIA TTMHTILSFI
60 70 80 90 100
IMILCIDLII KQDTCMKTNI MTVSSMNESA KTIKETITEL IRQEVISRTI
110 120 130 140 150
NIQSSVQSGI PILLNKQSRD LTQLIEKSCN RQELAQICEN TIAIHHADGI
160 170 180 190 200
SPLDPHDFWR CPVGEPLLSN NPNISLLPGP SLLSGSTTIS GCVRLPSLSI
210 220 230 240 250
GDAIYAYSSN LITQGCADIG KSYQVLQLGY ISLNSDMYPD LKPVISHTYD
260 270 280 290 300
INDNRKSCSV IAAGTRGYQL CSLPTVNETT DYSSEGIEDL VFDILDLKGK
310 320 330 340 350
TKSHRYKNED ITFDHPFSAM YPSVGSGIKI ENTLIFLGYG GLTTPLQGDT
360 370 380 390 400
KCVTNRCANV NQSVCNDALK ITWLKKRQVV NVLIRINNYL SDRPKIVVET
410 420 430 440 450
IPITQNYLGA EGRLLKLGKK IYIYTRSSGW HSHLQIGSLD INNPMTIKWA
460 470 480 490 500
PHEVLSRPGN QDCNWYNRCP RECISGVYTD AYPLSPDAVN VATTTLYANT
510 520 530 540 550
SRVNPTIMYS NTSEIINMLR LKNVQLEAAY TTTSCITHFG KGYCFHIVEI
560 570
NQTSLNTLQP MLFKTSIPKI CKITS
Length:575
Mass (Da):63,981
Last modified:February 1, 1996 - v2
Checksum:i63E55E481A0DB322
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M31228 Genomic RNA. Translation: AAA46798.1.
PIRiA34682. HNNZ39.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M31228 Genomic RNA. Translation: AAA46798.1 .
PIRi A34682. HNNZ39.

3D structure databases

ProteinModelPortali P16071.
SMRi P16071. Positions 144-572.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

CAZyi GH83. Glycoside Hydrolase Family 83.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 2.120.10.10. 1 hit.
InterProi IPR000665. Hemagglutn-neuramid.
IPR016285. Hemagglutn-neuramid_paramyxo.
IPR011040. Sialidases.
[Graphical view ]
Pfami PF00423. HN. 1 hit.
[Graphical view ]
PIRSFi PIRSF001072. Hemagglut-neuramid_paramyxoV. 1 hit.
SUPFAMi SSF50939. SSF50939. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The hemagglutinin-neuraminidase glycoproteins of human parainfluenza virus type 1 and Sendai virus have high structure-function similarity with limited antigenic cross-reactivity."
    Gorman W.L., Gill D.S., Scroggs R.A., Portner A.
    Virology 175:211-221(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Entry informationi

Entry nameiHN_PI1HW
AccessioniPrimary (citable) accession number: P16071
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: February 1, 1996
Last modified: October 29, 2014
This is version 93 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3