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Protein

CD44 antigen

Gene

CD44

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for hyaluronic acid (HA). Mediates cell-cell and cell-matrix interactions through its affinity for HA, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix metalloproteinases (MMPs). Adhesion with HA plays an important role in cell migration, tumor growth and progression. In cancer cells, may play an important role in invadopodia formation. Also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis. Altered expression or dysfunction causes numerous pathogenic phenotypes. Great protein heterogeneity due to numerous alternative splicing and post-translational modification events. Receptor for LGALS9; the interaction enhances binding of SMAD3 to the FOXP3 promoter, leading to up-regulation of FOXP3 expression and increased induced regulatory T (iTreg) cell stability and suppressive function (By similarity).By similarity1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei41HyaluronanBy similarity1
Binding sitei78HyaluronanBy similarity1
Binding sitei79HyaluronanBy similarity1
Binding sitei105HyaluronanBy similarity1

GO - Molecular functioni

  • collagen binding Source: UniProtKB
  • hyaluronic acid binding Source: UniProtKB

GO - Biological processi

  • cartilage development Source: UniProtKB
  • cell-matrix adhesion Source: UniProtKB
  • cellular response to fibroblast growth factor stimulus Source: UniProtKB
  • extracellular matrix disassembly Source: Reactome
  • extracellular matrix organization Source: Reactome
  • hyaluronan catabolic process Source: UniProtKB
  • interferon-gamma-mediated signaling pathway Source: Reactome
  • leukocyte migration Source: Reactome
  • monocyte aggregation Source: UniProtKB
  • negative regulation of apoptotic process Source: UniProtKB
  • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: UniProtKB
  • negative regulation of DNA damage response, signal transduction by p53 class mediator Source: BHF-UCL
  • negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator Source: BHF-UCL
  • positive regulation of ERK1 and ERK2 cascade Source: BHF-UCL
  • positive regulation of heterotypic cell-cell adhesion Source: UniProtKB
  • positive regulation of monocyte aggregation Source: BHF-UCL
  • positive regulation of peptidyl-serine phosphorylation Source: BHF-UCL
  • positive regulation of peptidyl-tyrosine phosphorylation Source: BHF-UCL
  • single organismal cell-cell adhesion Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Blood group antigen, Receptor

Keywords - Biological processi

Cell adhesion

Enzyme and pathway databases

BioCyciZFISH:ENSG00000026508-MONOMER.
ReactomeiR-HSA-1474228. Degradation of the extracellular matrix.
R-HSA-202733. Cell surface interactions at the vascular wall.
R-HSA-216083. Integrin cell surface interactions.
R-HSA-2160916. Hyaluronan uptake and degradation.
R-HSA-6798695. Neutrophil degranulation.
R-HSA-877300. Interferon gamma signaling.
SIGNORiP16070.

Names & Taxonomyi

Protein namesi
Recommended name:
CD44 antigen
Alternative name(s):
CDw44
Epican
Extracellular matrix receptor III
Short name:
ECMR-III
GP90 lymphocyte homing/adhesion receptor
HUTCH-I
Heparan sulfate proteoglycan
Hermes antigen
Hyaluronate receptor
Phagocytic glycoprotein 1
Short name:
PGP-1
Phagocytic glycoprotein I
Short name:
PGP-I
CD_antigen: CD44
Gene namesi
Name:CD44
Synonyms:LHR, MDU2, MDU3, MIC4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:1681. CD44.

Subcellular locationi

  • Cell membrane By similarity; Single-pass type I membrane protein By similarity

  • Note: Colocalizes with actin in membrane protrusions at wounding edges.By similarity

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini21 – 649ExtracellularSequence analysisAdd BLAST629
Transmembranei650 – 670HelicalSequence analysisAdd BLAST21
Topological domaini671 – 742CytoplasmicSequence analysisAdd BLAST72

GO - Cellular componenti

  • cell surface Source: UniProtKB
  • cytoplasm Source: HPA
  • extracellular exosome Source: UniProtKB
  • focal adhesion Source: UniProtKB
  • Golgi apparatus Source: HPA
  • integral component of plasma membrane Source: UniProtKB
  • macrophage migration inhibitory factor receptor complex Source: BHF-UCL
  • plasma membrane Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi960.
MIMi609027. phenotype.
OpenTargetsiENSG00000026508.
PharmGKBiPA26221.

Chemistry databases

ChEMBLiCHEMBL3232692.
DrugBankiDB08818. Hyaluronic acid.

Polymorphism and mutation databases

BioMutaiCD44.
DMDMi308153615.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20By similarityAdd BLAST20
ChainiPRO_000002668721 – 742CD44 antigenAdd BLAST722

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei21Pyrrolidone carboxylic acidCurated1
Glycosylationi25N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi28 ↔ 129PROSITE-ProRule annotation
Disulfide bondi53 ↔ 118PROSITE-ProRule annotation
Glycosylationi57N-linked (GlcNAc...)2 Publications1
Disulfide bondi77 ↔ 97PROSITE-ProRule annotation
Glycosylationi100N-linked (GlcNAc...)Sequence analysis1
Glycosylationi110N-linked (GlcNAc...)1 Publication1
Glycosylationi120N-linked (GlcNAc...)Sequence analysis1
Glycosylationi350N-linked (GlcNAc...)Sequence analysis1
Glycosylationi548N-linked (GlcNAc...)Sequence analysis1
Glycosylationi599N-linked (GlcNAc...)Sequence analysis1
Glycosylationi636N-linked (GlcNAc...)Sequence analysis1
Glycosylationi637O-linked (GalNAc...); or Thr-6381 Publication1
Glycosylationi638O-linked (GalNAc...); or Thr-6371 Publication1
Modified residuei672Phosphoserine; by PKC1 Publication1
Modified residuei686PhosphoserineCombined sources1
Modified residuei697PhosphoserineBy similarity1
Modified residuei706PhosphoserineCombined sources1 Publication1

Post-translational modificationi

Proteolytically cleaved in the extracellular matrix by specific proteinases (possibly MMPs) in several cell lines and tumors.1 Publication
N- and O-glycosylated. O-glycosylation contains more-or-less-sulfated chondroitin sulfate glycans, whose number may affect the accessibility of specific proteinases to their cleavage site(s). It is uncertain if O-glycosylation occurs on Thr-637 or Thr-638.4 Publications
Phosphorylated; activation of PKC results in the dephosphorylation of Ser-706 (constitutive phosphorylation site), and the phosphorylation of Ser-672.2 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein, Proteoglycan, Pyrrolidone carboxylic acid

Proteomic databases

EPDiP16070.
MaxQBiP16070.
PaxDbiP16070.
PeptideAtlasiP16070.
PRIDEiP16070.
TopDownProteomicsiP16070-12. [P16070-12]
P16070-14. [P16070-14]
P16070-18. [P16070-18]
P16070-4. [P16070-4]
P16070-7. [P16070-7]

2D gel databases

SWISS-2DPAGEP16070.

PTM databases

iPTMnetiP16070.
PhosphoSitePlusiP16070.
SwissPalmiP16070.
UniCarbKBiP16070.

Expressioni

Tissue specificityi

Isoform 10 (epithelial isoform) is expressed by cells of epithelium and highly expressed by carcinomas. Expression is repressed in neuroblastoma cells.

Gene expression databases

BgeeiENSG00000026508.
ExpressionAtlasiP16070. baseline and differential.
GenevisibleiP16070. HS.

Organism-specific databases

HPAiCAB000112.
CAB000316.
HPA005785.

Interactioni

Subunit structurei

Interacts with PKN2 (By similarity). Interacts with TIAM1 and TIAM2 (By similarity). Interacts with HA, as well as other glycosaminoglycans, collagen, laminin, and fibronectin via its N-terminal segment (PubMed:14992719, PubMed:17085435). Interacts with ANK, the ERM proteins (VIL2, RDX and MSN), and NF2 via its C-terminal segment. Interacts with UNC119 (PubMed:19381274).By similarity3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
ipaBP180114EBI-490245,EBI-490239From a different organism.
MSNP260386EBI-490245,EBI-528768
SLC7A11Q9UPY54EBI-490245,EBI-3843348
SPP1P104514EBI-490245,EBI-723648

GO - Molecular functioni

  • collagen binding Source: UniProtKB

Protein-protein interaction databases

BioGridi107398. 101 interactors.
DIPiDIP-1121N.
IntActiP16070. 53 interactors.
MINTiMINT-5000740.
STRINGi9606.ENSP00000398632.

Chemistry databases

BindingDBiP16070.

Structurei

Secondary structure

1742
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi21 – 26Combined sources6
Beta strandi33 – 38Combined sources6
Helixi46 – 55Combined sources10
Beta strandi57 – 59Combined sources3
Helixi63 – 71Combined sources9
Beta strandi80 – 82Combined sources3
Beta strandi85 – 92Combined sources8
Helixi98 – 100Combined sources3
Beta strandi103 – 106Combined sources4
Beta strandi109 – 111Combined sources3
Beta strandi114 – 119Combined sources6
Beta strandi121 – 123Combined sources3
Beta strandi125 – 128Combined sources4
Beta strandi130 – 132Combined sources3
Beta strandi139 – 148Combined sources10
Turni150 – 152Combined sources3
Beta strandi154 – 160Combined sources7
Helixi165 – 168Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1POZNMR-A20-178[»]
1UUHX-ray2.20A/B20-178[»]
2I83NMR-A21-178[»]
4PZ3X-ray1.08A/B18-170[»]
4PZ4X-ray1.60A/B18-171[»]
ProteinModelPortaliP16070.
SMRiP16070.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP16070.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini32 – 120LinkPROSITE-ProRule annotationAdd BLAST89

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni224 – 649StemAdd BLAST426

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi150 – 158Arg/Lys-rich (basic)9

Domaini

The lectin-like LINK domain is responsible for hyaluronan binding.By similarity

Sequence similaritiesi

Contains 1 Link domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IZCP. Eukaryota.
ENOG4111S6T. LUCA.
GeneTreeiENSGT00530000063822.
HOGENOMiHOG000115236.
HOVERGENiHBG003850.
InParanoidiP16070.
KOiK06256.
OMAiSHPMGRG.
OrthoDBiEOG091G0F98.
PhylomeDBiP16070.
TreeFamiTF334173.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR016186. C-type_lectin-like/link.
IPR001231. CD44_antigen.
IPR016187. CTDL_fold.
IPR000538. Link_dom.
[Graphical view]
PfamiPF00193. Xlink. 1 hit.
[Graphical view]
PRINTSiPR00658. CD44.
PR01265. LINKMODULE.
SMARTiSM00445. LINK. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS01241. LINK_1. 1 hit.
PS50963. LINK_2. 1 hit.
[Graphical view]

Sequences (19)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 19 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Additional isoforms seem to exist. Additional isoforms are produced by alternative splicing of 10 out of 19 exons within the extracellular domain. Additional diversity is generated through the utilization of internal splice donor and acceptor sites within 2 of the exons. A variation in the cytoplasmic domain was shown to result from the alternative splicing of 2 exons. Isoform CD44 is expected to be expressed in normal cells. Splice variants have been found in many tumor cell lines. Exons 5, 6, 7, 8, 9, 10, 11, 13, 14 and 19 are alternatively spliced. Experimental confirmation may be lacking for some isoforms.1 Publication
Isoform 1 (identifier: P16070-1) [UniParc]FASTAAdd to basket
Also known as: CD44

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDKFWWHAAW GLCLVPLSLA QIDLNITCRF AGVFHVEKNG RYSISRTEAA
60 70 80 90 100
DLCKAFNSTL PTMAQMEKAL SIGFETCRYG FIEGHVVIPR IHPNSICAAN
110 120 130 140 150
NTGVYILTSN TSQYDTYCFN ASAPPEEDCT SVTDLPNAFD GPITITIVNR
160 170 180 190 200
DGTRYVQKGE YRTNPEDIYP SNPTDDDVSS GSSSERSSTS GGYIFYTFST
210 220 230 240 250
VHPIPDEDSP WITDSTDRIP ATTLMSTSAT ATETATKRQE TWDWFSWLFL
260 270 280 290 300
PSESKNHLHT TTQMAGTSSN TISAGWEPNE ENEDERDRHL SFSGSGIDDD
310 320 330 340 350
EDFISSTIST TPRAFDHTKQ NQDWTQWNPS HSNPEVLLQT TTRMTDVDRN
360 370 380 390 400
GTTAYEGNWN PEAHPPLIHH EHHEEEETPH STSTIQATPS STTEETATQK
410 420 430 440 450
EQWFGNRWHE GYRQTPKEDS HSTTGTAAAS AHTSHPMQGR TTPSPEDSSW
460 470 480 490 500
TDFFNPISHP MGRGHQAGRR MDMDSSHSIT LQPTANPNTG LVEDLDRTGP
510 520 530 540 550
LSMTTQQSNS QSFSTSHEGL EEDKDHPTTS TLTSSNRNDV TGGRRDPNHS
560 570 580 590 600
EGSTTLLEGY TSHYPHTKES RTFIPVTSAK TGSFGVTAVT VGDSNSNVNR
610 620 630 640 650
SLSGDQDTFH PSGGSHTTHG SESDGHSHGS QEGGANTTSG PIRTPQIPEW
660 670 680 690 700
LIILASLLAL ALILAVCIAV NSRRRCGQKK KLVINSGNGA VEDRKPSGLN
710 720 730 740
GEASKSQEMV HLVNKESSET PDQFMTADET RNLQNVDMKI GV
Note: Corresponds to the largest isoform.
Length:742
Mass (Da):81,538
Last modified:October 5, 2010 - v3
Checksum:iBB9B66B19B970349
GO
Isoform 2 (identifier: P16070-2) [UniParc]FASTAAdd to basket
Also known as: CD44SP

The sequence of this isoform differs from the canonical sequence as follows:
     23-29: DLNITCR → GVGRRKS
     30-742: Missing.

Show »
Length:29
Mass (Da):3,327
Checksum:iFD28FA0E33AB08B9
GO
Isoform 3 (identifier: P16070-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     192-192: G → A
     193-223: Missing.

Note: Alternative splice donor/acceptor on exon 5.
Show »
Length:711
Mass (Da):77,983
Checksum:iEF48BFB8E4478B97
GO
Isoform 4 (identifier: P16070-4) [UniParc]FASTAAdd to basket
Also known as: Epidermal

The sequence of this isoform differs from the canonical sequence as follows:
     223-223: T → S
     224-266: Missing.

Note: Lacks exon 6.
Show »
Length:699
Mass (Da):76,612
Checksum:iCEC79496379F44FF
GO
Isoform 5 (identifier: P16070-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     266-273: Missing.

Note: Alternative splice donor/acceptor on exon 7.
Show »
Length:734
Mass (Da):80,790
Checksum:i48D27AD91375BCDC
GO
Isoform 6 (identifier: P16070-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     385-385: I → T
     386-428: Missing.

Note: Lacks exon 10.
Show »
Length:699
Mass (Da):76,705
Checksum:iA150D6FA11DAABD6
GO
Isoform 7 (identifier: P16070-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     506-506: Q → R
     507-535: Missing.

Note: Lacks exon 13.
Show »
Length:713
Mass (Da):78,446
Checksum:i2C2098B56FF4F30E
GO
Isoform 8 (identifier: P16070-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     536-536: N → R
     537-604: Missing.

Note: Lacks exon 14.
Show »
Length:674
Mass (Da):74,388
Checksum:i538CB559E671CF23
GO
Isoform 9 (identifier: P16070-9) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     675-675: R → S
     676-742: Missing.

Note: Lacks exon 19.
Show »
Length:675
Mass (Da):74,196
Checksum:i3891F679BC733F89
GO
Isoform 10 (identifier: P16070-10) [UniParc]FASTAAdd to basket
Also known as: CD44E, CD44R1, Epithelial, Keratinocyte

The sequence of this isoform differs from the canonical sequence as follows:
     223-223: T → N
     224-472: Missing.

Note: Lacks exons 6-11.
Show »
Length:493
Mass (Da):53,411
Checksum:iA494CCC37F161EF2
GO
Isoform 11 (identifier: P16070-11) [UniParc]FASTAAdd to basket
Also known as: CD44R2

The sequence of this isoform differs from the canonical sequence as follows:
     223-535: Missing.

Note: Lacks exons 6-13.
Show »
Length:429
Mass (Da):46,565
Checksum:i557BD4FED59E0867
GO
Isoform 12 (identifier: P16070-12) [UniParc]FASTAAdd to basket
Also known as: CDw44, Reticulocyte

The sequence of this isoform differs from the canonical sequence as follows:
     223-223: T → R
     224-604: Missing.

Note: Lacks exons 6-14.
Show »
Length:361
Mass (Da):39,416
Checksum:iF51A746B442E0D33
GO
Isoform 13 (identifier: P16070-13) [UniParc]FASTAAdd to basket
Also known as: CD44R4

The sequence of this isoform differs from the canonical sequence as follows:
     223-223: T → N
     224-472: Missing.
     536-536: N → R
     537-604: Missing.

Note: Lacks exons 6-11 and exon 14.
Show »
Length:425
Mass (Da):46,261
Checksum:i47F544DD9890917B
GO
Isoform 14 (identifier: P16070-14) [UniParc]FASTAAdd to basket
Also known as: CD44R5

The sequence of this isoform differs from the canonical sequence as follows:
     223-223: T → N
     224-472: Missing.
     506-506: Q → R
     507-535: Missing.
     536-536: N → R
     537-604: Missing.

Note: Lacks exons 6-11, exon 13 and exon 14.
Show »
Length:396
Mass (Da):43,169
Checksum:i5118DABF71C1F7D0
GO
Isoform 15 (identifier: P16070-15) [UniParc]FASTAAdd to basket
Also known as: Hermes

The sequence of this isoform differs from the canonical sequence as follows:
     223-223: T → R
     224-604: Missing.
     675-675: R → S
     676-742: Missing.

Note: Lacks exons 6-14 and exon 19.
Show »
Length:294
Mass (Da):32,075
Checksum:iE11B9B38F4A74817
GO
Isoform 16 (identifier: P16070-16) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     192-192: G → A
     193-223: Missing.
     385-385: I → T
     386-428: Missing.

Note: Alternative splice donor/acceptor on exon 5 and lacks exon 10.
Show »
Length:668
Mass (Da):73,150
Checksum:iD719820A01C4517F
GO
Isoform 17 (identifier: P16070-17) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     266-273: Missing.
     385-385: I → T
     386-428: Missing.

Note: Alternative splice donor/acceptor on exon 7 and lacks exon 10.
Show »
Length:691
Mass (Da):75,957
Checksum:i737967321EE8F579
GO
Isoform 18 (identifier: P16070-18) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     223-223: T → R
     224-604: Missing.
     605-625: Missing.

Note: No experimental confirmation available.
Show »
Length:340
Mass (Da):37,278
Checksum:iC2E036A7DAB5717B
GO
Isoform 19 (identifier: P16070-19) [UniParc]FASTAAdd to basket
Also known as: CD44RC

The sequence of this isoform differs from the canonical sequence as follows:
     78-139: RYGFIEGHVV...TSVTDLPNAF → SLHCSQQSKK...VRNSRPVYDS
     140-742: Missing.

Note: Soluble isoform, has enhanced hyaluronan binding.
Show »
Length:139
Mass (Da):15,635
Checksum:i4A127F5C54BB7B62
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti26I → M in AAA82949 (Ref. 10) Curated1
Sequence conflicti109S → Y in AAA35674 (PubMed:2466575).Curated1
Sequence conflicti109S → Y in AAA51950 (PubMed:1840487).Curated1
Sequence conflicti109S → Y in CAA38951 (PubMed:1991450).Curated1
Sequence conflicti109S → Y in CAB61878 (PubMed:7508842).Curated1
Sequence conflicti221A → R in CAA38951 (PubMed:1991450).Curated1
Sequence conflicti241T → A in CAB61878 (PubMed:7508842).Curated1
Sequence conflicti410E → V in CAA47271 (PubMed:1281868).Curated1
Sequence conflicti494D → N in CAB61878 (PubMed:7508842).Curated1
Sequence conflicti555T → H in CAA38951 (PubMed:1991450).Curated1
Sequence conflicti620G → E in AAA35674 (PubMed:2466575).Curated1
Sequence conflicti697S → I in AAM50041 (Ref. 11) Curated1
Sequence conflicti697S → I in AAH67348 (Ref. 16) Curated1

Polymorphismi

CD44 is responsible for the Indian blood group system. The molecular basis of the In(A)=In1/In(B)=In2 blood group antigens is a single variation in position 46; In(B), the most frequent allele, has Arg-46.1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_00649046R → P in In(A) antigen. 1 PublicationCorresponds to variant rs369473842dbSNPEnsembl.1
Natural variantiVAR_030325393T → M.Corresponds to variant rs11607491dbSNPEnsembl.1
Natural variantiVAR_021147417K → R.4 PublicationsCorresponds to variant rs9666607dbSNPEnsembl.1
Natural variantiVAR_030326479I → T.9 PublicationsCorresponds to variant rs1467558dbSNPEnsembl.1
Natural variantiVAR_030327494D → H.1 PublicationCorresponds to variant rs12273397dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00530323 – 29DLNITCR → GVGRRKS in isoform 2. 1 Publication7
Alternative sequenceiVSP_00530430 – 742Missing in isoform 2. 1 PublicationAdd BLAST713
Alternative sequenceiVSP_04387078 – 139RYGFI…LPNAF → SLHCSQQSKKVWAEEKASDQ QWQWSCGGQKAKWTQRRGQQ VSGNGAFGEQGVVRNSRPVY DS in isoform 19. 1 PublicationAdd BLAST62
Alternative sequenceiVSP_043871140 – 742Missing in isoform 19. 1 PublicationAdd BLAST603
Alternative sequenceiVSP_005305192G → A in isoform 3 and isoform 16. Curated1
Alternative sequenceiVSP_005306193 – 223Missing in isoform 3 and isoform 16. CuratedAdd BLAST31
Alternative sequenceiVSP_022797223 – 535Missing in isoform 11. 2 PublicationsAdd BLAST313
Alternative sequenceiVSP_005309223T → N in isoform 10, isoform 13 and isoform 14. 5 Publications1
Alternative sequenceiVSP_005311223T → R in isoform 12, isoform 15 and isoform 18. 8 Publications1
Alternative sequenceiVSP_005307223T → S in isoform 4. 2 Publications1
Alternative sequenceiVSP_005312224 – 604Missing in isoform 12, isoform 15 and isoform 18. 8 PublicationsAdd BLAST381
Alternative sequenceiVSP_005310224 – 472Missing in isoform 10, isoform 13 and isoform 14. 5 PublicationsAdd BLAST249
Alternative sequenceiVSP_005308224 – 266Missing in isoform 4. 2 PublicationsAdd BLAST43
Alternative sequenceiVSP_005313266 – 273Missing in isoform 5 and isoform 17. Curated8
Alternative sequenceiVSP_005314385I → T in isoform 6, isoform 16 and isoform 17. Curated1
Alternative sequenceiVSP_005315386 – 428Missing in isoform 6, isoform 16 and isoform 17. CuratedAdd BLAST43
Alternative sequenceiVSP_005316506Q → R in isoform 7 and isoform 14. 1 Publication1
Alternative sequenceiVSP_005317507 – 535Missing in isoform 7 and isoform 14. 1 PublicationAdd BLAST29
Alternative sequenceiVSP_005318536N → R in isoform 8, isoform 13 and isoform 14. 1 Publication1
Alternative sequenceiVSP_005319537 – 604Missing in isoform 8, isoform 13 and isoform 14. 1 PublicationAdd BLAST68
Alternative sequenceiVSP_043575605 – 625Missing in isoform 18. 1 PublicationAdd BLAST21
Alternative sequenceiVSP_005320675R → S in isoform 9 and isoform 15. 1 Publication1
Alternative sequenceiVSP_005321676 – 742Missing in isoform 9 and isoform 15. 1 PublicationAdd BLAST67

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M24915 mRNA. Translation: AAA35674.1.
M59040 mRNA. Translation: AAA51950.1.
X55150 mRNA. Translation: CAA38951.1.
X56794 mRNA. Translation: CAA40133.1.
X66733 mRNA. Translation: CAA47271.1.
L05423
, L05407, L05408, L05409, L05410, L05420, L05421, L05422, M69215 Genomic DNA. Translation: AAB13622.1.
L05423
, L05407, L05408, L05410, L05411, L05412, L05414, L05415, L05416, L05417, L05418, L05419, L05420, L05421, L05422, M69215 Genomic DNA. Translation: AAB13623.1.
L05424
, L05407, L05408, L05410, L05420, L05421, L05422, M69215 Genomic DNA. Translation: AAB13624.1.
L05424
, L05407, L05408, L05410, L05411, L05412, L05414, L05416, L05417, L05418, L05419, L05420, L05421, L05422, M69215 Genomic DNA. Translation: AAB13625.1.
L05424
, L05407, L05408, L05410, L05411, L05412, L05414, L05416, L05417, L05418, L05419, L05420, L05421, L05422, M69215 Genomic DNA. Translation: AAB13626.1.
L05424
, L05407, L05408, L05410, L05417, L05418, L05420, L05421, L05422, M69215 Genomic DNA. Translation: AAB13627.1.
L05424
, L05407, L05408, L05410, L05411, L05412, L05414, L05415, L05416, L05417, L05418, L05419, L05420, L05421, L05422, M69215 Genomic DNA. Translation: AAB13628.1.
AJ251595 mRNA. Translation: CAB61878.1.
S66400 mRNA. Translation: AAB27917.1.
S66400 mRNA. Translation: AAB27918.2.
S66400 mRNA. Translation: AAB27919.1.
AF098641 mRNA. Translation: AAC70782.1.
U40373 mRNA. Translation: AAA82949.1.
AY101192 mRNA. Translation: AAM50040.1.
AY101193 mRNA. Translation: AAM50041.1.
EF581837 mRNA. Translation: ABQ59315.1.
FJ216964 mRNA. Translation: ACI46596.1.
AL832642 mRNA. Translation: CAD89965.1.
AL133330 Genomic DNA. Translation: CAC10347.1.
AL136989 Genomic DNA. No translation available.
AL356215 Genomic DNA. No translation available.
CH471064 Genomic DNA. Translation: EAW68147.1.
CH471064 Genomic DNA. Translation: EAW68148.1.
CH471064 Genomic DNA. Translation: EAW68149.1.
CH471064 Genomic DNA. Translation: EAW68151.1.
CH471064 Genomic DNA. Translation: EAW68152.1.
BC004372 mRNA. Translation: AAH04372.1.
BC067348 mRNA. Translation: AAH67348.1.
M25078 mRNA. Translation: AAA36138.1.
X55938 mRNA. Translation: CAA39404.1.
S72928 Genomic DNA. Translation: AAB30429.1.
X62739 mRNA. Translation: CAA44602.1.
CCDSiCCDS31455.1. [P16070-4]
CCDS31456.1. [P16070-10]
CCDS31457.1. [P16070-12]
CCDS31458.1. [P16070-19]
CCDS55754.1. [P16070-11]
CCDS55755.1. [P16070-18]
CCDS7897.1. [P16070-1]
PIRiA47195.
I37369.
I77371.
I77372.
JH0417.
JH0518.
S13530.
S24222.
RefSeqiNP_000601.3. NM_000610.3. [P16070-1]
NP_001001389.1. NM_001001389.1. [P16070-4]
NP_001001390.1. NM_001001390.1. [P16070-10]
NP_001001391.1. NM_001001391.1. [P16070-12]
NP_001001392.1. NM_001001392.1. [P16070-19]
NP_001189484.1. NM_001202555.1. [P16070-11]
NP_001189485.1. NM_001202556.1. [P16070-18]
NP_001189486.1. NM_001202557.1. [P16070-15]
XP_011518790.1. XM_011520488.1. [P16070-13]
UniGeneiHs.502328.

Genome annotation databases

EnsembliENST00000263398; ENSP00000263398; ENSG00000026508. [P16070-12]
ENST00000278386; ENSP00000278386; ENSG00000026508. [P16070-19]
ENST00000352818; ENSP00000309732; ENSG00000026508. [P16070-18]
ENST00000415148; ENSP00000389830; ENSG00000026508. [P16070-4]
ENST00000428726; ENSP00000398632; ENSG00000026508. [P16070-1]
ENST00000433892; ENSP00000392331; ENSG00000026508. [P16070-10]
ENST00000434472; ENSP00000404447; ENSG00000026508. [P16070-11]
GeneIDi960.
KEGGihsa:960.
UCSCiuc001mvu.4. human. [P16070-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

dbRBC/BGMUT

Blood group antigen gene mutation database

Wikipedia

CD44 entry

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M24915 mRNA. Translation: AAA35674.1.
M59040 mRNA. Translation: AAA51950.1.
X55150 mRNA. Translation: CAA38951.1.
X56794 mRNA. Translation: CAA40133.1.
X66733 mRNA. Translation: CAA47271.1.
L05423
, L05407, L05408, L05409, L05410, L05420, L05421, L05422, M69215 Genomic DNA. Translation: AAB13622.1.
L05423
, L05407, L05408, L05410, L05411, L05412, L05414, L05415, L05416, L05417, L05418, L05419, L05420, L05421, L05422, M69215 Genomic DNA. Translation: AAB13623.1.
L05424
, L05407, L05408, L05410, L05420, L05421, L05422, M69215 Genomic DNA. Translation: AAB13624.1.
L05424
, L05407, L05408, L05410, L05411, L05412, L05414, L05416, L05417, L05418, L05419, L05420, L05421, L05422, M69215 Genomic DNA. Translation: AAB13625.1.
L05424
, L05407, L05408, L05410, L05411, L05412, L05414, L05416, L05417, L05418, L05419, L05420, L05421, L05422, M69215 Genomic DNA. Translation: AAB13626.1.
L05424
, L05407, L05408, L05410, L05417, L05418, L05420, L05421, L05422, M69215 Genomic DNA. Translation: AAB13627.1.
L05424
, L05407, L05408, L05410, L05411, L05412, L05414, L05415, L05416, L05417, L05418, L05419, L05420, L05421, L05422, M69215 Genomic DNA. Translation: AAB13628.1.
AJ251595 mRNA. Translation: CAB61878.1.
S66400 mRNA. Translation: AAB27917.1.
S66400 mRNA. Translation: AAB27918.2.
S66400 mRNA. Translation: AAB27919.1.
AF098641 mRNA. Translation: AAC70782.1.
U40373 mRNA. Translation: AAA82949.1.
AY101192 mRNA. Translation: AAM50040.1.
AY101193 mRNA. Translation: AAM50041.1.
EF581837 mRNA. Translation: ABQ59315.1.
FJ216964 mRNA. Translation: ACI46596.1.
AL832642 mRNA. Translation: CAD89965.1.
AL133330 Genomic DNA. Translation: CAC10347.1.
AL136989 Genomic DNA. No translation available.
AL356215 Genomic DNA. No translation available.
CH471064 Genomic DNA. Translation: EAW68147.1.
CH471064 Genomic DNA. Translation: EAW68148.1.
CH471064 Genomic DNA. Translation: EAW68149.1.
CH471064 Genomic DNA. Translation: EAW68151.1.
CH471064 Genomic DNA. Translation: EAW68152.1.
BC004372 mRNA. Translation: AAH04372.1.
BC067348 mRNA. Translation: AAH67348.1.
M25078 mRNA. Translation: AAA36138.1.
X55938 mRNA. Translation: CAA39404.1.
S72928 Genomic DNA. Translation: AAB30429.1.
X62739 mRNA. Translation: CAA44602.1.
CCDSiCCDS31455.1. [P16070-4]
CCDS31456.1. [P16070-10]
CCDS31457.1. [P16070-12]
CCDS31458.1. [P16070-19]
CCDS55754.1. [P16070-11]
CCDS55755.1. [P16070-18]
CCDS7897.1. [P16070-1]
PIRiA47195.
I37369.
I77371.
I77372.
JH0417.
JH0518.
S13530.
S24222.
RefSeqiNP_000601.3. NM_000610.3. [P16070-1]
NP_001001389.1. NM_001001389.1. [P16070-4]
NP_001001390.1. NM_001001390.1. [P16070-10]
NP_001001391.1. NM_001001391.1. [P16070-12]
NP_001001392.1. NM_001001392.1. [P16070-19]
NP_001189484.1. NM_001202555.1. [P16070-11]
NP_001189485.1. NM_001202556.1. [P16070-18]
NP_001189486.1. NM_001202557.1. [P16070-15]
XP_011518790.1. XM_011520488.1. [P16070-13]
UniGeneiHs.502328.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1POZNMR-A20-178[»]
1UUHX-ray2.20A/B20-178[»]
2I83NMR-A21-178[»]
4PZ3X-ray1.08A/B18-170[»]
4PZ4X-ray1.60A/B18-171[»]
ProteinModelPortaliP16070.
SMRiP16070.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107398. 101 interactors.
DIPiDIP-1121N.
IntActiP16070. 53 interactors.
MINTiMINT-5000740.
STRINGi9606.ENSP00000398632.

Chemistry databases

BindingDBiP16070.
ChEMBLiCHEMBL3232692.
DrugBankiDB08818. Hyaluronic acid.

PTM databases

iPTMnetiP16070.
PhosphoSitePlusiP16070.
SwissPalmiP16070.
UniCarbKBiP16070.

Polymorphism and mutation databases

BioMutaiCD44.
DMDMi308153615.

2D gel databases

SWISS-2DPAGEP16070.

Proteomic databases

EPDiP16070.
MaxQBiP16070.
PaxDbiP16070.
PeptideAtlasiP16070.
PRIDEiP16070.
TopDownProteomicsiP16070-12. [P16070-12]
P16070-14. [P16070-14]
P16070-18. [P16070-18]
P16070-4. [P16070-4]
P16070-7. [P16070-7]

Protocols and materials databases

DNASUi960.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000263398; ENSP00000263398; ENSG00000026508. [P16070-12]
ENST00000278386; ENSP00000278386; ENSG00000026508. [P16070-19]
ENST00000352818; ENSP00000309732; ENSG00000026508. [P16070-18]
ENST00000415148; ENSP00000389830; ENSG00000026508. [P16070-4]
ENST00000428726; ENSP00000398632; ENSG00000026508. [P16070-1]
ENST00000433892; ENSP00000392331; ENSG00000026508. [P16070-10]
ENST00000434472; ENSP00000404447; ENSG00000026508. [P16070-11]
GeneIDi960.
KEGGihsa:960.
UCSCiuc001mvu.4. human. [P16070-1]

Organism-specific databases

CTDi960.
DisGeNETi960.
GeneCardsiCD44.
HGNCiHGNC:1681. CD44.
HPAiCAB000112.
CAB000316.
HPA005785.
MIMi107269. gene.
172290. gene.
609027. phenotype.
neXtProtiNX_P16070.
OpenTargetsiENSG00000026508.
PharmGKBiPA26221.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IZCP. Eukaryota.
ENOG4111S6T. LUCA.
GeneTreeiENSGT00530000063822.
HOGENOMiHOG000115236.
HOVERGENiHBG003850.
InParanoidiP16070.
KOiK06256.
OMAiSHPMGRG.
OrthoDBiEOG091G0F98.
PhylomeDBiP16070.
TreeFamiTF334173.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000026508-MONOMER.
ReactomeiR-HSA-1474228. Degradation of the extracellular matrix.
R-HSA-202733. Cell surface interactions at the vascular wall.
R-HSA-216083. Integrin cell surface interactions.
R-HSA-2160916. Hyaluronan uptake and degradation.
R-HSA-6798695. Neutrophil degranulation.
R-HSA-877300. Interferon gamma signaling.
SIGNORiP16070.

Miscellaneous databases

ChiTaRSiCD44. human.
EvolutionaryTraceiP16070.
GeneWikiiCD44.
GenomeRNAii960.
PROiP16070.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000026508.
ExpressionAtlasiP16070. baseline and differential.
GenevisibleiP16070. HS.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR016186. C-type_lectin-like/link.
IPR001231. CD44_antigen.
IPR016187. CTDL_fold.
IPR000538. Link_dom.
[Graphical view]
PfamiPF00193. Xlink. 1 hit.
[Graphical view]
PRINTSiPR00658. CD44.
PR01265. LINKMODULE.
SMARTiSM00445. LINK. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS01241. LINK_1. 1 hit.
PS50963. LINK_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCD44_HUMAN
AccessioniPrimary (citable) accession number: P16070
Secondary accession number(s): A5YRN9
, B6EAT9, D3DR12, D3DR13, O95370, P22511, Q04858, Q13419, Q13957, Q13958, Q13959, Q13960, Q13961, Q13967, Q13968, Q13980, Q15861, Q16064, Q16065, Q16066, Q16208, Q16522, Q86T72, Q86Z27, Q8N694, Q92493, Q96J24, Q9H5A5, Q9UC28, Q9UC29, Q9UC30, Q9UCB0, Q9UJ36
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: October 5, 2010
Last modified: November 30, 2016
This is version 207 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Blood group antigen proteins
    Nomenclature of blood group antigens and list of entries
  2. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  3. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  7. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  8. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.