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P16070

- CD44_HUMAN

UniProt

P16070 - CD44_HUMAN

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Protein

CD44 antigen

Gene
CD44, LHR, MDU2, MDU3, MIC4
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Receptor for hyaluronic acid (HA). Mediates cell-cell and cell-matrix interactions through its affinity for HA, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix metalloproteinases (MMPs). Adhesion with HA plays an important role in cell migration, tumor growth and progression. In cancer cells, may play an important role in invadopodia formation. Also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis. Altered expression or dysfunction causes numerous pathogenic phenotypes. Great protein heterogeneity due to numerous alternative splicing and post-translational modification events.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei41 – 411Hyaluronan By similarity
Binding sitei78 – 781Hyaluronan By similarity
Binding sitei79 – 791Hyaluronan By similarity
Binding sitei105 – 1051Hyaluronan By similarity

GO - Molecular functioni

  1. collagen binding Source: UniProtKB
  2. hyaluronic acid binding Source: UniProtKB
  3. hyalurononglucosaminidase activity Source: UniProtKB
  4. protein binding Source: IntAct

GO - Biological processi

  1. blood coagulation Source: Reactome
  2. branching involved in prostate gland morphogenesis Source: Ensembl
  3. branching involved in ureteric bud morphogenesis Source: Ensembl
  4. carbohydrate metabolic process Source: Reactome
  5. cartilage development Source: UniProtKB
  6. cell-matrix adhesion Source: UniProtKB
  7. cellular response to fibroblast growth factor stimulus Source: UniProtKB
  8. cytokine-mediated signaling pathway Source: Reactome
  9. extracellular matrix disassembly Source: Reactome
  10. extracellular matrix organization Source: Reactome
  11. glycosaminoglycan metabolic process Source: Reactome
  12. hyaluronan catabolic process Source: UniProtKB
  13. hyaluronan metabolic process Source: Reactome
  14. interferon-gamma-mediated signaling pathway Source: Reactome
  15. leukocyte migration Source: Reactome
  16. monocyte aggregation Source: UniProtKB
  17. negative regulation of apoptotic process Source: UniProtKB
  18. negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: UniProtKB
  19. negative regulation of DNA damage response, signal transduction by p53 class mediator Source: BHF-UCL
  20. negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator Source: BHF-UCL
  21. positive regulation of ERK1 and ERK2 cascade Source: BHF-UCL
  22. positive regulation of gene expression Source: Ensembl
  23. positive regulation of heterotypic cell-cell adhesion Source: UniProtKB
  24. positive regulation of monocyte aggregation Source: BHF-UCL
  25. positive regulation of peptidyl-serine phosphorylation Source: BHF-UCL
  26. positive regulation of peptidyl-tyrosine phosphorylation Source: BHF-UCL
  27. single organismal cell-cell adhesion Source: UniProtKB
  28. small molecule metabolic process Source: Reactome
  29. Wnt signaling pathway Source: Ensembl
  30. wound healing involved in inflammatory response Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Blood group antigen, Receptor

Keywords - Biological processi

Cell adhesion

Enzyme and pathway databases

ReactomeiREACT_118572. Degradation of the extracellular matrix.
REACT_12051. Cell surface interactions at the vascular wall.
REACT_120996. Hyaluronan uptake and degradation.
REACT_13552. Integrin cell surface interactions.
REACT_25078. Interferon gamma signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
CD44 antigen
Alternative name(s):
CDw44
Epican
Extracellular matrix receptor III
Short name:
ECMR-III
GP90 lymphocyte homing/adhesion receptor
HUTCH-I
Heparan sulfate proteoglycan
Hermes antigen
Hyaluronate receptor
Phagocytic glycoprotein 1
Short name:
PGP-1
Phagocytic glycoprotein I
Short name:
PGP-I
CD_antigen: CD44
Gene namesi
Name:CD44
Synonyms:LHR, MDU2, MDU3, MIC4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:1681. CD44.

Subcellular locationi

Cell membrane; Single-pass type I membrane protein
Note: Colocalizes with actin in membrane protrusions at wounding edges By similarity.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini21 – 649629Extracellular Reviewed predictionAdd
BLAST
Transmembranei650 – 67021Helical; Reviewed predictionAdd
BLAST
Topological domaini671 – 74272Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. basolateral plasma membrane Source: Ensembl
  2. cell surface Source: UniProtKB
  3. cytoplasm Source: HPA
  4. external side of plasma membrane Source: Ensembl
  5. extracellular vesicular exosome Source: UniProt
  6. Golgi apparatus Source: HPA
  7. integral component of plasma membrane Source: UniProtKB
  8. plasma membrane Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

MIMi609027. phenotype.
PharmGKBiPA26221.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020 By similarityAdd
BLAST
Chaini21 – 742722CD44 antigenPRO_0000026687Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei21 – 211Pyrrolidone carboxylic acid Inferred
Glycosylationi25 – 251N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi28 ↔ 129 By similarity
Disulfide bondi53 ↔ 118 By similarity
Glycosylationi57 – 571N-linked (GlcNAc...)2 Publications
Disulfide bondi77 ↔ 97 By similarity
Glycosylationi100 – 1001N-linked (GlcNAc...) Reviewed prediction
Glycosylationi110 – 1101N-linked (GlcNAc...)1 Publication
Glycosylationi120 – 1201N-linked (GlcNAc...) Reviewed prediction
Glycosylationi350 – 3501N-linked (GlcNAc...) Reviewed prediction
Glycosylationi548 – 5481N-linked (GlcNAc...) Reviewed prediction
Glycosylationi599 – 5991N-linked (GlcNAc...) Reviewed prediction
Glycosylationi636 – 6361N-linked (GlcNAc...) Reviewed prediction
Glycosylationi637 – 6371O-linked (GalNAc...); or Thr-6381 Publication
Glycosylationi638 – 6381O-linked (GalNAc...); or Thr-6371 Publication
Modified residuei672 – 6721Phosphoserine; by PKC1 Publication
Modified residuei686 – 6861Phosphoserine2 Publications
Modified residuei697 – 6971Phosphoserine By similarity
Modified residuei706 – 7061Phosphoserine6 Publications

Post-translational modificationi

Proteolytically cleaved in the extracellular matrix by specific proteinases (possibly MMPs) in several cell lines and tumors.1 Publication
N- and O-glycosylated. O-glycosylation contains more-or-less-sulfated chondroitin sulfate glycans, whose number may affect the accessibility of specific proteinases to their cleavage site(s). It is uncertain if O-glycosylation occurs on Thr-637 or Thr-638.2 Publications
Phosphorylated; activation of PKC results in the dephosphorylation of Ser-706 (constitutive phosphorylation site), and the phosphorylation of Ser-672.2 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein, Proteoglycan, Pyrrolidone carboxylic acid

Proteomic databases

MaxQBiP16070.
PaxDbiP16070.
PRIDEiP16070.

2D gel databases

SWISS-2DPAGEP16070.

PTM databases

PhosphoSiteiP16070.

Expressioni

Tissue specificityi

Isoform 10 (epithelial isoform) is expressed by cells of epithelium and highly expressed by carcinomas. Expression is repressed in neuroblastoma cells.

Gene expression databases

ArrayExpressiP16070.
BgeeiP16070.
GenevestigatoriP16070.

Organism-specific databases

HPAiCAB000112.
CAB000316.
HPA005785.

Interactioni

Subunit structurei

Interacts with PKN2. Interacts with TIAM1 and TIAM2 By similarity. Interacts with HA, as well as other glycosaminoglycans, collagen, laminin, and fibronectin via its N-terminal segment. Interacts with ANK, the ERM proteins (VIL2, RDX and MSN), and NF2 via its C-terminal segment.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
ipaBP180114EBI-490245,EBI-490239From a different organism.
MSNP260386EBI-490245,EBI-528768
SLC7A11Q9UPY54EBI-490245,EBI-3843348
SPP1P104512EBI-490245,EBI-723648

Protein-protein interaction databases

BioGridi107398. 37 interactions.
DIPiDIP-1121N.
IntActiP16070. 16 interactions.
MINTiMINT-5000740.

Structurei

Secondary structure

1
742
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi21 – 266
Beta strandi33 – 386
Helixi46 – 5510
Beta strandi57 – 593
Helixi63 – 708
Turni71 – 733
Beta strandi80 – 823
Beta strandi85 – 928
Helixi98 – 1003
Beta strandi103 – 1064
Beta strandi109 – 1113
Beta strandi114 – 1196
Beta strandi121 – 1233
Beta strandi125 – 1284
Beta strandi130 – 1323
Beta strandi139 – 14810
Turni150 – 1523
Beta strandi154 – 1607
Helixi165 – 1684

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1POZNMR-A20-178[»]
1UUHX-ray2.20A/B20-178[»]
2I83NMR-A21-178[»]
ProteinModelPortaliP16070.
SMRiP16070. Positions 20-178.

Miscellaneous databases

EvolutionaryTraceiP16070.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini32 – 12089LinkAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni224 – 649426StemAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi150 – 1589Arg/Lys-rich (basic)

Domaini

The lectin-like LINK domain is responsible for hyaluronan binding By similarity.

Sequence similaritiesi

Contains 1 Link domain.

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG41023.
HOVERGENiHBG003850.
InParanoidiP16070.
KOiK06256.
OMAiSHPMGRG.
OrthoDBiEOG77HDFT.
PhylomeDBiP16070.
TreeFamiTF334173.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR016186. C-type_lectin-like.
IPR016187. C-type_lectin_fold.
IPR001231. CD44_antigen.
IPR000538. Link.
[Graphical view]
PfamiPF00193. Xlink. 1 hit.
[Graphical view]
PRINTSiPR00658. CD44.
PR01265. LINKMODULE.
SMARTiSM00445. LINK. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS01241. LINK_1. 1 hit.
PS50963. LINK_2. 1 hit.
[Graphical view]

Sequences (19)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 19 isoformsi produced by alternative splicing. Align

Note: Additional isoforms seem to exist. Additional isoforms are produced by alternative splicing of 10 out of 19 exons within the extracellular domain. Additional diversity is generated through the utilization of internal splice donor and acceptor sites within 2 of the exons. A variation in the cytoplasmic domain was shown to result from the alternative splicing of 2 exons. Isoform CD44 is expected to be expressed in normal cells. Splice variants have been found in many tumor cell lines. Exons 5, 6, 7, 8, 9, 10, 11, 13, 14 and 19 are alternatively spliced. Experimental confirmation may be lacking for some isoforms.

Isoform 1 (identifier: P16070-1) [UniParc]FASTAAdd to Basket

Also known as: CD44

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MDKFWWHAAW GLCLVPLSLA QIDLNITCRF AGVFHVEKNG RYSISRTEAA    50
DLCKAFNSTL PTMAQMEKAL SIGFETCRYG FIEGHVVIPR IHPNSICAAN 100
NTGVYILTSN TSQYDTYCFN ASAPPEEDCT SVTDLPNAFD GPITITIVNR 150
DGTRYVQKGE YRTNPEDIYP SNPTDDDVSS GSSSERSSTS GGYIFYTFST 200
VHPIPDEDSP WITDSTDRIP ATTLMSTSAT ATETATKRQE TWDWFSWLFL 250
PSESKNHLHT TTQMAGTSSN TISAGWEPNE ENEDERDRHL SFSGSGIDDD 300
EDFISSTIST TPRAFDHTKQ NQDWTQWNPS HSNPEVLLQT TTRMTDVDRN 350
GTTAYEGNWN PEAHPPLIHH EHHEEEETPH STSTIQATPS STTEETATQK 400
EQWFGNRWHE GYRQTPKEDS HSTTGTAAAS AHTSHPMQGR TTPSPEDSSW 450
TDFFNPISHP MGRGHQAGRR MDMDSSHSIT LQPTANPNTG LVEDLDRTGP 500
LSMTTQQSNS QSFSTSHEGL EEDKDHPTTS TLTSSNRNDV TGGRRDPNHS 550
EGSTTLLEGY TSHYPHTKES RTFIPVTSAK TGSFGVTAVT VGDSNSNVNR 600
SLSGDQDTFH PSGGSHTTHG SESDGHSHGS QEGGANTTSG PIRTPQIPEW 650
LIILASLLAL ALILAVCIAV NSRRRCGQKK KLVINSGNGA VEDRKPSGLN 700
GEASKSQEMV HLVNKESSET PDQFMTADET RNLQNVDMKI GV 742

Note: Corresponds to the largest isoform.

Length:742
Mass (Da):81,538
Last modified:October 5, 2010 - v3
Checksum:iBB9B66B19B970349
GO
Isoform 2 (identifier: P16070-2) [UniParc]FASTAAdd to Basket

Also known as: CD44SP

The sequence of this isoform differs from the canonical sequence as follows:
     23-29: DLNITCR → GVGRRKS
     30-742: Missing.

Show »
Length:29
Mass (Da):3,327
Checksum:iFD28FA0E33AB08B9
GO
Isoform 3 (identifier: P16070-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     192-192: G → A
     193-223: Missing.

Note: Alternative splice donor/acceptor on exon 5.

Show »
Length:711
Mass (Da):77,983
Checksum:iEF48BFB8E4478B97
GO
Isoform 4 (identifier: P16070-4) [UniParc]FASTAAdd to Basket

Also known as: Epidermal

The sequence of this isoform differs from the canonical sequence as follows:
     223-223: T → S
     224-266: Missing.

Note: Lacks exon 6.

Show »
Length:699
Mass (Da):76,612
Checksum:iCEC79496379F44FF
GO
Isoform 5 (identifier: P16070-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     266-273: Missing.

Note: Alternative splice donor/acceptor on exon 7.

Show »
Length:734
Mass (Da):80,790
Checksum:i48D27AD91375BCDC
GO
Isoform 6 (identifier: P16070-6) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     385-385: I → T
     386-428: Missing.

Note: Lacks exon 10.

Show »
Length:699
Mass (Da):76,705
Checksum:iA150D6FA11DAABD6
GO
Isoform 7 (identifier: P16070-7) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     506-506: Q → R
     507-535: Missing.

Note: Lacks exon 13.

Show »
Length:713
Mass (Da):78,446
Checksum:i2C2098B56FF4F30E
GO
Isoform 8 (identifier: P16070-8) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     536-536: N → R
     537-604: Missing.

Note: Lacks exon 14.

Show »
Length:674
Mass (Da):74,388
Checksum:i538CB559E671CF23
GO
Isoform 9 (identifier: P16070-9) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     675-675: R → S
     676-742: Missing.

Note: Lacks exon 19.

Show »
Length:675
Mass (Da):74,196
Checksum:i3891F679BC733F89
GO
Isoform 10 (identifier: P16070-10) [UniParc]FASTAAdd to Basket

Also known as: CD44E, CD44R1, Epithelial, Keratinocyte

The sequence of this isoform differs from the canonical sequence as follows:
     223-223: T → N
     224-472: Missing.

Note: Lacks exons 6-11.

Show »
Length:493
Mass (Da):53,411
Checksum:iA494CCC37F161EF2
GO
Isoform 11 (identifier: P16070-11) [UniParc]FASTAAdd to Basket

Also known as: CD44R2

The sequence of this isoform differs from the canonical sequence as follows:
     223-535: Missing.

Note: Lacks exons 6-13.

Show »
Length:429
Mass (Da):46,565
Checksum:i557BD4FED59E0867
GO
Isoform 12 (identifier: P16070-12) [UniParc]FASTAAdd to Basket

Also known as: CDw44, Reticulocyte

The sequence of this isoform differs from the canonical sequence as follows:
     223-223: T → R
     224-604: Missing.

Note: Lacks exons 6-14.

Show »
Length:361
Mass (Da):39,416
Checksum:iF51A746B442E0D33
GO
Isoform 13 (identifier: P16070-13) [UniParc]FASTAAdd to Basket

Also known as: CD44R4

The sequence of this isoform differs from the canonical sequence as follows:
     223-223: T → N
     224-472: Missing.
     536-536: N → R
     537-604: Missing.

Note: Lacks exons 6-11 and exon 14.

Show »
Length:425
Mass (Da):46,261
Checksum:i47F544DD9890917B
GO
Isoform 14 (identifier: P16070-14) [UniParc]FASTAAdd to Basket

Also known as: CD44R5

The sequence of this isoform differs from the canonical sequence as follows:
     223-223: T → N
     224-472: Missing.
     506-506: Q → R
     507-535: Missing.
     536-536: N → R
     537-604: Missing.

Note: Lacks exons 6-11, exon 13 and exon 14.

Show »
Length:396
Mass (Da):43,169
Checksum:i5118DABF71C1F7D0
GO
Isoform 15 (identifier: P16070-15) [UniParc]FASTAAdd to Basket

Also known as: Hermes

The sequence of this isoform differs from the canonical sequence as follows:
     223-223: T → R
     224-604: Missing.
     675-675: R → S
     676-742: Missing.

Note: Lacks exons 6-14 and exon 19.

Show »
Length:294
Mass (Da):32,075
Checksum:iE11B9B38F4A74817
GO
Isoform 16 (identifier: P16070-16) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     192-192: G → A
     193-223: Missing.
     385-385: I → T
     386-428: Missing.

Note: Alternative splice donor/acceptor on exon 5 and lacks exon 10.

Show »
Length:668
Mass (Da):73,150
Checksum:iD719820A01C4517F
GO
Isoform 17 (identifier: P16070-17) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     266-273: Missing.
     385-385: I → T
     386-428: Missing.

Note: Alternative splice donor/acceptor on exon 7 and lacks exon 10.

Show »
Length:691
Mass (Da):75,957
Checksum:i737967321EE8F579
GO
Isoform 18 (identifier: P16070-18) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     223-223: T → R
     224-604: Missing.
     605-625: Missing.

Note: No experimental confirmation available.

Show »
Length:340
Mass (Da):37,278
Checksum:iC2E036A7DAB5717B
GO
Isoform 19 (identifier: P16070-19) [UniParc]FASTAAdd to Basket

Also known as: CD44RC

The sequence of this isoform differs from the canonical sequence as follows:
     78-139: RYGFIEGHVV...TSVTDLPNAF → SLHCSQQSKK...VRNSRPVYDS
     140-742: Missing.

Note: Soluble isoform, has enhanced hyaluronan binding.

Show »
Length:139
Mass (Da):15,635
Checksum:i4A127F5C54BB7B62
GO

Polymorphismi

CD44 is responsible for the Indian blood group system. The molecular basis of the In(A)=In1/In(B)=In2 blood group antigens is a single variation in position 46; In(B), the most frequent allele, has Arg-46.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti46 – 461R → P in In(A) antigen. 1 Publication
VAR_006490
Natural varianti393 – 3931T → M.
Corresponds to variant rs11607491 [ dbSNP | Ensembl ].
VAR_030325
Natural varianti417 – 4171K → R.4 Publications
Corresponds to variant rs9666607 [ dbSNP | Ensembl ].
VAR_021147
Natural varianti479 – 4791I → T.9 Publications
Corresponds to variant rs1467558 [ dbSNP | Ensembl ].
VAR_030326
Natural varianti494 – 4941D → H.1 Publication
Corresponds to variant rs12273397 [ dbSNP | Ensembl ].
VAR_030327

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei23 – 297DLNITCR → GVGRRKS in isoform 2. VSP_005303
Alternative sequencei30 – 742713Missing in isoform 2. VSP_005304Add
BLAST
Alternative sequencei78 – 13962RYGFI…LPNAF → SLHCSQQSKKVWAEEKASDQ QWQWSCGGQKAKWTQRRGQQ VSGNGAFGEQGVVRNSRPVY DS in isoform 19. VSP_043870Add
BLAST
Alternative sequencei140 – 742603Missing in isoform 19. VSP_043871Add
BLAST
Alternative sequencei192 – 1921G → A in isoform 3 and isoform 16. VSP_005305
Alternative sequencei193 – 22331Missing in isoform 3 and isoform 16. VSP_005306Add
BLAST
Alternative sequencei223 – 535313Missing in isoform 11. VSP_022797Add
BLAST
Alternative sequencei223 – 2231T → N in isoform 10, isoform 13 and isoform 14. VSP_005309
Alternative sequencei223 – 2231T → R in isoform 12, isoform 15 and isoform 18. VSP_005311
Alternative sequencei223 – 2231T → S in isoform 4. VSP_005307
Alternative sequencei224 – 604381Missing in isoform 12, isoform 15 and isoform 18. VSP_005312Add
BLAST
Alternative sequencei224 – 472249Missing in isoform 10, isoform 13 and isoform 14. VSP_005310Add
BLAST
Alternative sequencei224 – 26643Missing in isoform 4. VSP_005308Add
BLAST
Alternative sequencei266 – 2738Missing in isoform 5 and isoform 17. VSP_005313
Alternative sequencei385 – 3851I → T in isoform 6, isoform 16 and isoform 17. VSP_005314
Alternative sequencei386 – 42843Missing in isoform 6, isoform 16 and isoform 17. VSP_005315Add
BLAST
Alternative sequencei506 – 5061Q → R in isoform 7 and isoform 14. VSP_005316
Alternative sequencei507 – 53529Missing in isoform 7 and isoform 14. VSP_005317Add
BLAST
Alternative sequencei536 – 5361N → R in isoform 8, isoform 13 and isoform 14. VSP_005318
Alternative sequencei537 – 60468Missing in isoform 8, isoform 13 and isoform 14. VSP_005319Add
BLAST
Alternative sequencei605 – 62521Missing in isoform 18. VSP_043575Add
BLAST
Alternative sequencei675 – 6751R → S in isoform 9 and isoform 15. VSP_005320
Alternative sequencei676 – 74267Missing in isoform 9 and isoform 15. VSP_005321Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti26 – 261I → M in AAA82949. 1 Publication
Sequence conflicti109 – 1091S → Y in AAA35674. 1 Publication
Sequence conflicti109 – 1091S → Y in AAA51950. 1 Publication
Sequence conflicti109 – 1091S → Y in CAA38951. 1 Publication
Sequence conflicti109 – 1091S → Y in CAB61878. 1 Publication
Sequence conflicti221 – 2211A → R in CAA38951. 1 Publication
Sequence conflicti241 – 2411T → A in CAB61878. 1 Publication
Sequence conflicti410 – 4101E → V in CAA47271. 1 Publication
Sequence conflicti494 – 4941D → N in CAB61878. 1 Publication
Sequence conflicti555 – 5551T → H in CAA38951. 1 Publication
Sequence conflicti620 – 6201G → E in AAA35674. 1 Publication
Sequence conflicti697 – 6971S → I in AAM50041. 1 Publication
Sequence conflicti697 – 6971S → I in AAH67348. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M24915 mRNA. Translation: AAA35674.1.
M59040 mRNA. Translation: AAA51950.1.
X55150 mRNA. Translation: CAA38951.1.
X56794 mRNA. Translation: CAA40133.1.
X66733 mRNA. Translation: CAA47271.1.
L05423
, L05407, L05408, L05409, L05410, L05420, L05421, L05422, M69215 Genomic DNA. Translation: AAB13622.1.
L05423
, L05407, L05408, L05410, L05411, L05412, L05414, L05415, L05416, L05417, L05418, L05419, L05420, L05421, L05422, M69215 Genomic DNA. Translation: AAB13623.1.
L05424
, L05407, L05408, L05410, L05420, L05421, L05422, M69215 Genomic DNA. Translation: AAB13624.1.
L05424
, L05407, L05408, L05410, L05411, L05412, L05414, L05416, L05417, L05418, L05419, L05420, L05421, L05422, M69215 Genomic DNA. Translation: AAB13625.1.
L05424
, L05407, L05408, L05410, L05411, L05412, L05414, L05416, L05417, L05418, L05419, L05420, L05421, L05422, M69215 Genomic DNA. Translation: AAB13626.1.
L05424
, L05407, L05408, L05410, L05417, L05418, L05420, L05421, L05422, M69215 Genomic DNA. Translation: AAB13627.1.
L05424
, L05407, L05408, L05410, L05411, L05412, L05414, L05415, L05416, L05417, L05418, L05419, L05420, L05421, L05422, M69215 Genomic DNA. Translation: AAB13628.1.
AJ251595 mRNA. Translation: CAB61878.1.
S66400 mRNA. Translation: AAB27917.1.
S66400 mRNA. Translation: AAB27918.2.
S66400 mRNA. Translation: AAB27919.1.
AF098641 mRNA. Translation: AAC70782.1.
U40373 mRNA. Translation: AAA82949.1.
AY101192 mRNA. Translation: AAM50040.1.
AY101193 mRNA. Translation: AAM50041.1.
EF581837 mRNA. Translation: ABQ59315.1.
FJ216964 mRNA. Translation: ACI46596.1.
AL832642 mRNA. Translation: CAD89965.1.
AL133330 Genomic DNA. Translation: CAC10347.1.
AL136989 Genomic DNA. No translation available.
AL356215 Genomic DNA. No translation available.
CH471064 Genomic DNA. Translation: EAW68147.1.
CH471064 Genomic DNA. Translation: EAW68148.1.
CH471064 Genomic DNA. Translation: EAW68149.1.
CH471064 Genomic DNA. Translation: EAW68151.1.
CH471064 Genomic DNA. Translation: EAW68152.1.
BC004372 mRNA. Translation: AAH04372.1.
BC067348 mRNA. Translation: AAH67348.1.
M25078 mRNA. Translation: AAA36138.1.
X55938 mRNA. Translation: CAA39404.1.
S72928 Genomic DNA. Translation: AAB30429.1.
X62739 mRNA. Translation: CAA44602.1.
CCDSiCCDS31455.1. [P16070-4]
CCDS31456.1. [P16070-10]
CCDS31457.1. [P16070-12]
CCDS31458.1. [P16070-19]
CCDS55754.1. [P16070-11]
CCDS55755.1. [P16070-18]
CCDS7897.1. [P16070-1]
PIRiA47195.
I37369.
I77371.
I77372.
JH0417.
JH0518.
S13530.
S24222.
RefSeqiNP_000601.3. NM_000610.3. [P16070-1]
NP_001001389.1. NM_001001389.1. [P16070-4]
NP_001001390.1. NM_001001390.1. [P16070-10]
NP_001001391.1. NM_001001391.1. [P16070-12]
NP_001001392.1. NM_001001392.1. [P16070-19]
NP_001189484.1. NM_001202555.1. [P16070-11]
NP_001189485.1. NM_001202556.1. [P16070-18]
NP_001189486.1. NM_001202557.1. [P16070-15]
UniGeneiHs.502328.

Genome annotation databases

EnsembliENST00000263398; ENSP00000263398; ENSG00000026508. [P16070-12]
ENST00000278386; ENSP00000278386; ENSG00000026508. [P16070-19]
ENST00000352818; ENSP00000309732; ENSG00000026508. [P16070-18]
ENST00000360158; ENSP00000353280; ENSG00000026508. [P16070-14]
ENST00000415148; ENSP00000389830; ENSG00000026508. [P16070-4]
ENST00000428726; ENSP00000398632; ENSG00000026508. [P16070-1]
ENST00000433892; ENSP00000392331; ENSG00000026508. [P16070-10]
ENST00000434472; ENSP00000404447; ENSG00000026508. [P16070-11]
ENST00000437706; ENSP00000403990; ENSG00000026508. [P16070-8]
ENST00000449691; ENSP00000391008; ENSG00000026508. [P16070-6]
GeneIDi960.
KEGGihsa:960.
UCSCiuc001mvu.3. human. [P16070-1]
uc001mvv.3. human. [P16070-4]
uc001mvw.3. human. [P16070-10]
uc001mvx.3. human. [P16070-12]
uc001mvy.3. human. [P16070-19]
uc001mwc.4. human. [P16070-11]
uc010rer.2. human. [P16070-18]
uc021qfw.1. human. [P16070-15]

Polymorphism databases

DMDMi308153615.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

dbRBC/BGMUT

Blood group antigen gene mutation database

Wikipedia

CD44 entry

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M24915 mRNA. Translation: AAA35674.1 .
M59040 mRNA. Translation: AAA51950.1 .
X55150 mRNA. Translation: CAA38951.1 .
X56794 mRNA. Translation: CAA40133.1 .
X66733 mRNA. Translation: CAA47271.1 .
L05423
, L05407 , L05408 , L05409 , L05410 , L05420 , L05421 , L05422 , M69215 Genomic DNA. Translation: AAB13622.1 .
L05423
, L05407 , L05408 , L05410 , L05411 , L05412 , L05414 , L05415 , L05416 , L05417 , L05418 , L05419 , L05420 , L05421 , L05422 , M69215 Genomic DNA. Translation: AAB13623.1 .
L05424
, L05407 , L05408 , L05410 , L05420 , L05421 , L05422 , M69215 Genomic DNA. Translation: AAB13624.1 .
L05424
, L05407 , L05408 , L05410 , L05411 , L05412 , L05414 , L05416 , L05417 , L05418 , L05419 , L05420 , L05421 , L05422 , M69215 Genomic DNA. Translation: AAB13625.1 .
L05424
, L05407 , L05408 , L05410 , L05411 , L05412 , L05414 , L05416 , L05417 , L05418 , L05419 , L05420 , L05421 , L05422 , M69215 Genomic DNA. Translation: AAB13626.1 .
L05424
, L05407 , L05408 , L05410 , L05417 , L05418 , L05420 , L05421 , L05422 , M69215 Genomic DNA. Translation: AAB13627.1 .
L05424
, L05407 , L05408 , L05410 , L05411 , L05412 , L05414 , L05415 , L05416 , L05417 , L05418 , L05419 , L05420 , L05421 , L05422 , M69215 Genomic DNA. Translation: AAB13628.1 .
AJ251595 mRNA. Translation: CAB61878.1 .
S66400 mRNA. Translation: AAB27917.1 .
S66400 mRNA. Translation: AAB27918.2 .
S66400 mRNA. Translation: AAB27919.1 .
AF098641 mRNA. Translation: AAC70782.1 .
U40373 mRNA. Translation: AAA82949.1 .
AY101192 mRNA. Translation: AAM50040.1 .
AY101193 mRNA. Translation: AAM50041.1 .
EF581837 mRNA. Translation: ABQ59315.1 .
FJ216964 mRNA. Translation: ACI46596.1 .
AL832642 mRNA. Translation: CAD89965.1 .
AL133330 Genomic DNA. Translation: CAC10347.1 .
AL136989 Genomic DNA. No translation available.
AL356215 Genomic DNA. No translation available.
CH471064 Genomic DNA. Translation: EAW68147.1 .
CH471064 Genomic DNA. Translation: EAW68148.1 .
CH471064 Genomic DNA. Translation: EAW68149.1 .
CH471064 Genomic DNA. Translation: EAW68151.1 .
CH471064 Genomic DNA. Translation: EAW68152.1 .
BC004372 mRNA. Translation: AAH04372.1 .
BC067348 mRNA. Translation: AAH67348.1 .
M25078 mRNA. Translation: AAA36138.1 .
X55938 mRNA. Translation: CAA39404.1 .
S72928 Genomic DNA. Translation: AAB30429.1 .
X62739 mRNA. Translation: CAA44602.1 .
CCDSi CCDS31455.1. [P16070-4 ]
CCDS31456.1. [P16070-10 ]
CCDS31457.1. [P16070-12 ]
CCDS31458.1. [P16070-19 ]
CCDS55754.1. [P16070-11 ]
CCDS55755.1. [P16070-18 ]
CCDS7897.1. [P16070-1 ]
PIRi A47195.
I37369.
I77371.
I77372.
JH0417.
JH0518.
S13530.
S24222.
RefSeqi NP_000601.3. NM_000610.3. [P16070-1 ]
NP_001001389.1. NM_001001389.1. [P16070-4 ]
NP_001001390.1. NM_001001390.1. [P16070-10 ]
NP_001001391.1. NM_001001391.1. [P16070-12 ]
NP_001001392.1. NM_001001392.1. [P16070-19 ]
NP_001189484.1. NM_001202555.1. [P16070-11 ]
NP_001189485.1. NM_001202556.1. [P16070-18 ]
NP_001189486.1. NM_001202557.1. [P16070-15 ]
UniGenei Hs.502328.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1POZ NMR - A 20-178 [» ]
1UUH X-ray 2.20 A/B 20-178 [» ]
2I83 NMR - A 21-178 [» ]
ProteinModelPortali P16070.
SMRi P16070. Positions 20-178.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 107398. 37 interactions.
DIPi DIP-1121N.
IntActi P16070. 16 interactions.
MINTi MINT-5000740.

Chemistry

DrugBanki DB00070. Hyaluronidase.

PTM databases

PhosphoSitei P16070.

Polymorphism databases

DMDMi 308153615.

2D gel databases

SWISS-2DPAGE P16070.

Proteomic databases

MaxQBi P16070.
PaxDbi P16070.
PRIDEi P16070.

Protocols and materials databases

DNASUi 960.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000263398 ; ENSP00000263398 ; ENSG00000026508 . [P16070-12 ]
ENST00000278386 ; ENSP00000278386 ; ENSG00000026508 . [P16070-19 ]
ENST00000352818 ; ENSP00000309732 ; ENSG00000026508 . [P16070-18 ]
ENST00000360158 ; ENSP00000353280 ; ENSG00000026508 . [P16070-14 ]
ENST00000415148 ; ENSP00000389830 ; ENSG00000026508 . [P16070-4 ]
ENST00000428726 ; ENSP00000398632 ; ENSG00000026508 . [P16070-1 ]
ENST00000433892 ; ENSP00000392331 ; ENSG00000026508 . [P16070-10 ]
ENST00000434472 ; ENSP00000404447 ; ENSG00000026508 . [P16070-11 ]
ENST00000437706 ; ENSP00000403990 ; ENSG00000026508 . [P16070-8 ]
ENST00000449691 ; ENSP00000391008 ; ENSG00000026508 . [P16070-6 ]
GeneIDi 960.
KEGGi hsa:960.
UCSCi uc001mvu.3. human. [P16070-1 ]
uc001mvv.3. human. [P16070-4 ]
uc001mvw.3. human. [P16070-10 ]
uc001mvx.3. human. [P16070-12 ]
uc001mvy.3. human. [P16070-19 ]
uc001mwc.4. human. [P16070-11 ]
uc010rer.2. human. [P16070-18 ]
uc021qfw.1. human. [P16070-15 ]

Organism-specific databases

CTDi 960.
GeneCardsi GC11P035116.
HGNCi HGNC:1681. CD44.
HPAi CAB000112.
CAB000316.
HPA005785.
MIMi 107269. gene.
172290. gene.
609027. phenotype.
neXtProti NX_P16070.
PharmGKBi PA26221.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG41023.
HOVERGENi HBG003850.
InParanoidi P16070.
KOi K06256.
OMAi SHPMGRG.
OrthoDBi EOG77HDFT.
PhylomeDBi P16070.
TreeFami TF334173.

Enzyme and pathway databases

Reactomei REACT_118572. Degradation of the extracellular matrix.
REACT_12051. Cell surface interactions at the vascular wall.
REACT_120996. Hyaluronan uptake and degradation.
REACT_13552. Integrin cell surface interactions.
REACT_25078. Interferon gamma signaling.

Miscellaneous databases

ChiTaRSi CD44. human.
EvolutionaryTracei P16070.
GeneWikii CD44.
GenomeRNAii 960.
NextBioi 4000.
PROi P16070.
SOURCEi Search...

Gene expression databases

ArrayExpressi P16070.
Bgeei P16070.
Genevestigatori P16070.

Family and domain databases

Gene3Di 3.10.100.10. 1 hit.
InterProi IPR016186. C-type_lectin-like.
IPR016187. C-type_lectin_fold.
IPR001231. CD44_antigen.
IPR000538. Link.
[Graphical view ]
Pfami PF00193. Xlink. 1 hit.
[Graphical view ]
PRINTSi PR00658. CD44.
PR01265. LINKMODULE.
SMARTi SM00445. LINK. 1 hit.
[Graphical view ]
SUPFAMi SSF56436. SSF56436. 1 hit.
PROSITEi PS01241. LINK_1. 1 hit.
PS50963. LINK_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A lymphocyte molecule implicated in lymph node homing is a member of the cartilage link protein family."
    Stamenkovic I., Amiot M., Pesando J.M., Seed B.
    Cell 56:1057-1062(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 12).
  2. "The multispecific cell adhesion molecule CD44 is represented in reticulocyte cDNA."
    Harn H.-J., Isola N., Cooper D.L.
    Biochem. Biophys. Res. Commun. 178:1127-1134(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 12).
    Tissue: Reticulocyte.
  3. "The hematopoietic and epithelial forms of CD44 are distinct polypeptides with different adhesion potentials for hyaluronate-bearing cells."
    Stamenkovic I., Aruffo A., Amiot M., Seed B.
    EMBO J. 10:343-348(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 10), VARIANT THR-479.
  4. "Molecular cloning of CD44R1 and CD44R2, two novel isoforms of the human CD44 lymphocyte 'homing' receptor expressed by hemopoietic cells."
    Dougherty G.J., Lansdorp P.M., Cooper D.L., Humphries R.K.
    J. Exp. Med. 174:1-5(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 10 AND 11), VARIANT THR-479.
    Tissue: Myeloid leukemia cell.
  5. "The core protein of epican, a heparan sulfate proteoglycan on keratinocytes, is an alternative form of CD44."
    Kugelman L.C., Ganguly S., Haggerty J.G., Weissman S.M., Milstone L.M.
    J. Invest. Dermatol. 99:886-891(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4), VARIANT THR-479.
    Tissue: Keratinocyte.
  6. "Genomic structure of DNA encoding the lymphocyte homing receptor CD44 reveals at least 12 alternatively spliced exons."
    Screaton G.R., Bell M.V., Jackson D.G., Cornelis F.B., Gerth U., Bell J.I.
    Proc. Natl. Acad. Sci. U.S.A. 89:12160-12164(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING, VARIANTS ARG-417 AND THR-479.
    Tissue: Lymphoblast.
  7. "CD44: a multitude of isoforms with diverse functions."
    Gunthert U.
    Curr. Top. Microbiol. Immunol. 184:47-63(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANTS ARG-417; THR-479 AND HIS-494.
  8. "Novel variants of CD44 arising from alternative splicing: changes in the CD44 alternative splicing pattern of MCF-7 breast carcinoma cells treated with hyaluronidase."
    Tanabe K.K., Nishi T., Saya H.
    Mol. Carcinog. 7:212-220(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2; 13 AND 14), VARIANT THR-479.
    Tissue: Mammary carcinoma.
  9. "Identification and characterization of CD44RC, a novel alternatively spliced soluble CD44 isoform that can potentiate the hyaluronan binding activity of cell surface CD44."
    Chiu R.K., Carpenito C., Dougherty S.T., Hayes G.M., Dougherty G.J.
    Neoplasia 1:446-452(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 19).
  10. "CD44 in normal and neoplastic human cartilage."
    Bosch P.P., Stevens J.W., Buckwalter J.A., Midura R.J.
    Submitted (DEC-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 12).
    Tissue: Articular cartilage.
  11. "Sequence analysis of the human CD44 antigen."
    Wiebe G.J., Freund D., Corbeil D.
    Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 10 AND 12), VARIANT THR-479.
    Tissue: Colon adenocarcinoma and Retinal pigment epithelium.
  12. "Sequence analysis of a novel human CD44 variant."
    Xiang Q., Wang J., Fan C., He X., Huang L., Zhu H., Qiu X., Luo W.
    Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 11).
  13. "Construction of human CD44 eukaryotic vector and its expression in mammary carcinoma cells MCF-7."
    Fang X., Xu W., Zhang X.
    Submitted (SEP-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 18).
  14. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 12).
    Tissue: Spinal cord.
  15. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  16. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  17. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 4 AND 12), VARIANTS ARG-417 AND THR-479.
    Tissue: Pancreas and Retinal pigment epithelium.
  18. "Expression of CD44 is repressed in neuroblastoma cells."
    Shtivelman E., Bishop J.M.
    Mol. Cell. Biol. 11:5446-5453(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-22.
    Tissue: Lymphoblast.
  19. "A human lymphocyte homing receptor, the hermes antigen, is related to cartilage proteoglycan core and link proteins."
    Goldstein L.A., Zhou D.F.H., Picker L.J., Minty C.N., Bargatze R.F., Ding J.F., Butcher E.C.
    Cell 56:1063-1072(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 2-742 (ISOFORM 15).
  20. "Anti-(glioma surface antigen) monoclonal antibody G-22 recognizes overexpressed CD44 in glioma cells."
    Okada H., Yoshida J., Seo H., Wakabayashi T., Sugita K., Hagiwara M.
    Cancer Immunol. Immunother. 39:313-317(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 55-108.
    Tissue: Glial tumor.
  21. "A monoclonal antibody that blocks poliovirus attachment recognizes the lymphocyte homing receptor CD44."
    Shepley M.P., Racaniello V.R.
    J. Virol. 68:1301-1308(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 67-89.
    Tissue: Peripheral blood.
  22. "Human keratinocytes express a new CD44 core protein (CD44E) as a heparan-sulfate intrinsic membrane proteoglycan with additional exons."
    Brown T.A., Bouchard T., St John T., Wayner E., Carter W.G.
    J. Cell Biol. 113:207-221(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 184-625 (ISOFORM 10), VARIANT THR-479.
    Tissue: Foreskin.
  23. "Non-invasive detection of malignancy by identification of unusual CD44 gene activity in exfoliated cancer cells."
    Matsumura Y., Hanbury D., Smith J., Tarin D.
    BMJ 308:619-624(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 221-267.
  24. "CD44 splice variants confer metastatic behavior in rats: homologous sequences are expressed in human tumor cell lines."
    Hofmann M., Rudy W., Zoeller M., Toelg C., Ponta H., Herrlich P., Guenthert U.
    Cancer Res. 51:5292-5297(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 267-603 (ISOFORM 1), VARIANT ARG-417.
    Tissue: Lung.
  25. "CD44: from adhesion molecules to signalling regulators."
    Ponta H., Sherman L., Herrlich P.A.
    Nat. Rev. Mol. Cell Biol. 4:33-45(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW ON FUNCTION, POST-TRANSLATIONAL MODIFICATIONS.
  26. "Hyaluronan-dependent cell migration can be blocked by a CD44 cytoplasmic domain peptide containing a phosphoserine at position 325."
    Peck D., Isacke C.M.
    J. Cell Sci. 111:1595-1601(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION AT SER-706.
  27. "A novel PKC-regulated mechanism controls CD44 ezrin association and directional cell motility."
    Legg J.W., Lewis C.A., Parsons M., Ng T., Isacke C.M.
    Nat. Cell Biol. 4:399-407(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION AT SER-672.
  28. "CD44s adhesive function spontaneous and PMA-inducible CD44 cleavage are regulated at post-translational level in cells of melanocytic lineage."
    Bartolazzi A.
    Melanoma Res. 13:325-337(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION, PROTEOLYTIC PROCESSING.
  29. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
    Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.
    J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-57.
    Tissue: Plasma.
  30. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-686 AND SER-706, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  31. "RNA-binding IMPs promote cell adhesion and invadopodia formation."
    Vikesaa J., Hansen T.V., Joenson L., Borup R., Wewer U.M., Christiansen J., Nielsen F.C.
    EMBO J. 25:1456-1468(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  32. "Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment."
    Carrascal M., Ovelleiro D., Casas V., Gay M., Abian J.
    J. Proteome Res. 7:5167-5176(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-706, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: T-cell.
  33. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
    Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
    Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-706, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  34. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  35. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
    Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
    J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-57 AND ASN-110.
    Tissue: Liver.
  36. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  37. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-686 AND SER-706, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  38. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  39. "Human urinary glycoproteomics; attachment site specific analysis of N-and O-linked glycosylations by CID and ECD."
    Halim A., Nilsson J., Ruetschi U., Hesse C., Larson G.
    Mol. Cell. Proteomics 0:0-0(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION AT THR-637 AND THR-638, STRUCTURE OF CARBOHYDRATES, IDENTIFICATION BY MASS SPECTROMETRY.
  40. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-706, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  41. "Structure of the regulatory hyaluronan binding domain in the inflammatory leukocyte homing receptor CD44."
    Teriete P., Banerji S., Noble M., Blundell C.D., Wright A.J., Pickford A.R., Lowe E., Mahoney D.J., Tammi M.I., Kahmann J.D., Campbell I.D., Day A.J., Jackson D.G.
    Mol. Cell 13:483-496(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 20-178, STRUCTURE BY NMR OF 20-178, INTERACTION WITH HA.
  42. "Ligand-induced structural changes of the CD44 hyaluronan-binding domain revealed by NMR."
    Takeda M., Ogino S., Umemoto R., Sakakura M., Kajiwara M., Sugahara K.N., Hayasaka H., Miyasaka M., Terasawa H., Shimada I.
    J. Biol. Chem. 281:40089-40095(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 20-178 IN COMPLEX WITH HA.
  43. "A blood group-related polymorphism of CD44 abolishes a hyaluronan-binding consensus sequence without preventing hyaluronan binding."
    Telen M.J., Udani M., Washington M.K., Levesque M.C., Lloyd E., Rao N.
    J. Biol. Chem. 271:7147-7153(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT BLOOD GROUP INDIAN PRO-46.

Entry informationi

Entry nameiCD44_HUMAN
AccessioniPrimary (citable) accession number: P16070
Secondary accession number(s): A5YRN9
, B6EAT9, D3DR12, D3DR13, O95370, P22511, Q04858, Q13419, Q13957, Q13958, Q13959, Q13960, Q13961, Q13967, Q13968, Q13980, Q15861, Q16064, Q16065, Q16066, Q16208, Q16522, Q86T72, Q86Z27, Q8N694, Q92493, Q96J24, Q9H5A5, Q9UC28, Q9UC29, Q9UC30, Q9UCB0, Q9UJ36
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: October 5, 2010
Last modified: September 3, 2014
This is version 182 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Blood group antigen proteins
    Nomenclature of blood group antigens and list of entries
  2. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  3. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  7. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  8. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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