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Protein

Estrogen receptor

Gene

esr1

Organism
Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.

Miscellaneous

In the absence of ligand, steroid hormone receptors are thought to be weakly associated with nuclear components; hormone binding greatly increases receptor affinity. The hormone-receptor complex appears to recognize discrete DNA sequences upstream of transcriptional start sites.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi193 – 258Nuclear receptorPROSITE-ProRule annotationAdd BLAST66
Zinc fingeri193 – 213NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri229 – 253NR C4-typePROSITE-ProRule annotationAdd BLAST25

GO - Molecular functioni

  • androgen binding Source: AgBase
  • DNA binding Source: AgBase
  • DNA binding transcription factor activity Source: InterPro
  • estradiol binding Source: AgBase
  • estrogen receptor activity Source: AgBase
  • estrogen receptor binding Source: AgBase
  • estrogen response element binding Source: AgBase
  • protein homodimerization activity Source: AgBase
  • steroid hormone binding Source: AgBase
  • zinc ion binding Source: InterPro

GO - Biological processi

  • intracellular estrogen receptor signaling pathway Source: AgBase
  • positive regulation of receptor biosynthetic process Source: AgBase
  • response to cadmium ion Source: AgBase
  • response to estradiol Source: AgBase
  • response to testosterone Source: AgBase
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionDNA-binding, Receptor
Biological processTranscription, Transcription regulation
LigandLipid-binding, Metal-binding, Steroid-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Estrogen receptor
Short name:
ER
Alternative name(s):
ER-alpha
Estradiol receptor
Nuclear receptor subfamily 3 group A member 1
Gene namesi
Name:esr1
Synonyms:esr, nr3a1
OrganismiOncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Taxonomic identifieri8022 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiProtacanthopterygiiSalmoniformesSalmonidaeSalmoninaeOncorhynchus

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000536311 – 622Estrogen receptorAdd BLAST622

Proteomic databases

PRIDEiP16058

Interactioni

Subunit structurei

Binds DNA as a homodimer. Can form a heterodimer with ER-beta (By similarity).By similarity

GO - Molecular functioni

  • estrogen receptor binding Source: AgBase
  • protein homodimerization activity Source: AgBase

Structurei

3D structure databases

ProteinModelPortaliP16058
SMRiP16058
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini324 – 560NR LBDPROSITE-ProRule annotationAdd BLAST237

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 192ModulatingAdd BLAST192
Regioni259 – 323HingeAdd BLAST65

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi580 – 586Poly-Thr7

Domaini

Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri193 – 213NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri229 – 253NR C4-typePROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Zinc-finger

Phylogenomic databases

HOVERGENiHBG108344

Family and domain databases

Gene3Di3.30.50.10, 1 hit
InterProiView protein in InterPro
IPR035500 NHR_like_dom_sf
IPR000536 Nucl_hrmn_rcpt_lig-bd
IPR001723 Nuclear_hrmn_rcpt
IPR024178 Oest_rcpt/oest-rel_rcp
IPR001292 Oestr_rcpt
IPR001628 Znf_hrmn_rcpt
IPR013088 Znf_NHR/GATA
PfamiView protein in Pfam
PF00104 Hormone_recep, 1 hit
PF02159 Oest_recep, 1 hit
PF00105 zf-C4, 1 hit
PIRSFiPIRSF500101 ER-a, 1 hit
PIRSF002527 ER-like_NR, 1 hit
PRINTSiPR00398 STRDHORMONER
PR00047 STROIDFINGER
SMARTiView protein in SMART
SM00430 HOLI, 1 hit
SM00399 ZnF_C4, 1 hit
SUPFAMiSSF48508 SSF48508, 1 hit
PROSITEiView protein in PROSITE
PS51843 NR_LBD, 1 hit
PS00031 NUCLEAR_REC_DBD_1, 1 hit
PS51030 NUCLEAR_REC_DBD_2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P16058-1) [UniParc]FASTAAdd to basket
Also known as: ER(L)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLVRQSHTQI SKPLGAPLRS RTTLESHVIS PPKLSPQQPT TPNSNMYPEE
60 70 80 90 100
TRGGGGAAAF NYLDGGYDYT APAQGPAPLY YSTTPQDAHG PPSDGSMQSL
110 120 130 140 150
GSSPTGPLVF VSSSPQLSPQ LSPFLHPPSH HGLPSQSYYL ETSSTPLYRS
160 170 180 190 200
SVVTNQLSAS EEKLCIASDR QQSYSAAGSG VRVFEMANET RYCAVCSDFA
210 220 230 240 250
SGYHYGVWSC EGCKAFFKRS IQGHNDYMCP ATNQCTMDRN RRKSCQACRL
260 270 280 290 300
RKCYEVGMVK GGLRKDRGGR VLRKDKRYCG PAGDREKPYG DLEHRTAPPQ
310 320 330 340 350
DGGRNSSSSL NGGGGWRGPR ITMPPEQVLF LLQGAEPPAL CSRQKVARPY
360 370 380 390 400
TEVTMMTLLT SMADKELVHM IAWAKKVPGF QELSLHDQVQ LLESSWLEVL
410 420 430 440 450
MIGLIWRSIH CPGKLIFAQD LILDRSEGDC VEGMAEIFDM LLATVSRFRM
460 470 480 490 500
LKLKPEEFVC LKAIILLNSG AFSFCSNSVE SLHNSSAVES MLDNITDALI
510 520 530 540 550
HHISHSGASV QQQPRRQAQL LLLLSHIRHM SNKGMEHLYS IKCKNKVPLY
560 570 580 590 600
DLLLEMLDGH RLQSPGKVAQ AGEQTEGPST TTTTSTGSSI GPMRGSQDTH
610 620
IRSPGSGVLQ YGSPSSDQMP IP
Length:622
Mass (Da):68,084
Last modified:January 11, 2001 - v3
Checksum:iAD70DD7136B5A6F3
GO
Isoform 2 (identifier: P16058-2) [UniParc]FASTAAdd to basket
Also known as: ER(S)

The sequence of this isoform differs from the canonical sequence as follows:
     1-45: Missing.

Show »
Length:577
Mass (Da):63,171
Checksum:i47E167376DFB2B2B
GO

Sequence cautioni

The sequence AAA49552 differs from that shown. Reason: Frameshift at positions 288, 298, 334 and 337.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti60 – 91FNYLD…DAHGP → LTTWMEGMTTQPLPKARPLS ITPPPPRMPTD (PubMed:2210031).CuratedAdd BLAST32
Sequence conflicti289 – 298YGDLEHRTAP → TVTWSTGQR (PubMed:2210031).Curated10
Sequence conflicti335 – 337AEP → QT (PubMed:2210031).Curated3
Sequence conflicti449R → G in AAA49552 (PubMed:2915648).Curated1
Sequence conflicti469S → P in AAA49552 (PubMed:2915648).Curated1
Sequence conflicti564S → A in AAA49552 (PubMed:2915648).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0036831 – 45Missing in isoform 2. 2 PublicationsAdd BLAST45

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M31559 mRNA Translation: AAA49552.1 Frameshift.
AJ242740 mRNA Translation: CAB45139.1
AJ242741 mRNA Translation: CAB45140.1
AF099079 mRNA Translation: AAD13610.2
RefSeqiNP_001117821.1, NM_001124349.1 [P16058-1]
UniGeneiOmy.11637

Genome annotation databases

GeneIDi100136026

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiESR1_ONCMY
AccessioniPrimary (citable) accession number: P16058
Secondary accession number(s): Q9PSZ8, Q9PSZ9, Q9YGE6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: January 11, 2001
Last modified: May 23, 2018
This is version 135 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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