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P16047

- TGFB3_CHICK

UniProt

P16047 - TGFB3_CHICK

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Protein

Transforming growth factor beta-3

Gene
TGFB3
Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Involved in embryogenesis and cell differentiation.

GO - Biological processi

  1. cardiac epithelial to mesenchymal transition Source: DFLAT
  2. cell activation Source: AgBase
  3. cell growth Source: InterPro
  4. embryonic digestive tract development Source: AgBase
  5. epithelial to mesenchymal transition involved in endocardial cushion formation Source: DFLAT
  6. mesenchyme migration Source: DFLAT
  7. nervous system development Source: AgBase
  8. positive regulation of cell division Source: UniProtKB-KW
  9. positive regulation of cell migration Source: AgBase
  10. positive regulation of transcription, DNA-templated Source: DFLAT
  11. spleen development Source: AgBase
Complete GO annotation...

Keywords - Molecular functioni

Growth factor, Mitogen

Names & Taxonomyi

Protein namesi
Recommended name:
Transforming growth factor beta-3
Short name:
TGF-beta-3
Cleaved into the following chain:
Gene namesi
Name:TGFB3
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323 Reviewed predictionAdd
BLAST
Chaini24 – 300277Latency-associated peptidePRO_0000033804Add
BLAST
Chaini301 – 412112Transforming growth factor beta-3PRO_0000033805Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi74 – 741N-linked (GlcNAc...) Reviewed prediction
Glycosylationi135 – 1351N-linked (GlcNAc...) Reviewed prediction
Glycosylationi142 – 1421N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi307 ↔ 316 By similarity
Disulfide bondi315 ↔ 378 By similarity
Disulfide bondi344 ↔ 409 By similarity
Disulfide bondi348 ↔ 411 By similarity
Disulfide bondi377 – 377Interchain By similarity

Post-translational modificationi

The precursor is cleaved into mature TGF-beta-3 and LAP, which remains non-covalently linked to mature TGF-beta-3 rendering it inactive By similarity.

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP16047.

Interactioni

Subunit structurei

Homodimer; disulfide-linked.

Protein-protein interaction databases

STRINGi9031.ENSGALP00000036912.

Structurei

3D structure databases

ProteinModelPortaliP16047.
SMRiP16047. Positions 301-412.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi261 – 2633Cell attachment site Reviewed prediction

Sequence similaritiesi

Belongs to the TGF-beta family.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG269146.
HOGENOMiHOG000290198.
HOVERGENiHBG074115.
KOiK13377.
PhylomeDBiP16047.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR016319. TGF-beta.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
IPR015618. Transform_grow_fac_b3.
[Graphical view]
PANTHERiPTHR11848. PTHR11848. 1 hit.
PfamiPF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view]
PIRSFiPIRSF001787. TGF-beta. 1 hit.
PRINTSiPR01423. TGFBETA.
PR01426. TGFBETA3.
SMARTiSM00204. TGFB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P16047-1 [UniParc]FASTAAdd to Basket

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MKMYAQRALV LLSLLSFATV SLALSSCTTL DLEHIKKKRV EAIRGQILSK    50
LRLTSPPESV GPAHVPYQIL ALYNSTRELL EEMEEEKEES CSQENTESEY 100
YAKEIHKFDM IQGLPEHNEL GICPKGVTSN VFRFNVSSAE KNSTNLFRAE 150
FRVLRVPNPS SKRSEQRIEL FQILRPDEHI AKQRYLSGRN VQTRGSPEWL 200
SFDVTDTVRE WLLHRESNLG LEISIHCPCH TFQPNGDILE NLHEVLEIKF 250
KGIDSEDDYG RGDLGRLKKQ KDLHNPHLIL MMLPPHRLES PTLGGQRKKR 300
ALDTNYCFRN LEENCCVRPL YIELPTDLGW KWVHEPKGYF ANFCSGPCPY 350
LRSADTTHST VLGLYNTLNP EASASPCCVP QDLEPLTILY YVGRTPKVEQ 400
LSNMVVKSCK CS 412
Length:412
Mass (Da):47,078
Last modified:August 29, 2001 - v2
Checksum:i1CAB883170069D55
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti323 – 3264ELPT → DFRQ in AAA49089. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M31154 mRNA. Translation: AAA49089.1.
X58127
, X60055, X60091, X60090 Genomic DNA. Translation: CAA41128.2.
S46000 Genomic DNA. Translation: AAB23575.1.
PIRiA34939.
RefSeqiNP_990785.1. NM_205454.1.
UniGeneiGga.42150.

Genome annotation databases

GeneIDi396438.
KEGGigga:396438.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M31154 mRNA. Translation: AAA49089.1 .
X58127
, X60055 , X60091 , X60090 Genomic DNA. Translation: CAA41128.2 .
S46000 Genomic DNA. Translation: AAB23575.1 .
PIRi A34939.
RefSeqi NP_990785.1. NM_205454.1.
UniGenei Gga.42150.

3D structure databases

ProteinModelPortali P16047.
SMRi P16047. Positions 301-412.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9031.ENSGALP00000036912.

Proteomic databases

PaxDbi P16047.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 396438.
KEGGi gga:396438.

Organism-specific databases

CTDi 7043.

Phylogenomic databases

eggNOGi NOG269146.
HOGENOMi HOG000290198.
HOVERGENi HBG074115.
KOi K13377.
PhylomeDBi P16047.

Miscellaneous databases

NextBioi 20816479.
PROi P16047.

Family and domain databases

Gene3Di 2.10.90.10. 1 hit.
InterProi IPR029034. Cystine-knot_cytokine.
IPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR016319. TGF-beta.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
IPR015618. Transform_grow_fac_b3.
[Graphical view ]
PANTHERi PTHR11848. PTHR11848. 1 hit.
Pfami PF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view ]
PIRSFi PIRSF001787. TGF-beta. 1 hit.
PRINTSi PR01423. TGFBETA.
PR01426. TGFBETA3.
SMARTi SM00204. TGFB. 1 hit.
[Graphical view ]
SUPFAMi SSF57501. SSF57501. 1 hit.
PROSITEi PS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complementary deoxyribonucleic acid cloning of a novel transforming growth factor-beta messenger ribonucleic acid from chick embryo chondrocytes."
    Jakowlew S.B., Dillard P.J., Kondaiah P., Sporn M.B., Roberts A.B.
    Mol. Endocrinol. 2:747-755(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The chicken transforming growth factor-beta 3 gene: genomic structure, transcriptional analysis, and chromosomal location."
    Burt D.W., Dey B.R., Paton I.R., Morrice D.R., Law A.S.
    DNA Cell Biol. 14:111-123(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: White leghorn.
  3. "Comparative analysis of human and chicken transforming growth factor-beta 2 and -beta 3 promoters."
    Burt D.W., Dey B.R., Paton I.R.
    J. Mol. Endocrinol. 7:175-183(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-117.
    Strain: White leghorn.
    Tissue: Blood.
  4. "Identification and characterization of the chicken transforming growth factor-beta 3 promoter."
    Jakowlew S.B., Lechleider R., Geiser A.G., Kim S.J., Santa-Coloma T.A., Cubert J., Sporn M.B., Roberts A.B.
    Mol. Endocrinol. 6:1285-1298(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-117.

Entry informationi

Entry nameiTGFB3_CHICK
AccessioniPrimary (citable) accession number: P16047
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: August 29, 2001
Last modified: July 9, 2014
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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