Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Transforming growth factor beta-3

Gene

TGFB3

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in embryogenesis and cell differentiation.

GO - Molecular functioni

  1. identical protein binding Source: AgBase
  2. transforming growth factor beta binding Source: AgBase
  3. type III transforming growth factor beta receptor binding Source: AgBase
  4. type II transforming growth factor beta receptor binding Source: AgBase
  5. type I transforming growth factor beta receptor binding Source: AgBase

GO - Biological processi

  1. cardiac epithelial to mesenchymal transition Source: DFLAT
  2. cell activation Source: AgBase
  3. cell-cell junction organization Source: AgBase
  4. cell growth Source: InterPro
  5. detection of hypoxia Source: AgBase
  6. embryonic digestive tract development Source: AgBase
  7. epithelial to mesenchymal transition involved in endocardial cushion formation Source: DFLAT
  8. face morphogenesis Source: AgBase
  9. mesenchyme migration Source: DFLAT
  10. negative regulation of DNA replication Source: AgBase
  11. negative regulation of macrophage cytokine production Source: AgBase
  12. nervous system development Source: AgBase
  13. ossification involved in bone remodeling Source: AgBase
  14. positive regulation of bone mineralization Source: AgBase
  15. positive regulation of cell division Source: UniProtKB-KW
  16. positive regulation of cell migration Source: AgBase
  17. positive regulation of collagen biosynthetic process Source: AgBase
  18. positive regulation of DNA replication Source: AgBase
  19. positive regulation of epithelial to mesenchymal transition Source: AgBase
  20. positive regulation of transcription, DNA-templated Source: DFLAT
  21. response to hypoxia Source: AgBase
  22. response to progesterone Source: AgBase
  23. salivary gland morphogenesis Source: AgBase
  24. spleen development Source: AgBase
  25. transforming growth factor beta receptor signaling pathway Source: AgBase
Complete GO annotation...

Keywords - Molecular functioni

Growth factor, Mitogen

Names & Taxonomyi

Protein namesi
Recommended name:
Transforming growth factor beta-3
Short name:
TGF-beta-3
Cleaved into the following chain:
Gene namesi
Name:TGFB3
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. extracellular matrix Source: AgBase
  2. extracellular space Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence AnalysisAdd
BLAST
Chaini24 – 300277Latency-associated peptidePRO_0000033804Add
BLAST
Chaini301 – 412112Transforming growth factor beta-3PRO_0000033805Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi74 – 741N-linked (GlcNAc...)Sequence Analysis
Glycosylationi135 – 1351N-linked (GlcNAc...)Sequence Analysis
Glycosylationi142 – 1421N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi307 ↔ 316By similarity
Disulfide bondi315 ↔ 378By similarity
Disulfide bondi344 ↔ 409By similarity
Disulfide bondi348 ↔ 411By similarity
Disulfide bondi377 – 377InterchainBy similarity

Post-translational modificationi

The precursor is cleaved into mature TGF-beta-3 and LAP, which remains non-covalently linked to mature TGF-beta-3 rendering it inactive.By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP16047.

Interactioni

Subunit structurei

Homodimer; disulfide-linked.

Protein-protein interaction databases

STRINGi9031.ENSGALP00000036912.

Structurei

3D structure databases

ProteinModelPortaliP16047.
SMRiP16047. Positions 301-412.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi261 – 2633Cell attachment siteSequence Analysis

Sequence similaritiesi

Belongs to the TGF-beta family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG269146.
HOGENOMiHOG000290198.
HOVERGENiHBG074115.
InParanoidiP16047.
KOiK13377.
PhylomeDBiP16047.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR016319. TGF-beta.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
IPR015618. Transform_grow_fac_b3.
[Graphical view]
PANTHERiPTHR11848. PTHR11848. 1 hit.
PfamiPF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view]
PIRSFiPIRSF001787. TGF-beta. 1 hit.
PRINTSiPR01423. TGFBETA.
PR01426. TGFBETA3.
SMARTiSM00204. TGFB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P16047-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKMYAQRALV LLSLLSFATV SLALSSCTTL DLEHIKKKRV EAIRGQILSK
60 70 80 90 100
LRLTSPPESV GPAHVPYQIL ALYNSTRELL EEMEEEKEES CSQENTESEY
110 120 130 140 150
YAKEIHKFDM IQGLPEHNEL GICPKGVTSN VFRFNVSSAE KNSTNLFRAE
160 170 180 190 200
FRVLRVPNPS SKRSEQRIEL FQILRPDEHI AKQRYLSGRN VQTRGSPEWL
210 220 230 240 250
SFDVTDTVRE WLLHRESNLG LEISIHCPCH TFQPNGDILE NLHEVLEIKF
260 270 280 290 300
KGIDSEDDYG RGDLGRLKKQ KDLHNPHLIL MMLPPHRLES PTLGGQRKKR
310 320 330 340 350
ALDTNYCFRN LEENCCVRPL YIELPTDLGW KWVHEPKGYF ANFCSGPCPY
360 370 380 390 400
LRSADTTHST VLGLYNTLNP EASASPCCVP QDLEPLTILY YVGRTPKVEQ
410
LSNMVVKSCK CS
Length:412
Mass (Da):47,078
Last modified:August 29, 2001 - v2
Checksum:i1CAB883170069D55
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti323 – 3264ELPT → DFRQ in AAA49089 (PubMed:3211158).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M31154 mRNA. Translation: AAA49089.1.
X58127
, X60055, X60091, X60090 Genomic DNA. Translation: CAA41128.2.
S46000 Genomic DNA. Translation: AAB23575.1.
PIRiA34939.
RefSeqiNP_990785.1. NM_205454.1.
UniGeneiGga.42150.

Genome annotation databases

GeneIDi396438.
KEGGigga:396438.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M31154 mRNA. Translation: AAA49089.1.
X58127
, X60055, X60091, X60090 Genomic DNA. Translation: CAA41128.2.
S46000 Genomic DNA. Translation: AAB23575.1.
PIRiA34939.
RefSeqiNP_990785.1. NM_205454.1.
UniGeneiGga.42150.

3D structure databases

ProteinModelPortaliP16047.
SMRiP16047. Positions 301-412.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000036912.

Proteomic databases

PaxDbiP16047.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi396438.
KEGGigga:396438.

Organism-specific databases

CTDi7043.

Phylogenomic databases

eggNOGiNOG269146.
HOGENOMiHOG000290198.
HOVERGENiHBG074115.
InParanoidiP16047.
KOiK13377.
PhylomeDBiP16047.

Miscellaneous databases

NextBioi20816479.
PROiP16047.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR016319. TGF-beta.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
IPR015618. Transform_grow_fac_b3.
[Graphical view]
PANTHERiPTHR11848. PTHR11848. 1 hit.
PfamiPF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view]
PIRSFiPIRSF001787. TGF-beta. 1 hit.
PRINTSiPR01423. TGFBETA.
PR01426. TGFBETA3.
SMARTiSM00204. TGFB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complementary deoxyribonucleic acid cloning of a novel transforming growth factor-beta messenger ribonucleic acid from chick embryo chondrocytes."
    Jakowlew S.B., Dillard P.J., Kondaiah P., Sporn M.B., Roberts A.B.
    Mol. Endocrinol. 2:747-755(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The chicken transforming growth factor-beta 3 gene: genomic structure, transcriptional analysis, and chromosomal location."
    Burt D.W., Dey B.R., Paton I.R., Morrice D.R., Law A.S.
    DNA Cell Biol. 14:111-123(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: White leghorn.
  3. "Comparative analysis of human and chicken transforming growth factor-beta 2 and -beta 3 promoters."
    Burt D.W., Dey B.R., Paton I.R.
    J. Mol. Endocrinol. 7:175-183(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-117.
    Strain: White leghorn.
    Tissue: Blood.
  4. "Identification and characterization of the chicken transforming growth factor-beta 3 promoter."
    Jakowlew S.B., Lechleider R., Geiser A.G., Kim S.J., Santa-Coloma T.A., Cubert J., Sporn M.B., Roberts A.B.
    Mol. Endocrinol. 6:1285-1298(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-117.

Entry informationi

Entry nameiTGFB3_CHICK
AccessioniPrimary (citable) accession number: P16047
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: August 29, 2001
Last modified: April 1, 2015
This is version 112 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.