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P16047

- TGFB3_CHICK

UniProt

P16047 - TGFB3_CHICK

Protein

Transforming growth factor beta-3

Gene

TGFB3

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 106 (01 Oct 2014)
      Sequence version 2 (29 Aug 2001)
      Previous versions | rss
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    Functioni

    Involved in embryogenesis and cell differentiation.

    GO - Biological processi

    1. cardiac epithelial to mesenchymal transition Source: DFLAT
    2. cell activation Source: AgBase
    3. cell growth Source: InterPro
    4. embryonic digestive tract development Source: AgBase
    5. epithelial to mesenchymal transition involved in endocardial cushion formation Source: DFLAT
    6. mesenchyme migration Source: DFLAT
    7. nervous system development Source: AgBase
    8. positive regulation of cell division Source: UniProtKB-KW
    9. positive regulation of cell migration Source: AgBase
    10. positive regulation of transcription, DNA-templated Source: DFLAT
    11. spleen development Source: AgBase

    Keywords - Molecular functioni

    Growth factor, Mitogen

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transforming growth factor beta-3
    Short name:
    TGF-beta-3
    Cleaved into the following chain:
    Gene namesi
    Name:TGFB3
    OrganismiGallus gallus (Chicken)
    Taxonomic identifieri9031 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
    ProteomesiUP000000539: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: InterPro

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323Sequence AnalysisAdd
    BLAST
    Chaini24 – 300277Latency-associated peptidePRO_0000033804Add
    BLAST
    Chaini301 – 412112Transforming growth factor beta-3PRO_0000033805Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi74 – 741N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi135 – 1351N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi142 – 1421N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi307 ↔ 316By similarity
    Disulfide bondi315 ↔ 378By similarity
    Disulfide bondi344 ↔ 409By similarity
    Disulfide bondi348 ↔ 411By similarity
    Disulfide bondi377 – 377InterchainBy similarity

    Post-translational modificationi

    The precursor is cleaved into mature TGF-beta-3 and LAP, which remains non-covalently linked to mature TGF-beta-3 rendering it inactive.By similarity

    Keywords - PTMi

    Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiP16047.

    Interactioni

    Subunit structurei

    Homodimer; disulfide-linked.

    Protein-protein interaction databases

    STRINGi9031.ENSGALP00000036912.

    Structurei

    3D structure databases

    ProteinModelPortaliP16047.
    SMRiP16047. Positions 301-412.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi261 – 2633Cell attachment siteSequence Analysis

    Sequence similaritiesi

    Belongs to the TGF-beta family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG269146.
    HOGENOMiHOG000290198.
    HOVERGENiHBG074115.
    KOiK13377.
    PhylomeDBiP16047.

    Family and domain databases

    Gene3Di2.10.90.10. 1 hit.
    InterProiIPR029034. Cystine-knot_cytokine.
    IPR001839. TGF-b_C.
    IPR001111. TGF-b_N.
    IPR016319. TGF-beta.
    IPR015615. TGF-beta-rel.
    IPR017948. TGFb_CS.
    IPR015618. Transform_grow_fac_b3.
    [Graphical view]
    PANTHERiPTHR11848. PTHR11848. 1 hit.
    PfamiPF00019. TGF_beta. 1 hit.
    PF00688. TGFb_propeptide. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001787. TGF-beta. 1 hit.
    PRINTSiPR01423. TGFBETA.
    PR01426. TGFBETA3.
    SMARTiSM00204. TGFB. 1 hit.
    [Graphical view]
    SUPFAMiSSF57501. SSF57501. 1 hit.
    PROSITEiPS00250. TGF_BETA_1. 1 hit.
    PS51362. TGF_BETA_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P16047-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKMYAQRALV LLSLLSFATV SLALSSCTTL DLEHIKKKRV EAIRGQILSK    50
    LRLTSPPESV GPAHVPYQIL ALYNSTRELL EEMEEEKEES CSQENTESEY 100
    YAKEIHKFDM IQGLPEHNEL GICPKGVTSN VFRFNVSSAE KNSTNLFRAE 150
    FRVLRVPNPS SKRSEQRIEL FQILRPDEHI AKQRYLSGRN VQTRGSPEWL 200
    SFDVTDTVRE WLLHRESNLG LEISIHCPCH TFQPNGDILE NLHEVLEIKF 250
    KGIDSEDDYG RGDLGRLKKQ KDLHNPHLIL MMLPPHRLES PTLGGQRKKR 300
    ALDTNYCFRN LEENCCVRPL YIELPTDLGW KWVHEPKGYF ANFCSGPCPY 350
    LRSADTTHST VLGLYNTLNP EASASPCCVP QDLEPLTILY YVGRTPKVEQ 400
    LSNMVVKSCK CS 412
    Length:412
    Mass (Da):47,078
    Last modified:August 29, 2001 - v2
    Checksum:i1CAB883170069D55
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti323 – 3264ELPT → DFRQ in AAA49089. (PubMed:3211158)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M31154 mRNA. Translation: AAA49089.1.
    X58127
    , X60055, X60091, X60090 Genomic DNA. Translation: CAA41128.2.
    S46000 Genomic DNA. Translation: AAB23575.1.
    PIRiA34939.
    RefSeqiNP_990785.1. NM_205454.1.
    UniGeneiGga.42150.

    Genome annotation databases

    GeneIDi396438.
    KEGGigga:396438.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M31154 mRNA. Translation: AAA49089.1 .
    X58127
    , X60055 , X60091 , X60090 Genomic DNA. Translation: CAA41128.2 .
    S46000 Genomic DNA. Translation: AAB23575.1 .
    PIRi A34939.
    RefSeqi NP_990785.1. NM_205454.1.
    UniGenei Gga.42150.

    3D structure databases

    ProteinModelPortali P16047.
    SMRi P16047. Positions 301-412.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9031.ENSGALP00000036912.

    Proteomic databases

    PaxDbi P16047.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 396438.
    KEGGi gga:396438.

    Organism-specific databases

    CTDi 7043.

    Phylogenomic databases

    eggNOGi NOG269146.
    HOGENOMi HOG000290198.
    HOVERGENi HBG074115.
    KOi K13377.
    PhylomeDBi P16047.

    Miscellaneous databases

    NextBioi 20816479.
    PROi P16047.

    Family and domain databases

    Gene3Di 2.10.90.10. 1 hit.
    InterProi IPR029034. Cystine-knot_cytokine.
    IPR001839. TGF-b_C.
    IPR001111. TGF-b_N.
    IPR016319. TGF-beta.
    IPR015615. TGF-beta-rel.
    IPR017948. TGFb_CS.
    IPR015618. Transform_grow_fac_b3.
    [Graphical view ]
    PANTHERi PTHR11848. PTHR11848. 1 hit.
    Pfami PF00019. TGF_beta. 1 hit.
    PF00688. TGFb_propeptide. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001787. TGF-beta. 1 hit.
    PRINTSi PR01423. TGFBETA.
    PR01426. TGFBETA3.
    SMARTi SM00204. TGFB. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57501. SSF57501. 1 hit.
    PROSITEi PS00250. TGF_BETA_1. 1 hit.
    PS51362. TGF_BETA_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complementary deoxyribonucleic acid cloning of a novel transforming growth factor-beta messenger ribonucleic acid from chick embryo chondrocytes."
      Jakowlew S.B., Dillard P.J., Kondaiah P., Sporn M.B., Roberts A.B.
      Mol. Endocrinol. 2:747-755(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The chicken transforming growth factor-beta 3 gene: genomic structure, transcriptional analysis, and chromosomal location."
      Burt D.W., Dey B.R., Paton I.R., Morrice D.R., Law A.S.
      DNA Cell Biol. 14:111-123(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: White leghorn.
    3. "Comparative analysis of human and chicken transforming growth factor-beta 2 and -beta 3 promoters."
      Burt D.W., Dey B.R., Paton I.R.
      J. Mol. Endocrinol. 7:175-183(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-117.
      Strain: White leghorn.
      Tissue: Blood.
    4. "Identification and characterization of the chicken transforming growth factor-beta 3 promoter."
      Jakowlew S.B., Lechleider R., Geiser A.G., Kim S.J., Santa-Coloma T.A., Cubert J., Sporn M.B., Roberts A.B.
      Mol. Endocrinol. 6:1285-1298(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-117.

    Entry informationi

    Entry nameiTGFB3_CHICK
    AccessioniPrimary (citable) accession number: P16047
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1990
    Last sequence update: August 29, 2001
    Last modified: October 1, 2014
    This is version 106 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3