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Protein

Galectin-1

Gene

Lgals1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Lectin that binds beta-galactoside and a wide array of complex carbohydrates. Plays a role in regulating apoptosis, cell proliferation and cell differentiation. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase. Strong inducer of T-cell apoptosis.By similarity1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei53 – 531Beta-galactosideBy similarity
Binding sitei62 – 621Beta-galactosideBy similarity

GO - Molecular functioni

  • carbohydrate binding Source: MGI
  • galactose binding Source: UniProtKB
  • lactose binding Source: Ensembl
  • poly(A) RNA binding Source: MGI
  • signal transducer activity Source: MGI

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Apoptosis

Keywords - Ligandi

Lectin

Names & Taxonomyi

Protein namesi
Recommended name:
Galectin-1
Short name:
Gal-1
Alternative name(s):
14 kDa lectin
Beta-galactoside-binding lectin L-14-I
Galaptin
Lactose-binding lectin 1
Lectin galactoside-binding soluble 1
S-Lac lectin 1
Gene namesi
Name:Lgals1
Synonyms:Gbp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:96777. Lgals1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 135134Galectin-1PRO_0000076918Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei13 – 131N6-acetyllysineCombined sources
Modified residuei19 – 191N6-acetyllysineCombined sources
Modified residuei29 – 291N6-acetyllysineCombined sources
Modified residuei30 – 301PhosphoserineBy similarity
Modified residuei108 – 1081N6-acetyllysine; alternateCombined sources
Modified residuei108 – 1081N6-succinyllysine; alternateCombined sources
Modified residuei128 – 1281N6-acetyllysineCombined sources

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP16045.
MaxQBiP16045.
PaxDbiP16045.
PeptideAtlasiP16045.
PRIDEiP16045.
TopDownProteomicsiP16045.

2D gel databases

REPRODUCTION-2DPAGEIPI00229517.
P16045.
SWISS-2DPAGEP16045.
UCD-2DPAGEP16045.

PTM databases

iPTMnetiP16045.
PhosphoSiteiP16045.
SwissPalmiP16045.

Expressioni

Gene expression databases

BgeeiENSMUSG00000068220.
CleanExiMM_LGALS1.
GenevisibleiP16045. MM.

Interactioni

Subunit structurei

Homodimer. Binds LGALS3BP. Interacts with CD2, CD3, CD4, CD6, CD7, CD43, ALCAM and CD45. Interacts with laminin (via poly-N-acetyllactosamine). Interacts with SUSD2.By similarity

Protein-protein interaction databases

BioGridi201142. 2 interactions.
IntActiP16045. 5 interactions.
MINTiMINT-4100323.
STRINGi10090.ENSMUSP00000086795.

Structurei

Secondary structure

1
135
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi6 – 83Combined sources
Beta strandi17 – 248Combined sources
Beta strandi33 – 386Combined sources
Beta strandi41 – 499Combined sources
Beta strandi58 – 658Combined sources
Beta strandi73 – 753Combined sources
Beta strandi84 – 929Combined sources
Beta strandi94 – 1007Combined sources
Beta strandi106 – 1105Combined sources
Beta strandi120 – 1234Combined sources
Beta strandi127 – 1359Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4LBQX-ray2.40A/B/C/D1-135[»]
ProteinModelPortaliP16045.
SMRiP16045. Positions 3-135.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 135132GalectinPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni45 – 495Beta-galactoside bindingBy similarity
Regioni69 – 724Beta-galactoside bindingBy similarity

Sequence similaritiesi

Contains 1 galectin domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3587. Eukaryota.
ENOG4111EA0. LUCA.
GeneTreeiENSGT00440000034263.
HOVERGENiHBG006255.
InParanoidiP16045.
KOiK06830.
OMAiCNSKEDG.
OrthoDBiEOG091G0S7H.
PhylomeDBiP16045.
TreeFamiTF315551.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
InterProiIPR013320. ConA-like_dom.
IPR001079. Galectin_CRD.
[Graphical view]
PfamiPF00337. Gal-bind_lectin. 1 hit.
[Graphical view]
SMARTiSM00908. Gal-bind_lectin. 1 hit.
SM00276. GLECT. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS51304. GALECTIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P16045-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MACGLVASNL NLKPGECLKV RGEVASDAKS FVLNLGKDSN NLCLHFNPRF
60 70 80 90 100
NAHGDANTIV CNTKEDGTWG TEHREPAFPF QPGSITEVCI TFDQADLTIK
110 120 130
LPDGHEFKFP NRLNMEAINY MAADGDFKIK CVAFE
Length:135
Mass (Da):14,866
Last modified:January 23, 2007 - v3
Checksum:iFD6967C1F4117122
GO

Sequence cautioni

The sequence AAA37313 differs from that shown. Reason: Frameshift at several positions. Curated
The sequence AK004298 differs from that shown. Reason: Frameshift at position 117. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti78 – 781F → S in AAA37667 (PubMed:1986871).Curated
Sequence conflicti86 – 861T → I in AAH02063 (PubMed:15489334).Curated
Sequence conflicti131 – 1344CVAF → VRGL in AAA36172 (PubMed:3020551).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X15986 mRNA. Translation: CAA34117.1.
X53067 mRNA. Translation: CAA37242.1.
X51577, X51578, X51579 Genomic DNA. Translation: CAA35930.1.
M57470 mRNA. Translation: AAA37667.1.
X66532 mRNA. Translation: CAA47143.1.
AK004298 mRNA. No translation available.
BC002063 mRNA. Translation: AAH02063.1.
BC099479 mRNA. Translation: AAH99479.1.
X51903 mRNA. Translation: CAA36183.1.
M33214 mRNA. Translation: AAA37313.1. Frameshift.
M14087 mRNA. Translation: AAA36172.1.
CCDSiCCDS27628.1.
PIRiB26495.
S07162.
S11718. LNMSGB.
RefSeqiNP_032521.1. NM_008495.2.
UniGeneiMm.43831.

Genome annotation databases

EnsembliENSMUST00000089377; ENSMUSP00000086795; ENSMUSG00000068220.
GeneIDi16852.
KEGGimmu:16852.
UCSCiuc007wrv.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X15986 mRNA. Translation: CAA34117.1.
X53067 mRNA. Translation: CAA37242.1.
X51577, X51578, X51579 Genomic DNA. Translation: CAA35930.1.
M57470 mRNA. Translation: AAA37667.1.
X66532 mRNA. Translation: CAA47143.1.
AK004298 mRNA. No translation available.
BC002063 mRNA. Translation: AAH02063.1.
BC099479 mRNA. Translation: AAH99479.1.
X51903 mRNA. Translation: CAA36183.1.
M33214 mRNA. Translation: AAA37313.1. Frameshift.
M14087 mRNA. Translation: AAA36172.1.
CCDSiCCDS27628.1.
PIRiB26495.
S07162.
S11718. LNMSGB.
RefSeqiNP_032521.1. NM_008495.2.
UniGeneiMm.43831.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4LBQX-ray2.40A/B/C/D1-135[»]
ProteinModelPortaliP16045.
SMRiP16045. Positions 3-135.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi201142. 2 interactions.
IntActiP16045. 5 interactions.
MINTiMINT-4100323.
STRINGi10090.ENSMUSP00000086795.

PTM databases

iPTMnetiP16045.
PhosphoSiteiP16045.
SwissPalmiP16045.

2D gel databases

REPRODUCTION-2DPAGEIPI00229517.
P16045.
SWISS-2DPAGEP16045.
UCD-2DPAGEP16045.

Proteomic databases

EPDiP16045.
MaxQBiP16045.
PaxDbiP16045.
PeptideAtlasiP16045.
PRIDEiP16045.
TopDownProteomicsiP16045.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000089377; ENSMUSP00000086795; ENSMUSG00000068220.
GeneIDi16852.
KEGGimmu:16852.
UCSCiuc007wrv.1. mouse.

Organism-specific databases

CTDi3956.
MGIiMGI:96777. Lgals1.

Phylogenomic databases

eggNOGiKOG3587. Eukaryota.
ENOG4111EA0. LUCA.
GeneTreeiENSGT00440000034263.
HOVERGENiHBG006255.
InParanoidiP16045.
KOiK06830.
OMAiCNSKEDG.
OrthoDBiEOG091G0S7H.
PhylomeDBiP16045.
TreeFamiTF315551.

Miscellaneous databases

PROiP16045.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000068220.
CleanExiMM_LGALS1.
GenevisibleiP16045. MM.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
InterProiIPR013320. ConA-like_dom.
IPR001079. Galectin_CRD.
[Graphical view]
PfamiPF00337. Gal-bind_lectin. 1 hit.
[Graphical view]
SMARTiSM00908. Gal-bind_lectin. 1 hit.
SM00276. GLECT. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS51304. GALECTIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLEG1_MOUSE
AccessioniPrimary (citable) accession number: P16045
Secondary accession number(s): P05163
, P11946, P17601, Q4FZH4, Q99M27, Q9D0X0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: January 23, 2007
Last modified: September 7, 2016
This is version 162 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

Was originally thought to originate from human.1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.