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Protein

Somatoliberin

Gene

Ghrh

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Protein inferred from homologyi

Functioni

GRF is released by the hypothalamus and acts on the adenohypophyse to stimulate the secretion of growth hormone.

GO - Molecular functioni

GO - Biological processi

  • adenohypophysis development Source: MGI
  • adenylate cyclase-activating G-protein coupled receptor signaling pathway Source: MGI
  • cAMP-mediated signaling Source: MGI
  • growth hormone secretion Source: MGI
  • positive regulation of cAMP biosynthetic process Source: BHF-UCL
  • positive regulation of cell proliferation Source: BHF-UCL
  • positive regulation of growth hormone secretion Source: MGI
  • positive regulation of hormone secretion Source: MGI
  • positive regulation of multicellular organism growth Source: MGI
  • response to food Source: MGI
Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-MMU-418555. G alpha (s) signalling events.
R-MMU-420092. Glucagon-type ligand receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Somatoliberin
Alternative name(s):
Growth hormone-releasing factor
Short name:
GRF
Growth hormone-releasing hormone
Short name:
GHRH
Gene namesi
Name:Ghrh
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:95709. Ghrh.

Subcellular locationi

GO - Cellular componenti

  • extracellular space Source: MGI
  • intracellular Source: MGI
  • terminal bouton Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence analysisAdd
BLAST
Propeptidei20 – 3011PRO_0000011444Add
BLAST
Peptidei31 – 7242SomatoliberinPRO_0000011445Add
BLAST
Propeptidei74 – 10330PRO_0000011446Add
BLAST

Proteomic databases

PaxDbiP16043.
PRIDEiP16043.

PTM databases

PhosphoSiteiP16043.

Expressioni

Gene expression databases

BgeeiP16043.
CleanExiMM_GHRH.
ExpressionAtlasiP16043. baseline and differential.
GenevisibleiP16043. MM.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi199916. 1 interaction.
STRINGi10090.ENSMUSP00000029172.

Structurei

3D structure databases

ProteinModelPortaliP16043.
SMRiP16043. Positions 31-59.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glucagon family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J1XI. Eukaryota.
ENOG410ZCJQ. LUCA.
HOGENOMiHOG000115417.
HOVERGENiHBG004478.
InParanoidiP16043.
KOiK05260.
OMAiIMSRQQG.
OrthoDBiEOG7WQ7VQ.
PhylomeDBiP16043.
TreeFamiTF353187.

Family and domain databases

InterProiIPR000532. Glucagon_GIP_secretin_VIP.
[Graphical view]
PfamiPF00123. Hormone_2. 1 hit.
[Graphical view]
SMARTiSM00070. GLUCA. 1 hit.
[Graphical view]
PROSITEiPS00260. GLUCAGON. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P16043-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLWVLFVIL ILTSGSHCSL PPSPPFRMQR HVDAIFTTNY RKLLSQLYAR
60 70 80 90 100
KVIQDIMNKQ GERIQEQRAR LSRQEDSMWT EDKQMTLESI LQGFPRMKPS

ADA
Length:103
Mass (Da):12,064
Last modified:April 1, 1990 - v1
Checksum:iF3BA6870BF2CA8DC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M31654 mRNA. Translation: AAA37691.1.
M31658 mRNA. Translation: AAA37739.1.
AK018796 mRNA. Translation: BAB31418.1.
BC068204 mRNA. Translation: AAH68204.1.
CCDSiCCDS16976.1.
PIRiA41410.
RefSeqiNP_034415.1. NM_010285.2.
XP_006498835.1. XM_006498772.2.
UniGeneiMm.389327.

Genome annotation databases

EnsembliENSMUST00000029172; ENSMUSP00000029172; ENSMUSG00000027643.
ENSMUST00000109536; ENSMUSP00000105162; ENSMUSG00000027643.
GeneIDi14601.
KEGGimmu:14601.
UCSCiuc008nox.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M31654 mRNA. Translation: AAA37691.1.
M31658 mRNA. Translation: AAA37739.1.
AK018796 mRNA. Translation: BAB31418.1.
BC068204 mRNA. Translation: AAH68204.1.
CCDSiCCDS16976.1.
PIRiA41410.
RefSeqiNP_034415.1. NM_010285.2.
XP_006498835.1. XM_006498772.2.
UniGeneiMm.389327.

3D structure databases

ProteinModelPortaliP16043.
SMRiP16043. Positions 31-59.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi199916. 1 interaction.
STRINGi10090.ENSMUSP00000029172.

PTM databases

PhosphoSiteiP16043.

Proteomic databases

PaxDbiP16043.
PRIDEiP16043.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000029172; ENSMUSP00000029172; ENSMUSG00000027643.
ENSMUST00000109536; ENSMUSP00000105162; ENSMUSG00000027643.
GeneIDi14601.
KEGGimmu:14601.
UCSCiuc008nox.1. mouse.

Organism-specific databases

CTDi2691.
MGIiMGI:95709. Ghrh.

Phylogenomic databases

eggNOGiENOG410J1XI. Eukaryota.
ENOG410ZCJQ. LUCA.
HOGENOMiHOG000115417.
HOVERGENiHBG004478.
InParanoidiP16043.
KOiK05260.
OMAiIMSRQQG.
OrthoDBiEOG7WQ7VQ.
PhylomeDBiP16043.
TreeFamiTF353187.

Enzyme and pathway databases

ReactomeiR-MMU-418555. G alpha (s) signalling events.
R-MMU-420092. Glucagon-type ligand receptors.

Miscellaneous databases

NextBioi286376.
PROiP16043.
SOURCEiSearch...

Gene expression databases

BgeeiP16043.
CleanExiMM_GHRH.
ExpressionAtlasiP16043. baseline and differential.
GenevisibleiP16043. MM.

Family and domain databases

InterProiIPR000532. Glucagon_GIP_secretin_VIP.
[Graphical view]
PfamiPF00123. Hormone_2. 1 hit.
[Graphical view]
SMARTiSM00070. GLUCA. 1 hit.
[Graphical view]
PROSITEiPS00260. GLUCAGON. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Mouse growth-hormone-releasing hormone: precursor structure and expression in brain and placenta."
    Suhr S.T., Rahal J.O., Mayo K.E.
    Mol. Endocrinol. 3:1693-1700(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Cloning and characterization of mouse growth hormone-releasing hormone (GRH) complementary DNA: increased GRH messenger RNA levels in the growth hormone-deficient lit/lit mouse."
    Frohman M.A., Downs T.R., Chomczynski P., Frohman L.A.
    Mol. Endocrinol. 3:1529-1536(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Placenta.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Uterus.

Entry informationi

Entry nameiSLIB_MOUSE
AccessioniPrimary (citable) accession number: P16043
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: May 11, 2016
This is version 131 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.