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Protein

Somatoliberin

Gene

Ghrh

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Protein inferred from homologyi

Functioni

GRF is released by the hypothalamus and acts on the adenohypophyse to stimulate the secretion of growth hormone.

GO - Molecular functioni

GO - Biological processi

  • adenohypophysis development Source: MGI
  • adenylate cyclase-activating G-protein coupled receptor signaling pathway Source: MGI
  • cAMP-mediated signaling Source: MGI
  • growth hormone secretion Source: MGI
  • positive regulation of cAMP biosynthetic process Source: BHF-UCL
  • positive regulation of cell proliferation Source: BHF-UCL
  • positive regulation of growth hormone secretion Source: MGI
  • positive regulation of hormone secretion Source: MGI
  • positive regulation of multicellular organism growth Source: MGI
  • response to food Source: MGI
Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-MMU-418555. G alpha (s) signalling events.
R-MMU-420092. Glucagon-type ligand receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Somatoliberin
Alternative name(s):
Growth hormone-releasing factor
Short name:
GRF
Growth hormone-releasing hormone
Short name:
GHRH
Gene namesi
Name:Ghrh
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:95709. Ghrh.

Subcellular locationi

GO - Cellular componenti

  • extracellular space Source: MGI
  • intracellular Source: Ensembl
  • terminal bouton Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence analysisAdd
BLAST
Propeptidei20 – 3011PRO_0000011444Add
BLAST
Peptidei31 – 7242SomatoliberinPRO_0000011445Add
BLAST
Propeptidei74 – 10330PRO_0000011446Add
BLAST

Proteomic databases

PaxDbiP16043.
PRIDEiP16043.

Expressioni

Gene expression databases

BgeeiENSMUSG00000027643.
CleanExiMM_GHRH.
ExpressionAtlasiP16043. baseline and differential.
GenevisibleiP16043. MM.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi199916. 1 interaction.
STRINGi10090.ENSMUSP00000029172.

Structurei

3D structure databases

ProteinModelPortaliP16043.
SMRiP16043. Positions 31-59.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glucagon family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J1XI. Eukaryota.
ENOG410ZCJQ. LUCA.
HOGENOMiHOG000115417.
HOVERGENiHBG004478.
InParanoidiP16043.
KOiK05260.
OMAiIMSRQQG.
OrthoDBiEOG091G11MO.
PhylomeDBiP16043.
TreeFamiTF353187.

Family and domain databases

InterProiIPR000532. Glucagon_GIP_secretin_VIP.
[Graphical view]
PfamiPF00123. Hormone_2. 1 hit.
[Graphical view]
SMARTiSM00070. GLUCA. 1 hit.
[Graphical view]
PROSITEiPS00260. GLUCAGON. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P16043-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLWVLFVIL ILTSGSHCSL PPSPPFRMQR HVDAIFTTNY RKLLSQLYAR
60 70 80 90 100
KVIQDIMNKQ GERIQEQRAR LSRQEDSMWT EDKQMTLESI LQGFPRMKPS

ADA
Length:103
Mass (Da):12,064
Last modified:April 1, 1990 - v1
Checksum:iF3BA6870BF2CA8DC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M31654 mRNA. Translation: AAA37691.1.
M31658 mRNA. Translation: AAA37739.1.
AK018796 mRNA. Translation: BAB31418.1.
BC068204 mRNA. Translation: AAH68204.1.
CCDSiCCDS16976.1.
PIRiA41410.
RefSeqiNP_034415.1. NM_010285.2.
XP_006498835.1. XM_006498772.2.
UniGeneiMm.389327.

Genome annotation databases

EnsembliENSMUST00000029172; ENSMUSP00000029172; ENSMUSG00000027643.
ENSMUST00000109536; ENSMUSP00000105162; ENSMUSG00000027643.
GeneIDi14601.
KEGGimmu:14601.
UCSCiuc008nox.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M31654 mRNA. Translation: AAA37691.1.
M31658 mRNA. Translation: AAA37739.1.
AK018796 mRNA. Translation: BAB31418.1.
BC068204 mRNA. Translation: AAH68204.1.
CCDSiCCDS16976.1.
PIRiA41410.
RefSeqiNP_034415.1. NM_010285.2.
XP_006498835.1. XM_006498772.2.
UniGeneiMm.389327.

3D structure databases

ProteinModelPortaliP16043.
SMRiP16043. Positions 31-59.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi199916. 1 interaction.
STRINGi10090.ENSMUSP00000029172.

Proteomic databases

PaxDbiP16043.
PRIDEiP16043.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000029172; ENSMUSP00000029172; ENSMUSG00000027643.
ENSMUST00000109536; ENSMUSP00000105162; ENSMUSG00000027643.
GeneIDi14601.
KEGGimmu:14601.
UCSCiuc008nox.1. mouse.

Organism-specific databases

CTDi2691.
MGIiMGI:95709. Ghrh.

Phylogenomic databases

eggNOGiENOG410J1XI. Eukaryota.
ENOG410ZCJQ. LUCA.
HOGENOMiHOG000115417.
HOVERGENiHBG004478.
InParanoidiP16043.
KOiK05260.
OMAiIMSRQQG.
OrthoDBiEOG091G11MO.
PhylomeDBiP16043.
TreeFamiTF353187.

Enzyme and pathway databases

ReactomeiR-MMU-418555. G alpha (s) signalling events.
R-MMU-420092. Glucagon-type ligand receptors.

Miscellaneous databases

PROiP16043.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000027643.
CleanExiMM_GHRH.
ExpressionAtlasiP16043. baseline and differential.
GenevisibleiP16043. MM.

Family and domain databases

InterProiIPR000532. Glucagon_GIP_secretin_VIP.
[Graphical view]
PfamiPF00123. Hormone_2. 1 hit.
[Graphical view]
SMARTiSM00070. GLUCA. 1 hit.
[Graphical view]
PROSITEiPS00260. GLUCAGON. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSLIB_MOUSE
AccessioniPrimary (citable) accession number: P16043
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: September 7, 2016
This is version 134 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.