P16042 (NEU4_ONCKE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Vasotocin-neurophysin VT 2 Cleaved into the following 2 chains: Vasotocin Short name=VT Neurophysin VT 2
Organism	Oncorhynchus keta (Chum salmon) (Salmo keta)
Taxonomic identifier	8018 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Actinopterygii › Actinopteri › Neopterygii › Teleostei › Elopocephala › Clupeocephala › Euteleostei › Protacanthopterygii › Salmoniformes › Salmonoidei › Salmonidae › Salmoninae › Oncorhynchus

Protein attributes

Sequence length	158 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Vasotocin is an antidiuretic hormone.
Subcellular location	Secreted.
Post-translational modification	Seven disulfide bonds are present in neurophysin By similarity.
Sequence similarities	Belongs to the vasopressin/oxytocin family.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Molecular function	Hormone
PTM	Amidation Cleavage on pair of basic residues Disulfide bond
Gene Ontology (GO)
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 19	19
	Peptide	20 – 28	9	Vasotocin		PRO_0000020568
	Chain	32 – 158	127	Neurophysin VT 2		PRO_0000020569
Amino acid modifications
	Modified residue	28	1	Glycine amide By similarity
	Disulfide bond	20 ↔ 25		By similarity

Sequences

	Sequence		Length	Mass (Da)
	P16042 [UniParc]. Last modified April 1, 1990. Version 1. Checksum: F8002437A89611C4	FASTA	158	16,670
	10 20 30 40 50 60 MPHSTLLLCV IGLLAFSSAC YIQNCPRGGK RALQDTGIRQ CMTCGPGDQG HCFGPSICCG 70 80 90 100 110 120 EGLGCWMGSP ETARCFEENY LPTPCQTGGR PCGSDAGRCA APGVCCDSES CVLDPDCLSE 130 140 150 SRYHSPADHS AGATSDSPGE LLLRLLHFAT RGQSEYKQ

References

[1]	"Molecular cloning of two distinct vasotocin precursor cDNAs from chum salmon (Oncorhynchus keta) suggests an ancient gene duplication." Heierhorst J., Mahlmann S., Morley S.D., Coe I.R., Sherwood N.M., Richter D. FEBS Lett. 260:301-304(1990) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain.
[2]	"Cloning and sequence analyses of cDNAs encoding vasotocin and isotocin precursors of chum salmon, Oncorhynchus keta: evolutionary relationships of neurohypophysial hormone precursors." Hyodo S., Kato Y., Ono M., Urano A. J. Comp. Physiol. B 160:601-608(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Tsugaruishi. Tissue: Brain.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X17328 mRNA. Translation: CAA35206.1. D10943 mRNA. Translation: BAA01737.1. Sequence problems.
PIR	B34132.
3D structure databases
ProteinModelPortal	P16042.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
HOVERGEN	HBG004462.
Family and domain databases
Gene3D	2.60.9.10. 1 hit.
InterPro	IPR000981. Neurhyp_horm. IPR022423. Neurohypophysial_hormone_CS. [Graphical view]
PANTHER	PTHR11681. PTHR11681. 1 hit.
Pfam	PF00220. Hormone_4. 1 hit. PF00184. Hormone_5. 1 hit. [Graphical view]
PIRSF	PIRSF001815. Nonapeptide_hormone_precursor. 1 hit.
PRINTS	PR00831. NEUROPHYSIN.
ProDom	PD001676. Neurhyp_horm. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00003. NH. 1 hit. [Graphical view]
SUPFAM	SSF49606. Neurhyp_horm. 1 hit.
PROSITE	PS00264. NEUROHYPOPHYS_HORM. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

NEU4_ONCKE

Accession

Primary (citable) accession number: P16042
Secondary accession number(s): Q91174

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 1, 1990
Last sequence update:	April 1, 1990
Last modified:	May 1, 2013
This is version 74 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program