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P16039

- NPM_CHICK

UniProt

P16039 - NPM_CHICK

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Protein

Nucleophosmin

Gene

NPM1

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Acts as a chaperonin for the core histones H3, H2B and H4. Associated with nucleolar ribonucleoprotein structures and bind single-stranded nucleic acids. It may function in the assembly and/or transport of ribosome. May stimulate endonuclease activity on apurinic/apyrimidinic (AP) double-stranded DNA. May inhibit endonuclease activity on AP single-stranded RNA By similarity.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei57 – 571Interaction between pentamersBy similarity
Sitei82 – 821Interaction between pentamersBy similarity

GO - Molecular functioni

  1. NF-kappaB binding Source: UniProtKB
  2. RNA binding Source: UniProtKB-KW
  3. unfolded protein binding Source: UniProtKB

GO - Biological processi

  1. cell aging Source: UniProtKB
  2. centrosome cycle Source: UniProtKB
  3. DNA repair Source: UniProtKB
  4. negative regulation of cell proliferation Source: UniProtKB
  5. regulation of endodeoxyribonuclease activity Source: UniProtKB
  6. regulation of endoribonuclease activity Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleophosmin
Short name:
NPM
Alternative name(s):
Nucleolar phosphoprotein B23
Nucleolar protein NO38
Numatrin
Gene namesi
Name:NPM1
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Unplaced

Subcellular locationi

Cytoplasm By similarity. Nucleusnucleoplasm By similarity. Nucleusnucleolus By similarity
Note: Generally nucleolar, but is translocated to the nucleoplasm in case of serum starvation or treatment with anticancer drugs.By similarity

GO - Cellular componenti

  1. centrosome Source: UniProtKB
  2. cytoplasm Source: UniProtKB
  3. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 294294NucleophosminPRO_0000219484Add
BLAST

Post-translational modificationi

Phosphorylated.

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP16039.
PRIDEiP16039.

Interactioni

Subunit structurei

Decamer formed by two pentameric rings associated in a head-to-head fashion.By similarity

Protein-protein interaction databases

BioGridi676463. 1 interaction.
STRINGi9031.ENSGALP00000034087.

Structurei

3D structure databases

ProteinModelPortaliP16039.
SMRiP16039. Positions 17-120, 243-294.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi153 – 1586Nuclear localization signalSequence Analysis
Motifi190 – 1967Nuclear localization signalSequence Analysis

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi1 – 1111Met-richAdd
BLAST
Compositional biasi122 – 13312Asp/Glu-rich (acidic)Add
BLAST
Compositional biasi161 – 18626Asp/Glu-rich (highly acidic)Add
BLAST

Sequence similaritiesi

Belongs to the nucleoplasmin family.Curated

Phylogenomic databases

eggNOGiNOG79897.
HOGENOMiHOG000013061.
HOVERGENiHBG001860.
InParanoidiP16039.
KOiK11276.
PhylomeDBiP16039.

Family and domain databases

Gene3Di2.60.120.340. 1 hit.
InterProiIPR004301. Nucleoplasmin.
IPR024057. Nucleoplasmin_core_dom.
[Graphical view]
PANTHERiPTHR22747. PTHR22747. 1 hit.
SUPFAMiSSF69203. SSF69203. 1 hit.

Sequencei

Sequence statusi: Complete.

P16039-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEDSAMDMES MGPLRPQTFL FGCELKAEKE YQFKVDDEEN EHQLSLRTVT
60 70 80 90 100
LGAGAKDELH VVEAEALDYE GNPTKVVLAS LKMSVQPTVS LGGFEITPPF
110 120 130 140 150
VLRLKCGSGP VYVSGQHLVA LEEEPESEDE EEDTKIGNAS TKRPASGGGA
160 170 180 190 200
KTPQKKPKLS EDDEDDDEDE DDDEDDEDDL DDDEEEIKTP MKKPAREPAG
210 220 230 240 250
KNMQKAKQNG KDSKPSTPAS KTKTPDSKKD KSLTPKTPKV PLSLEEIKAK
260 270 280 290
MQASVDKGCS LPKLEPKFAN YVKNCFRTED QKVIQALWQW RQTL
Length:294
Mass (Da):32,632
Last modified:April 1, 1990 - v1
Checksum:iB1FF89B5F2322DED
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X17200 mRNA. Translation: CAA35061.1.
PIRiS08415. DNCHFM.
RefSeqiNP_990598.1. NM_205267.1.
UniGeneiGga.4847.

Genome annotation databases

GeneIDi396203.
KEGGigga:396203.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X17200 mRNA. Translation: CAA35061.1 .
PIRi S08415. DNCHFM.
RefSeqi NP_990598.1. NM_205267.1.
UniGenei Gga.4847.

3D structure databases

ProteinModelPortali P16039.
SMRi P16039. Positions 17-120, 243-294.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 676463. 1 interaction.
STRINGi 9031.ENSGALP00000034087.

Proteomic databases

PaxDbi P16039.
PRIDEi P16039.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 396203.
KEGGi gga:396203.

Organism-specific databases

CTDi 4869.

Phylogenomic databases

eggNOGi NOG79897.
HOGENOMi HOG000013061.
HOVERGENi HBG001860.
InParanoidi P16039.
KOi K11276.
PhylomeDBi P16039.

Miscellaneous databases

NextBioi 20816255.
PROi P16039.

Family and domain databases

Gene3Di 2.60.120.340. 1 hit.
InterProi IPR004301. Nucleoplasmin.
IPR024057. Nucleoplasmin_core_dom.
[Graphical view ]
PANTHERi PTHR22747. PTHR22747. 1 hit.
SUPFAMi SSF69203. SSF69203. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "cDNA sequences of chicken nucleolin/C23 and NO38/B23, two major nucleolar proteins."
    Maridor G., Nigg E.A.
    Nucleic Acids Res. 18:1286-1286(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Structure and developmental expression of chicken nucleolin and NO38: coordinate expression of two abundant non-ribosomal nucleolar proteins."
    Maridor G., Krek W., Nigg E.A.
    Biochim. Biophys. Acta 1049:126-133(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISCUSSION OF SEQUENCE.
  3. "Major nucleolar proteins shuttle between nucleus and cytoplasm."
    Borer R.A., Lehner C.F., Eppenberger H.M., Nigg E.A.
    Cell 56:379-390(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.

Entry informationi

Entry nameiNPM_CHICK
AccessioniPrimary (citable) accession number: P16039
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: October 29, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3