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P16039

- NPM_CHICK

UniProt

P16039 - NPM_CHICK

Protein

Nucleophosmin

Gene

NPM1

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 83 (01 Oct 2014)
      Sequence version 1 (01 Apr 1990)
      Previous versions | rss
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    Functioni

    Acts as a chaperonin for the core histones H3, H2B and H4. Associated with nucleolar ribonucleoprotein structures and bind single-stranded nucleic acids. It may function in the assembly and/or transport of ribosome. May stimulate endonuclease activity on apurinic/apyrimidinic (AP) double-stranded DNA. May inhibit endonuclease activity on AP single-stranded RNA By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei57 – 571Interaction between pentamersBy similarity
    Sitei82 – 821Interaction between pentamersBy similarity

    GO - Molecular functioni

    1. NF-kappaB binding Source: UniProtKB
    2. RNA binding Source: UniProtKB-KW
    3. unfolded protein binding Source: UniProtKB

    GO - Biological processi

    1. cell aging Source: UniProtKB
    2. centrosome cycle Source: UniProtKB
    3. DNA repair Source: UniProtKB
    4. negative regulation of cell proliferation Source: UniProtKB
    5. regulation of endodeoxyribonuclease activity Source: UniProtKB
    6. regulation of endoribonuclease activity Source: UniProtKB

    Keywords - Molecular functioni

    Chaperone

    Keywords - Ligandi

    RNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Nucleophosmin
    Short name:
    NPM
    Alternative name(s):
    Nucleolar phosphoprotein B23
    Nucleolar protein NO38
    Numatrin
    Gene namesi
    Name:NPM1
    OrganismiGallus gallus (Chicken)
    Taxonomic identifieri9031 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
    ProteomesiUP000000539: Unplaced

    Subcellular locationi

    Cytoplasm By similarity. Nucleusnucleoplasm By similarity. Nucleusnucleolus By similarity
    Note: Generally nucleolar, but is translocated to the nucleoplasm in case of serum starvation or treatment with anticancer drugs.By similarity

    GO - Cellular componenti

    1. centrosome Source: UniProtKB
    2. cytoplasm Source: UniProtKB
    3. nucleolus Source: UniProtKB-SubCell
    4. nucleoplasm Source: UniProtKB-SubCell
    5. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 294294NucleophosminPRO_0000219484Add
    BLAST

    Post-translational modificationi

    Phosphorylated.

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiP16039.
    PRIDEiP16039.

    Interactioni

    Subunit structurei

    Decamer formed by two pentameric rings associated in a head-to-head fashion.By similarity

    Protein-protein interaction databases

    BioGridi676463. 1 interaction.
    STRINGi9031.ENSGALP00000034087.

    Structurei

    3D structure databases

    ProteinModelPortaliP16039.
    SMRiP16039. Positions 17-120, 243-294.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi153 – 1586Nuclear localization signalSequence Analysis
    Motifi190 – 1967Nuclear localization signalSequence Analysis

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi1 – 1111Met-richAdd
    BLAST
    Compositional biasi122 – 13312Asp/Glu-rich (acidic)Add
    BLAST
    Compositional biasi161 – 18626Asp/Glu-rich (highly acidic)Add
    BLAST

    Sequence similaritiesi

    Belongs to the nucleoplasmin family.Curated

    Phylogenomic databases

    eggNOGiNOG79897.
    HOGENOMiHOG000013061.
    HOVERGENiHBG001860.
    InParanoidiP16039.
    KOiK11276.
    PhylomeDBiP16039.

    Family and domain databases

    Gene3Di2.60.120.340. 1 hit.
    InterProiIPR004301. Nucleoplasmin.
    IPR024057. Nucleoplasmin_core_dom.
    [Graphical view]
    PANTHERiPTHR22747. PTHR22747. 1 hit.
    SUPFAMiSSF69203. SSF69203. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P16039-1 [UniParc]FASTAAdd to Basket

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    MEDSAMDMES MGPLRPQTFL FGCELKAEKE YQFKVDDEEN EHQLSLRTVT    50
    LGAGAKDELH VVEAEALDYE GNPTKVVLAS LKMSVQPTVS LGGFEITPPF 100
    VLRLKCGSGP VYVSGQHLVA LEEEPESEDE EEDTKIGNAS TKRPASGGGA 150
    KTPQKKPKLS EDDEDDDEDE DDDEDDEDDL DDDEEEIKTP MKKPAREPAG 200
    KNMQKAKQNG KDSKPSTPAS KTKTPDSKKD KSLTPKTPKV PLSLEEIKAK 250
    MQASVDKGCS LPKLEPKFAN YVKNCFRTED QKVIQALWQW RQTL 294
    Length:294
    Mass (Da):32,632
    Last modified:April 1, 1990 - v1
    Checksum:iB1FF89B5F2322DED
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X17200 mRNA. Translation: CAA35061.1.
    PIRiS08415. DNCHFM.
    RefSeqiNP_990598.1. NM_205267.1.
    UniGeneiGga.4847.

    Genome annotation databases

    GeneIDi396203.
    KEGGigga:396203.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X17200 mRNA. Translation: CAA35061.1 .
    PIRi S08415. DNCHFM.
    RefSeqi NP_990598.1. NM_205267.1.
    UniGenei Gga.4847.

    3D structure databases

    ProteinModelPortali P16039.
    SMRi P16039. Positions 17-120, 243-294.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 676463. 1 interaction.
    STRINGi 9031.ENSGALP00000034087.

    Proteomic databases

    PaxDbi P16039.
    PRIDEi P16039.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 396203.
    KEGGi gga:396203.

    Organism-specific databases

    CTDi 4869.

    Phylogenomic databases

    eggNOGi NOG79897.
    HOGENOMi HOG000013061.
    HOVERGENi HBG001860.
    InParanoidi P16039.
    KOi K11276.
    PhylomeDBi P16039.

    Miscellaneous databases

    NextBioi 20816255.
    PROi P16039.

    Family and domain databases

    Gene3Di 2.60.120.340. 1 hit.
    InterProi IPR004301. Nucleoplasmin.
    IPR024057. Nucleoplasmin_core_dom.
    [Graphical view ]
    PANTHERi PTHR22747. PTHR22747. 1 hit.
    SUPFAMi SSF69203. SSF69203. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "cDNA sequences of chicken nucleolin/C23 and NO38/B23, two major nucleolar proteins."
      Maridor G., Nigg E.A.
      Nucleic Acids Res. 18:1286-1286(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Structure and developmental expression of chicken nucleolin and NO38: coordinate expression of two abundant non-ribosomal nucleolar proteins."
      Maridor G., Krek W., Nigg E.A.
      Biochim. Biophys. Acta 1049:126-133(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: DISCUSSION OF SEQUENCE.
    3. "Major nucleolar proteins shuttle between nucleus and cytoplasm."
      Borer R.A., Lehner C.F., Eppenberger H.M., Nigg E.A.
      Cell 56:379-390(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiNPM_CHICK
    AccessioniPrimary (citable) accession number: P16039
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1990
    Last sequence update: April 1, 1990
    Last modified: October 1, 2014
    This is version 83 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3