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P16039 (NPM_CHICK) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 82. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Nucleophosmin

Short name=NPM
Alternative name(s):
Nucleolar phosphoprotein B23
Nucleolar protein NO38
Numatrin
Gene names
Name:NPM1
OrganismGallus gallus (Chicken) [Reference proteome]
Taxonomic identifier9031 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus

Protein attributes

Sequence length294 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Acts as a chaperonin for the core histones H3, H2B and H4. Associated with nucleolar ribonucleoprotein structures and bind single-stranded nucleic acids. It may function in the assembly and/or transport of ribosome. May stimulate endonuclease activity on apurinic/apyrimidinic (AP) double-stranded DNA. May inhibit endonuclease activity on AP single-stranded RNA By similarity.

Subunit structure

Decamer formed by two pentameric rings associated in a head-to-head fashion By similarity.

Subcellular location

Cytoplasm By similarity. Nucleusnucleoplasm By similarity. Nucleusnucleolus By similarity. Note: Generally nucleolar, but is translocated to the nucleoplasm in case of serum starvation or treatment with anticancer drugs By similarity. Ref.3

Post-translational modification

Phosphorylated.

Sequence similarities

Belongs to the nucleoplasmin family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 294294Nucleophosmin
PRO_0000219484

Regions

Motif153 – 1586Nuclear localization signal Potential
Motif190 – 1967Nuclear localization signal Potential
Compositional bias1 – 1111Met-rich
Compositional bias122 – 13312Asp/Glu-rich (acidic)
Compositional bias161 – 18626Asp/Glu-rich (highly acidic)

Sites

Site571Interaction between pentamers By similarity
Site821Interaction between pentamers By similarity

Sequences

Sequence LengthMass (Da)Tools
P16039 [UniParc].

Last modified April 1, 1990. Version 1.
Checksum: B1FF89B5F2322DED

FASTA29432,632
        10         20         30         40         50         60 
MEDSAMDMES MGPLRPQTFL FGCELKAEKE YQFKVDDEEN EHQLSLRTVT LGAGAKDELH 

        70         80         90        100        110        120 
VVEAEALDYE GNPTKVVLAS LKMSVQPTVS LGGFEITPPF VLRLKCGSGP VYVSGQHLVA 

       130        140        150        160        170        180 
LEEEPESEDE EEDTKIGNAS TKRPASGGGA KTPQKKPKLS EDDEDDDEDE DDDEDDEDDL 

       190        200        210        220        230        240 
DDDEEEIKTP MKKPAREPAG KNMQKAKQNG KDSKPSTPAS KTKTPDSKKD KSLTPKTPKV 

       250        260        270        280        290 
PLSLEEIKAK MQASVDKGCS LPKLEPKFAN YVKNCFRTED QKVIQALWQW RQTL 

« Hide

References

[1]"cDNA sequences of chicken nucleolin/C23 and NO38/B23, two major nucleolar proteins."
Maridor G., Nigg E.A.
Nucleic Acids Res. 18:1286-1286(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Structure and developmental expression of chicken nucleolin and NO38: coordinate expression of two abundant non-ribosomal nucleolar proteins."
Maridor G., Krek W., Nigg E.A.
Biochim. Biophys. Acta 1049:126-133(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: DISCUSSION OF SEQUENCE.
[3]"Major nucleolar proteins shuttle between nucleus and cytoplasm."
Borer R.A., Lehner C.F., Eppenberger H.M., Nigg E.A.
Cell 56:379-390(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X17200 mRNA. Translation: CAA35061.1.
PIRDNCHFM. S08415.
RefSeqNP_990598.1. NM_205267.1.
UniGeneGga.4847.

3D structure databases

ProteinModelPortalP16039.
SMRP16039. Positions 17-120, 243-294.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid676463. 1 interaction.
STRING9031.ENSGALP00000034087.

Proteomic databases

PaxDbP16039.
PRIDEP16039.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID396203.
KEGGgga:396203.

Organism-specific databases

CTD4869.

Phylogenomic databases

eggNOGNOG79897.
HOGENOMHOG000013061.
HOVERGENHBG001860.
InParanoidP16039.
KOK11276.
PhylomeDBP16039.

Family and domain databases

Gene3D2.60.120.340. 1 hit.
InterProIPR004301. Nucleoplasmin.
IPR024057. Nucleoplasmin_core_dom.
[Graphical view]
PANTHERPTHR22747. PTHR22747. 1 hit.
SUPFAMSSF69203. SSF69203. 1 hit.
ProtoNetSearch...

Other

NextBio20816255.
PROP16039.

Entry information

Entry nameNPM_CHICK
AccessionPrimary (citable) accession number: P16039
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: April 16, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families