P16026 (SODE_SCHMA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Extracellular superoxide dismutase [Cu-Zn] Short name=EC-SOD EC=1.15.1.1
Organism	Schistosoma mansoni (Blood fluke)
Taxonomic identifier	6183 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Platyhelminthes › Trematoda › Digenea › Strigeidida › Schistosomatoidea › Schistosomatidae › Schistosoma

Protein attributes

Sequence length	184 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
Catalytic activity	2 superoxide + 2 H+ = O2 + H2O2.
Cofactor	Binds 1 copper ion per subunit By similarity. Binds 1 zinc ion per subunit By similarity.
Subunit structure	Homodimer.
Subcellular location	Secreted › extracellular space.
Sequence similarities	Belongs to the Cu-Zn superoxide dismutase family.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Ligand	Copper Metal-binding Zinc
Molecular function	Antioxidant Oxidoreductase
PTM	Disulfide bond Glycoprotein
Gene Ontology (GO)
Biological_process	superoxide metabolic process Inferred from electronic annotation. Source: InterPro
Cellular_component	extracellular space Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW superoxide dismutase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 18	18
	Chain	19 – 184	166	Extracellular superoxide dismutase [Cu-Zn]		PRO_0000032865
Sites
	Metal binding	76	1	Copper; catalytic By similarity
	Metal binding	78	1	Copper; catalytic By similarity
	Metal binding	93	1	Copper; catalytic By similarity
	Metal binding	93	1	Zinc; structural By similarity
	Metal binding	101	1	Zinc; structural By similarity
	Metal binding	110	1	Zinc; structural By similarity
	Metal binding	113	1	Zinc; structural By similarity
	Metal binding	150	1	Copper; catalytic By similarity
Amino acid modifications
	Glycosylation	61	1	N-linked (GlcNAc...) Potential
	Disulfide bond	87 ↔ 176		By similarity

Sequences

	Sequence		Length	Mass (Da)
	P16026 [UniParc]. Last modified April 1, 1990. Version 1. Checksum: C14FD37026FA88B3	FASTA	184	20,346
	10 20 30 40 50 60 MTVYSYLVIL FILLDNYCSA YGYGYSYYHR RHFDPAIASF TKEPYIGAVW FTQHGDYMYV 70 80 90 100 110 120 NGSVAGLPPG KLLGTHVHRY GGLGNMCLEA GPHFNPFNQR HGPRHGYPRH AGDLGNIRVG 130 140 150 160 170 180 RGGVAKFDFY VTIKGLGPFD GFIGRALVIH ANRDDLGRNR DEGSRTTGNS GPRLACATIG FRAP

References

[1]	"Schistosoma mansoni: identification and analysis of an mRNA and a gene encoding superoxide dismutase (Cu/Zn)." Simurda M.C., van Kuelen H., Rekosh D.M., Loverde P.T. Exp. Parasitol. 67:73-84(1988) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	M27529 mRNA. Translation: AAA29937.1. M28545, M28543, M28544 Genomic DNA. Translation: AAA29934.1.
PIR	A37019.
RefSeq	XP_002580485.1. XM_002580439.1.
UniGene	Sma.277.
3D structure databases
ProteinModelPortal	P16026.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	8341691.
KEGG	smm:Smp_095980.
Organism-specific databases
CTD	8341691.
Phylogenomic databases
HOGENOM	HOG000263447.
PhylomeDB	P16026.
Family and domain databases
Gene3D	2.60.40.200. 1 hit.
InterPro	IPR024134. SOD_Cu/Zn_/chaperones. IPR018152. SOD_Cu/Zn_BS. IPR001424. SOD_Cu_Zn_dom. [Graphical view]
PANTHER	PTHR10003. PTHR10003. 1 hit.
Pfam	PF00080. Sod_Cu. 1 hit. [Graphical view]
PRINTS	PR00068. CUZNDISMTASE.
SUPFAM	SSF49329. SOD_Cu_Zn. 1 hit.
PROSITE	PS00087. SOD_CU_ZN_1. 1 hit. PS00332. SOD_CU_ZN_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SODE_SCHMA

Accession

Primary (citable) accession number: P16026

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 1, 1990
Last sequence update:	April 1, 1990
Last modified:	April 3, 2013
This is version 87 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)